Neural processing of cry sounds in the transition to fatherhood: Effects of a prenatal intervention program and associations with paternal caregiving.

This study examined whether neural processing of infant cry sounds changes across the transition to fatherhood (i.e., from the prenatal to postnatal period), and examined whether an interaction-based prenatal intervention modulated these changes. Furthermore, we explored whether postnatal activation in brain regions showing transition or intervention effects was associated with sensitive care and involvement. In a randomized controlled trial, 73 first-time expectant fathers were enrolled, of whom 59 had at least 1 available fMRI scan. Intervention and transition effects on cry processing were analyzed in the amygdala and superior frontal gyrus (SFG) using linear mixed effect models with all available data and with intent-to-treat analyses. Further, exploratory whole-brain analyses were performed. ROI analyses suggest that the transition to fatherhood is characterized by decreasing activation in response to cry vs control sounds in the amygdala but not SFG. Exploratory whole-brain analyses also show a decrease in activation over the transition to fatherhood in the sensorimotor cortex, superior lateral occipital cortex, hippocampus, and regions of the default mode network. In the putamen and insula, larger decreases were found in fathers with more adverse childhood caregiving experiences. In regions showing transitional changes, higher postnatal activation was associated with more concurrent parenting sensitivity. No effects of the intervention were found. The decrease in activation from the pre- to postnatal period may reflect fathers' habituation to cry sounds over repeated exposures. The positive association between postnatal neural activation and paternal sensitive care suggest that continued sensitivity to cry sounds may be conducive to parenting quality.

Fathers' sensitive parenting enhanced by prenatal video-feedback: a randomized controlled trial using ultrasound imaging.

BACKGROUND: The aim of this study was to evaluate an interaction-based prenatal parenting intervention program aimed at promoting parental sensitivity and involvement in expectant fathers using ultrasound images: Prenatal Video-Feedback Intervention to Promote Positive Parenting (VIPP-PRE). METHODS: In this randomized controlled trial, 73 first-time, healthy expectant fathers were enrolled. Participants were randomly assigned to the VIPP-PRE intervention (n = 39) or a dummy intervention (n = 34). Parental sensitivity was coded from video-recorded 10-min interactions with an infant simulator at a prenatal pretest and with fathers' own infant at a postnatal posttest. Prenatal and postnatal involvement was assessed via an application on participants' smartphones. RESULTS: Fathers receiving VIPP-PRE demonstrated increased sensitivity across the perinatal period, relative to fathers receiving a dummy intervention. Fathers' involvement with the infant increased significantly from the prenatal to postnatal period, regardless of the intervention. CONCLUSIONS: Prenatal video-feedback using ultrasound imaging of the unborn child has the potential to promote the quality of parenting in an important, but understudied, population and period: men in the transition to fatherhood. Future research should examine the long-term effectiveness of VIPP-PRE and its effectiveness in increasing parenting quality in at-risk families. IMPACT: This study identifies a brief and focused prenatal intervention using assisted interactions between the father and his baby by means of ultrasound imaging as a promising strategy to improve sensitive fathering in the early postnatal phase. Our study shows that pregnancy provides a window of opportunity for promoting prenatal involvement and bonding in expectant fathers, with potential long-term benefits for the future father-child relationship. Ultrasound measures are currently used to monitor fetal growth and development, but our results suggest that they may also create an opportunity for stimulating father-infant interaction to promote postnatal caregiving quality.

The prenatal video-feedback intervention to promote positive parenting for expectant fathers (VIPP-PRE): Two case studies.

