A great inspiration for today's vaccination efforts: Biographical sketch of Francisco Xavier Balmis (1753-1819).

The management of the coronavirus pandemic required huge worldwide vaccination efforts. In this endeavour, healthcare workers faced the twofold challenge of reaching remote areas, and persuading people to take the vaccine. As it happens, this is nothing new in the history of medicine. Health workers may indeed continue to take inspiration from Francisco Xavier Balmis, a Spanish physician of the 19th century who realised the importance of Jenner's vaccine against smallpox, and led a successful expedition to administer the vaccines in the Spanish colonial possessions of the Western hemisphere and Asia. This article presents a biographical sketch of Balmis, focusing on his expedition.

José Gregorio Hernández: At the crossroads of medicine and religion in Venezuela.

After being ravished by a bloody civil war in the 1860 s, Venezuela's healthcare system was very precarious. In this context, one particularly bright medical student stood out, José Gregorio Hernández. As part of a program to modernize medicine in Venezuela, José Gregorio was sent on a scholarship to pursue medical studies in Europe. He brought back to Venezuela equipment and medical knowledge in bacteriology and pathophysiology. This was instrumental in laying the foundations for major healthcare modernization in Venezuela. Throughout his life, José Gregorio negotiated his intense Catholic faith, with his scientific leanings as a physician. His untimely tragic death in 1919 elevated him to a saintly status amongst Venezuelans. Consequently, his image became a powerful symbol for practitioners of prescientific medicine.

Polio in Pakistan: Political, Sociological, and Epidemiological Factors.

Pakistan, Nigeria, and Afghanistan remain the only countries in the world where polio is still a serious threat. This review article addresses the political, sociological, and epidemiological factors behind the failure in eradication. A relatively popular Nigerian conspiracy theory about polio vaccines spread in Pakistan and, as a result, there is some considerable resistance to polio vaccination. Conspiracy theories about vaccines have a long history, and the fact that polio vaccinators were used as spies in order to plan for Bin Laden's death has made polio vaccination a bigger challenge. Furthermore, vaccination is strongly correlated with literacy and Pakistan is still struggling against illiteracy. However, these obstacles are by no means insurmountable, and a joint effort by the government, policymakers, education department, community mobilizers, and public health professionals can indeed make major improvements.