Analysis of WSI Images by Hybrid Systems with Fusion Features for Early Diagnosis of Cervical Cancer.

Cervical cancer is one of the most common types of malignant tumors in women. In addition, it causes death in the latter stages. Squamous cell carcinoma is the most common and aggressive form of cervical cancer and must be diagnosed early before it progresses to a dangerous stage. Liquid-based cytology (LBC) swabs are best and most commonly used for cervical cancer screening and are converted from glass slides to whole-slide images (WSIs) for computer-assisted analysis. Manual diagnosis by microscopes is limited and prone to manual errors, and tracking all cells is difficult. Therefore, the development of computational techniques is important as diagnosing many samples can be done automatically, quickly, and efficiently, which is beneficial for medical laboratories and medical professionals. This study aims to develop automated WSI image analysis models for early diagnosis of a cervical squamous cell dataset. Several systems have been designed to analyze WSI images and accurately distinguish cervical cancer progression. For all proposed systems, the WSI images were optimized to show the contrast of edges of the low-contrast cells. Then, the cells to be analyzed were segmented and isolated from the rest of the image using the Active Contour Algorithm (ACA). WSI images were diagnosed by a hybrid method between deep learning (ResNet50, VGG19 and GoogLeNet), Random Forest (RF), and Support Vector Machine (SVM) algorithms based on the ACA algorithm. Another hybrid method for diagnosing WSI images by RF and SVM algorithms is based on fused features of deep-learning (DL) models (ResNet50-VGG19, VGG19-GoogLeNet, and ResNet50-GoogLeNet). It is concluded from the systems' performance that the DL models' combined features help significantly improve the performance of the RF and SVM networks. The novelty of this research is the hybrid method that combines the features extracted from deep-learning models (ResNet50-VGG19, VGG19-GoogLeNet, and ResNet50-GoogLeNet) with RF and SVM algorithms for diagnosing WSI images. The results demonstrate that the combined features from deep-learning models significantly improve the performance of RF and SVM. The RF network with fused features of ResNet50-VGG19 achieved an AUC of 98.75%, a sensitivity of 97.4%, an accuracy of 99%, a precision of 99.6%, and a specificity of 99.2%.

Hybrid Models Based on Fusion Features of a CNN and Handcrafted Features for Accurate Histopathological Image Analysis for Diagnosing Malignant Lymphomas.

Malignant lymphoma is one of the most severe types of disease that leads to death as a result of exposure of lymphocytes to malignant tumors. The transformation of cells from indolent B-cell lymphoma to B-cell lymphoma (DBCL) is life-threatening. Biopsies taken from the patient are the gold standard for lymphoma analysis. Glass slides under a microscope are converted into whole slide images (WSI) to be analyzed by AI techniques through biomedical image processing. Because of the multiplicity of types of malignant lymphomas, manual diagnosis by pathologists is difficult, tedious, and subject to disagreement among physicians. The importance of artificial intelligence (AI) in the early diagnosis of malignant lymphoma is significant and has revolutionized the field of oncology. The use of AI in the early diagnosis of malignant lymphoma offers numerous benefits, including improved accuracy, faster diagnosis, and risk stratification. This study developed several strategies based on hybrid systems to analyze histopathological images of malignant lymphomas. For all proposed models, the images and extraction of malignant lymphocytes were optimized by the gradient vector flow (GVF) algorithm. The first strategy for diagnosing malignant lymphoma images relied on a hybrid system between three types of deep learning (DL) networks, XGBoost algorithms, and decision tree (DT) algorithms based on the GVF algorithm. The second strategy for diagnosing malignant lymphoma images was based on fusing the features of the MobileNet-VGG16, VGG16-AlexNet, and MobileNet-AlexNet models and classifying them by XGBoost and DT algorithms based on the ant colony optimization (ACO) algorithm. The color, shape, and texture features, which are called handcrafted features, were extracted by four traditional feature extraction algorithms. Because of the similarity in the biological characteristics of early-stage malignant lymphomas, the features of the fused MobileNet-VGG16, VGG16-AlexNet, and MobileNet-AlexNet models were combined with the handcrafted features and classified by the XGBoost and DT algorithms based on the ACO algorithm. We concluded that the performance of the two networks XGBoost and DT, with fused features between DL networks and handcrafted, achieved the best performance. The XGBoost network based on the fused features of MobileNet-VGG16 and handcrafted features resulted in an AUC of 99.43%, accuracy of 99.8%, precision of 99.77%, sensitivity of 99.7%, and specificity of 99.8%. This highlights the significant role of AI in the early diagnosis of malignant lymphoma, offering improved accuracy, expedited diagnosis, and enhanced risk stratification. This study highlights leveraging AI techniques and biomedical image processing; the analysis of whole slide images (WSI) converted from biopsies allows for improved accuracy, faster diagnosis, and risk stratification. The developed strategies based on hybrid systems, combining deep learning networks, XGBoost and decision tree algorithms, demonstrated promising results in diagnosing malignant lymphoma images. Furthermore, the fusion of handcrafted features with features extracted from DL networks enhanced the performance of the classification models.

