Effects of Self-Myofascial Release on Athletes' Physical Performance: A Systematic Review.

Therapists and strength and conditioning specialists use self-myofascial release (SMR) as an intervention tool through foam rollers or massage rollers for soft tissue massage, with the purpose of improving mobility in the muscular fascia. Moreover, the use of SMR by professional and amateur athletes during warm-ups, cool downs, and workouts can have significant effects on their physical performance attributes, such as range of motion (ROM) and strength. The purpose of this study was to analyse the literature pertaining to these types of interventions and their effects found in different physical performance attributes for athletes. A systematic search was carried out using the following databases: PUBMED, ISI Web of Science, ScienceDirect, and Cochrane, including articles up to September 2023. A total of 25 articles with 517 athletes were studied in depth. SMR seems to have acute positive effects on flexibility and range of motion, without affecting muscle performance during maximal strength and power actions, but favouring recovery perception and decreasing delayed-onset muscle soreness. Some positive effects on agility and very short-range high-speed actions were identified, as well. In conclusion, although there is little evidence of its method of application due to the heterogeneity in that regard, according to our findings, SMR could be used as an intervention to improve athletes' perceptual recovery parameters, in addition to flexibility and range of motion, without negatively affecting muscle performance.

Ligament Injuries in Professional Male Handball Players: A 6-Year Longitudinal Study.

Handball is a sport that involves high-intensity actions throughout the game, such as sprints, jumps, landings, and high-speed, repeated throws. This, along with competitive and tactical factors, congested schedules, and the need to maintain a high level of performance throughout the season, contributes to a high injury rate. This study aimed to analyse ligament injuries in a professional handball team over six consecutive seasons. A total of 68 elite male Spanish handball players participated, with 54 time-loss injuries (i.e., injuries involving at least one day of absence) observed during this study period. Ligament injury information was recorded following the International Olympic Committee consensus statement. The overall incidence was 0.89 ligament injuries per 1000 h of exposure. Additionally, a higher incidence and burden of ligament injuries was observed during match-play compared to training. Most ligament injuries were classified as minor or moderate (i.e., 79.63% of the total), and 46.29% were reinjuries. A significantly higher incidence of ligament injuries was suffered in the lower limbs compared to the upper limbs (0.81 vs. 0.08 ligament injuries per 1000 h; p < 0.001). Specifically, the highest incidence was observed in the anterior talofibular ligament of the ankle (0.57 injuries per 1000 h of exposure), while the greatest burden was related to the anterior cruciate ligament (24.08 absence days per 1000 h of exposure). This study provides an overview of ligament injuries among professional handball players, highlighting the need to implement strategies with positive effects during competition (e.g., specific activation strategies or training programmes based on strength and balance) and to reduce injury recurrences.

Relationship between Physical Fitness and Cyberbullying Patterns (Cybervictimization and Cyberperpetration) in Spanish Adolescents.

(1) Background: Cyberbullying is a growing problem among adolescents, and deeper knowledge of this phenomenon could facilitate the implementation of adequate prevention and intervention strategies. Therefore, the aim of this study was to analyze the relationships between victimization and aggression patterns in cyberbullying and physical fitness levels in Spanish adolescents. (2) Methods: A total of 741 adolescents aged 12 to 19 years from two high schools in Andalusia, Spain (mean = 14.52 ± 1.96 years; 50.9% girls, 49.1% boys) participated in the study. The participants underwent the EUROFIT battery test and completed the Spanish version of the European Cyberbullying Intervention Project Questionnaire (ECIPQ) scale. T-test, bivariate correlations and a linear regression analysis were used for statistical analysis. (3) Results: The study results indicated positive relationships between cyberbullying patterns, especially cybervictimization, and age, as well as several physical fitness measures, including BMI, sit-ups, sit-and-reach, and handgrip tests. On the other hand, cyberperpetration was positively related only to age and the specific grip strength test. Further statistical analysis revealed that cybervictimization was primarily influenced by age, while cyberperpetration was mainly influenced by age and performance in a functional test (sit-and-reach). (4) Conclusions: Cyberbullying roles, both as victims and aggressors, may not be strongly influenced by isolated physical fitness factors. Thus, in order to reach a more comprehensive understanding and better explanations of individual involvement in cyberbullying behavior, future studies should analyze psychological and social factors along with the variables considered in this study.

