[OUTPATIENT ANTIMICROBIAL TREATMENT FOR ACUTE TONSILLOPHARYNGITIS].

UNLABELLED: One of the most significant problems in antimicrobial therapy (AMT) is widespread administration of antimicrobial agents without relevant medical conditions. The aim of the research was the analysis of antimicrobial agent prescribing practices for outpatient treatment of acute tonsillopharyngitis at the Karaganda Polyclinic №1 and Polyclinic №2. The analysis of antimicrobial agents prescribing practices for outpatient treatment of acute tonsillopharyngitis was conducted; medical records of outpatients with acute tonsillopharyngitis treated in 2014 at Polyclinics №1 and №2 were analyzed. INCLUSION CRITERIA: patients ranging in age from18 to 44, verified diagnosis - acute tonsillopharyngitis. It was found that in all cases antimicrobial agents have been prescribed speculatively, without previous bacteriological study or method of express diagnostics of Group A beta-hemolytic streptococcus (GABHS). In a majority of cases ß-lactams were prescribed. Flemoxin Solutab was the most commonly prescribed ß-lactam in Polyclinic №1; Amoxicillin was the most commonly prescribed ß-lactam at Polyclinic №2; it associated with personal experience of administration of these agents rather than data of evidentiary medicine. Study of actual medicine administration showed that in half of the cases dosage regimen, rout of administration, dosage and treatment session duration have not been followed. For the development of clinical guidelines for rational treatment of acute tonsillopharyngitis is necessary to study the local spectrum of the major pathogens and their antimicribial resistance.

[Microecologic characteristic of intestine microbiocenosis of frequently ill children].

AIM: Study microecologic features of intestine microbiocenosis of frequently ill children. MATERIALS AND METHODS: Composition of intestine microbiocenosis of 86 children aged 3 - 7 years living in the city of Karaganda (Kazakhstan) by bacteriological method. A number of microecologic coefficients was calculated: species saturation index, consistency index, relative occurrence coefficient, modified Sanders dominance index, chi2 criteria, Jaccard similarity coefficient. RESULTS: The constants members of the biocenosis were Escherichia coli with high enzymatic activity, enterococci, lactobacilli and bifidobacteria. Additional species were opportunistic bacteria and fungi of the Candida genus. A tendency to collective existence between members of the normal microflora (E. coli, lactobacilli and bifidobacteria) and opportunistic bacteria and Candida genus fungi was detected. CONCLUSION: A change of characteristics of intermicrobial interactions in intestine microbiocenosis with a formation of pathologic connections between members of normal and opportunistic microflora and Candida genus fungi was noted.

[Experimental study of the effects of impulse-electric discharge on chemotaxis and cytoadhesion of urinary infection pathogens].

The aim of the experimental study was to evaluate effects of impulse-electric discharge in liquid on chemotaxis and cytoadhesion of urinary infection pathogens. Chemotaxis was determined in respect to the lung, liver, spleen, kidney, ureter, urinary bladder, urethra of white mice by S. Likholetov's modified method. Cytoadhesion was assessed by V. Brilis. The experiments show that the impulse-electric discharge holds promise for urological practice.

[Electrostimulation therapy--a new method of preventing postoperative wound complications in abdominal surgery]. / Elektroimpul'snaia obrabotka tkanei--novyi metod profilaktiki posleoperatsionnykh ranevykh oslozhnenii v abdominan'noi khirurgii.

Experimental investigations have shown that chemotaxic activity of microorganisms in the parietal peritoneum and abdominal organ tissues is inhibited when they are treated with impulse electric discharges preventing the process of infecting the tissues. Results of the experiments underlay the development of a new method of prophylactics of postoperative complications in abdominal surgery based on the electroimpulsive treatment of the operation wound. Clinical approbation of the method showed its effectiveness, simplicity and safety.

[Effects of benzonal on intracardiac hemodynamics in experimental myocardial infarct]. / Vliianie benzonala na vnutriserdechnuiu gemodinamiku pri éksperimental'nom infarkte miokarda.

Benzonal was tested for effects on the natural history of experimental myocardial infarction. Systemic and intracardiac hemodynamic parameters were studied in 35 Shinshilla rabbits. Benzonal was found to exert a positive action of myocardial diastolic relaxation and to be beneficial on the natural history of experimental myocardial infarction.

[Effect of chronic stimulation of the emotionogenic zones of the hypothalamus on the status of carbohydrate metabolism in the rabbit]. / Vliianie khronicheskogo razdrazheniia émotsiogennykh zon gipotalamusa na sostoianie uglevodnogo obmena u krolikov.

In chronic experiments on rabbits receiving for 3 months low doses of cholesterol (60 mg per 1 kg of body weight daily), a repeated prolonged (2 h daily) intermittent stimulation of negative and positive emotive zones of the hypothalamus through implanted electrodes (eliciting avoidance and self-stimulation reactions correspondingly),--resulted in uniform disturbances of carbohydrate metabolism. There was a significant reduction of glucose tolerance in comparison with the control group of rabbits with implanted electrodes, as well as a gradual development of a slight, but stable neurogenic hyperglycemia. Simultaneously, in both experimental rabbits groups there were an equal increase of alimentary hypercholesterolemia and a development of persistent neurogenic arterial hypertension.

[Role of emotional stress in disorders of carbohydrate tolerance]. / Rol' émotsional'nogo stressa v narusheniiakh tolerantnosti k uglevodam.

Two series of rabbit experiments were carried out to study the influence of emotional stress on glucose tolerance. Relatively short-term (10 days) chronic emotional stress induced by prolonged (2 h daily) intermittent stimulation of negative emotiogenic zones of the hypothalamus through implanted electrodes led to decreased glucose tolerance. Repeated powerful emotional stresses induced by the clash of food and pain irritation did not pass traceless and manifested in the same glucose tolerance disturbances after a lengthy period of time (1 year).

[Vascular reactivity changes in chronic emotional stress of hypothalamic origin]. / Izmenenie sosudistoi reaktivnosti v usloviiakh khronicheskogo émotsional'nogo stressa gipotalamicheskogo proiskhozhdeniia.

The vessels of rabbits undergoing a long irritation of the negative emotional zones of the hypothalamus have shown a tendency to increase a constrictive reaction in response to the quantitatively dozed electrostimulation of the vessel walls. This is expressed in the decrease of the range of the stimulation parametres which cause the weakening reaction during 10 days of emotional stress, and in showing only a constrictory reaction to all the parameters of stimulation during a 4-month stress.