Although parenting interventions including expectant fathers are scarce, they yield promising results. The Prenatal Video-feedback Intervention to promote Positive Parenting (VIPP-PRE) is a recently developed intervention, that is both manualized and personalized, aiming to enhance paternal sensitivity and involvement before the birth of the baby. Illustrating the intervention process, the current study presents two case studies of expectant fathers receiving VIPP-PRE (clinical trial registration NL62696.058.17). The VIPP-PRE program is described along with the individual dyads' prenatal video fragments and feedback specific for each father-fetus dyad. In addition, changes in paternal sensitivity and involvement levels are presented, as well as fathers' and intervener's evaluation of the intervention. VIPP-PRE promises to be a feasible short-term and potentially effective parenting intervention for expectant fathers. Currently, a randomized controlled trial (RCT) is under review that systematically investigates the efficacy of the VIPP-PRE. Here we aim to provide further information on the intervention process, as well as fathers' and intervener's evaluations of this process, and the benefits of using ultrasound imaging in a parenting intervention.

Aunque las intervenciones de crianza incluyendo a los papás en espera son escasas, las mismas producen resultados prometedores. La Intervención Prenatal de Información en Video para promover la Crianza Positiva (VIPP-PRE) es una intervención recientemente desarrollada, la cual es manejada a mano y personalizada, con el objetivo de mejorar la sensibilidad y la participación paterna antes del nacimiento del bebé. Demostrando el proceso de intervención, el presente estudio presenta dos casos de estudio de papás en espera que reciben VIPP-PRE (registro de ensayo clínico NL62696.058.17). El programa VIPP-PRE se describe junto con los fragmentos e información del video prenatal de las díadas individuales específicas para cada díada papá-feto. Adicionalmente, se presentan los cambios en los niveles de sensibilidad y participación paterna, así como también la evaluación de la intervención por parte de los papás y de quien condujo la intervención. VIPP-PRE promete ser una intervención de crianza factible a corto plazo y potencialmente efectiva para papás en espera. Actualmente, se encuentra bajo revisión un ensayo controlado al azar (RCT) que sistemáticamente investiga la efectividad de VIPP-PRE. Aquí nos proponemos ofrecer mayor información sobre el proceso de intervención, así como también las evaluaciones que del proceso hicieron los papás y quien condujo la intervención, y los beneficios de usar las imágenes de ultrasonido en una intervención de crianza.

Bien que les interventions de parentage in incluent des futurs pères soient rares, elles donnent des résultats prometteurs. L'Intervention de Retour-Vidéo Prénatale pour promouvoir le Parentage Positif (abrégé en anglais VIPP-PRE) est une intervention récemment développée. Elle est à la fois manualisée et personnalisée, se donnant pour but de renforcer la sensibilité et l'engagement avant la naissance du bébé. Illustrant le processus d'intervention cette étude présente deux études de cas de futurs pères recevant la CVIP-PRE (enregistrement des essais cliniques NL62696.058.17). Le programme VIPP-PRE est décrit ainsi que les fragments vidéo prénatale des dyades individuelles et le retour spécifique pour chaque dyade père-fœtus. De plus les changements dans la sensibilité paternelle et dans les niveaux d'engagement sont présentés, ainsi que l'évaluation des pères et des intervenants de l'intervention. La VIPP-PRE promet d'être une intervention de parentage viable à court terme et potentiellement efficace pour les futurs pères. Pour l'instant un essai contrôlé randomisé est à l'étude, étudiant systématiquement l'efficacité de la VIPP-PRE. Ici nous nous donnons pour but d'offrir des informations plus amples sur le processus d'intervention, ainsi que sur les évaluations du processus faites par les pères et les intervenants, et sur les bénéfices qu'il y a à utiliser les images ultrasons dans une intervention de parentage.

Is paternal oxytocin an oxymoron? Oxytocin, vasopressin, testosterone, oestradiol and cortisol in emerging fatherhood.

How do hormonal levels in men change from pregnancy to after the birth of their firstborn child, and what is the role of oxytocin, alone or in interplay with other hormones, in explaining variance in their parenting quality? We explored in 73 first-time fathers the development of five hormones that have been suggested to play a role in parenting: oxytocin (OT), vasopressin (AVP), testosterone (T), oestradiol (E2) and cortisol (Cort). In an extended group of fathers (N = 152) we examined associations with fathers' behaviour with their 2-month-old infants. OT and E2 showed stability from the prenatal to the postnatal assessments, whereas AVP and T decreased significantly, and Cort decreased marginally. OT on its own or in interplay with other hormones was not related to paternal sensitivity. Using an exploratory approach, the interaction between T and E2 emerged as relevant for fathers' sensitive parenting. Among fathers with high E2, high T was associated with lower sensitivity. Although we did not find evidence for the importance of OT as stand-alone hormone or in interplay with other hormones in this important phase in men's lives, the interaction between T and E2 in explaining variation in paternal behaviour is a promising hypothesis for further research. This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.