Silver Supported Nanoparticles on [Mg4 Al-LDH] as an Efficient Catalyst for the α-Alkylation of Nitriles, Oxindoles and Other Carboxylic Acid Derivatives with Alcohols.

An efficient heterogeneous silver-catalyzed α-alkylation of nitriles and oxindoles using alcohols via borrowing hydrogen strategy has been developed for the first time. The active nanostructured material, namely [Ag/Mg4 Al-LDH], composed by silver nanoparticles (3-4 nm average particle size) homogeneously stabilized onto a [Mg4 Al-LDH] support with suitable Brønsted basic properties, constitutes a stable catalyst for the sustainable building of novel C-C bonds from alcohols and C-nucleophiles. By applying this catalyst, a broad range of α-functionalized nitriles and oxindoles has been accessed with good to excellent isolated yields and without the addition of external bases. Moreover, the novel silver nanocatalyst has also demonstrated its successful application to the cyclization of N-[2-(hydroxymethyl)phenyl]-2-phenylacetamides to afford 3-arylquinolin-2(1H)-ones, through a one-pot dehydrogenation and intramolecular α-alkylation. Control experiments, kinetic studies, and characterization data of a variety of [Ag/LDH]-type materials confirmed the silver role in the dehydrogenation and hydrogenation steps, while [Mg4 Al-LDH] matrix is able to catalyze condensation. Interestingly, these studies suggest as key point for the successful activity of [Ag/Mg4 Al-LDH], in comparison with other [Ag/LDH]-type nanocatalysts, the suitable acid-base properties of this material.

Effects of Different Rapid Weight Loss Strategies and Percentages on Performance-Related Parameters in Combat Sports: An Updated Systematic Review.

Most combat sports (CS) are structured in weight categories, and it is very common to carry out body weight adjustment strategies in order to compete in lower weight categories. For this reason, different rapid weight loss (RWL) strategies are usually performed to pass the pre-competition weigh-in test, and then a replenishment of fluids and carbohydrate-rich foods is conducted in an attempt to recover the weight and avoid a performance loss. In this context, no clear references have been found on whether these types of strategies have negative effects, impairing the athlete's combat and/or physical performance. For this reason, the aim of this study was to review the scientific literature on the effect of rapid weight reduction strategies on the performance of CS athletes. A literature search was performed through four different databases (PubMed, SPORTDiscus, Web of Science and ScienceDirect). Four inclusion criteria were established as follows: (1) the subjects had to be competitors in the CS and carry out RWL strategies; (2) at least two measurement points, that is, normal conditions and dehydration condition; (3) measurements in a real competition or simulating the same conditions; (4) original research articles written in English or Spanish and available in full text. Finally, a total of 16 articles were finally included in this research. All subjects (n = 184) were athletes from combat disciplines, with a minimum of 3-4 years of practice, as well as with certain experience in RWL. Six of the studies reported that an RWL strategy of around 5% of body weight loss did not affect performance parameters. However, the other ten studies with RWL between 3 and 6% or even higher reported negative effects or impairments on different parameters related to performance and/or athlete's psychophysiology, such as perceived fatigue, mood states, strength and power production, as well as changes in hormonal, blood and urine parameters, body composition, or the kinematics of the technical gesture. Although there is still no clear answer to the issue approached in this research, in general terms, it seems that in order to guarantee an acceptable athletic performance of the competitor, the weight loss should not exceed 3% to ≤5% of body weight together with ≥24 h for adequate (or at least partial) recovery and rehydration processes. In addition, it is highly recommended to lose weight progressively over several weeks, especially focusing on competitions lasting several days, as well as multiple rounds or qualifying stages.

Free amino acid and acylcarnitine values in Ursus americanus Pallas 1780 (black bear) from Northeastern Mexico.

