Antinociceptive and anti-inflammatory activities of Ayapana triplinervis essential oil rich in thymohydroquinone dimethyl ether from Brazil.

Ayapana triplinervis (M.Vahl) R.M.King & H.Rob. (Asteraceae), popularly known as japana, is a tropical, aromatic subshrub widely used as tea to combat some diseases. The essential oil was obtained from the leaves by hydrodistillation (3 h), and the chemical composition was analyzed by gas chromatography coupled to mass spectrometry. For in vivo assays, Mus musculus/Swiss mice were used to evaluate oral acute toxicological (at dose of 2000 mg/kg); peripheral and central analgesic for abdominal contortion (doses of 6.25, 12.5, 25, 50 and 100 mg/kg), hot plate test (12.5, 25, 50, and 100 mg/kg) and formalin (25, 50 and 100 mg/kg); open field test (100 mg/kg); and anti-inflammatory by ear swelling induced by xylene (6.25,12.5, 25, 50, and 100 mg/kg). The yield of A. triplinervis essential oil (AtEO) was 4.6%, and the oxygenated monoterpene 2,5-dimethoxy-p-cymene was the major compound in this study (63.6%). AtEO at a dose of 2,000 mg/kg orally did not change the behavior patterns or mortality of the animals; liver and kidney biochemical levels were similar to the control group, indicating no liver and kidney toxicity. Moreover, AtEO, at doses of 6.25, 12.5, 25, 50, and 100 mg/kg, reduced abdominal contortions by 21%, 54%, 91%, 58%, and 55%, respectively. In the hot plate test, AtEO showed a significant increase in latency time in the 60-min interval at doses of 25 mg/kg (11.3 ± 3.3 s) and 100 mg/kg (11.9 ± 0.9 s). In the first phase of the formalin test, AtEO decreased paw licking time at doses of 25, 50, and 100 mg/kg, with inhibition of 22%, 38%, and 83%; in the second phase, the same doses, decreased licking time with inhibition of 24%, 34%, and 76%. AtEO did not present a significant change in the spontaneous locomotor activity of the animals. Doses of 6.25, 12.5, 25, 50, and 100 mg/kg significantly reduced ear edema induced by topical application of xylene with percentages of 40%, 39%, 54%, 45%, and 45%, respectively. So, AtEO demonstrated low acute oral toxicity and exhibited significant antinociceptive and anti-inflammatory actions, consistent with the use of A. triplinervis in traditional medicine.

Lippia alba essential oil: A powerful and valuable antinociceptive and anti-inflammatory medicinal plant from Brazil.

ETHNOPHARMACOLOGICAL RELEVANCE: In Brazilian popular medicine, Lippia alba leaves are used in teas to treat pain and inflammatory diseases. AIM OF THE STUDY: to evaluate the chemical composition, antinociceptive, and anti-inflammatory activities of Lippia alba essential oil and its major compound geraniol. MATERIAL AND METHODS: Lippia alba leaves were collected in Pará state, Brazil. The leaf essential oil was obtained using a modified Clevenger-type extractor. Then, the oil was analyzed by GC and GC-MS analyses. To evaluate the toxicity of LaEO and geraniol, the doses of 50, 300, and 2000 mg/kg were used in a mouse model. For antinociception tests, abdominal contortion, hot plate, and formalin tests were used; all groups were treated with LaEO and geraniol at doses of 25, 50, and 100 mg/kg; and to evaluate inflammation using the ear edema model. RESULTS: The constituents identified in the highest content were oxygenated monoterpenes: geraniol (37.5%), geranial (6.7%) and neral (3.8%). The animals treated with LaEO and geraniol demonstrated atypical behaviors with aspects of lethargy and drowsiness, characteristics of animals in a state of sedation; the relative weights showed no significant difference compared to the controls. In the abdominal contortion test, LaEO at 25 mg/kg, 50 mg/kg doses, and 100 mg/kg reduced the number of contortions, representing a percentage reduction of 84.64%, 81.23%, and 66.21% respectively. In the hot plate test, LaEO and geraniol increased the latency time at doses of 25, 50, and 100 mg/kg in all test periods; there was no statistical difference between LaEO and geraniol. In the first phase of the formalin test, only doses of 25 mg/kg and 100 mg/kg of LaEO showed significant activity, reducing the latency time by 53.40% and 58.90%. LaEO at doses of 25 mg/kg and 100 mg/kg reduced the size of the edema, demonstrating an anti-inflammatory activity of 59.38% (25 mg/kg) and 50% (100 mg/kg). CONCLUSION: Lippia alba essential oil and geraniol showed central/peripheral analgesic and anti-inflammatory potential and can be used as an alternative or complementary treatment to conventional drugs. More studies are needed to evaluate its action mechanisms and its analgesic effects.

