The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.

Examination of patients with various forms of anxiety and phobic disorders (according to DSM-4 criteria) demonstrated a considerable shortening of enkephalin half-life and reduced total enkephalinase activity in the blood during generalized anxiety, but not during panic disorders and agoraphobia. This was probably related to low blood concentration of endogenous inhibitors of enkephalin-degrading enzymes in patients with generalized anxiety disorders. Heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which attenuates behavioral anxiety reactions and does not cause side effects typical of most anxiolytics, dose-dependently inhibited enzymatic hydrolysis of plasma enkephalin (IC50 15 microM). Selank was more potent than peptidase inhibitors bacitracin and puromycin in inhibiting enkephalinases. These results suggest that high efficiency of Selank in the therapy of anxiety and phobic disorders, including generalized anxiety, is due to its ability to inhibit enkephalin hydrolysis.

[Rationale for maximum permissible concentration of arbidole and thiophenol in water reservoirs]. / Obosnovanie predelno dopustimoi kontsentratsii arbidola i tiofenola v vode vodnykh obektov.

Maximum allowable concentrations (MAC) for Arbidole and thiophenoi in water were substantiated. MAC of this substances accordingly are (mg/dm3): 0.04 and 0.002.

[Status of immunologic reactivity and prospects of the implementation of occupational selection of workers at a microbiological plant]. / Sostoianie immunologicheskoi reaktivnosti i perspektivy realizatsii professional'nogo otbora rabotnikov mikrobiologicheskogo proizvodstva.

The results of immunologic studies of different groups of workers engaged in the microbiologic synthesis production are presented. The study reveals a very important role of the immune system in the development of various forms of diseases. Differentiated shifts in various chains of cellular and humoral immunity have been identified in practically healthy people and in patients with occupational diseases both in acute condition and at the remittance stage. These shifts are specified by the form and stage of the disease, length of service at the given enterprise and individual immunity characteristics. By means of using immunograms it is possible to select patients with stable, adequate immune type enabling one to go on working at the industrial enterprise without any significant pathologic changes in the body.

[Effect of levamisole on the immunological reactivity of patients with chronic postoperative osteomyelitis]. / Vliianie levamizola na immunologicheskuiu reaktivnost' bol'nykh khronicheskim posleoperatsionnym osteomielitom.

Clinical observations of 31 patients have shown that levamisole promotes the improvement of immunological indices in patients with chronic postoperative osteomyelitis. In a group of patients treated with levamisole good results were obtained in 84%, while in the group of patients treated without levamisole good results were obtained in 63,9%.