INTRODUCTION: Ursus americanus Pallas 1780 is the largest carnivore and the only ursid in Mexico. It is considered an endangered species in the country because its distribution and population have been reduced by up to 80% because of habitat loss or furtive hunting. These problems can lead to a diet change, which could result in metabolic disorders, such as fatty acid ß-oxidation defects or organic acid metabolism disorders. In our study, a free amino acid and acylcarnitine profile was characterized. METHODS: Peripheral blood samples were drawn from nine free-ranging black bears in a period of five months, from June to October of 2019 in Northeastern Mexico, and 12 amino acids and 30 acylcarnitines were determined and quantified. Age differences were observed in the samples through ANOVA and post-hoc Tukey test. RESULTS: Only three metabolites showed a significant difference with age: alanine (Ala) [cubs vs juvenile], free-carnitine (C0) [juvenile vs cubs] and acetylcarnitine (C2) [cubs vs adults and juvenile vs cubs]. CONCLUSION: Metabolites with variability due to age were identified, making them potential biomarkers to monitor metabolic status as early diagnosis in endangered species. This is the first study of black bear amino acid and acylcarnitine profiles, and the values found could be used as reference for free amino acid and acylcarnitine concentrations in further studies of the species.

Limited effect of over-the-counter doses of ibuprofen on mechanisms regulating muscle hypertrophy during resistance training in young adults.

We have previously shown that maximal over-the-counter doses of ibuprofen, compared with low doses of acetylsalicylic acid, reduce muscle hypertrophy in young individuals after 8 wk of resistance training. Because the mechanism behind this effect has not been fully elucidated, we here investigated skeletal muscle molecular responses and myofiber adaptations in response to acute and chronic resistance training with concomitant drug intake. Thirty-one young (aged 18-35 yr) healthy men (n = 17) and women (n = 14) were randomized to receive either ibuprofen (IBU; 1,200 mg daily; n = 15) or acetylsalicylic acid (ASA; 75 mg daily; n = 16) while undergoing 8 wk of knee extension training. Muscle biopsies from the vastus lateralis were obtained before, at week 4 after an acute exercise session, and after 8 wk of resistance training and analyzed for mRNA markers and mTOR signaling, as well as quantification of total RNA content (marker of ribosome biogenesis) and immunohistochemical analysis of muscle fiber size, satellite cell content, myonuclear accretion, and capillarization. There were only two treatment × time interaction in selected molecular markers after acute exercise (atrogin-1 and MuRF1 mRNA), but several exercise effects. Muscle fiber size, satellite cell and myonuclear accretion, and capillarization were not affected by chronic training or drug intake. RNA content increased comparably (∼14%) in both groups. Collectively, these data suggest that established acute and chronic hypertrophy regulators (including mTOR signaling, ribosome biogenesis, satellite cell content, myonuclear accretion, and angiogenesis) were not differentially affected between groups and therefore do not explain the deleterious effects of ibuprofen on muscle hypertrophy in young adults.NEW & NOTEWORTHY Here we show that mTOR signaling, fiber size, ribosome biogenesis, satellite cell content, myonuclear accretion, and angiogenesis were not differentially affected between groups undergoing 8 wk of resistance training with concomitant anti-inflammatory medication (ibuprofen versus low-dose aspirin). Atrogin-1 and MuRF-1 mRNA were more downregulated after acute exercise in the low-dose aspirin group than in the ibuprofen group. Taken together it appears that these established hypertrophy regulators do not explain the previously reported deleterious effects of high doses of ibuprofen on muscle hypertrophy in young adults.

Microdosing Sprint Distribution as an Alternative to Achieve Better Sprint Performance in Field Hockey Players.

Introduction: The implementation of optimal sprint training volume is a relevant component of team sport performance. This study aimed to compare the efficiency and effectiveness of two different configurations of within-season training load distribution on sprint performance over 6 weeks. Methods: Twenty male professional FH players participated in the study. Players were conveniently assigned to two groups: the experimental group (MG; n = 11; applying the microdosing training methodology) and the control group (TG; n = 9; traditional training, with players being selected by the national team). Sprint performance was evaluated through 20 m sprint time (T20) m and horizontal force−velocity profile (HFVP) tests before (Pre) and after (Post) intervention. Both measurements were separated by a period of 6 weeks. The specific sprint training program was performed for each group (for vs. two weekly sessions for MG and TG, respectively) attempting to influence the full spectrum of the F-V relationship. Results: Conditional demands analysis (matches and training sessions) showed no significant differences between the groups during the intervention period (p > 0.05). No significant between-group differences were found at Pre or Post for any sprint-related performance (p > 0.05). Nevertheless, intra-group analysis revealed significant differences in F0, Pmax, RFmean at 10 m and every achieved time for distances ranging from 5 to 25 m for MG (p < 0.05). Such changes in mechanical capabilities and sprint performance were characterized by an increase in stride length and a decrease in stride frequency during the maximal velocity phase (p < 0.05). Conclusion: Implementing strategies such as microdosed training load distribution appears to be an effective and efficient alternative for sprint training in team sports such as hockey.

