Tratamento de feridas com utilização de fitoterápico em paciente vítima de atropelamento: relato de caso / Treatment of wounds with the use of phytotherapy in a patient victim of training: case report / Tratamiento de heridas con uso de fitoterapia en paciente víctima de entrenamiento: reporte de caso

Objetivo: descrever a utilização do fitoterápico tópico na cicatrização de feridas e demonstrar sua eficácia no tratamento de pacientes com feridas crônicas. Método: Estudo qualitativo, descritivo, retrospectivo, com paciente domiciliar, na cidade de Duque de Caxias, Rio de Janeiro. A coleta de dados ocorreu de 31 de março de 2022 a 29 de junho de 2022, utilizando registros em fichas de avaliação, evolução clínica e evolução de registros de enfermagem focando nos principais aspectos relacionados ao histórico de enfermagem, avaliação de feridas, contexto clínico econduta tópica para o tratamento da ferida. Resultados: Paciente de 19 anos, do sexo feminino, vítima de atropelamento no dia 10/12, previamente hígida, sem nenhuma comorbidade, eutrófica, IMC de 19,7. Manteve 24h de internação, alta em 11/12 com lesão extensa. Lesão com curso desfavorável sendo necessário desbridamento no dia 07/02/2022. Trata-se de ferida traumática, crônica, complexa e de difícil cicatrização. Considerações Finais: O uso de fitoterápicos no tratamento da ferida mostrou-se eficiente e trouxe resultados satisfatórios quanto à cicatrização e o desfecho do caso, durante todo o tratamento. Percebeu-se no desfecho do caso uma completa cicatrização da ferida em um curto período de tempo, durante a utilização do produto não houve nenhuma reação alérgica ou irritabilidade reforçando os benefícios da utilização de componentes naturais no tratamento de feridas.

Objective: to describe the use of a topical herbal medicine in wound healing and to show its effectiveness in treating patients with chronic wounds. Method: a retrospective, descriptive, qualitative study with a home care patient in the city of Duque de Caxias, Rio de Janeiro, Brazil. Data were collected from March 31st, 2022, to June 29th, 2022, from patient assessment charts, clinical course, and evolution of nursing records focusing on the main aspects related to nursing history, wound assessment, clinical context, and topical treatment of the wound. Results: a 19 -year-old female patient, victim of a hit-and-run on December 10th, previously healthy, with no comorbidity, and with normal weight (BMI of 19.7). She remained hospitalized for 24 hours and was discharged on December 11thwith an extensive injury. Due to the unfavorable course of the injury, it was removed on February 07th, 2022. It was a complex, chronic, traumatic, and difficult-to-heal wound. Conclusions: topical herbal medicine was shown to be effective in the treatmentof wounds and had positive results as for both healing and the outcome of the case, throughout the treatment. The outcome of the case has shown a complete wound healing in a short period of time. There was no allergic reaction or irritability while using the herbal medicine, which reinforces the benefits of natural components in the treatment of wounds.

Objetivo: describir el uso de producto fitoterapéutico tópico para cicatrización de heridas y demostrar su eficacia en el tratamiento de pacientes con heridas crónicas. Método: Estudio cualitativo, descriptivo, retrospectivo, con paciente domiciliar, en la ciudad de Duque de Caxias, Rio de Janeiro, Brasil. La recolección de los datos ocurrió durante el período de 31 de marzo a 29 de junio de 2022, utilizando registros de fichas de evaluación, evolución clínica y evolución de registros de enfermería, concentrando en los principales aspectos relacionados al histórico de enfermería, evaluación de heridas, contexto clínico y conducta tópica para el tratamiento de la herida. Resultados: Paciente de 19 años, del sexo femenino, víctima de atropellamiento en el día 10/12, previamente saludable, sin ninguna comorbilidad, eutrófica, IMC de 19,7. Fue hospitalizada por 24h, recibiendo alta el día 11/12 con lesión extensa. Lesión con curso desfavorable, siendo necesario desbridamiento el día 07/02/2022. Se trata de herida traumática, crónica, compleja y de difícil cicatrización. Consideraciones finales: El uso de productos fitoterapéuticos para el tratamiento de la herida demostró ser eficiente y proporcionó resultados satisfactorios con relación a la cicatrización y al resultado final del caso, durante todo el tratamiento. En el resultado del caso fueron observadas que la cicatrización completa de la herida ocurrió en un período corto de tiempo y que no hubo ninguna reacción alérgica o irritabilidad durante la utilización del producto, reforzando los beneficios del uso de substancias naturales en el tratamiento de heridas.

Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infection.

This study investigated the association between COVID-19 infection and host metabolic signatures as prognostic markers for disease severity and mortality. We enrolled 82 patients with RT-PCR confirmed COVID-19 infection who were classified as mild, moderate, or severe/critical based upon their WHO clinical severity score and compared their results with 31 healthy volunteers. Data on demographics, comorbidities and clinical/laboratory characteristics were obtained from medical records. Peripheral blood samples were collected at the time of clinical evaluation or admission and tested by quantitative mass spectrometry to characterize metabolic profiles using selected metabolites. The findings in COVID-19 (+) patients reveal changes in the concentrations of glutamate, valeryl-carnitine, and the ratios of Kynurenine/Tryptophan (Kyn/Trp) to Citrulline/Ornithine (Cit/Orn). The observed changes may serve as predictors of disease severity with a (Kyn/Trp)/(Cit/Orn) Receiver Operator Curve (ROC) AUC = 0.95. Additional metabolite measures further characterized those likely to develop severe complications of their disease, suggesting that underlying immune signatures (Kyn/Trp), glutaminolysis (Glutamate), urea cycle abnormalities (Cit/Orn) and alterations in organic acid metabolism (C5) can be applied to identify individuals at the highest risk of morbidity and mortality from COVID-19 infection. We conclude that host metabolic factors, measured by plasma based biochemical signatures, could prove to be important determinants of Covid-19 severity with implications for prognosis, risk stratification and clinical management.