New records of Pseudopomyzidae in Brazil and description of the male of Latheticomyia infumata Wheeler (Diptera: Brachycera).

Latheticomyia Wheeler is recorded for the first time from Brazil, with records of Latheticomyia infumata Wheeler and Latheticomyia longiterebra Hennig. The male of L. infumata is described and the terminalia are illustrated. New records of Pseudopomyzella flava Hennig for the Brazilian Amazon are presented.

Seasonal Variation in Essential Oil Composition and Antioxidant Capacity of Aniba canelilla (Lauraceae): A Reliable Source of 1-Nitro-2-phenylethane.

Aniba canelilla (Kunth) Mez essential oil has many biological activities due to its main compound 1-nitro-2-phenylethane (1N2F), followed by methyleugenol, a carcinogenic agent. This study analyzed the influence of seasonality on yields, antioxidant capacity, and 1N2F content of A. canelilla leaf and twig essential oils. Essential oils (EOs) were extracted with hydrodistillation and analyzed with gas chromatography coupled to mass spectrometry and a flame ionization detector. Antioxidant capacity was measured using the free radical scavenging method (DPPH). Chemometric analyses were carried out to verify the influence of climatic factors on the production and composition of EOs. 1-Nitro-2-phenylethane was the major constituent in A. canelilla EOs throughout the seasonal period (68.0-89.9%); methyleugenol was not detected. Essential oil yields and the 1N2F average did not show a statistically significant difference between the dry and rainy seasons in leaves and twigs. Moderate and significant correlations between major compounds and climate factor were observed. The twig oils (36.0 ± 5.9%) a showed greater antioxidant capacity than the leaf oils (20.4 ± 5.0%). The PCA and HCA analyses showed no statistical differences between the oil samples from the dry and rainy seasons. The absence of methyleugenolin in all months of study, described for the first time, makes this specimen a reliable source of 1N2F.

Two new species of the genus Hoplopeza Bezzi (Diptera, Hybotidae, Ocydromiinae) from the high Andean forests of Colombia.

Two new Andean species of Hoplopeza Bezzi are described and illustrated: Hoplopeza colombiana sp. nov. and Hoplopeza rafaeli sp. nov. These species are the first record from the Andean ecosystem of Colombia. In addition, the genus is diagnosed, the first description of the female terminalia, as well as a key and distribution map of the Andean species of the genus are presented.

Change in Rotavirus Vaccine Coverage in Brazil from before (2015-2019) through the COVID-19 Pandemic Period (2020-2021).

During the COVID-19 pandemic, a reduction in vaccination coverage of children and adolescents was observed in several countries. The aim of this study was to assess the impact of the pandemic, in the first two years, on human rotavirus vaccine (HRV) coverage in Brazil compared with previous years. The number of doses of HRV administered in the period from January 2015 to December 2021 and its annual vaccination coverage were analyzed. The vaccination coverage decreased to 77.3% in 2020 and to 70.4% in 2021, substantially lower than the minimum that would be expected (89.2%); the decline was more pronounced in the second year of the pandemic despite the fact that in this period, the circulation restrictions were already less tight. Of the five Brazilian macro-regions, the northeast had the largest decline, and the south had the smallest impact on coverage. At the municipal level, less than half of the Brazilian municipalities managed to achieve vaccination coverage above 90% in either pandemic year. Although there was already a downward trend in coverage in the pre-pandemic years, the present study shows that the values recorded in 2020 and 2021 were significantly lower. Monitoring of vaccination coverage in the coming years should be carried out continuously in order to avoid a possible resurgence of rotavirus-induced diarrhea.

