Methanolic extract of S. securidaca flowers, leaves, and seeds' antihyperlipidemic effects on high fat diet-induced hyperlipidemia in Wistar rats.

Significant risk factors for atherosclerosis include hyperlipidemia and oxidative stress, which together rank as three of the most significant risk factors for cardiovascular diseases. Securigera securidaca lowers cholesterol levels in diabetic rats' blood. This investigation's objective was to determine how methanolic extracts affected the flowers, leaves, and seeds of plants in rats that were fed a high-fat diet (HFD). Five groups of animals were created (n = 5). A total of 35 days, divided into two intervals, were used for the study. Rats received HFD during the first 15-day interval, while during the second 20-day interval, they also received extracts or the Atorvastatin reference drug. The extract of seeds has a high phenol content as well as DPPH radical antioxidant activity. Extracts were given at a dose of 200 mg/kg; p.o. Methanolic treatment of S. securidaca flowers, leaves, and seeds in HFD-induced hyperlipidemic rats resulted in significant reductions in total cholesterol, triglycerides, LDLC, and VLDL-C levels. HDL-C levels increased significantly because of the leaves. While in hyperlipidemic rats, seeds significantly reduced the activities of the enzymes ALT and ALP. The findings showed that, to a certain extent, seeds, flowers, and leaves may have benefits in reducing hyperlipidemia brought on by HFD in terms of lipid profiles and liver function enzymes. The findings of this study indicate a promising application prospect, but more research is needed to determine the exact mechanism of these novel compounds as antihyperlipidemic agents and to clarify their potential combination effect with synthetic drugs such as Atorvastatin. Combinations can reduce the dose of chemical medications required, which lowers the risk of side effects.

Comparative Analysis of Phytochemical Composition of Ethanolic Extract of Jordanian Silvia officinalis.

BACKGROUND AND OBJECTIVES: Salvia officinalis (Sage) is a plant native to the Middle East and Mediterranean areas. It is from the family of Labiatae used for the treatment of different kinds of disorders. In the present study, ethanolic extracts of Salvia officinalis screened for its chemical composition. MATERIALS AND METHODS: The extract obtained from Silvia officinalis growing wild in Al-Karak, Jordan, investigated for its photo components for the first time. The extract analyzed by GC-MS and HPLC instruments. The aerial part of the plant collected at the beginning of spring 2018. RESULTS: Results show that the ethanolic extract has 28 natural compounds with 95.30% of the total identified components. Two peaks with 4.70% of total composition could not be identified. This analysis revealed that the compounds are mainly composed of aromatics and oxygenated hydrocarbons. Such as; L-Ascorbic acid, Silane, D-Glucuronic acid, Phenobarbital and Undecanedioic acid. CONCLUSION: Overall this study highlights the identification of several oxygenated hydrocarbons of phytochemical compounds with two unknown components. Further investigation is needed for structural elucidation directed with pharmacological activity.