Association between VO2max, anthropometrical measures and change of direction test in young soccer players / Asociación entre V02max, medidas antropométricas y test de cambio de dirección en futbolistas jóvenes

Objective: The use of the aerobic system is especially relevant due to the duration of the soccer game. In fact, the correct development of the aerobicsystem benefits the soccer player giving greater energy efficiency because the continuous change of energy system due to the intermittent nature of thegame causes a high consumption of glycogen. The purpose of the present study was to evaluate oxygen consumption by means of the Yo-Yo intermittenttest and anthropometrical measures, and different COD (change of direction) tests in young soccer players and to observe their possible relationship. Methods: A total of forty-seven young male soccer players (age= 15.7 ± 1.2 years; height = 188.8 ± 5.8 cm, and body mass= of 75.7 ± 8.3 kg; 7.6 ± 2.0 yearsof experience) from the region of Baleares, Spain, performed the Yo-yo test and subsequently, COD was evaluated by tests in the following order (i) V-cuttest; (ii) 505-COD test; and (iii) Illinois test. Results: A correlation analysis between VO2max and BMI revealed a moderate negative correlation, r=-0.35, p=0.01, and between VO2max and 505-COD,showed a large negative correlation, r=-0.55, p=0.001. Conclusions: The finding of the present study reveals that there is no relationship between VO2max and agility. Therefore, there is no single method toimprove VO2max and agility since both are independent variables. The different agents involved should take this into account if they want to improveVO2max and plan some aerobic resistance exercises; and to improve agility they must plan agility exercises separately.(AU)

Objetivo: El uso del sistema aeróbico es especialmente relevante debido a la duración del partido de fútbol. De hecho, el correcto desarrollo del sistemaaeróbico beneficia al futbolista otorgándole una mayor eficiencia energética ya que el continuo cambio de sistema energético debido a la naturalezaintermitente del juego provoca un alto consumo de glucógeno. El propósito del presente estudio fue evaluar el consumo de oxígeno mediante la pruebaYo-Yo intermitente y medidas antropométricas, y diferentes pruebas COD (cambio de dirección) en jóvenes futbolistas y observar su posible relación. Métodos: Un total de cuarenta y siete jóvenes futbolistas masculinos (edad= 15.7 ± 1.2 años; altura = 188.8 ± 5.8 cm, y masa corporal= de 75.7 ± 8.3 kg;7.6 ± 2.0 años de experiencia) de la región de Baleares, España, realizó la prueba Yo-yo y posteriormente, se evaluó la DQO mediante pruebas en elsiguiente orden (i) prueba de corte en V; (ii) prueba 505-COD; y (iii) prueba de Illinois. Resultados: Un análisis de correlación entre VO2max e IMC reveló una correlación negativa moderada, r=-0.35, p=0.01, y entre VO2max y 505-CODmostró una correlación negativa grande, r=-0.55, p=0.001. Conclusiones: El hallazgo del presente estudio revela que no existe una relación entre el VO2max y la agilidad. Por lo tanto, no existe un método único paramejorar el VO2max y la agilidad ya que ambas son variables independientes. Los diferentes agentes implicados deberían tener esto en cuenta si quierenmejorar el VO2max y planificar algunos ejercicios de resistencia aeróbica; y para mejorar la agilidad deben planificar ejercicios de agilidad por separado.(AU)

Inter-stroke steadiness: a new kinematic variable related to 200m performance in young canoeists.