Revision of the New Zealand endemic genus Pseudoscelolabes Collin (Diptera: Hybotidae: Ocydromiinae).

Pseudoscelolabes Collin, 1933, an endemic New Zealand genus, is revised, including the description of a new species, P. lesagei Sinclair Barros sp. nov. The male and female terminalia of the genus are described and illustrated for the first time. An identification key to the two included species and a map with distribution records are provided. The relationships of the genus within Ocydromiinae are discussed.

Furuncular Myiasis by Dermatobia hominis (Diptera: Oestridae) in Wild Jaguars in the Amazon Rainforest.

Two individuals of the jaguar, Panthera onca (L.), were captured near the municipality of Presidente Figueiredo, Brazilian Amazon, during the years of 2017 and 2018. The jaguars presented furuncular myiasis caused by the human botfly Dermatobia hominis (L.) on the rear thighs and tail. This is the first record of infestation of D. hominis in P. onca in the Amazon region.

Envelhecimento, trabalho e tecnologia: motorista de aplicativos como possibilidade laboral para a população 50+ / Aging, work and technology: application driver as a laboral possibility for the 50+ population

Resumo Introdução A transição demográfica no Brasil tem levado indivíduos com mais de 50 anos a permanecer por mais tempo envolvidos em atividades laborais. Concomitantemente, nota-se o surgimento da chamada economia "gig", caracterizada pela oferta de serviços, por meio de plataformas online ou aplicativos móveis, como o caso dos aplicativos de transporte. Tais mudanças no contexto laboral podem acarretar desafios e vivências, positivas e negativas ao trabalhador. Nessa direção, destaca-se o papel do terapeuta ocupacional como o profissional que pode apoiar adultos mais velhos e idosos na busca e no envolvimento em ocupações cotidianas modificadas pela tecnologia e impactadas por crises na economia. Objetivo Analisar a motivação e a percepção de trabalhadores com 50 anos ou mais acerca do trabalho com aplicativos móveis de transporte. Método Estudo com abordagem qualitativa, transversal, exploratório e descritivo. Os participantes foram recrutados por meio de convite em grupos de redes sociais formados por trabalhadores de aplicativos móveis de transporte e por indicação. Para coleta de dados, utilizou-se questionário socioeconômico e entrevista analisada por meio da Análise de Temática de Conteúdo. Resultados Participaram 10 motoristas, com idade entre 50 e 63 anos, que apontaram como principal motivação para o trabalho com aplicativos o fato de estarem desempregados no período da crise econômica brasileira e terem encontrado dificuldade de conquistar recolocação no mercado de trabalho devido à preferência por pessoas mais jovens. O principal aspecto negativo elencado pelos motoristas foi a insegurança e como aspecto positivo foi citada a flexibilidade de horário e a importância do envolvimento em atividades laborais para a construção da identidade. Conclusão Em meio às alterações no perfil etário populacional e nos modos de trabalho, é necessário o desenvolvimento de novos estudos que relacionem envelhecimento, trabalho e tecnologia visando à prática da terapia ocupacional.

