Antibacterial Activity and Shear Bond Strength of Orthodontic Adhesive Containing Various Sizes of Chitosan Nanoparticles: An In Vitro Study.

INTRODUCTION: White spot lesions are common after orthodontic treatment. Chitosan nanoparticles (CS-NPs) have emerged as promising antibacterial agents that inhibit the growth of Streptococcus mutans. The aim of the study was to investigate the nano-effect of adhesives containing CS-NPs on S. mutans and their effects on shear bond strength. MATERIALS AND METHODS: The inhibitory effects of two sizes of CS-NPs were assessed using the disc agar diffusion method. Four wells were created in the petri dishes, and each was inoculated with broth (negative control), chlorhexidine (positive control), CS-NPs (20 nm), or CS-NPs (131 nm). An Instron machine was used to evaluate shear bond strength by allocating 24 teeth into three groups, and all measurements were recorded in megapascals. Caries progression was assessed using the International Caries Detection and Assessment System and surface profilometry. Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 27.0 (Released 2020; IBM Corp., Armonk, New York, United States) for a one-way ANOVA followed by Tukey's multiple comparison test. RESULTS: Disc agar diffusion showed a reduction in S. mutans in the CS-NP group compared to the control (p < 0.001), with no statistical significance between the sizes of 20 and 131 nm (p = 0.95). Regarding shear bond strength, no differences were recorded when adhesive-containing CS-NPs and the control were compared (p = 0.44). Additionally, no differences were found within the CS-NP groups (p = 0.91). Caries assessments showed excellent agreement, as indicated by a weighted kappa. Profilometry readings showed higher surface roughness in the control than in the CS-NP groups (p < 0.001), with no statistically significant difference between the CS-NP groups (p = 0.72). CONCLUSION: CS-NPs of both sizes tested had similar antibacterial effects. In addition, the incorporation of CS-NPs did not affect shear bond strength.

Evaluation of marginal and internal adaptation of veneers generated by the guided prosthetic tooth preparation system.

OBJECTIVE: This in vitro study aimed to assess and contrast the marginal and internal adaptation of all-ceramic prefabricated veneers manufactured via the FirstFit guided tooth preparation system against all-ceramic veneers produced using the chairside Computer-Aided Design/Computer Aided Manufacture (CAD/CAM) system following identical guided preparation protocols. MATERIALS AND METHODS: Two main groups were included, with 16 lithium disilicate veneers per group. Four typodonts were used for the test (FirstFit) and control CAD/CAM groups. Intraoral scans created master casts and preparation guides. Guides performed preparations on typodont teeth (two central incisors and two lateral incisors). Prepared teeth were scanned (CEREC Omnicam) to design and mill CAD/CAM veneers. Marginal gap thickness and cement space thickness were measured using light microscopy at four locations: marginal, cervical internal, middle internal, and incisal internal. RESULTS: No significant difference existed between groups for marginal adaptation (p = 0.058) or incisal internal adaptation (p = 0.076). The control group had significantly lower values for middle internal adaptation (p = 0.023) and cervical internal adaptation (p = 0.019). CONCLUSIONS: Guided preparation evaluation showed no significant differences in marginal or incisal internal adaptation. The CAD/CAM group had significantly lower middle and cervical internal adaptation values.

Effects of Oral Sodium Bicarbonate Supplementation on Protein Metabolism and Inflammation in Iraqi Hemodialysis Patients: An Open-Label Randomized Controlled Trial.