Development and feasibility of the prenatal video-feedback intervention to promote positive parenting for expectant fathers.

OBJECTIVE: the transition period in which men become fathers might provide an important window of opportunity for parenting interventions that may produce long-term positive effects on paternal care and, consequently, child development. Existing prenatal programs traditionally focus on maternal and infant health and seldom involve the father. STUDY DESIGN: This paper describes an interaction-based prenatal parenting intervention program for first-time fathers using ultrasound images, the Prenatal video Feedback Intervention to promote Positive Parenting (VIPP-PRE). We randomised a group of expectant fathers (N = 73) to either the VIPP-PRE or a control condition. RESULTS: Expectant fathers thought the VIPP-PRE was more helpful and influenced their insights into their babies to a greater extent than the control condition. Expectant fathers receiving the VIPP-PRE reported that they particularly liked seeing and interacting with their unborn children as well as receiving feedback on these interactions. The intervention was well received and was considered feasible by both expectant fathers and sonographers and midwives. DISCUSSION: We discuss the VIPP-PRE based on the experiences and perspectives of fathers, interveners, and sonographers and midwives.

Fathers' involvement in early childcare is associated with amygdala resting-state connectivity.

Becoming a parent requires new skills and frequent task switching during daily childcare. Little is known about the paternal brain during the transition to fatherhood. The present study examined intrinsic neuronal network connectivity in a group of first-time expectant and new fathers (total N = 131) using amygdala seed-based resting-state functional connectivity analysis. Furthermore, we examined the association between paternal involvement (i.e. hours spent in childcare and real-time push notifications on smartphone) and connectivity within the parental brain network in new fathers. There were no significant differences in functional connectivity between expectant and new fathers. However, results show that in new fathers, time spent in childcare was positively related to amygdala connectivity with the supramarginal gyrus, postcentral gyrus and the superior parietal lobule-all regions within the cognition/mentalizing network that have been associated with empathy and social cognition. Our results suggest that fathers' time investment in childcare is related to connectivity networks in the parental brain.

A soft baby carrier intervention enhances amygdala responses to infant crying in fathers: A randomized controlled trial.

New fathers may grow into their parental role through active involvement in childcare. Spending time in physical contact with the child may promote an adaptive transition to fatherhood. In this randomized controlled trial, we tested the effects of a baby carrier intervention on fathers' hormonal and neural functioning. Using functional magnetic resonance imaging (fMRI), we examined whether infant carrying affects neural reactivity to infant crying in first-time fathers, taking into account the role of the hormone oxytocin as a mediating mechanism and fathers' own childhood experiences as a potential moderating factor. Sixty first-time fathers (infant age M = 11.18 weeks, SD = 2.08) were randomly assigned to a baby carrier intervention group (n = 32 fathers) or a control group (n = 28 fathers). Fathers in the intervention group were instructed to use a baby carrier for three weeks, whereas fathers in the control group were instructed to use a baby seat. Before and after the intervention salivary oxytocin was measured and neural reactivity to infant crying was assessed using fMRI. Results showed that the infant carrier intervention increased amygdala reactivity to infant crying compared to the infant seat users. This effect was most pronounced in fathers with experiences of childhood abuse. The carrier intervention did not affect fathers' oxytocin levels. Our findings indicate that spending time in physical contact with the infant may promote attention to and accurate perception of infant signals, in particular in fathers with more adverse childhood experiences. Soft baby carriers may, therefore, facilitate an adaptive transition to fatherhood.