Abstract Introduction The demographic transition in Brazil has led individuals over 50 years old to remain involved in labor activities for a longer time. Concomitantly, there is the appearance of the "gig" economy, characterized by the provision of services, through online platforms or mobile applications, as in the case of transport applications. Such changes in the work context can bring challenges and experiences, positive and negative to the worker. In this sense, the role of the occupational therapist stands out as the professional who can support older adults and elderly people in the search for and involvement in everyday occupations modified by technology and impacted by crises in the economy. Objective to analyze the motivation and perception of workers aged 50 or over about working with mobile transport apps. Method a study with a qualitative, transversal, exploratory, and descriptive approach. Participants were recruited by invitation from social networking groups of mobile transport application workers and by referral. For data collection, a socioeconomic questionnaire and an interview were analyzed using Bardin's Content Analysis. Results The participants were ten drivers, aged between 50 and 63 years old, in which the main motivation for working with applications was due to be unemployed in the period of the Brazilian economic crisis and found it difficult to gain replacement in the job market due to the preference for young people. The main negative aspect listed by the drivers was insecurity, and as a positive aspect, the flexibility of working hours and the importance of involvement in work activities for the construction of identity. Conclusion During the changes in the population's age profile and in the ways of working, it is necessary to develop more analyzes on aging, work, and technology aimed at the practice of Occupational Therapy.

A remarkable new species of Micropeza Meigen (Diptera: Micropezidae) from Caatinga biome, Brazil.

We report for the first time the occurrence of genus Micropeza from Caatinga biome, through the description of M. chiroptera sp. nov. The new species is probably closely related to M. dactyloptera Harterreiten-Souza, Sujii Pujol-Luz, 2014 by the finger-shaped projection on costal vein. A key of Micropeza species with a finger-shaped projection on costal vein and a distribution map of these species are provided.

Chvalaea yolkamini sp. nov. (Diptera: Hybotidae), the first Mexican species of genus discovered on Instagram.

A new species of Chvalaea Papp Földvári, 2002 is discovered after a photo on a social network and later collected in nature. Chvalaea yolkamini sp. nov. is described and illustrated here. In addition, for the first time we describe eggs with scanning electron microscopy and report on adult hunting behavior.

Neotropical Chvalaea Papp amp; Földvári (Diptera: Hybotidae: Ocydromiinae): new records, an illustrated key to species and description of three new species.

Three new species of Chvalaea Papp Földvári are described and illustrated: Chvalaea annularis sp. nov., C. ecuadoriensis sp. nov., and Chvalaea sinclairi sp. nov. In addition, an illustrated key, distribution map, new records, and updated diagnoses of all Neotropical species are presented.

First records of Leptopezella Sinclair amp; Cumming (Diptera: Hybotidae: Ocydromiinae) from Brazil.

Leptopezella Sinclair Cumming, 2007 is a small genus of Ocydromiinae characterized by the absence of cell dm (Fig. 3) and presence of ventral spine-like setae on the hind first tarsomere (Fig. 2). It was first mentioned as "undescribed genus A" in the key of Sinclair Cumming (2000) and later described including four species: L. anatolica Sinclair Cumming, 2007, L. perata Sinclair Cumming, 2007 and L. spinosa Sinclair Cumming, 2007 from Australia and L. masneri Sinclair Cumming, 2007 from Bolivia (Sinclair Cumming 2007). In South America the genus has been recorded so far from Bolivia and Argentina (Sinclair Cumming 2000, 2007). In the present study we record the genus occurring for the first time in several administrative states from Brazil.

Morphological description of the immature stages of Hermetia illucens (Linnaeus, 1758) (Diptera: Stratiomyidae).

In the dipteran genus Hermetia, only 6 of the 78 valid species have documented immature stages: H. albitarsis Fabricius, 1805, H. aurata Bellardi, 1859, H. concinna Williston, 1900, H. illucens (Linnaeus, 1758), H. panamensis Greene, 1940 and H. pulchra Weidemann, 1830. In particular, H. illucens stands out due to its reported applicability for forensic, medical and economic purposes. Here, we described the morphology of eggs and immature stages of this species, with a view to detecting differences between instars and in the pupal stage, which should eventually help properly identifying larval age. We utilized both optical and scanning electron microscopy tools. The eggs are elliptical and elongated, and color varies from cream white to yellowish. The larvae are apodal, hemichephalic and holopneustic, flattened dorso-ventrally and may be recognized by the head elongated, dorsal and ventral chaetotaxy of the cephalic capsule, thoracic and abdominal segments, and the morphology of the anterior and posterior spiracles. The pupae are adecticous and coarctate, tegument dark brown and pruinescence varying from brown to golden. The overall morphology across instars is similar, but marked variations were observed in the shape of the antennal articuli and the shape of the setae (first instar compared to the others). Our results supplement the biological information on Hermetia illucens and should aid the proper identification and aging of juveniles in the field, as a way to minimize errors in the calculation of the post-mortem interval.

