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1.
Environ Geochem Health ; 46(8): 285, 2024 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-38967745

RESUMEN

Water scarcity is a growing concern due to rapid urbanization and population growth. This study assesses spring water quality at 20 stations in Giresun province, Türkiye, focusing on potentially toxic elements and physicochemical parameters. The Water Quality Index rated most samples as "excellent" during the rainy season and "good" during the dry season, except at stations 4 (40° 35' 12″ North/38° 26' 34″ East) and 19 (40° 44' 28″ North/38° 06' 53″ West), indicating "poor" quality. Mean macro-element concentrations (mg/L) were: Ca (34.27), Na (10.36), Mg (8.26), and K (1.48). Mean trace element values (µg/L) were: Al (1093), Zn (110.54), Fe (67.45), Mn (23.03), Cu (9.79), As (3.75), Ni (3.00), Cr (2.84), Pb (2.70), Co (1.93), and Cd (0.76). Health risk assessments showed minimal non-carcinogenic risks, while carcinogenic risk from arsenic slightly exceeded safe limits (CR = 1.75E-04). Higher arsenic concentrations during the rainy season were due to increased recharge, arsenic-laden surface runoff, and human activities. Statistical analyses (PCA, PCC, HCA) suggested that metals and physico-chemical parameters originated from lithogenic, anthropogenic, or mixed sources. Regular monitoring of spring water is recommended to mitigate potential public health risks from waterborne contaminants.


Asunto(s)
Monitoreo del Ambiente , Estaciones del Año , Contaminantes Químicos del Agua , Calidad del Agua , Medición de Riesgo , Contaminantes Químicos del Agua/análisis , Monitoreo del Ambiente/métodos , Humanos , Manantiales Naturales/química , Oligoelementos/análisis , Metales Pesados/análisis
2.
Mar Pollut Bull ; 203: 116488, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38759467

RESUMEN

This study examines the levels and patterns of potentially toxic elements (PTEs) in surface sediment of Almus Dam Lake (ADL), a key fish breeding site in Türkiye. PTE concentrations in sediment were ranked: Hg (0.05 ± 0.01) < Cd (0.16 ± 0.01) < Pb (9.34 ± 1.42) < As (18.75 ± 15.65) < Cu (63.30 ± 15.17) < Ni (72.64 ± 20.54) < Zn (86.66 ± 11.95) < Cr (108.35 ± 36.40) < Mn (1008 ± 151) < Fe (53,998 ± 6468), with no significant seasonal or spatial differences. Ecological risk indices (mHQ, EF, Igeo, CF, PLI, Eri, mCd, NPI, PERI, MPI, and TRI) showed low contamination levels. Health risk assessments, including LCR, HQ, and THI, indicated minimal risks to humans from sediment PTEs. Statistical analyses (PCA, HCA, SCC) identified natural, transportation, and anthropogenic PTE sources, with slight impacts from agriculture and fish farming. This research underlines contamination status of ADL and emphasizes the need for targeted management strategies, offering critical insights for environmental safeguarding.


Asunto(s)
Monitoreo del Ambiente , Peces , Sedimentos Geológicos , Contaminantes Químicos del Agua , Animales , Sedimentos Geológicos/química , Contaminantes Químicos del Agua/análisis , Medición de Riesgo , Monitoreo del Ambiente/métodos , Metales/análisis , Ecotoxicología , Lagos/química
3.
Mar Pollut Bull ; 203: 116514, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38788275

RESUMEN

This study investigates potentially toxic elements (PTEs) in the surface sediments of the Abdal River system, a critical water source for Samsun province, Türkiye, due to the presence of the Çakmak Dam. PTE concentrations, measured in mg/kg, show significant variability: Hg (0.03) < Cd (0.26) < As (10.98) < Pb (13.88) < Cu (48.61) < Ni (62.45) < Zn (70.97) < Cr (96.28) < Mn (1015) < Fe (38357). Seasonal variations were observed, in particular increased concentrations of As, Cd and Pb in summer (p < 0.05). Contamination and ecological risk indices (mHQ, EF, Igeo, CF, PLI, Eri, mCd, NPI, PERI, MPI, and TRI) indicate moderate to low levels of contamination, suggesting potential ecological effects. Health risk assessments suggest minimal risks to human health from sediment PTEs. Statistical analyses (PCC, PCA and HCA) improve the understanding of the sediment environment and contamination sources, while the coefficient of variation assists in source identification.


