RESUMEN
PURPOSE: This retrospective study evaluated and compared the 2-year outcomes for sinus floor elevation performed via either an osteotome-mediated sinus floor elevation (OSFE) technique or a reamer-mediated sinus floor elevation (RSFE) technique. Implant survival, as well as surgical and postoperative complications, were used as measures of comparison. MATERIALS AND METHODS: Patients were analyzed according to defined inclusion criteria. Orthopantography was used to assess preoperative; immediate postoperative; and 6-, 12-, and 24-month postoperative bone level changes. Implant survival and the incidence of complications, including sinus membrane perforation, were evaluated using appropriate statistical tests. RESULTS: From 2008 to 2010, 126 implants were placed simultaneously with sinus floor elevation in 85 patients (n = 43 women and 42 men; mean age ± standard deviation [SD] = 58.1 ± 10.2 years). The OSFE procedure (control) was used to place 65 implants in 45 patients, and the RSFE procedure (experimental) was used to place 61 implants in 40 patients. The mean maxillary residual bone height was 7.1 ± 1.6 mm. Endosinus bone gains were 5.7 ± 1.5 mm and 5.6 ± 2.3 mm for the experimental and control groups (P = .164), respectively, and the 2-year survival rates were 98.4% and 98.5%, respectively. Although no significant differences were observed between the two groups, three (6.7%) membrane perforations occurred in the OSFE group, and none occurred in the RSFE group. Other postoperative complications, including nasal bleeding, postoperative headache, and dizziness, were documented in 7 (15.6%) of 45 OSFE cases and 3 (7.5%) of 40 RSFE cases. CONCLUSION: The results presented herein indicate that comparable survival rates were achieved for implants placed in conjunction with a reamer- vs osteotome-mediated technique. Therefore, RSFE is a reliable and predictable procedure for implant placement in the posterior maxilla, with a low incidence of complications.
Asunto(s)
Implantación Dental Endoósea/métodos , Implantes Dentales , Osteotomía/instrumentación , Elevación del Piso del Seno Maxilar/instrumentación , Adulto , Anciano , Sustitutos de Huesos/uso terapéutico , Mareo/etiología , Epistaxis/etiología , Femenino , Estudios de Seguimiento , Cefalea/etiología , Humanos , Complicaciones Intraoperatorias , Masculino , Maxilar/patología , Maxilar/cirugía , Persona de Mediana Edad , Minerales/uso terapéutico , Mucosa Nasal/lesiones , Osteotomía/métodos , Complicaciones Posoperatorias , Radiografía Panorámica/métodos , Estudios Retrospectivos , Elevación del Piso del Seno Maxilar/métodos , Análisis de Supervivencia , Resultado del Tratamiento , Adulto JovenRESUMEN
Computer Assisted Simulation Surgery (CASS) is a reliable method that permits oral and maxillofacial surgeons to visualize the position of the maxilla and the mandible as observed in the patient. The purpose of this report was to introduce a newly developed strategy for proximal segment management according to Balanced Orthognathic Surgery (BOS) protocol which is a type of CASS, and to establish the clinical feasibility of the BOS protocol in the treatment of complex maxillo-facial deformities. The BOS protocol consists of the following 4 phases: 1) Planning and simulation phase, 2) Modeling phase, 3) Surgical phase, and 4) Evaluation phase. The surgical interventions in 80 consecutive patients were planned and executed by the BOS protocol. The BOS protocol ensures accuracy during surgery, thereby facilitating the completion of procedures without any complications. The BOS protocol may be a complete solution that enables an orthognatic surgeon to perform accurate surgery based on a surgical plan, making real outcomes as close to pre-planned outcomes as possible.
RESUMEN
Nuclear factor of activated T cell (NFAT) is a key transcription factor for receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. However, it is unclear whether NFAT plays a role in the expression of RANKL in osteoblasts. High extracellular calcium ([Ca(2+)](o)) increases intracellular calcium, enhances RANKL expression in osteoblasts/stromal cells, and induces osteoclastogenesis in a coculture of osteoblasts and hematopoietic bone marrow cells. Because intracellular calcium signaling activates the calcineurin/NFAT pathway, we examined the role of NFAT activation on high [Ca(2+)](o)-induced RANKL expression in MC3T3-E1 subclone 4 (MC4) cells. Among the family of NFAT transcription factors, expression of NFATc1 and NFATc3, but not NFATc2, NFATc4 or NFAT5, was observed in MC4 cells. High [Ca(2+)](o) increased the expression levels of NFATc1, NFATc3 and RANKL. Cyclosporin A and FK506, inhibitors of calcineurin phosphatase, blocked high [Ca(2+)](o)-induced expression of NFAT and RANKL. Knockdown of NFATc1 and NFATc3 by siRNA prevented high [Ca(2+)](o)-induced RANKL expression, whereas overexpression of NFATc1 and NFATc3 induced RANKL expression. Furthermore, overexpressed NFATc1 upregulated NFATc3 expression, but NFATc1 knockdown decreased NFATc3 expression. Chromatin immunoprecipitation and reporter assay results showed that NFATc3, but not NFATc1, directly binds to the RANKL promoter and stimulates RANKL expression. In summary, these results demonstrate that high [Ca(2+)](o) increases expression of RANKL via activation of the calcineurin/NFAT pathway in osteoblasts. In addition, high [Ca(2+)](o) induces the activation and expression of NFATc1; NFATc3 expression and activity are subsequently increased; and NFATc3 directly binds to the RANKL promoter to increase its expression.