Automatic and Early Detection of Parkinson's Disease by Analyzing Acoustic Signals Using Classification Algorithms Based on Recursive Feature Elimination Method.

Parkinson's disease (PD) is a neurodegenerative condition generated by the dysfunction of brain cells and their 60-80% inability to produce dopamine, an organic chemical responsible for controlling a person's movement. This condition causes PD symptoms to appear. Diagnosis involves many physical and psychological tests and specialist examinations of the patient's nervous system, which causes several issues. The methodology method of early diagnosis of PD is based on analysing voice disorders. This method extracts a set of features from a recording of the person's voice. Then machine-learning (ML) methods are used to analyse and diagnose the recorded voice to distinguish Parkinson's cases from healthy ones. This paper proposes novel techniques to optimize the techniques for early diagnosis of PD by evaluating selected features and hyperparameter tuning of ML algorithms for diagnosing PD based on voice disorders. The dataset was balanced by the synthetic minority oversampling technique (SMOTE) and features were arranged according to their contribution to the target characteristic by the recursive feature elimination (RFE) algorithm. We applied two algorithms, t-distributed stochastic neighbour embedding (t-SNE) and principal component analysis (PCA), to reduce the dimensions of the dataset. Both t-SNE and PCA finally fed the resulting features into the classifiers support-vector machine (SVM), K-nearest neighbours (KNN), decision tree (DT), random forest (RF), and multilayer perception (MLP). Experimental results proved that the proposed techniques were superior to existing studies in which RF with the t-SNE algorithm yielded an accuracy of 97%, precision of 96.50%, recall of 94%, and F1-score of 95%. In addition, MLP with the PCA algorithm yielded an accuracy of 98%, precision of 97.66%, recall of 96%, and F1-score of 96.66%.

Effective Early Detection of Epileptic Seizures through EEG Signals Using Classification Algorithms Based on t-Distributed Stochastic Neighbor Embedding and K-Means.

Epilepsy is a neurological disorder in the activity of brain cells that leads to seizures. An electroencephalogram (EEG) can detect seizures as it contains physiological information of the neural activity of the brain. However, visual examination of EEG by experts is time consuming, and their diagnoses may even contradict each other. Thus, an automated computer-aided diagnosis for EEG diagnostics is necessary. Therefore, this paper proposes an effective approach for the early detection of epilepsy. The proposed approach involves the extraction of important features and classification. First, signal components are decomposed to extract the features via the discrete wavelet transform (DWT) method. Principal component analysis (PCA) and the t-distributed stochastic neighbor embedding (t-SNE) algorithm were applied to reduce the dimensions and focus on the most important features. Subsequently, K-means clustering + PCA and K-means clustering + t-SNE were used to divide the dataset into subgroups to reduce the dimensions and focus on the most important representative features of epilepsy. The features extracted from these steps were fed to extreme gradient boosting, K-nearest neighbors (K-NN), decision tree (DT), random forest (RF) and multilayer perceptron (MLP) classifiers. The experimental results demonstrated that the proposed approach provides superior results to those of existing studies. During the testing phase, the RF classifier with DWT and PCA achieved an accuracy of 97.96%, precision of 99.1%, recall of 94.41% and F1 score of 97.41%. Moreover, the RF classifier with DWT and t-SNE attained an accuracy of 98.09%, precision of 99.1%, recall of 93.9% and F1 score of 96.21%. In comparison, the MLP classifier with PCA + K-means reached an accuracy of 98.98%, precision of 99.16%, recall of 95.69% and F1 score of 97.4%.

An Optimization-Linked Intelligent Security Algorithm for Smart Healthcare Organizations.

IoT-enabled healthcare apps are providing significant value to society by offering cost-effective patient monitoring solutions in IoT-enabled buildings. However, with a large number of users and sensitive personal information readily available in today's fast-paced, internet, and cloud-based environment, the security of these healthcare systems must be a top priority. The idea of safely storing a patient's health data in an electronic format raises issues regarding patient data privacy and security. Furthermore, with traditional classifiers, processing large amounts of data is a difficult challenge. Several computational intelligence approaches are useful for effectively categorizing massive quantities of data for this goal. For many of these reasons, a novel healthcare monitoring system that tracks disease processes and forecasts diseases based on the available data obtained from patients in distant communities is proposed in this study. The proposed framework consists of three major stages, namely data collection, secured storage, and disease detection. The data are collected using IoT sensor devices. After that, the homomorphic encryption (HE) model is used for secured data storage. Finally, the disease detection framework is designed with the help of Centered Convolutional Restricted Boltzmann Machines-based whale optimization (CCRBM-WO) algorithm. The experiment is conducted on a Python-based cloud tool. The proposed system outperforms current e-healthcare solutions, according to the findings of the experiments. The accuracy, precision, F1-measure, and recall of our suggested technique are 96.87%, 97.45%, 97.78%, and 98.57%, respectively, according to the proposed method.