Apoptosis of immature peripheral B cells may be due to a lack of survival signals rather than clonal deletion.
B-Lymphocytes , Humans , B-Lymphocytes/metabolism , B-Lymphocytes/immunology , B-Lymphocytes/cytology , Animals , Apoptosis , Signal Transduction
Highlights from the Science family of journals.
Prostaglandins in the tumor microenvironment block IL-2-induced expansion of killer T cells.
Interleukin-2 , Tumor Microenvironment , Interleukin-2/immunology , Interleukin-2/metabolism , Humans , Tumor Microenvironment/immunology , Animals , Neoplasms/immunology , Neoplasms/metabolism , Prostaglandins/metabolism
Microglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner.
Alzheimer Disease , Humans , Alzheimer Disease/drug therapy , Lipids , Apolipoproteins E/genetics
Highlights from the Science family of journals.
Highlights from the Science family of journals.
Highlights from the Science family of journals.
ATP released by osteoblasts signals through the purinergic receptor P2RX4 to optimize plasma cell survival.
Osteoblasts , Plasma Cells , Cell Survival
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
DNA Breaks, Double-Stranded , Nucleotidyltransferases , Nucleotidyltransferases/genetics
The noncanonical caspase caspase-4 processes the pro form of IL-18 in response to LPS.
Caspases , Lipopolysaccharides , Caspase 1
Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell-driven myelin perturbation.
Demyelinating Diseases , Humans , Animals , Axons , Myelin Sheath , Microglia , Disease Models, Animal
Catecholamines associated with stress promote T cell exhaustion through the ß1-adrenergic receptor.
Catecholamines , T-Lymphocytes
Highlights from the Science family of journals.
Interferon-ε has antitumor activity and activates antitumor immunity in ovarian cancer in mice.
Interferons , Ovarian Neoplasms , Animals , Mice , Female , Humans , Ovarian Neoplasms/drug therapy
Loss of phosphatidylinositol transfer protein alpha underlies pancreatic ß cell failure.
Insulin-Secreting Cells , Insulin-Secreting Cells/metabolism
Adrenergic receptor stimulation improves cancer immunotherapy in a range of immune-competent tumor models.
Camping , Neoplasms , Humans , Models, Theoretical , Neoplasms/therapy , Immunotherapy
Remodeling of neural circuits by glioma cells decreases patient survival.
Brain Neoplasms , Glioma , Humans , Glioma/genetics , Signal Transduction , Neurons , Brain Neoplasms/genetics
STING activity in cancer cells prevents the progression of dormant metastasis.
Highlights from the Science family of journals.
LncRNA-derived peptides enhance T lymphocyte responses to tumors in mice.
Neoplasms , RNA, Long Noncoding , Animals , Mice , Neoplasms/genetics , Neoplasms/therapy
