Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). Patient's state was assessed with psychometric scales (Hamilton, Zung, CGI). Enkephalin activity in the blood serum was measured as well. The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects. The clinical-biological study revealed that patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders. The increase of this parameter and stronger positive correlations with anxiety level were observed during the treatment with selank mostly in patients with GAD.
Anxiety Disorders/drug therapy , Neurasthenia/drug therapy , Oligopeptides/administration & dosage , Administration, Intranasal , Administration, Oral , Adolescent , Adult , Anti-Anxiety Agents/administration & dosage , Anti-Anxiety Agents/pharmacokinetics , Anxiety Disorders/blood , Anxiety Disorders/psychology , Biomarkers/blood , Dose-Response Relationship, Drug , Enkephalins/blood , Female , Follow-Up Studies , Humans , Male , Medazepam/administration & dosage , Medazepam/pharmacokinetics , Middle Aged , Neurasthenia/blood , Neurasthenia/psychology , Oligopeptides/pharmacokinetics , Psychometrics/methods , Severity of Illness Index , Treatment Outcome
The paper presents an analysis of the disorders with manifestations of non-delirious pathologic love as a response to the action of psychogenic factor on the basis of constitutional predisposition. By the results of the examination of 31 patients with prolonged psychogenic depressions, characterized by the phenomenon of erotic possession, 2 types of the pathologic reactions were distinguished: with a predominance of the possessed images and with a predominance of the delirious-like fantasies. Psycho-traumatic situations that reflected loss of significant relations (either real or imaginary) as a result of the divorce, broken relations, "love triangle", etc. were investigated. Estimation of the premorbid state in the patients allowed both to reveal accentuation in a sphere of love relationship and to single out a main mechanism of the development of pathologic reactions (by type of "key" experience) as well as to define typological differentiation of psychogenic by type of erotic possession taking into consideration the constitutional anomalies.
Delusions/diagnosis , Love , Sexual Dysfunctions, Psychological/diagnosis , Adult , Delusions/etiology , Delusions/psychology , Depression/diagnosis , Depression/etiology , Depression/psychology , Female , Humans , Interpersonal Relations , Male , Middle Aged , Sexual Dysfunctions, Psychological/etiology , Sexual Dysfunctions, Psychological/psychology , Stress, Psychological/complications , Stress, Psychological/psychology