Atenção ao idoso com demência: as ações dos terapeutas ocupacionais inseridos nas instituições de longa permanência de Curitiba­Paraná, Brasil / Atención para personas mayores con demencia: las acciones de los terapeutas ocupacionales insertados en hogares para ancianos de Curitiba-Paraná, Brasil / Attention to older adults with dementia: the actions of the occupational therapists placed in long-term care institutions of Curitiba-Paraná, Brazil

O objetivo desse estudo era compreender o processo de trabalho de terapeutas ocupacionais brasileiros que atuam em instituições de longa permanência, no município de Curitiba, Paraná - Brasil, junto à clientela de idosos com demência. Foi realizado um estudo descritivo transversal, com profissionais que atuam há mais de seis meses nestes estabelecimentos. A coleta de dados foi realizada por meio de um questionário on-line, para identificação do perfil profissional, demandas dos idosos, ações avaliativas e interventivas. Verificou-se que os idosos atendidos são, em sua maioria, do gênero feminino e com o diagnóstico de doença de Alzheimer. As avaliações mais utilizadas foram o Mini Exame do Estado Mental e o Montreal Cognitive Assessment, e as intervenções mais citadas foram as atividades expressivas, artesanais, recreativas e de lazer. Destacam-se também as inúmeras intervenções cognitivas. Como resultado, foram apontadas melhorias nas funções cognitivas, principalmente nos aspectos da atenção, orientação temporal e iniciativa, além de diminuição da apatia, melhora na autoestima, participação e interação social. No entanto, muitas intervenções identificadas na pesquisa ainda possuem modestas ou baixas evidências científicas e esses estudos precisam ser aprofundados. Na atenção aos cuidadores, poucas ações são realizadas. Conclui-se que, neste estudo, a atuação do terapeuta ocupacional mostrou seguir uma linha singular de atuação, com repercussões que apontam para melhorias nos aspectos cognitivos e comportamentais e/ou melhor desempenho ocupacional do idoso demenciado.

El objetivo de este estudio fue comprender el proceso de trabajo de los terapeutas ocupacionales brasileños que actúan en instituciones de larga permanencia, en el municipio de Curitiba, Paraná - Brasil, junto a la clientela de ancianos con demencia. Se realizó un estudio descriptivo transversal, con profesionales que actúan desde hace más de seis meses en estos establecimientos. La recolección de datos fue realizada por medio de un cuestionario on-line, para identificación del perfil profesional, demandas de los ancianos, acciones evaluativas e intervencionistas. Se verificó que los ancianos atendidos son, en su mayoría, del género femenino y con el diagnóstico de enfermedad de Alzheimer. La evaluación más utilizada fue el Mini Examen del Estado Mental y la Montreal Cognitive Assessment, y las intervenciones más citadas fueron las actividades expresivas, artesanales, recreativas y de entretenimiento. Se destacan también las innumerables intervenciones cognitivas. Como resultado, se señalaron mejoras en las funciones cognitivas, principalmente en los aspectos de la atención, orientación temporal e iniciativa, además de disminución de la apatía, mejora en la autoestima, participación e interacción social. Sin embargo, muchas intervenciones identificadas en la investigación todavía tienen modestas o bajas evidencias científicas y estos estudios necesitan ser profundizados. Se concluye que, en este estudio, la actuación del terapeuta ocupacional reveló seguir una línea singular de actuación, con resultados que apuntan hacia el mejor desempeño ocupacional del anciano demenciado o para mejoras en los aspectos cognitivos y comportamentales.