Traditionally, canoeing analyses have always been carried out by calculating mean values over a certain distance. However, a simple analysis of mean values in cyclic actions, such as canoe paddling, can lead to the loss of decisive data. Therefore, the objective of this study was to investigate whether the relationship between the periods of consecutive strokes can be an important aspect in all-out 200-m canoeing performance. A total of 22 young male canoeists aged 13.51 ± 0.43 years old voluntarily participated in the present study. Lateral recordings were taken from all participants when performing an all-out 200 m to subsequently analyse the kinematic variables of time, speed and cycle frequency, length and index. The time of each stroke was calculated by the frame differencesbetween two successive paddles. Likewise, short-term and long-term steadiness of consecutive strokes were analysed. Positive correlations were observed between all-out 200-m time and inter-stroke steadiness, identifying significant associations with long-term (r ≈ 0.8; p < 0.05) and short-term steadiness (r ≈ 0.7; p < 0.05). In conclusion, the present investigation defines and identifies inter-stroke steadiness as a new original kinematic variable that might be considered for performance analysis since it seems to be a key factor in all-out 200-m canoeing.

Cognitive and Physical Effects of Warm-Up on Young Soccer Players.

This study analyzed the effects of with (WC) or without conducting a warm up on youth soccer players immediately before performing physical and cognitive tests. Fourteen youth soccer player (age 11.64 ± 0.50) participated in a counterbalanced cross-sectional study in which three conditions were tested: (a) basal lineal condition; (b) WC (immediately before the physical and cognitive tests); and (c) without WC (passive resting for 15 min between the warm-up and physical and cognitive tests). A 30-m sprint test, countermovement jump, and psychomotor vigilance task were also applied. The WC revealed significant improvements in countermovement jump (p < .05), 30-m sprint test performance (p < .05), and reaction time in psychomotor vigilance task (p < .05) in comparison to basal lineal condition and without WC. A 15-min rest after a warm-up has a meaningfully decremental effect on the physical and cognitive readiness of youth soccer players, in comparison with when they warm-up immediately before the demands are imposed.

Exploring the Y-Balance-Test scores and inter-limb asymmetry in soccer players: differences between competitive level and field positions.

BACKGROUND: The postural stability seems to be important in the physical development of the soccer player and the specific tasks related to the game. In addition, it is related to the injury risk and therefore, with the injury prevention and retraining processes. In this context, the Y Balance Test (YBT) is presented as a tool to assess dynamic postural control. OBJECTIVE: This study aimed to explore the differences and possible correlations in the YBT scores and inter-limb asymmetry for anterior (ANT), posteromedial (PM) and posterolateral (PL) directions by category and field position in soccer players. METHODS: 173 males soccer players aged between 14 and 33 years old agreed to participate. Five categories and six field position were considered in this study. A standardised protocol was used at multiple clubs during the pre-season assessment of musculoskeletal function in soccer players. All the players performed the Y Balance Test (YBT) (official YBT Kit), assessing the dominant and non-dominant leg for three YBT directions (anterior-AN, posteromedial-PM and posterolateral-PL), inter-limb asymmetry and composite score. RESULTS: For AN, amateur and semiprofessional obtained the highest values for Dominant and Non-Dominant legs (Rangemean = 101.8-109.4%) and the lowest level in PRO players (mean: 62.0%). Concerning PM-PL, semiprofessional (Rangemean = 126.4-132.7%, dominant and non-Dominant respectively), followed by professional and amateur reported higher scores compared to youth categories. Inter-limb asymmetry showed higher values in lower age categories. The best composite scores were detected in semiprofessionals (Rangemean = 113.3-126.7% for dominant and Rangemean = 113.8-129.7% for non-Dominant leg), compared with the rest of the categories and for each field position evaluated. CONCLUSION: Comparisons between field-positions revealed that centre-backs were worse than wingers and forwards. In order to explain variations in dynamic balance between competitive levels within the same age-group, special considerations about training programmes and related co-variables should be considered.

Response of Muscle Damage Markers to an Accentuated Eccentric Training Protocol: Do Serum and Saliva Measurements Agree?