Background: The effect of correcting metabolic acidosis on protein metabolism in hemodialysis patients is controversial. Objectives: To study the effects of oral sodium bicarbonate on protein metabolism and markers of inflammation in acidotic hemodialysis patients. Patients and Methods. An open-label randomized controlled trial was conducted at a single center. Sixty-six clinically stable adult hemodialysis patients were recruited with an average predialysis serum bicarbonate level of <22 mmol/l and a dialysate bicarbonate concentration of 35 mmol/l. Forty-nine participants have completed the study. Oral sodium bicarbonate tablets of 500 mg were given daily in the intervention group (n = 25) for 12 weeks versus the standard of care in the control group (n = 24). Outcomes compared intervention versus nonintervention in both groups at equivalent time points (0 and 3 months). The clinical data, anthropometry, dialysis adequacy, albumin, normalized protein catabolism rate, blood gas analysis, and bicarbonate were recorded at 0 and 3 months. In addition, muscle mass and handgrip strength were measured. Finally, IL-6 as a marker of inflammation was measured at randomization and three months. Results: Serum bicarbonate and pH increased significantly from 17.57 ± 3.34 mmol/L to 20.69 ± 2.54 mmol/L and from 7.26 ± 0.06 to 7.34 ± 0.04, respectively (p < 0.0001). Serum albumin was significantly higher in the intervention group at three months than in the control group, 4.11 ± 0.45 vs. 3.79 ± 0.47 (p value 0.011). Serum potassium significantly decreased in the intervention group at three months compared to the control group, 5.00 ± 0.43 mEq/l vs. 5.33 ± 0.63 mEq/l (p value 0.03). Muscle strength expressed as handgrip has improved significantly in the intervention group at three months compared to the control group, 45.01 ± 19.19 vs. 33.93 ± 15.06 (p value 0.03). The IL-6 values were less in the intervention group at 3 months with a p value of 0.01. The interdialytic weight of the intervention group at three months was 2.42 ± 0.64 compared to the 2.20 ± 1.14 control group, but this did not reach statistical significance (p value of 0.4). The composite of (albumin + nPCR) at three months was achieved in 59.18% of the intervention group compared to 14.28% with a p value of 0.01. Conclusions: Correcting metabolic acidosis in hemodialysis patients improved serum albumin and nPCR without hypokalemia or significant interdialytic weight gain. This was particularly evident in patients with minimal inflammation with low IL-6 values.

Lung Ultrasound and Caval Indices to Assess Volume Status in Maintenance Hemodialysis Patients.

Background: Volume overload is common in end stage kidney disease (ESKD) and dialysis patients. Hence, the need for objective tools to detect such volume excess. Point of care ultrasound (POCUS) is a goal-directed, bedside examination to answer such a specific diagnostic question. Methods: One hundred Iraqi adult hemodialysis patients were recruited from February 1 to May 31, 2022. Primary clinical, dialysis data, and prescriptions were recorded. A nephrologist performed a POCUS examination after the last dialysis session of the week. In addition, an ultrasound examination of the chest was performed to detect B-lines and pleural effusion. Caval parameters included inferior vena cava (IVC) diameter and collapsibility index. Results: The mean age of the study group was 51.48 ± 14.6 years, with 53% males. The mean interdialytic weight gain was 2.74 ± 1.15 Kg. Lower limb edema and pleural effusion were present in 33% and 27%, respectively. Forty-seven percent of patients had >3 B-lines on lung ultrasound with a range of 12. Forty-three percent of patients had an IVC diameter of >2 cm, and 93% had <50% IVC collapsibility. In total, 97% of patients had evidence of excess volume by ultrasound criteria. IVC collapsibility index was the most prevalent sign of excess volume (93%). Patients without lower limb edema and pleural effusion had positive B-lines in 38.8% and 38.3%, an IVC diameter >2 cm in 46.2% and 38.3%, and IVC collapsibility <50% in 89.5% and 95.8% respectively. Conclusion: Iraqi maintenance hemodialysis patients are volume overloaded, which warrants proper intervention for detection and dialysis management. POCUS is a useful and easily performed technique to assess the volume status.

Perception and satisfaction of nephrology education and training in Iraq.

BACKGROUND: Interest in training in nephrology is declining around the world. This is a particularly worrisome issue for future nephrology practice with the aging population and the increasing number of patients with kidney disease. We wished to understand the perception and measure the satisfaction of Iraqi medical interns regarding nephrology and explore factors affecting career decisions towards becoming a specialist nephrologist. METHODS: A web-based authors-constructed survey consisting of a Likert-type scale questionnaire to assess perception and satisfaction was used. It comprised multiple-choice yes/no/maybe questions and addressed the willingness to pursue a career in nephrology. Iraqi medical interns in their final 2 years of training, 2021-2022, were assessed. RESULTS: One hundred and twenty internal medicine Iraqi fellows participated in the survey (response rate 84.2%). Sixty-eight fellows (74%) described nephrology as a complex science. Acid-base and electrolytes disorders and transplantation were the most challenging topics, followed by glomerular diseases. Twenty-one fellows (23%) were satisfied with the quality of training and nephrology education during their medical school, residency and internship. In addition, 14% stated that they would pursue a future career in nephrology. The most selected barrier (34%) against choosing nephrology was a fellow's perception of the patient's complexity and the potentially futile outcome. CONCLUSION: The majority (76%) of Iraqi medical interns are currently not satisfied with nephrology training and education. One in seven would pursue a future career in nephrology. New targeted innovative approaches are urgently needed for the various grades of trainees to highlight the benefits of nephrology as a career.

