Addressing Drug Resistance in Cancer: A Team Medicine Approach.

Drug resistance remains one of the major impediments to treating cancer. Although many patients respond well initially, resistance to therapy typically ensues. Several confounding factors appear to contribute to this challenge. Here, we first discuss some of the challenges associated with drug resistance. We then discuss how a 'Team Medicine' approach, involving an interdisciplinary team of basic scientists working together with clinicians, has uncovered new therapeutic strategies. These strategies, referred to as intermittent or 'adaptive' therapy, which are based on eco-evolutionary principles, have met with remarkable success in potentially precluding or delaying the emergence of drug resistance in several cancers. Incorporating such treatment strategies into clinical protocols could potentially enhance the precision of delivering personalized medicine to patients. Furthermore, reaching out to patients in the network of hospitals affiliated with leading academic centers could help them benefit from such innovative treatment options. Finally, lowering the dose of the drug and its frequency (because of intermittent rather than continuous therapy) can also have a significant impact on lowering the toxicity and undesirable side effects of the drugs while lowering the financial burden carried by the patient and insurance providers.

Can Patients Travel by Air Less Than 1 Week After Lung Nodulectomy?

Objective: The study objective was to determine empirically based timing recommendations for safe air travel following lung nodulectomy. Methods: All patients who underwent pulmonary nonanatomic resection followed by air travel home immediately after discharge were identified at 2 institutions between 2014 and 2018. These patients were surveyed via telephone regarding any complications they may have experienced during their travel home and within the first week after discharge. These complications included shortness of breath, chest pain, drainage from their surgical sites, and evaluation by a health care provider in the interim, if they required. Results: Our study identified 27 patients who fit the inclusion criteria. The median number of days between surgery and flight home in the studied population was 4 days. The median number of days between chest tube removal and flight home was 2 days. None of the 27 patients reported experiencing shortness of breath, chest pain, drainage from their surgical sites, or need for evaluation by a health care provider within 1 week of discharge. Nine patients (33%) traveled by air with a small (<5%) pneumothorax documented on chest radiography after removal of thoracostomy tube. One (4%) patient successfully traveled without complication with a 10% pneumothorax. Conclusions: The findings of our study support the safety of air travel following lung nodulectomy in patients who have undergone uneventful wedge resection and have no significant pulmonary or cardiac comorbidities. It is not necessary for patients to wait the recommended 7 days prior to traveling.

The story of the lost needle: Foreign body embolization to the heart.

A 61-year-old female was evaluated because of severe symptomatic mitral regurgitation. She was found to have a foreign body in the heart by cardiac catheterization. Through a retrospective review of serial imaging studies, we found that a hypodermic needle had been retained in the body from a prior abdominal wall surgery and had subsequently migrated to the heart. During surgical mitral valve replacement the needle was identified and removed. We demonstrate the trajectory of this foreign body from the abdominal wall into the heart. .

Assessment and reduction of diaphragmatic tension during hiatal hernia repair.

BACKGROUND: During hiatal hernia repair there are two vectors of tension: axial and radial. An optimal repair minimizes the tension along these vectors. Radial tension is not easily recognized. There are no simple maneuvers like measuring length that facilitate assessment of radial tension. The aims of this project were to: (1) establish a simple intraoperative method to evaluate baseline tension of the diaphragmatic hiatal muscle closure; and, (2) assess if tension is reduced by relaxing maneuvers and if so, to what degree. METHODS: Diaphragmatic characteristics and tension were assessed during hiatal hernia repair with a tension gage. We compared tension measured after hiatal dissection and after relaxing maneuvers were performed. RESULTS: Sixty-four patients (29 M:35F) underwent laparoscopic hiatal hernia repair. Baseline hiatal width was 2.84 cm and tension 13.6 dag. There was a positive correlation between hiatal width and tension (r = 0.55) but the strength of association was low (r (2) = 0.31). Four different hiatal shapes (slit, teardrop, "D", and oval) were identified and appear to influence tension and the need for relaxing incision. Tension was reduced by 35.8 % after a left pleurotomy (12 patients); by 46.2 % after a right crural relaxing incision (15 patients); and by 56.1 % if both maneuvers were performed (6 patients). CONCLUSIONS: Tension on the diaphragmatic hiatus can be measured with a novel device. There was a limited correlation with width of the hiatal opening. Relaxing maneuvers such as a left pleurotomy or a right crural relaxing incision reduced tension. Longer term follow-up will determine whether outcomes are improved by quantifying and reducing radial tension.