ABSTRACT: González-Hernández, JM, Jiménez-Reyes, P, Cerón, JJ, Tvarijonaviciute, A, Llorente-Canterano, FJ, Martínez-Aranda, LM, and García-Ramos, A. Response of muscle damage markers to an accentuated eccentric training protocol: do serum and saliva measurements agree? J Strength Cond Res 36(8): 2132-2138, 2022-This study aimed (a) to examine the acute and delayed responses of 3 muscle damage biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) to an accentuated eccentric training protocol in serum, and (b) to explore the changes of these biomarkers in saliva and compare them with serum. Sixteen resistance-trained university students (10 men [age = 26.6 ± 4.8 years, full squat one repetition maximum [1RM] = 103.4 ± 14.4 kg] and 6 women [age = 22.7 ± 1.4 years, full squat estimated 1RM = 68.3 ± 10.5 kg]) completed an accentuated eccentric strength training protocol with the full squat exercise consisting of 8 sets of 10 repetitions against the 120% estimated 1RM load with 5 minutes of interset rest. The activity of muscle damage biomarkers (CK, AST, and LDH) was measured in serum and saliva before training (Pre), 24 hours after training (Post24), and 96 hours after training (Post96). In serum, lower values of the 3 muscle damage markers were observed at Pre compared to Post24 and Post96, whereas no significant differences were observed between Post24 and Post96 for any analyte. In saliva, there was a significant increase in men at Post96 compared with Pre in CK. The correlations between the measurements in serum and saliva ranged from trivial to small ( r = -0.034 to 0.212). These results suggest that the measurement of muscle damage markers in serum and saliva do not provide the same information in the conditions of our study.

Neural activity in self-related brain regions in response to tailored nutritional messages predicts dietary change.

Overweight and obesity have become international public health problems, so there is an urgent need to implement effective interventions that prevent these concerning health issues. Designing personalized (tailored) dietary communications has become one of the most effective tools in reducing unhealthy eating behavior, when compared with one-size-fits-all messages (untailored). However, more research is required to gain a complete understanding of the underlying mechanisms by which tailored nutritional messages elicit reductions in unhealthy dietary behavior. To the best of our knowledge, our study may be the first to use neuroimaging, namely functional magnetic resonance imaging (fMRI), aiming to evaluate the neural basis of tailored and untailored nutritional messages and assess how these neural responses predict unhealthy food intake reduction after a month receiving tailored nutritional messages. To that goal, 30 participants were scanned while reading tailored and untailored nutritional messages. Subsequently, for a month, they received tailored interventions encouraging healthy food intake. The neural findings reveal that when compared to untailored communications, tailored messages elicit brain networks associated with self-relevance, such as the precuneus, the middle temporal gyrus, the hippocampus, the inferior orbitofrontal cortex (OBC), the dorsomedial prefrontal cortex (dMPFC), and the angular gyrus. Interestingly, among these self-related brain areas, the dMPFC, OFC, angular gyrus, and hippocampus forecast reductions in unhealthy food intake after a one-month tailored intervention for the cessation of unhealthy eating. These results may offer implications for clinicians, practitioners, and/or policymakers who should implement substantial efforts in creating individualized campaigns focused on their target's perceived needs, goals, and drivers in relation to eating healthy to reduce overweight issues. This research therefore constitutes a step forward in showing a direct association between the neural responses to tailored nutritional messages and changes in real-life healthy eating behavior.

Effects of the COVID-19 Health Crisis on Sports Practice, Life Quality, and Emotional Status in Spanish High-Performance Athletes.

Spain is one of the many countries highly affected by the COVID-19 crisis, establishing very restrictive measures with a complete lockdown for more than 3 months. This situation forced the complete closure of sport practice and national or international competitions, leading to a negative impact on physical and psychological health of high-performance athletes. Therefore, the objectives of this study were (a) to determine the effects of the COVID-19 health crisis on Spanish high-performance athletes in terms of sports practice, life quality, and emotional state and (b) to identify the profile with the greatest difficulties during and after the lockdown. A sample of 130 high-performance athletes aged between 18 and 34 years (67 women and 63 men) participated in this study (83.1% achieved a medal in National-International elite competitions; 86.9% were considered student-athletes). Measures included socio-demographic data through a 5-dimension ad hoc survey: physical activity and exercise using an adapted version from the International Physical Activity Questionnaire (IPAQ); health status and limitations using an adapted version of SF-12 Health Questionnaire; Perceived stress (Short-PSS); and Mood States (29-item POMS). All participants have shown a significant decrease pre-post-lockdown in both health and performance perception, especially in women, individual athletes, medalists, and student-athletes. Strong limitations of training, attention, and motivation as well as a moderate negative emotional state during lockdown were reported, in women, individual athletes, medalists, and student-athletes. Even with an improved emotional state and energy level in the post-lockdown period, moderate-to-high stress scores were reported by women and medalists. Our findings highlight the importance of paying attention to the physical and psychological health of elite athletes on three profiles: team athletes (due to social distance), student-athletes (dual-career issues), and women athletes (prevalence of implicit gender inequalities in sport).

