RESUMEN
Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed in the skeleton and connective tissue, while 8% is expressed in muscles. In physiological conditions, HA functions as a lubricant and viscoelastic shock absorber. Additionally, HA is part of complex cellular signaling which modulates nociception and inflammation. This study aims to understand the role that HA plays in the musculoskeletal system, specifically in muscles and the surrounding fascia. This review is also intended to further understand HA homeostasis and the process of its synthesis, degradation, and clearance from the local tissue. The authors examined muscle pain and stiffness as pathological conditions associated with HA accumulation.
Asunto(s)
Matriz Extracelular , Ácido Hialurónico , Humanos , Ácido Hialurónico/metabolismo , Matriz Extracelular/metabolismo , Dolor , Homeostasis , Músculos/metabolismoRESUMEN
Sex surrogacy, or sex partner therapy (SPT), is a form of therapy that aims to increase patients' comfort and confidence in sexual activity through a supportive, often sexually (though not necessarily) intimate connection with a trained surrogate partner/sex therapist. The therapy has been used to treat various disabilities, sexual dysfunctions, and anxieties related to sexual activity. Recently, there has been discussion about using SPT as a treatment for sexual distress and dysfunction in transgender patients who have undergone gender confirmation surgery (GCS). The use of SPT in this patient population has not been studied. The purpose of this letter to the editor is to call attention to and encourage discussion about the potential benefits and risks of using SPT as a treatment modality for sexual distress and dysfunction in post-GCS patients.