Benefits of plasma rich in growth factors (PRGF) in skin photodamage: clinical response and histological assessment.

Skin ageing is characterized by small and fine wrinkles, roughness, laxity, and pigmentation as a result of epidermal thinning, collagen degradation, dermal atrophy, and fewer fibroblasts. Plasma rich in growth factors (PRGF) is an autologous plasma preparation enriched in proteins obtained from patient's own blood aimed at accelerating tissue repair and regeneration. To evaluate the benefits of PRGF in skin photodamage, 10 healthy volunteers were treated with three consecutive intradermal injections of PRGF in the facial area. Clinical outcomes and histological analysis were performed. A statistically significant increase in the epidermis and papillary dermis thickness was seen after PRGF treatment (p < 0.001). Skin thickening was observed in all patients studied, being more intense in the group of patients with photodamage (p < 0.001). After PRGF treatment, a reduction of the average area fraction of solar elastosis was observed in patients with clinical and histological signs of skin photodamage (p < 0.05).No changeswere observed in the number of CD31, XIIIa factor, cKit, CD10, nor p53-positive cells. The improvement score after PRGF use was 0.75 (9/12) for the group of patients with signs of skin photodamage. Intradermal PRGF infiltration appears to be an effective treatment for the photodamaged skin.

Hemangiomas infantiles tratados con aplicación secuencial de láser de colorante pulsado y Nd:YAG: estudio retrospectivo / Infantile Hemangiomas Treated by Sequential Application of Pulsed Dye Laser and Nd:YAG Laser Radiation: A Retrospective Study

Introducción: Los hemangiomas infantiles son los tumores benignos más frecuentes en la infancia, presentando una fase proliferativa, una fase de involución y una fase residual. En muchas ocasiones no precisan de un tratamiento activo. No obstante, en algunos pacientes se impone la necesidad de un tratamiento. Entre las posibilidades terapéuticas ha demostrado utilidad, durante todas las fases evolutivas de la lesión, el tratamiento con láser. Comunicamos nuestra experiencia con el láser dual secuencial de colorante pulsado (LCP) y Nd:YAG. Material y métodos: Se efectuó un estudio retrospectivo y descriptivo de los pacientes con hemangiomas infantiles en diversas fases evolutivas tratados con el láser dual de LCP y Nd:YAG. Cuatro dermatólogos valoraron el grado de efectividad en una escala del 10 al 0. Se recogieron los efectos adversos e incidencias relativas al tratamiento. En el análisis se utilizó para los valores descriptivos la mediana y el rango intercuartílico y la prueba de Wilcoxon para la comparación pre y postratamiento. Resultados: Se recogieron 22 pacientes con hemangiomas en distintos estadios evolutivos, obteniéndose una mejoría estadísticamente significativa tanto en el conjunto de todos los pacientes como en los distintos subgrupos. Cuatro pacientes presentaron incidencias postratamiento: edema y ulceración, atrofia cutánea e hiperpigmentación. Conclusiones: Consideramos que el láser dual de LCP y Nd:YAG puede ser una alternativa para el tratamiento de hemangiomas infantiles cuando las terapias consideradas de primera línea se muestran ineficaces o están contraindicadas (AU)

Background and objectives: Infantile hemangiomas are the most common benign tumor in children. They have 3 phases of development: a proliferative phase, an involuting phase, and involution. Although active treatment is often not required, it is necessary in some cases. Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. We report our experience with dual-wavelength sequential pulses from a pulsed dye laser and an Nd:YAG laser. Material and methods: This was a retrospective, descriptive study of patients with infantile hemangioma in different phases of development treated with pulsed dye laser pulses followed by Nd:YAG laser pulses. Four dermatologists assessed the effectiveness of treatment on a scale of 10 to 0. Adverse effects and incidents related to treatment were recorded. The median and interquartile range were calculated as descriptive statistics. Pretreatment and posttreatment comparisons were performed using the Wilcoxon test. Results: Twenty-two patients with hemangiomas in different phases of development were included. A statistically significant improvement was obtained both for the entire group and for different subgroups. Posttreatment events were reported in 4 patients, and included edema and ulceration, skin atrophy, and hyperpigmentation. Conclusions: We believe that treatment with dual-wavelength light from a pulsed dye laser and a Nd:YAG laser is a viable treatment option for infantile hemangiomas when first-line therapies are ineffective or contraindicated (AU)

Infantile hemangiomas treated by sequential application of pulsed dye laser and Nd:YAG laser radiation: a retrospective study.