Has COVID-19 changed the workload for primary care physicians? The case of Spain.

BACKGROUND: The COVID-19 pandemic has led to a massive over-exertion of doctors, multiplying their work intensity, overload and stress. Yet no studies have been conducted on the changes in primary care physician overload during the pandemic. OBJECTIVE: To address this research gap, the aim of this article is to document the subjective dimensions of physicians' work during the peak of the pandemic for comparison with a pre-COVID-19 situation. In addition, the relationship between workload and the individual characteristics of the physician or the percentage of tele-assistance is examined. METHODS: This study performs a subjective measurement procedure for the analysis of work overload through the NASA-TLX questionnaire, with a total of 102 records from 16 doctors from a Primary Health Centers of the Granada-Metropolitan Health district (Andalusia, Spain). RESULTS: The results reflect a significantly higher workload during COVID-19 in relation to a previous situation (66.1% versus 48.6% before COVID-19). All the dimensions of the NASA-TLX test suffered an increase during the COVID-19, this increase being higher in the physical, temporal and frustration levels. Interestingly, the findings reflect the higher the percentage of telematic consultations, the lower workload. CONCLUSIONS: Work overload and the emotional state of health workers is one of the many repercussions of the COVID-19 pandemic. The results derived from this study may be useful in formulating policies and practices related to the workforce development, funding streams to prepare for the next wave of COVID-19 infections as well as for future public health emergencies.

Calidad Biofarmacéutica e Intercambiabilidad de Medicamento / Biopharmaceutical Quality and Interchange of Drugs

Introducción: La industria farmacéutica que busca la aprobación para comercializar un medicamento genérico debe presentar datos que demuestren que la formulación genérica proporciona la misma calidad, eficacia y seguridad que el medicamento innovador. Por lo tanto, la mayoría de los medicamentos genéricos administrados por vía oral están aprobados en función de los resultados de uno o más estudios fisicoquímicos y biofarmacéuticos para demostrar bioequivalencia y posterior intercambiabilidad.Objetivo: Identificar en los artículos de investigación las posibles diferencias entre las pruebas fisicoquímicas y biofarmacéuticas de bioequivalencia de medicamentos genéricos con la de sus homólogos ya comercializados.Método: Se realizó la revisión de estudios de investigación originales, publicados desde enero del año 2003 hasta diciembre del 2019. Se consultaron 4 bases de datos Pubmed, ScienceDirect, Lilacs, Scielo. En inglés y español. Los descriptores utilizados fueron medicamento genérico, bioequivalencia, equivalencia terapéutica e intercambialidad, así mismo solo se seleccionaron aquellos artículos donde su forma farmacéutica de estudio fuese comprimidos.Resultados: Se seleccionaron en total 40 artículos para su evaluación, de los cuales 19 llegaron a la conclusión de bioequivalencia, otros 19 determinaron no bioequivalencia, para 1 no existía una conclusión definitiva, mientras que en 1 estudio que evaluaba a 3 medicamentos, la conclusión fue no bioequivalencia para 2 de ellos y para el tercero sí la había.Conclusión: La revisión revela que los estudios son insuficientes para indicar bioequivalencia entre los fármacos multifuentes (genéricos) y los innovadores, por lo que se necesita ampliar los estudios de bioequivalencia. (AU)

