Intranasal administration of dopamine (0.3; 3 and 30 microg/kg) on anxious behaviour of mice was studied using elevated plus-maze and open fields tests and the pinch-induced catalepsy on parallel bars test. Dopamine was introduced as nose drops or inhalation of nanoparticles of the compound solution in C57B1/6J and CBA/Lac mice with differences of dopaminergic function features. In our experiment, dopamine had anxiolytic and elevated motor activity effects in C57B1/6J, but not in the CBA/Lac mice. Nose drops were more effective than inhalation; perhaps, it was a more stressful manipulation. Apparently dopamine increased the number of CBA/Lac mice who demonstrated catalepsy and the reflex duration. Indeed, the neurotransmitter is active in different psycho-emotional phenomena.
Anti-Anxiety Agents/pharmacology , Anxiety/physiopathology , Behavior, Animal/drug effects , Dopamine/pharmacology , Emotions/drug effects , Maze Learning/drug effects , Motor Activity/drug effects , Administration, Inhalation , Administration, Intranasal , Animals , Anxiety/drug therapy , Anxiety/metabolism , Anxiety Disorders/metabolism , Anxiety Disorders/physiopathology , Behavior, Animal/physiology , Catalepsy/metabolism , Catalepsy/physiopathology , Dosage Forms , Dose-Response Relationship, Drug , Male , Maze Learning/physiology , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Models, Animal , Nanoparticles/administration & dosage , Species Specificity
Calcium/metabolism , Biological Transport, Active , Bone and Bones/metabolism , Calcitonin/physiology , Dihydroxycholecalciferols/metabolism , Humans , Hydroxycholecalciferols/metabolism , Intestinal Absorption , Kidney/metabolism , Parathyroid Hormone/physiology , Prednisolone/pharmacology , Protein Binding , Protein Biosynthesis , Vitamin D/physiology
