Comparison of modified mallampati classification with Cormack and Lehane grading in predicting difficult laryngoscopy among elective surgical patients who took general anesthesia in Werabie comprehensive specialized hospital - Cross sectional study. Ethiopia, 2021.

Background: Difficult laryngoscopy/intubation can cause a multitude of issues, including hypoxia, brain damage, and even death if not addressed swiftly. The Modified Mallampati test (MMT) is frequently used to predict difficult airway in patients with no clear difficult airway signal, despite its limited predictive power, in patients with no obvious difficult airway signal. Cormack and Lehane grading (CLG) is the gold standard, however it is not utilized before anesthesia. Objective: To compare modified Mallampati classification (MMC) with Cormack and Lehane grading in predicting difficult laryngoscopy among patients who took general anesthesia. Method: An institutionally based cross sectional survey study of 141 elective surgical patients with no obvious difficult airway sign was conducted from February to April 2021. The correlation between MMC and CLG was computed using spearman's correlation coefficient, and the area under the curve (AUC) for MMT was assessed using receiver operating characteristics (ROC) curve analysis. Result: The incidence of difficult laryngoscopy and intubation, respectively, was 14.9% and 9.2%. The Spearman correlation coefficient (ρ) was 0.330, with a significance level of 0.001. The AUCs for difficult laryngoscopy and intubation, respectively, were 0.705 and 0.726. MMT had 47.6% sensitivity and 93.3% specificity for difficult laryngoscopy and 53.8% and 91.4% specificity for difficult intubation, respectively. Conclusion: and Recommendation: There was little correlation between MMC and CLG. MMT sensitivity was similarly low. As a result, as part of the screening test for difficult airway, extra clinical tests are required.

Hemodynamic and analgesic effect of intrathecal fentanyl with bupivacaine in patients undergoing elective cesarean section; a prospective cohort study.

BACKGROUND: Spinal anesthesia with bupivacaine has side effects such as hypotension, respiratory depression, vomiting, and shivering. The side effects are dose-dependent, therefore different approaches have been attempted to avoid spinal-induced complications including lowering the dose of local anesthetic and mixing it with additives like Neuraxial opioids. OBJECTIVE: To compare the Hemodynamic and analgesic effects of intrathecal fentanyl as an adjuvant with low and conventional doses of bupivacaine in patients undergoing elective cesarean section under spinal anesthesia. METHODOLOGY: An institutional-based prospective cohort study was conducted on 90 patients. Data was collected with chart review, intraoperative observation, and postoperatively patient interview. Data was entered into EPI INFO and transport to SPSS version 23 for analysis of variables using one-way ANOVA, Kruskal Wallis H rank test, and chi-square. RESULT: Hypotension but not bradycardia, was significantly frequent in a conventional dose of bupivacaine alone (CB) group and a conventional dose of bupivacaine with fentanyl (CBF) groups than that of the lower dose of bupivacaine with fentanyl (LBF) groups. Duration of analgesia was significantly longer in LBF (248± 35.6 minutes) and in CBF groups (260.3±40.3 minutes) than in CB group (167.10 ± 31.45 minutes). Time for the first analgesic request was significantly later in LBF (304±47.8 minutes) and CBF (294.6±99.5 minutes) groups than that in CB group (177±25.88 minutes). CONCLUSION: The Lower dose of bupivacaine is associated with less risk of hypotension and faster recovery. Adding fentanyl with the lower dose of bupivacaine in spinal anesthesia for cesarean section could provide comparable anesthesia with the lower risk of hypotension and longer postoperative analgesia.

The use of perineural dexamethasone and transverse abdominal plane block for postoperative analgesia in cesarean section operations under spinal anesthesia: an observational study.

BACKGROUND: During transverses abdominal plane block (TAP) procedure to provide analgesia in cesarean section (CS) operation, the use of perineural dexamethasone as an additive agent may improve pain relief and may cause a prolonged block duration. This study aims to investigate whether perineural dexamethasone, when added to bupivacaine local anesthetic agent during a TAP block, may provide adequate pain relief without adverse events. METHODS: This is a prospective cohort study of fifty-eight patients undergoing elective CS with spinal anesthesia. We hypothesized to perform bilateral TAP block using perineural dexamethasone as an additive agent. The patients were randomly divided into two groups using a systematic random sampling method. While one group of patients received perineural dexamethasone of 8 mg additive agent together with bupivacaine 0.25% 40 ml (Group TAPD), the other group received only bupivacaine 0.25% 40 ml in TAP block (Group TAPA). The primary outcomes are the period for the first request of postoperative pain relief medication and the numerical rating scale (NRS) pain intensity scores at 2, 6, 12, and 24 h after surgery. The secondary outcomes are comparing the 24-h tramadol and diclofenac analgesic requirements and the incidences of side effects on postoperative day one. A p-value of < 0.05 is statistically significant. RESULTS: The time to first analgesic request was 8.5 h (8.39-9.79) in the TAPD group versus 5.3 h (5.23-5.59) in the TAPA group, respectively. (p < 0.001) The median NRS scores were significantly reduced in the TAPD group compared to the TAPA group at 6, 12, and 24 h after surgery (p-values < 0.001). The total analgesics consumption over 24 h postoperatively was lower in Group TAPD compared to Group TAPA (p < 0.05). CONCLUSION: An additive agent of perineural dexamethasone at a dose of 8 mg during bilateral TAP block for elective CS operation under spinal anesthesia provided better pain relief on postoperative day 1.