Introduction: The pharmaceutical industry seeking approval to market a generic drug must submit data demon-strating that the generic formulation provides the same quality, efficacy, and safety of the innovative drug. There-fore, most orally administered generic drugs are approved based on the results of one or more physicochemical and biopharmaceutical studies to demonstrate bioequivalence and subsequent interchangeability. Objective: Identify in research articles the possible differences between the physicochemical and biopharmaceuti-cal tests of bioequivalence of generic drugs with that of their corresponding innovative equivalents. Method: The original research studies, published from January 2003 to December 2019, were reviewed. 4 databases were consulted Pubmed, ScienceDirect, Lilacs, Scielo. In English and Spanish. The descriptors used were generic medicine, bioequivalence, therapeutic equivalence and interchangeability, likewise only those articles where their study pharmaceutical form was tablets were selected. Results: A total of 40 articles were selected for evaluation, of which 19 reached the conclusion of bioequivalence, another 19 determined non-bioequivalence, for 1 there was no definitive conclusion, while in a study that evaluated 3 drugs, the conclusion was no bioequivalence for 2 of them and bioequivalence for one. Conclusions: The review reveals that the studies are insufficient to indicate bioequivalence between multi-source (generic) and innovative drugs, so that bioequivalence studies need to be expanded. (AU)

Catalytic Reductive Alcohol Etherifications with Carbonyl-Based Compounds or CO2 and Related Transformations for the Synthesis of Ether Derivatives.

Ether derivatives have myriad applications in several areas of chemical industry and academia. Hence, the development of more effective and sustainable protocols for their production is highly desired. Among the different methodologies reported for ether synthesis, catalytic reductive alcohol etherifications with carbonyl-based moieties (aldehydes/ketones and carboxylic acid derivatives) have emerged in the last years as a potential tool. These processes constitute appealing routes for the selective production of both symmetrical and asymmetrical ethers (including O-heterocycles) with an increased molecular complexity. Likewise, ester-to-ether catalytic reductions and hydrogenative alcohol etherifications with CO2 to dialkoxymethanes and other acetals, albeit in less extent, have undergone important advances, too. In this Review, an update of the recent progresses in the area of catalytic reductive alcohol etherifications using carbonyl-based compounds and CO2 have been described with a special focus on organic synthetic applications and catalyst design. Complementarily, recent progress made in catalytic acetal/ketal-to-ether or ester-to-ether reductions and other related transformations have been also summarized.

Effects of Whole-Body Vibration Training on Body Composition, Cardiometabolic Risk, and Strength in the Population Who Are Overweight and Obese: A Systematic Review With Meta-analysis.

OBJECTIVES: To assess the effects of whole-body vibration training (WBVT) on body composition, metabolic and cardiovascular risk variables, and lower limb strength in participants who are overweight/obese. DATA SOURCES: A systematic review with meta-analysis was conducted in 3 databases (PubMed-MEDLINE, Web of Science, and Cochrane Library) from inception through to January 26, 2020. STUDY SELECTION: Studies analyzing the effect of WBVT on body composition variables, metabolic profile, blood pressure, heart rate, and lower limb strength in the population who are overweight/obese, with interventions of a minimum length of 2 weeks were included. DATA EXTRACTION: After applying the inclusion and exclusion criteria, 23 studies involving 884 participants who were obese/overweight (experimental group: 543; weight=79.9 kg; body mass index (BMI) =31.3 kg/m2, obesity class I according to World Health Organization) were used in the quantitative analysis. The sex of the participants involved in the studies were as follows: (1) 17 studies included only female participants; (2) 1 study included only boys, and (3) 5 studies included both sexes. Meta-analysis, subgroup analysis, and meta-regression methods were used to calculate the mean difference and standardized mean difference (SMD; ± 95% confidence intervals [CIs]) as well as to analyze the effects of pre-post intervention WBVT and differences from control groups. DATA SYNTHESIS: WBVT led to a significant decrease in fat mass (-1.07 kg, not clinically significant). In addition, WBVT reduced systolic blood pressure (-7.01 mmHg, clinically significant), diastolic blood pressure (-1.83 mmHg), and heart rate (-2.23 bpm), as well as increased the lower extremity strength (SMD=0.63; range, 0.40-0.86). On the other hand, WBVT did not modify the weight, BMI, muscle mass, cholesterol, triglycerides, or glucose. CONCLUSIONS: WBVT could be an effective training modality to reduce blood pressure (clinically relevant) and resting heart rate. In addition, WBVT led to improved lower limb strength. However, these findings were not consistent with significant improvements on other variables associated with metabolic syndrome (body composition, cholesterol, triglycerides, glucose).