Living Kidney Donation: Glomerular Filtration Rate-Based Donor Selection Criteria.

Despite different guidelines and recommendations for evaluating the renal function of living kidney donors, there is still no consensus about the best approach. It is uncertain whether to have measured glomerular filtration rate, estimated it, or both. The absolute value, body surface area-dependent, and age-specified estimated glomerular filtration rates have not been consistent across different populations and practices. The increasing demand for donors has mandated clear selection criteria for glomerular filtration rate. Thus, the next big question is how low should the glomerular filtration be? Indeed, a low level would preclude the misclassification of donors and mitigate future donor risks of chronic kidney disease. The recent consensus on removing factors on race and ethnicity in the estimated glomerular filtration rate equations added a new perspective to the concept of donor assessment of glomerular filtration rate. Furthermore, the increasing use of point of care devices to assess creatinine and estimated glomerular filtration rate will be a paradigm shift in the practice of nephrology. These challenges and updates make glomerular filtration rate-based donor selection criteria an always timely topic in living kidney donation.

Relapsing De Novo Membranous Nephropathy.

Allograft membranous glomerulopathy can be a recurrent or de novo disease. Both instead have different underlying immune pathophysiology and disease pattern. While the introduction of ANTI-PLAR2 and THS7A brought new insights into the management of Immune/primary MN, the treatment of de novo MN is not clear. Relapsing de novo MN in a kidney transplant was rarely reported. Here, we present a case of relapsing de novo MN without evidence of rejection and a gratifying response to rituximab.

Young Transplant Professionals in the Middle East Society for Organ Transplantation Region: Challenges and Opportunities.

The power of youth represents the versatility of the Middle East, which has the largest number of youths among other world regions. Therefore, when addressing the future of organ transplantation in this region, the perspectives of young transplant professionals would be invaluable. Organ donation and transplantation in the Middle East face many challenges. These challenges, which would be transferred to young professionals pursuing a career in transplantation, are related to transplant education, training, and the health system itself. Young transplant professionals are seeking a platform that will bring the wisdom of leaders and the energy of youth transplant professionals together. This platform would focus on increasing recruitment and engagement of young physicians and surgeons and decreasing the hurdles mentioned above. A team of young professionals from the Middle East Society for Organ Transplantation countries hopes to bring their different perspectives into fruitful actions. Online education, career development, basic science research, and others are potential goals to be tackled. However, achieving this could not be possible without mutual collaborations with other young colleague teams from other transplant societies. Indeed, these actions can improve transplant science globally and in the MESOT region.

Adherence to Immunosuppressive Medication in Iraqi Kidney Transplant Recipients During the First Year of Transplant. A Single-Center Experience.

OBJECTIVES: Our objective was to measure adherence to immunosuppressive medications among Iraqi renal transplant patients at a single center. MATERIALS AND METHODS: This cross-sectional study was conducted from January to November 2020 in the outpatient unit of the Nephrology and Renal Transplantation Center in Baghdad's Medical City. Seventy-five adult Iraqi renal transplant recipients were recruited. An Arabic version of the Basel Assessment of Adherence to Immunosuppressive Medications (BAASIS) scale was used to evaluate adherence. RESULTS: The study included 75 adult renal transplant recipients (51 men/24 women) with a mean age of 39.44 ± 12.06 years. The mean time posttransplant was 8.11 ± 3.12 months. In our patient group, 65.33% reported total adherence and 34.6% did not adhere to one (25.3%) or more (9.3%) drug. We observed a statistically significant association between nonadherence and complications (P = .015, chi-square test). Four patients had biopsy-proven acute rejection, and all 4 patients were noncompliant with medications. Binary logistic regression model P values for employment, time after transplant, and complications were .06, .06, and .08, respectively. CONCLUSIONS: There was a high rate of nonadherence among our sample of Iraqi renal transplant recipients in the first year posttransplant. Time after transplant and transplant complications were related to nonadherence. More extensive multicenter studies are needed to define the actual rate of adherence to immune suppression in Iraq.

Knowledge and Attitude of People With or Without a Medical Education Regarding Organ Donation and Transplant: A Sample From the City of Baghdad.