BACKGROUND AND OBJECTIVES: Infantile hemangiomas are the most common benign tumor in children. They have 3 phases of development: a proliferative phase, an involuting phase, and involution. Although active treatment is often not required, it is necessary in some cases. Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. We report our experience with dual-wavelength sequential pulses from a pulsed dye laser and an Nd:YAG laser. MATERIAL AND METHODS: This was a retrospective, descriptive study of patients with infantile hemangioma in different phases of development treated with pulsed dye laser pulses followed by Nd:YAG laser pulses. Four dermatologists assessed the effectiveness of treatment on a scale of 10 to 0. Adverse effects and incidents related to treatment were recorded. The median and interquartile range were calculated as descriptive statistics. Pretreatment and posttreatment comparisons were performed using the Wilcoxon test. RESULTS: Twenty-two patients with hemangiomas in different phases of development were included. A statistically significant improvement was obtained both for the entire group and for different subgroups. Posttreatment events were reported in 4 patients, and included edema and ulceration, skin atrophy, and hyperpigmentation. CONCLUSIONS: We believe that treatment with dual-wavelength light from a pulsed dye laser and a Nd:YAG laser is a viable treatment option for infantile hemangiomas when first-line therapies are ineffective or contraindicated.

Nevos epidérmicos tratados con láser de CO 2: respuesta y seguimiento a largo plazo / Carbon Dioxide Laser Treatment of Epidermal Nevi: Response and Long-Term Follow-Up

Introducción y objetivos: Los nevos epidérmicos son proliferaciones benignas de la epidermis para los que se han utilizado múltiples tratamientos con resultados variables. Las terapias tópicas resultan ineficaces y el tratamiento quirúrgico obtiene resultados más definitivos, pero conlleva la aparición de cicatrices. En las últimas décadas se han utilizado diversas modalidades de láser. El objetivo del trabajo es describir nuestra experiencia en el tratamiento de nevos epidérmicos y nevos epidérmicos verrugosos inflamatorios lineales (NEVIL) con láser de CO2. Pacientes y métodos: Veinte pacientes (15 con nevos epidérmicos y 5 con nevo epidérmico verrugoso inflamatorio lineal) fueron tratados con láser de CO2 entre 2002 y 2010 en nuestro centro. Resultados: Un 50% de los pacientes presentaron buena respuesta (reducción de la lesión mayor del 50%) y un 30% respuesta excelente (reducción mayor del 75%). Los pacientes con NEVIL mostraron mayor resistencia al tratamiento (40% buena respuesta). Se realizó seguimiento a largo plazo (mínimo de 18 meses) y se observaron recurrencias en el 30% de los pacientes. Los efectos secundarios detectados fueron: hipopigmentación en el 25% de los pacientes y cicatrices en el 20%. Conclusiones: Consideramos el láser de CO2 como el tratamiento de elección para estas lesiones, ya que es bien tolerado y se ha demostrado su eficacia y seguridad a largo plazo. Aunque la respuesta es limitada en los NEVIL, no existen en la actualidad otros tratamientos eficaces, por lo que podría ser una buena opción terapéutica en casos seleccionados o como tratamiento paliativo para la mejoría de los síntomas (AU)

Background and objectives: Epidermal nevi, which are benign skin growths, have been treated using a range of approaches, with varying results. Topical treatments are ineffective and, while surgical excision is a more definitive treatment, it causes scar formation. In recent decades, epidermal nevi have been treated with various types of laser therapy. We describe our experience with the use of carbon dioxide (CO2) laser therapy to treat epidermal nevi and inflammatory linear verrucous epidermal nevi (ILVEN). Patients and methods: Twenty patients (15 with epidermal nevi and 5 with ILVEN) underwent CO2 laser treatment at our hospital between 2002 and 2010. Results: Response was good (> 50% reduction in lesion size) in 50% of cases and excellent (> 75%reduction) in 30%. A greater resistance to treatment was observed in patients with ILVEN (only40% had a good response). Long-term follow-up (at least 18 months) showed a recurrence rate of 30%. The side effects were hypopigmentation (25% of patients) and scarring (20%). Conclusions: We consider CO2 laser therapy to be the treatment of choice for epidermal nevi as it is well tolerated and has proven to be safe and effective in the long term. While the response in patients with ILVEN was limited, CO2 laser therapy might be a good option for selected cases or for palliative treatment since no other treatments have yet proven effective in this setting (AU)

Carbon dioxide laser treatment of epidermal nevi: response and long-term follow-up.

