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1.
AJNR Am J Neuroradiol ; 40(10): 1681-1688, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31515216

RESUMEN

BACKGROUND AND PURPOSE: Paracoccidioidomycosis is a fungal infection mainly caused by the thermodimorphic fungus Paracoccidioides. The purpose of our study was to demonstrate the neuroimaging findings from 24 patients with CNS paracoccidioidomycosis. MATERIALS AND METHODS: We performed a retrospective analysis focusing on the radiologic characteristics of CNS paracoccidioidomycosis. The 24 selected patients underwent MR imaging and/or CT, and the diagnosis was made by the presence of typical neuroimaging features, combined with fungus isolation, a serologic test, or the presence of disseminated disease. RESULTS: Headache was the most common neurologic symptom, while the pseudotumoral form was the most common pattern. The number of lesions ranged from 1 to 11, with most localized on the frontal lobe with >2-cm lesions. CT showed mainly hypoattenuating lesions, whereas MR imaging demonstrated mainly hyposignal lesions on T1WI and T2WI. Furthermore, ring enhancement was present in most patients. The "dual rim sign" on SWI occurred in 100% of our patients with lesions of >2 cm. CONCLUSIONS: The diagnosis of CNS paracoccidioidomycosis is difficult. Nevertheless, imaging examinations can play an important role in the diagnosis and evaluation of the disease.


Asunto(s)
Infecciones Fúngicas del Sistema Nervioso Central/diagnóstico por imagen , Imagen por Resonancia Magnética , Paracoccidioidomicosis/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto , Anciano , Infecciones Fúngicas del Sistema Nervioso Central/patología , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Neuroimagen/métodos , Paracoccidioidomicosis/patología , Estudios Retrospectivos , Tomografía Computarizada por Rayos X/métodos
2.
Vet Parasitol ; 181(2-4): 83-90, 2011 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-21641721

RESUMEN

Dogs naturally infected with Leishmania Infantum (=L. chagasi) were treated with miltefosine using different therapeutic regimens. The animals were evaluated for clinical evolution, biochemical parameters, parasite load (by real-time PCR), cytokine levels and humoral response. After treatment and during the following 24 months, there was progressive clinical improvement and complete recovery in 50% (7/14) of the treated animals. There was a decrease in the smear positivity of the bone marrow after treatment, and there was also a gradual and constant decrease in positive cultures at the end of the follow-up period. However, the PCR detection of parasite DNA remained positive. In general, all animals presented a significant increase in parasite load 6 months after treatment. The IFN-γ levels in all the groups tended to increase during follow-up period, regardless of the miltefosine dose administered. The IL-4 and IL-10 levels of the animals tended to decrease during follow-up, except after 300 days when only IL-10 increased. The serum antibodies identified antigens that ranged from 116 kDa to less than 29 kDa in the Western blot assay. Furthermore, 300 days after treatment, qualitative and quantitative differences in the antigen profiles were observed. Antigens of 97 and 46 kDa were the most intensely recognized. Higher levels of antigen-specific Leishmania IgG were detected before and 300 days after treatment in all groups. Taking together, the improvement in the clinical symptoms was not followed by parasitological clearance, suggesting that treatment with miltefosine is not recommended, especially in endemic areas like Brazil, where children are the major victims and dogs are involved in the maintenance of the parasite cycle.


Asunto(s)
Antiprotozoarios/uso terapéutico , Enfermedades de los Perros/tratamiento farmacológico , Leishmania infantum , Leishmaniasis Visceral/veterinaria , Fosforilcolina/análogos & derivados , Animales , Brasil/epidemiología , Enfermedades de los Perros/sangre , Enfermedades de los Perros/parasitología , Perros , Inmunoglobulina G/sangre , Leishmaniasis Visceral/sangre , Leishmaniasis Visceral/tratamiento farmacológico , Fosforilcolina/uso terapéutico , Factores de Tiempo
3.
Ann Trop Med Parasitol ; 104(2): 137-43, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20406580

RESUMEN

The performance of the less expensive SYBR-Green-based PCR assay, for quantifying Leishmania chagasi in smears of bone-marrow aspirates from naturally infected, mongrel dogs, was recently compared with that of a similar PCR based on TaqMan chemistry. Aspirates were obtained from 36 infected dogs and examined for parasites by direct examination, culture, and quantitative PCR (qPCR) using specific primers (based on the parasite's kinetoplast DNA), DNA extracted from a smear, and either the SYBR-Green or TaqMan chemistries. Every aspirate smear was found PCR-positive for L. chagasi (whether the assay employed SYBR Green or TaqMan) but only 74% of the aspirates were found positive by culture and only 33% by direct, microscopical examination. There was no evidence of PCR inhibition when the DNA was collected from smears, and the parasite loads estimated using the SYBR-Green PCR were almost identical to those estimated using the TaqMan PCR (r=0.99). As a method for quantifying parasite loads in dogs infected with L. chagasi (and, probably, other mammals infected with other leishmanial parasites), PCR based on SYBR Green may therefore be an appropriate and inexpensive alternative to PCR based on TaqMan, and a reliable clinical tool.


Asunto(s)
Enfermedades de los Perros/diagnóstico , Leishmania infantum/aislamiento & purificación , Leishmaniasis Visceral/veterinaria , Reacción en Cadena de la Polimerasa/veterinaria , Animales , Médula Ósea/virología , Cartilla de ADN , ADN Protozoario/análisis , Enfermedades de los Perros/parasitología , Perros , Leishmaniasis Visceral/parasitología , Reacción en Cadena de la Polimerasa/métodos , Sensibilidad y Especificidad , Carga Viral
4.
Arq Neuropsiquiatr ; 40(2): 201-7, 1982 Jun.
Artículo en Portugués | MEDLINE | ID: mdl-7125953

RESUMEN

A case of chronic bulb-pontine paralysis with deafness, with early onset, coursing along nine years is reported. There seem to be histopathologic and electromyographic evidences on which is concluded to be a variant form of juvenile amyotrophic lateral sclerosis (Van Laere form).


Asunto(s)
Esclerosis Amiotrófica Lateral/complicaciones , Parálisis Bulbar Progresiva/complicaciones , Sordera/complicaciones , Adulto , Esclerosis Amiotrófica Lateral/diagnóstico , Esclerosis Amiotrófica Lateral/patología , Parálisis Bulbar Progresiva/patología , Diagnóstico Diferencial , Femenino , Humanos , Músculos/patología , Lengua/patología
5.
Arq. neuropsiquiatr ; 40(2): 201-7, 1982.
Artículo en Portugués | LILACS | ID: lil-7322

RESUMEN

E relatado um caso de paralisia bulbo-pontina cronica progressiva com surdez,de inicio precoce, evoluindo de maneira protraida ha 9 anos. Pelos achados histopatologicos e eletromiograficos concluem tratar-se de variante da forma juvenil de esclerose lateral amiotrofica, forma de Van Laere


Asunto(s)
Esclerosis Amiotrófica Lateral , Sordera
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