OBJECTIVES: Organ donation is the driving force for transplant. Awareness about donation and transplant is invaluable for improved transplant services in any country. Our objective was to assess the knowledge and attitude toward organ donation and transplant among medically educated adult Iraqis versus adult Iraqis who were not medically educated, in Baghdad, Iraq. MATERIALS AND METHODS: For this study, we recruited 400 Iraqi residents of Baghdad city from December 1, 2018, to March 1, 2019. We used an interviewer-adm-inistered questionnaire to survey 200 health care professionals and 200 adults who lacked medical education, and then we analyzed the responses from the 2 groups. RESULTS: The study included 165 males and 235 females (mean age 33.73 ± 10.38 years). Most participants (60%) were aware of organ donation, and a health care provider was the main source of their knowledge. Only 11.25% were aware of Iraqi legislation that permits donation after brain death. Nearly 50% of the participants volunteered to be living donors, and 229/400 (57.25%%) volunteered to donate after death. About 50% accepted the idea of organ donation as an act to save life, whomever the donor. The most important barrier was the fear of future risks to health after living donation and body disfigurement after death. There was a statistically significant difference in the knowledge and attitude scores between the 2 groups. From the study sample, 46.5% accepted the concept of incenting living donors or families of deceased donors. CONCLUSIONS: Iraqi people are moderately informed about organ donation and transplant. Medically educated people demonstrated an attitude of greater acceptance. Religion and social beliefs were not barriers to organ donation in the study sample. Regulated governmental application of incentive programs may be a useful strategy at present.

Biaxial flexural strength of various CAD-CAM glass-ceramic materials.

PURPOSE: To evaluate and compare the flexural strength of three CAD-CAM glass-ceramic materials and to investigate the effect of various surface treatments on their flexural strength. METHODS: 120 rectangular specimens were fabricated from three different types of CAD-CAM ceramic blocks and were divided into three groups: zirconia-reinforced lithium silicate (Celtra Duo, Group 1), leucite-reinforced glass-ceramic (IPS Empress CAD, Group 2), and lithium disilicate ceramic (IPS e.max CAD, Group 3). Dimensions of the specimens were standardized to 14.5x12.5 mm and 1.5 mm thickness. Specimens in each group were randomized into four subgroups. The first subgroup (NS) did not undergo any surface treatment; the second subgroup (P) underwent polishing only; the third subgroup (G) underwent glazing only; and the fourth subgroup (PG) underwent both polishing and glazing surface treatments. Biaxial flexural strength (FS) testing was performed until fracture occurred; FS was calculated in MPa. All analyses were performed using SPSS version 24. RESULTS: Group NS2 showed the lowest FS (89.34 ± 25.30 MPa). Group PG3 showed a significantly higher FS (365.38 ± 52.52 MPa) than Group P3 (268.15 ± 48.34). There was a statistically significant difference among the material groups for each surface treatment: IPS e.max CAD showed the highest FS, which was significantly greater than that of both Celtra Duo and IPS Empress CAD. The combination of polishing and glazing surface treatment resulted in significantly higher flexural strength than polishing alone for all three materials tested. For each material, no significant difference was found between the following surface treatments: control and polishing-only surface treatments; glazing-alone and the combination of polishing and glazing surface treatments. For each surface treatment, Celtra Duo showed significantly lower flexural strength than IPS e.max CAD. However, it displayed higher flexural strength than IPS Empress CAD, although the difference was only significant for glazing and the combination of polishing and glazing. CLINICAL SIGNIFICANCE: This study provides the clinician with an estimate of the flexural strength of glass-ceramic materials and shows how various surface treatments affect their strength.

Insights into Futuristic Renal Medicine.

The revolutionary innovations in biology and information technology influenced many medical and health disciplines. Although it is lagging behind others, renal medicine entered this chain of events. Nephrology and renal transplantation have many inherent challenges that needed to be addressed innovatively to receive these new frontiers in medicine. In a connected high biotech future, the applications of regenerative medicine, nanotechnology, genomics, artificial intelligence, 3D organ bioprinting, and smartphone applications will reshape the practice and research of renal medicine. Certainly, this will have a positive impact on patients' outcomes and the health-care system. These changes are coming, but with new challenges such as excess costs, and many moral challenges. Providing precise equitable care with maintaining patient's privacy and values will be difficult. In this review, we provide insights into future approaches to renal care.

A rare cause of tumour lysis syndrome and acute kidney injury.