BACKGROUND AND OBJECTIVES: Epidermal nevi, which are benign skin growths, have been treated using a range of approaches, with varying results. Topical treatments are ineffective and, while surgical excision is a more definitive treatment, it causes scar formation. In recent decades, epidermal nevi have been treated with various types of laser therapy. We describe our experience with the use of carbon dioxide (CO(2)) laser therapy to treat epidermal nevi and inflammatory linear verrucous epidermal nevi (ILVEN). PATIENTS AND METHODS: Twenty patients (15 with epidermal nevi and 5 with ILVEN) underwent CO(2) laser treatment at our hospital between 2002 and 2010. RESULTS: Response was good (>50% reduction in lesion size) in 50% of cases and excellent (>75% reduction) in 30%. A greater resistance to treatment was observed in patients with ILVEN (only 40% had a good response). Long-term follow-up (at least 18 months) showed a recurrence rate of 30%. The side effects were hypopigmentation (25% of patients) and scarring (20%). CONCLUSIONS: We consider CO(2) laser therapy to be the treatment of choice for epidermal nevi as it is well tolerated and has proven to be safe and effective in the long term. While the response in patients with ILVEN was limited, CO(2) laser therapy might be a good option for selected cases or for palliative treatment since no other treatments have yet proven effective in this setting.

Eosinophilic pustular folliculitis in infancy: report of a new case.

We report a new case of eosinophilic pustular folliculitis in a 23-month-old boy. He presented with a seven-month history of recurrent episodes of pustular lesions on the scalp after having been treated with oral antifungal and topic antibiotics without response. The diagnosis was based on the clinical course and typical histopathological findings. Eosinophilic pustular folliculitis in infancy is an idiopathic and rare inflammatory disease characterized by recurrent crops of sterile pustules involving mainly the scalp. Because it is a benign, self-limiting condition an accurate diagnosis is essential to avoid unnecessary therapies.

Carbon Dioxide Laser Treatment of Epidermal Nevi: Response and Long-Term Follow-Up. / Nevos epidérmicos tratados con láser de CO(2): respuesta y seguimiento a largo plazo.

BACKGROUND AND OBJECTIVES: Epidermal nevi, which are benign skin growths, have been treated using a range of approaches, with varying results. Topical treatments are ineffective and, while surgical excision is a more definitive treatment, it causes scar formation. In recent decades, epidermal nevi have been treated with various types of laser therapy. We describe our experience with the use of carbon dioxide (CO(2)) laser therapy to treat epidermal nevi and inflammatory linear verrucous epidermal nevi (ILVEN). PATIENTS AND METHODS: Twenty patients (15 with epidermal nevi and 5 with ILVEN) underwent CO(2) laser treatment at our hospital between 2002 and 2010. RESULTS: Response was good (>50% reduction in lesion size) in 50% of cases and excellent (>75% reduction) in 30%. A greater resistance to treatment was observed in patients with ILVEN (only 40% had a good response). Long-term follow-up (at least 18 months) showed a recurrence rate of 30%. The side effects were hypopigmentation (25% of patients) and scarring (20%). CONCLUSIONS: We consider CO(2) laser therapy to be the treatment of choice for epidermal nevi as it is well tolerated and has proven to be safe and effective in the long term. While the response in patients with ILVEN was limited, CO(2) laser therapy might be a good option for selected cases or for palliative treatment since no other treatments have yet proven effective in this setting.

Dermatofibromas treated with pulsed dye laser: Clinical and dermoscopic outcomes.

Dermatofibroma (DF), a common benign skin tumour, sometimes requires treatment either because of cosmetic concern or for associated symptoms. However, no effective treatment with optimal cosmetic outcomes has been reported. An effective and safe therapeutic option could be treatment with pulsed dye laser (PDL). Twenty-two DFs in 15 patients were treated with PDL at 595-nm wavelength, using a spot size of 7 mm, a pulse duration of 2 ms and a fluence of 11 J/cm(2) with 2 or 3 stacked pulses. Clinical and dermoscopic photographs were taken before and after therapy. Global clinical improvement was higher than 50% in 12 lesions. Patient satisfaction assessment showed 73% of patients as satisfied or very satisfied. All lesions showed changes from the previous dermoscopic pattern. We consider that PDL could be a safe, palliative treatment as it is well accepted by patients and has a better cosmetic outcome than surgical excision.