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Theor Popul Biol
; 142: 46-56, 2021 12.
Article
En
| MEDLINE
| ID: mdl-34520824
Recently, the selection-recombination equation with a single selected site and an arbitrary number of neutral sites was solved by Alberti and Baake (2021) by means of the ancestral selection-recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection-recombination equation. We apply our method to systematically explain a long-standing observation concerning the dynamics of linkage disequilibrium between two neutral loci hitchhiking along with a selected one. In particular, this clarifies the nontrivial dependence on the position of the selected site.
Models, Genetic , Recombination, Genetic , Genetics, Population , Linkage Disequilibrium , Selection, Genetic