Tumour lysis syndrome is rare in solid malignancies. Here, we report a case of tumour lysis syndrome and acute kidney injury in a 23-year-old female with gestational trophoblastic neoplasia. Hydration and early dialysis therapy were started with good recovery. On follow up she progressed to chronic kidney disease. After 6 years of follow up, the patient conceived and delivered successfully.

Effect of acidic pH on surface roughness of esthetic dental materials.

STATEMENT OF PROBLEM: Exposure to gastric acid in patients with bulimia nervosa and gastroesophageal reflux disease (GERD) causes demineralization of hard tooth structures. This chemical attack also causes the degradation of dental ceramics, which results in increased surface roughness and reduced strength. However, studies comparing the effect of acidic pH on resin matrix ceramic with other computer-aided design and computer-aided manufacturing (CAD-CAM) esthetic materials are lacking. PURPOSE: The purpose of this in vitro study was to compare the surface roughness changes of different CAD-CAM restorative dental materials after exposure to acidic pH by using a 3D optical interferometer. MATERIAL AND METHODS: Five esthetic CAD-CAM block materials, a leucite glass-ceramic (IPS Empress CAD), a zirconia (BruxZir Solid Zirconia), a resin matrix ceramic (VITA Enamic), a lithium disilicate glass-ceramic (IPS e.max CAD), and a feldspathic porcelain (VITABLOCS Mark II CAD) were tested. Eighteen specimens were sectioned from CAD-CAM blocks into 2-mm-thick rectangular plates and immersed in 10 mL of 5% hydrochloric acid (HCl) with (pH=2) at 37 °C for 45 and 91 hours. The surface roughness average (Ra) of the specimens was measured by using a 3D optical interferometer before the storage period (baseline), after 45 hours, and after 91 hours of exposure to HCl. Statistical analyses were performed with the Kruskal-Wallis test and the post hoc Dunn test with Bonferroni correction (α=.05). RESULTS: Regarding the comparison of surface roughness changes at different periods of evaluation (baseline, 45 hours, 91 hours), there were no statistically significant differences for lithium disilicate (P=.063) or zirconia (P=.513). Leucite glass-ceramic, feldspathic porcelain, and the resin matrix ceramic demonstrated statistically significant differences (P<.001). For all tests that were statistically significant, greater surface roughness was found at the time point with the longer HCl exposure. Regarding the comparison of materials in terms of change in surface roughness between baseline to 45 hours and baseline to 91 hours, the Kruskal-Wallis test indicated a statistically significant difference among the materials in both cases (P<.001). Lithium disilicate and zirconia exhibited the least change in surface roughness among the 5 materials. CONCLUSIONS: Leucite glass-ceramic, feldspathic porcelain, and resin matrix ceramic showed statistically significant increases in surface roughness when they were exposed to simulated gastric acid for 45 and 91 hours. Lithium disilicate and zirconia showed no statistically significant change in surface roughness after exposure to HCl for 45 and 91 hours.

Clinical Relevance of Pretransplant Testing for Anti-Human Leukocyte Antigen Antibodies in Iraqi Renal Transplant Patients.

OBJECTIVES: The use of highly sensitive Luminex technology to assess the immunologic risk of renal transplant candidates have greatly added to the ability of stratifying patients and have paved the way to avoid hyperacute antibody-mediated rejection. Our aim was to understand how much the testing for pretransplant anti-HLA antibodies affects the decision for transplant and survival at 1 year posttransplant. MATERIALS AND METHODS: From January 2014 to June 2017, 336 transplant candidates were tested by complement-dependent cytotoxicity and by the Luminex platform for anti-HLA antibodies in our nephrology and renal transplant center (The Medical City, Baghdad, Iraq). All clinical and laboratory data were noted. Our program is a living-donor, blood group-compatible donor program. All transplant patients (sensitized or not) were followed for 1 year, and the Kaplan-Meier method was used to determine survival rate. RESULTS: Mean age of the study group was 34.07 ± 12.4 years. Of 336 transplant patients who were tested, there were 63 (18.75%) sensitized patients and 159 (47.35%) nonsensitized patients. Blood transfusion was the main cause of sensitization. Class I anti-HLA antibodies were detected in 54 of 63 sensitized patients (85.7%), and class II anti-HLA antibodies were detected in 39 of 63 sensitized patients (61.9%). Donor-specific antibodies were detected in 33/63 (52.3%). Thirteen sensitized patients (15.3%) underwent transplant. No incidences of hyperacute rejection were recorded. The 1-year survival of the nonsensitized patient group was 90%, whereas survival was 61.5% for the sensitized patient group. CONCLUSIONS: Pretransplant testing for anti-HLA antibodies is undoubtedly useful for assessment of patient risk, to facilitate decisions regarding patient and donor selection, and to plan treatment strategies. The 1-year survival for sensitized patient was lower than for nonsensitized patients. More knowledge, experience, technology advancements, and support are needed to improve the Iraqi practice of transplanting sensitized patients.