Child maltreatment affects fathers' response to infant crying, not mediated by cortisol or testosterone.

Parents' ability to appropriately respond to infant crying is essential for parental care and has been found to relate to parents' own childhood experiences. Additionally, childhood experiences can affect endocrine factors, which may subsequently affect behavior. In the current study, preregistered on https://osf.io/hwgtu, we examined in expectant and new fathers (N = 152) associations between experiences of maltreatment in their own childhood, hair cortisol and testosterone concentrations and their ability to modulate handgrip force when exposed to infant crying. Cortisol and testosterone were quantified from the 1 cm of hair most proximal to the scalp using Liquid chromatography-tandem mass spectrometry. Participants were asked to squeeze a handgrip dynamometer at full and half strength while listening to infant cries and control sounds. Results indicated that fathers who experienced more childhood maltreatment used more excessive handgrip force during infant cry sounds. Hair cortisol and testosterone were not related to either experienced childhood maltreatment or handgrip strength modulation. These findings confirm that fathers' early experiences of maltreatment reduce their ability to modulate their behavioral responses during infant cries, but suggest that hair cortisol and testosterone concentrations do not identify the underlying mechanism of this association.

White matter integrity moderates the relation between experienced childhood maltreatment and fathers' behavioral response to infant crying.

The ability to provide appropriate responses to infant distress is vital to paternal care, but may be affected by fathers' experiences of childhood maltreatment. Detrimental effects of childhood maltreatment have been found in the adult brain's white matter fibers, accompanied with impaired emotional and cognitive functioning. In the current study (N = 121), we examined new and expectant fathers' childhood maltreatment experiences (i.e. emotional and physical abuse and neglect), current behavioral responses (i.e. handgrip force) to infant cry sounds, and white matter integrity using diffusion tensor imaging. First, more exposure to childhood maltreatment was associated with more use of excessive handgrip force in response to infant crying by fathers. Second, the association between experienced childhood maltreatment and white matter integrity was not significant in whole-brain analyses. Lastly, we found that the association between maltreatment exposure and excessive handgrip force during infant crying was absent in fathers with high tract integrity in the bilateral uncinate fasciculus. These findings possibly point to insufficient behavioral inhibition or emotional dysregulation in fathers who experienced childhood maltreatment, but buffering for this effect in those with larger integrity in brain fibers connecting the amygdala and prefrontal cortex.

Vasopressin Differentially Affects Handgrip Force of Expectant Fathers in Reaction to Own and Unknown Infant Faces.

The underlying mechanisms of paternal responses to infant signals are poorly understood. Vasopressin has previously been proposed to affect these responses. Using a double-blind, placebo-controlled, within-subject design (N = 25 expectant fathers), we examined the effect of vasopressin administration on the use of excessive handgrip force during exposure to infant crying versus matched control sounds, while participants saw morphed images representing their own infant versus an unknown infant. We found that, compared to placebo, AVP administration elicited more excessive force while viewing an unknown infant image compared to viewing the image representing one's own infant, while the reverse was true under placebo. The results are discussed in light of vasopressin's role in parenting and parental protection among human fathers.

Birth of a Father: Fathering in the First 1,000 Days.

As a result of societal changes, fathers participate more actively in child care than they used to. In this article, we propose a context-dependent biobehavioral model of emergent fatherhood in which sociocultural, behavioral, hormonal, and neural factors develop and interact during the first 1,000 days of fatherhood. Sociocultural factors, including different expectations of fathers and varying opportunities for paternal caregiving through paid paternal leave, influence paternal involvement. Levels of hormones (e.g., testosterone, vasopressin, oxytocin, cortisol) predict fathers' parenting behaviors, and involvement in caregiving in turn affects their hormones and brain responses to infant stimuli. The birth of the first child marks the transition to fatherhood and may be a critical period in men's lives, with a smoother transition to fatherhood predicting more optimal involvement by fathers in subsequent years. A focus on prenatal and early postnatal fathering may pave the way for developing interventions that effectively support fathering during pregnancy and in the first years of their children's lives.