[Possibilities of neurotrophic therapy for delayed speech development]. / Vozmozhnosti neirotroficheskoi terapii zaderzhki rechevogo razvitiya.

The article provides an analysis of the possibility of neurotrophic therapy of delayed speech development (DSD) in 266 children who underwent dynamic clinical, laboratory, functional and neuropsychological examinations and received neurotrophic therapy. This study confirmed the effectiveness of neurotrophic therapy in the treatment of as isolated speech disorder (ISD) as well speech disorder in the structure of the general psychomotor developmental delay (PDD). The lack of effect in the use of neuroprotective therapy in every sixth child of the latter group can be a marker for the individualization of the treatment of each individual with an emphasis on non-drug rehabilitation methods. The use of cortexin in monotherapy in the treatment of delayed speech development is justified not only by its effectiveness in improving speech development and good tolerance, but also in connection with an improvement in behavior in children of the studied groups, which is possibly associated with a positive effect on mental activity in general, and on self-control function in particular.

[A Study of the Fertility of a Drosophila melanogaster MS Strain with Impaired Transposition Control of the gypsy Mobile Element].

The flamenco locus is one of the main components of the piRNA pathway of regulation of mobile genetic elements (MGEs) in Drosophila melanogaster. Mutations at this locus lead to an increase in the transposition activity of MGEs and, as a result, to genetic instability. In this paper, the fertility of a genetically unstable MS strain obtained more than 25 years ago and characterized by a mutation in the flamenco locus and the presence of a functionally active copy of gypsy retrotransposon was investigated. Complex violations of the ovarian morphology were revealed in the MS strain in females: defects in the follicular layer and ring channels, as well as degradation of trophocytes, which in turn led to a decrease in reproductive abilities. Analysis of the MS strain transcriptome showed a decrease in the expression level of 40 genes encoding chorionic proteins and expression specificity at different stages of follicle development. In the F1 and F2 hybrid females from the crosses of MS females with wild type males, restoration of reproductive abilities was observed, despite the fact that half of the F2 females had the flamenco genotype and genetic instability caused by transposition of gypsy (according to the ovo^(D) test). Moreover, the frequency of gypsy transposition in the hybrid F2 females with the flamenco genotype doubled in comparison with the MS strain females. Thus, the MS strain had acquired partial suppression of the flamenco phenotype and accumulated several recessive mutations in the genes that control oogenesis after cultivation for over 25 years.