Comparison of microleakage between bulk-fill flowable and nanofilled resin-based composites.

AIM: The objective was to compare the marginal leakage (silver nitrate uptake) of nanohybrid resin-based composite (RBC) and two bulk-fill flowable RBCs with specific clinical protocols. METHODS: Four experimental groups of RBC were investigated including conventional composite Filtek™ Supreme in 2 mm increment (FS2), Filtek™ Supreme in 4 mm increment (FS4), Filtek™ Supreme Flowable (BFF), and SureFil® SDR® flow (SDR). Class II box preparation (4 × 4 × 3 mm) in extracted intact human molars was carried out and restored using the experimental groups, all according to the manufacturers' recommendations except FS4. Samples were aged by thermocycling (2,000 cycles). Microleakage was calculated by measuring dye penetration in sectioned teeth using a stereomicroscope. Level of significance was set at P < 0.05. RESULTS: BFF and FS2 exhibited the least dye penetration and microleakage measurement with no significant difference between the two groups, followed by SDR. FS4 showed the highest microleakage with significant difference in comparison with BFF and FS2. Gingival microleakage was found to be significantly higher than occlusal microleakage. CONCLUSION: The microleakage of the bulk-fill composites BFF and SDR are comparable with conventional composite FS2; however, it is more predictable to use FS2.

Methods and Purposes for Conducting Students' Course Evaluations Reported by North American Dental School and Dental Hygiene Program Leaders: A Preliminary Survey Study.

The aim of this preliminary survey study was to determine the perceptions of leaders of dental schools and dental hygiene programs regarding methods of and purposes for conducting students' course evaluations and their role in course improvement, curriculum design, and faculty assessment. A short electronic survey was distributed in 2016 to the academic deans of all 76 dental schools in the U.S. and Canada and a convenience sample of program directors of 232 of the total 332 accredited dental hygiene programs. Individuals from 93 institutions responded for an overall response rate of 30%: 30 of 76 dental schools (39.5% response rate) and 63 of the 232 dental hygiene programs (27% response rate). All of the respondents (100%) reported that their institutions' full-time faculty members were assessed by students in course evaluations for each course and semester they taught. However, only 78% reported that their part-time faculty members were evaluated by students. Course evaluations were mandatory in 62% (n=58) of the responding institutions, with the remaining 38% (n=35) optional. Respondents indicated course directors received the evaluation results for purposes of annual review (n=73, 78%) and instructional review (n=70, 75%). Further investigation of the use and effects of student evaluations is needed to better understand their role in faculty assessment and other aspects of the administration of dental schools and dental hygiene programs.

Renal anemia syndromes in iraqi hemodialysis patients according to iron status.

Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013. Seventy prevalent adult HD Iraqi patients were enrolled. All patients were tested for full blood counts and iron parameters. They were categorized as nonanemic and those with absolute or functional iron deficiency. The patients were also tested for serum albumin, C-reactive protein (CRP), parathyroid hormone, and serum hepcidin levels. Data were expressed as mean ± standard deviation, and frequencies (number) and proportions (%). The mean age of the study group was 49.8 ± 12.3 years. Diabetes was the primary cause of end-stage renal disease, seen in 30 patients (42.8%). Majority of the HD patients were anemic, [51 (82.9%)] and among them, 39 (76.4%), had functional IDA. The mean serum iron, serum ferritin, and transferrin saturation were significantly higher in patients with functional IDA than those with absolute IDA (P <0.05). The mean highly sensitive CRP, parathormone and hepcidin values were also significantly higher in functional IDA patients than in those with absolute IDA and the nonanemic group (P <0.05). More than half of the study patients had functional IDA, and this can explain ESA hyporesponsiveness. This is besides the interplay of other factors including inflammation, inadequate dialysis, and secondary hyperparathyroidism. It is essential to diagnose functional IDA early, before the initiation of unnecessary iron therapy.