RESUMEN
The aim of the present investigation was to describe a new model of liver regeneration in growing rats with reduced portal flow. In addition, it was studied whether tacrolimus and insulin could have any pro-regenerative effect under such conditions. Ninety-five rats were divided into five groups: Group 1 (sham), abdominal incision without intervention; Group 2, 70% hepatectomy; Group 3, 70% hepatectomy + PV stenosis; Group 4, 70% hepatectomy + portal vein stenosis + insulin; and Group 5, 70% hepatectomy + portal vein stenosis + tacrolimus. The remnant liver lobes were harvested for analyses. The liver weight decreased in the PV stenosis group and it increased with the use of insulin and tacrolimus. The mitotic activity was higher in the hepatectomy, insulin and tacrolimus groups and this parameter was reduced by portal stenosis. Levels of interleukin 6 (IL-6) were higher in the hepatectomy group compared to the sham and PV stenosis groups. The expression of IL-6 and Ki67 was significantly increased in the insulin and tacrolimus groups compared to the portal stenosis group. A highly reproducible model was standardized to study liver regeneration with portal blood inflow reduction in weaning rats. It was demonstrated that insulin or tacrolimus administration may partially reverse the harmful effects of PV stenosis.
Asunto(s)
Inhibidores de la Calcineurina/farmacología , Insulina/farmacología , Regeneración Hepática/efectos de los fármacos , Vena Porta/patología , Tacrolimus/farmacología , Animales , Constricción Patológica , Inmunohistoquímica , Interleucina-6/genética , Hígado/irrigación sanguínea , Masculino , Modelos Animales , Reacción en Cadena de la Polimerasa , ARN/análisis , Ratas , Ratas Wistar , Flujo Sanguíneo RegionalRESUMEN
Este trabalho procura identificar os sentimentos do homem antes e apos o divorcio com relacao a familia, profissao, relacionamento social e auto-estima. A amostra se compoe de dez homens divorciados com idade entre 25 e 45 anos. Pode-se verificar, atraves das entrevistas, de modo geral, sentimentos de decepcao com relacao a instituicao casamento, aumento da infidelidade, uma reaproximacao da familia de origem, bem como aumento da auto-estima apos o divorcio. Estes dados podem indicar tanto uma adaptacao satisfatoria a nova condicao, como tambem uma tentativa de negar o fracasso obtido no casamento.