RESUMEN
Clinical efficacy of including cycloferon liniment in combined treatment of herpetic infection in a group of 40 patients with atopic dermatitis has been analyzed. It is concluded that the administration of cycloferon favors dynamic disappearance of general infectious syndrome, reduces timeline of rash as well as length of local inflammation, accelerates epithelization of erosions (on the average 1.2 - 1.4 times, p < 0.05), decreases frequency of recurrent infections, and reduces the level of pro-inflammatory cytokines in the blood of patients.
Asunto(s)
Acridinas/uso terapéutico , Dermatitis Atópica/tratamiento farmacológico , Herpes Labial/tratamiento farmacológico , Inductores de Interferón/uso terapéutico , Adulto , Dermatitis Atópica/complicaciones , Dermatitis Atópica/inmunología , Dermatitis Atópica/patología , Quimioterapia Combinada , Femenino , Glucocorticoides/uso terapéutico , Herpes Labial/complicaciones , Herpes Labial/inmunología , Herpes Labial/patología , Humanos , Interleucina-1beta/sangre , Interleucina-1beta/inmunología , Masculino , Persona de Mediana Edad , Factor de Necrosis Tumoral alfa/sangre , Factor de Necrosis Tumoral alfa/inmunologíaRESUMEN
The aim of the study was to estimate the efficacy of liniment cycloferon included in combined therapy of herpetic infection in 30 patients with psoriasis divided into 2 groups. Combined treatment of patients with recurrent herpetic infection promoted elimination of general infection syndrome, shortened duration of eruption and local inflammation, accelerated epithelization of herpetic erosion, and decreased the frequency of relapses during the follow-up.
Asunto(s)
Acridinas , Infecciones por Herpesviridae , Herpesvirus Humano 1 , Psoriasis , Repitelización/efectos de los fármacos , Acridinas/administración & dosificación , Acridinas/efectos adversos , Aciclovir/uso terapéutico , Adulto , Antiinfecciosos Locales , Antivirales/uso terapéutico , Comorbilidad , Quimioterapia Combinada , Femenino , Infecciones por Herpesviridae/tratamiento farmacológico , Infecciones por Herpesviridae/epidemiología , Infecciones por Herpesviridae/fisiopatología , Infecciones por Herpesviridae/virología , Herpesvirus Humano 1/efectos de los fármacos , Herpesvirus Humano 1/aislamiento & purificación , Humanos , Inmunomodulación , Inductores de Interferón/administración & dosificación , Inductores de Interferón/efectos adversos , Linimentos , Masculino , Psoriasis/epidemiología , Psoriasis/fisiopatología , Recurrencia , Resultado del TratamientoRESUMEN
The efficiency of cycloferon liniment in combined treatment of herpetic infection in patients with latent form of HIV infection has been assess by observations of 40 patients divided into two groups. In the first group, the standard treatment was supplemented with the application of cycloferon liniment twice a day during 7 days; in the second group, the therapy was conducted according to standard recommendations. It was established that the application of cycloferon liniment in combination with standard therapy in patients with relapse of herpetic infection against the background of HIV infection ensures faster disappearance of general infectious syndrome, decreases the period of eruptions and the duration of local inflammations, and accelerates the epithelialization of erosions.