Asunto(s)
Monitoreo del Ambiente , Sedimentos Geológicos , Ríos , Contaminantes Químicos del Agua , Sedimentos Geológicos/química , Ríos/química , Medición de Riesgo , Contaminantes Químicos del Agua/análisis , Metales/análisis , Metales Pesados/análisis
4.
Acta Derm Venereol ; 104: adv18452, 2024 May 06.
Artículo en Inglés | MEDLINE | ID: mdl-38708991

RESUMEN

A treat-to-target approach was recently developed to guide systemic treatment for adults with atopic dermatitis (AD). Recommendations outlined criteria for a 3-month initial acceptable treatment target and a 6-month optimal target, evaluated using global assessment of patient-reported disease severity, as well as Eczema Area and Severity Index, itch assessed on an 11-point numerical rating scale, Dermatology Life Quality Index, or Patient-Oriented Eczema Measure. Achievement of these targets with once-daily upadacitinib (15 mg and 30 mg) monotherapy was evaluated using integrated adult data from the Measure Up 1 and 2 phase 3 studies. Among the 852 patients treated with upadacitinib 15 mg or 30 mg, the 3-month initial acceptable target was achieved by >80%, >78%, and ≥87% of patients, and the 6-month optimal target was achieved by ≥53%, >61%, and >73% of patients at weeks 2, 16, and 52, respectively. Achievement of all 6 individual criteria for each of the target goals also increased over time. These findings suggest that upadacitinib 15 mg and 30 mg may help improve standards of care in patients with moderate-to-severe AD by achieving 6-month target goals at 16 weeks and as early as 2 weeks for most patients.


Asunto(s)
Dermatitis Atópica , Compuestos Heterocíclicos con 3 Anillos , Índice de Severidad de la Enfermedad , Humanos , Dermatitis Atópica/tratamiento farmacológico , Dermatitis Atópica/diagnóstico , Compuestos Heterocíclicos con 3 Anillos/uso terapéutico , Adulto , Resultado del Tratamiento , Masculino , Femenino , Persona de Mediana Edad , Calidad de Vida , Factores de Tiempo , Inhibidores de las Cinasas Janus/uso terapéutico , Medición de Resultados Informados por el Paciente
5.
BMC Urol ; 24(1): 106, 2024 May 14.
Artículo en Inglés | MEDLINE | ID: mdl-38745203

RESUMEN

BACKGROUND: Microplastics are ubiquitous, widespread environmental pollutants with unavoidable human exposure. Herein, it was aimed to investigate the presence of microplastics in prostate tissue. METHODS: Prostate tissues from 12 patients who underwent Trans Urethral Resection of the Prostate (TUR-P) were analyzed to investigate the presence of microplastics. Initially, the prostate tissues were analyzed for microplastic particles using a light microscope after extraction. Subsequently, the chemical composition of the particles found in the prostate tissues was characterized using Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) spectrophotometry. RESULTS: Microplastic particles of various types were detected in 6 out of 12 patients. All detected plastic particles in this study were microplastics, with sizes below 26 µm in size. These microplastics exhibited different shapes as pellets, spheres or fibers. Overall, among the 12 analyzed prostate tissue samples, four different types of plastic were identified in six samples. The most common type of microplastic detected was Polyamide (Nylon 6), found in samples from three patients. Other detected types, Polypropylene, Polyacrylic Acid and Poly (dimethylsiloxane) were each determined in samples from one patient. CONCLUSIONS: This is the first study to demonstrate the presence of microplastics in prostate tissue, serving as an exploratory investigation, which can trigger further research to validate the results in a larger patient cohort.


Asunto(s)
Microplásticos , Próstata , Humanos , Masculino , Microplásticos/análisis , Próstata/química , Próstata/cirugía , Anciano , Persona de Mediana Edad
6.
Mar Pollut Bull ; 189: 114732, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36841212

RESUMEN

The estuarine sediments were sampled seasonally along the southeast coast of the Black Sea, to assess the concentrations, sources, distributions, and possible ecological risks of trace elements (TEs). The mean concentrations of TEs (mg/kg) were ranked as Fe (56,659.83) > Al (39,758.00) > Mn (1168.53) > Zn (155.03) > Cr (120.75) > Pb (93.71) > Cu (82.66) > Ni (44.93) > Co (17.98) > As (13.66) > Cd (0.99) > Hg (0.18), respectively. The stations S4 and S6 showed "very high contamination" for Pb, "significantly enrichment" for Pb and Cd, "high ecological risk" for Cd, and "heavily polluted" for Pb and Cd according to the results of CF, EF, Eri, Igeo, respectively. The rest of the stations were in the low or moderate contamination through the all seasons as assessed by different eco-geochemical risk assessment indices. The integrated risk evaluation indices indicated no contamination in stations S3 and S5.


Asunto(s)
Metales Pesados , Oligoelementos , Contaminantes Químicos del Agua , Metales Pesados/análisis , Oligoelementos/análisis , Contaminantes Químicos del Agua/análisis , Mar Negro , Cadmio , Plomo , Sedimentos Geológicos , Monitoreo del Ambiente/métodos , Medición de Riesgo
7.
Mar Pollut Bull ; 187: 114583, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36630793

RESUMEN

Samples of surface water were collected seasonally along the 121 km long Giresun coastline to comparatively evaluate the source, distribution, and ecological risk of 16 polycyclic aromatic hydrocarbons (PAHs). The total PAHs levels, varied between 47.42 and 576.69 ng L-1 with the mean of 161.5 ng L-1, were consistent with seawater studies worldwide. Diagnosis rates evinced that PAHs in seawater along the Giresun coastline are primarily sourced from biomass, coal and petroleum combustion and petroleum at lesser extent. The three-ring PAHs (40.2 %) was proportionally high, followed by 2-ring PAHs (26.5 %). The toxicity equivalent quotient (TEQ) and risk quotients (RQ) were employed to assess ecological risk posed by PAHs in Giresun coastal seawater. As a result, the ecological risk in all seasons was at moderate to high risk level, except for autumn, which shows low to moderate risk according to TEQ. RQ values of ∑PAHs displayed low to moderate ecological risk.


