[Treatment with the peptide bioregulator retinalamine in patients with tuberculosis of the organ of vision].

The efficacy of the bioregulator retinalamine in the complex pathogenetic treatment was studied in patients with ocular tuberculosis. Ninety-seven patients (132 eyes) with tuberculous chorioretinitis in the inactive phase were examined. According to the treatment option, the patients were divided into 2 groups: 1) a study group and 2) a control one. Parabulbar injections of retinalamine were made in the study group. In the control one, conventional treatment was used as parabulbar injections of emoxypine (a synthetic antioxidant). As compared with the traditional treatment, retinalamine used in the treatment of patients with tuberculous choriorenitis without clinical signs was ascertained to substantially to improve retinal functional activity, as manifested as a 66.3% increase in visual acuity, a reduction in abnormal scotomas in the field of vision in 72.7% of cases, and electrophysiological parameters as the enhanced activity of the first retinal neuron in 88.3% of case, as shown by the ganz-feld electroretinogram and in 14.3% of cases, as indicated by macular electroretinogram. The higher activity of the second retinal neuron was recorded in 89.6 and 58.4% of cases, as seen in the ganz-feld and macular electroretinograms, respectively. Moreover, inclusion of retinalamine into the complex treatment in patients with tuberculous chorioretinitis slowed down the maturation rate of concomitant age-related cataract and prevented diminished vision in 97.8, 95.6, 66.7, and 53.3% of cases within the first, second, third, and fourth years after treatment, respectively.

[Results of retinalamine use in the treatment of tuberculous chorioretinitis].

The efficiency of the peptide bioregulator retinalamine in the complex treatment of patients with tuberculous chorioretinitis was studied. Ninety-seven patients (69 females and 28 males) with inactive tuberculous chorioretinitis (132 eyes) were followed up. According to the treatment option, the patients were divided into 2 groups: a study group and a control one. Parabulbar injections of retinalamine were used in the study group. The conventional treatment using parabulbar injections of emoxipine (an agent from the group of synthetic antioxidants) was performed in the control group. The results of treatment were assessed by visual acuity, the number of pathological scotomas in the field of vision and the findings of electrophysiological investigations (EPI). Analysis of the results of conventional versus peptide bioregulator therapy used in patients with inactive tuberculous chorioretinitis showed the advantages of retinalamine. This manifested itself as increased visual acuity in 66.3% of the patients receiving retinalamine while in the emoxipine-treated patients, visual acuity increased only in 20% of cases. In the patients taking retinalamine, the positive changes in the field of vision were statistically significant in the number of normal test objects, relative and absolute scotomas while in the emoxipine group, only the reduction in the number of absolute scotomas was significant. The values of EPI suggest that the peptide bioregulator is more effective in enhancing the functional activity of retinal neurons than the synthetic antioxidant.

[Criteria for the clinical cure of tuberculosis of the eye]. / O kriteriiakh klinicheskogo izlecheniia tuberkuleza glaz.

The results of examination were analyzed in 314 patients with tuberculosis of the eye, including 120 patients having its inactive phase. Tuberculin skin tests were performed in 31 patients; fluorescence angiography and photostress tests were conducted in 122 patients, and 120 patients underwent lacrimal fluid crystallography. To define the cure rate in tuberculosis of the eye, it is necessary to have a complex of criteria: no clinical signs of active tuberculous inflammation in the ocular tunics and environments; no clinical, X-ray, and laboratory manifestations of tuberculosis of other organs; no focal and significant overall reaction to tuberculin injected in doses of 2 and 50 TU. If there are contraindications to tuberculin skin tests to conclude whether the disease is cured, it is necessary to use fluorescence angiography of the fundus of the eye, lacrimal fluid crystallography, and/or photostress tests in combination with biochemical and immunological blood studies.

[Criteria for clinical recovery in ocular tuberculosis]. / Kriterii klinicheskogo islecheniia tuberkuleza glaz.

The paper analyzes the results of examination of 314 patients with ocular tuberculosis, 120 of them had quiescent tuberculosis. Thirty one patients underwent tuberculin tests; 122 had fluorescence angiography and photo stress test; 120, lacrimal crystallography. To determine the degree of recovery requires a complex of criteria: neither clinical signs of active tuberculous inflammation in the retina and medium of the eye, no clinical, X-ray, and laboratory manifestations of tuberculosis of other sites, or a focal and much significant overall response to tuberculin in doses of 2 TE and 50 TE. If there are contraindications to tuberculin tests, a conclusion on recovery should be made by using fluorescence angiography of the fundus of the eye, crystallography of the tear and/or photo stress test in combination with blood biochemical and immunological studies.

[On the Kraup-Posner-Schlossmann syndrome]. / K voprosu o sindrome Kraupa-Poznera-Shlossmana.

Five patients with the Kraup-Posner-Schlossmann syndrome are described. The disease has been erroneously taken for chronic serous iridocyclitis of tuberculous origin with hypertension. One patients later developed a true glaucomatous process. The authors believe that the complex of characteristic symptoms of glaucomatous crisis in general can be considered pathognomonic for this disease. No differential diagnosis for ruling out tuberculous or other (endogenous) iridocyclitis is needed in cases when this complex is present. Patients with symptomatic ophthalmic hypertension are in need of regular check-ups.

[Peripapillary geographic choriopathy]. / Peripapilliarnaia geograficheskaia khoriopatiia.

Examinations of 179 patients with peripapillary geographic choriopathy (PGC) revealed that peripapillary landscape-like foci often involving the macula and periphery of the fundus oculi are the pathognomonic symptom of PGC which permits the diagnosis of the condition without additional examinations in more than 90% of patients. The incidence and types of complications are assessed. The possibility of a unilateral disease is proven. Previous data on the nontuberculous origin of PGC have been confirmed.