Asunto(s)
Petróleo , Hidrocarburos Policíclicos Aromáticos , Contaminantes Químicos del Agua , Agua , Mar Negro , Contaminantes Químicos del Agua/análisis , Monitoreo del Ambiente , Hidrocarburos Policíclicos Aromáticos/análisis , China , Medición de Riesgo , Sedimentos Geológicos
8.
Mar Pollut Bull ; 178: 113585, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-35339061

RESUMEN

Seasonal sediment samples were collected along the Giresun coastline of southeastern Black Sea and analyzed to detect the levels of 16 polycyclic aromatic hydrocarbons (PAHs). The PAH levels, ranging from 28.47 to 444.36 ng g-1 with the mean of 102.57 ng g-1 remained lower than those detected in most of the other sediment studies conducted worldwide. The percentage of three-ring PAHs (38.9%) was rather high, followed by that of 5-ring PAHs (21.8%). Detection rates revealed that PAHs in surface sediments along the Giresun coastline are mainly associated with coal combustion and local emissions. The evaluation with sediment quality guidelines (SQGs) showed that the level of PAHs was comparable to that at which the risk of adverse biological effects cannot be ruled out (≥TEL and

Asunto(s)
Hidrocarburos Policíclicos Aromáticos , Contaminantes Químicos del Agua , Mar Negro , Monitoreo del Ambiente , Sedimentos Geológicos , Hidrocarburos Policíclicos Aromáticos/análisis , Medición de Riesgo , Estaciones del Año , Contaminantes Químicos del Agua/análisis
9.
J Nanosci Nanotechnol ; 19(5): 2547-2555, 2019 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-30501751

RESUMEN

Lanthanum Ferrite based nanocomposites were prepared with various Graphene oxide contents by the hydrothermal method. The crystalline structure, morphological properties, electrical and optical properties of samples were investigated. X-ray diffraction results indicate that all the nano electroceramics are polycrystalline with an Orthorhombic structure. Results from scanning and transmission electron microscopes indicate that the Bismuth ferrite/Graphene oxide powders have nanostructure. The optical band gaps of the nano electroceramics were calculated for the various amount of Graphene oxide. The electrical properties of samples were investigated with the temperature depend on conductivity measurements. The measurement shows that the electrical conductivity changes with increasing temperature and graphene oxide dopants of all samples. Activation energy (EA) values of the nanocomposites decrease with increasing graphene oxide content. The dielectric properties of Lanthanum Ferrite/Graphene Oxide nanocomposites (real and imaginer) with respect to frequency variation (1 KHz-5 MHz) were measured at room temperature. The relative permittivity (ɛ'), dielectric loss (ɛ″) and alternating current conductivity (σac) values of the samples were estimated. It is show that (ɛ'), (ɛ″) and (σac) increase with increasing frequency. The polarization-electric field hysteresis loop of all Lanthanum Ferrite/Graphene Oxide nano electroceramics was measured at the room temperature. The loop shows proper saturation with enhanced saturation polarization (Ps), remnant polarization (Pr) and coercive electric field (Ec). The obtained findings suggest that the physical and electrical properties of Lanthanum Ferrite/Graphene Oxide nano electroceramics can be changed by Graphene Oxide doping. These materials can be used for a variety of technological applications in the field of dielectric and ferroelectric.

10.
Forensic Sci Int ; 153(1): 53-7, 2005 Oct 04.
Artículo en Inglés | MEDLINE | ID: mdl-15935583

RESUMEN

The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and female Sprague-Dawley rats were given 2,4-D in drinking water and food for 30 days. Group A (control group) was fed a normal diet, Group B was fed 50 ppm 2,4-D in 15 g food, Group C received 100 ppm 2,4-D in 15 g food, Group D received 25 ppm 2,4-D in 15 ml drinking water and Group E was given 50 ppm 2,4-D in 15 ml of drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high performance liquid chromatography (HPLC). It was observed that at low doses of 2,4-D, the metabolite, 2,4-DCP found in the kidneys.


Asunto(s)
Ácido 2,4-Diclorofenoxiacético/análisis , Herbicidas/análisis , Riñón/química , Ácido 2,4-Diclorofenoxiacético/administración & dosificación , Alimentación Animal , Animales , Antihelmínticos/análisis , Clorofenoles/análisis , Cromatografía Líquida de Alta Presión , Relación Dosis-Respuesta a Droga , Femenino , Medicina Legal , Herbicidas/administración & dosificación , Masculino , Ratas , Ratas Sprague-Dawley , Agua/química
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