The aim of this study was to understand the work process of Brazilian occupational therapists who work in long-term care institutions in the city of Curitiba, Paraná - Brazil, with elderly people with dementia. A cross - sectional descriptive study was carried out, with professionals who have been working for more than six months in these institutions. Data collection was by means of an online questionnaire, to identify the professional profile, demands of the elderly, assessment and intervention actions. It was verified that the elderly patients are mostly female and diagnosed with Alzheimer's disease. The most used assessment was the Mini Mental State Examination and the Montreal Cognitive Assessment, and the most cited interventions were expressive, artisan, recreational and leisure activities. Also the numerous cognitive interventions are highlighted. As a result, improvements in cognitive functions were pointed out, especially in aspects of attention, temporal orientation and initiative, as well as a decrease in apathy, improvement in self-esteem, participation and social interaction. However, many interventions identified in the research still have modest or low scientific evidence and these studies need to be further developed. In caring for caregivers, few actions are taken. It is concluded that, in this study, the occupational therapist's performance showed a unique line of action, with repercussions that point to the better occupational performance of the deferred elderly or to improvements in cognitive and behavioral aspects.

Facial pressure zones of an oronasal interface for noninvasive ventilation: a computer model analysis / Pontos de tensão de uma interface oronasal para ventilação não invasiva: uma análise através de um modelo computacional

OBJECTIVE: To study the effects of an oronasal interface (OI) for noninvasive ventilation, using a three-dimensional (3D) computational model with the ability to simulate and evaluate the main pressure zones (PZs) of the OI on the human face. METHODS: We used a 3D digital model of the human face, based on a pre-established geometric model. The model simulated soft tissues, skull, and nasal cartilage. The geometric model was obtained by 3D laser scanning and post-processed for use in the model created, with the objective of separating the cushion from the frame. A computer simulation was performed to determine the pressure required in order to create the facial PZs. We obtained descriptive graphical images of the PZs and their intensity. RESULTS: For the graphical analyses of each face-OI model pair and their respective evaluations, we ran 21 simulations. The computer model identified several high-impact PZs in the nasal bridge and paranasal regions. The variation in soft tissue depth had a direct impact on the amount of pressure applied (438-724 cmH2O). CONCLUSIONS: The computer simulation results indicate that, in patients submitted to noninvasive ventilation with an OI, the probability of skin lesion is higher in the nasal bridge and paranasal regions. This methodology could increase the applicability of biomechanical research on noninvasive ventilation interfaces, providing the information needed in order to choose the interface that best minimizes the risk of skin lesion. .

OBJETIVO: Estudar os efeitos de uma interface oronasal (IO) durante a ventilação não invasiva usando um modelo computacional tridimensional (3D) com a capacidade de simular e avaliar os principais pontos de pressão (PP) na face humana. MÉTODOS: Foi utilizado um modelo digital 3D da face humana, baseado em um geométrico pré-estabelecido. O modelo simulava tecidos moles, crânio e cartilagem nasal. O modelo geométrico foi obtido por varredura a laser 3D e pós-processado para uso no modelo criado. Uma simulação computacional foi realizada para determinar a pressão necessária para criar os PP faciais com o objetivo de separar a almofada da parte rígida da IO. Imagens gráficas descritivas dos PP e de sua intensidade foram obtidas. RESULTADOS: Para as análises gráficas de cada par de modelos face-IO e suas respectivas avaliações, foram realizadas 21 simulações. O modelo computacional identificou vários PP com alto impacto sobre a ponte nasal e área paranasal. A variação da profundidade nos tecidos moles teve um impacto direto na quantidade da pressão aplicada (438-724 cmH2O). CONCLUSÕES: Os resultados da simulação computacional indicam que, em pacientes submetidos à ventilação não invasiva com uma IO, a probabilidade de ocorrência de lesões cutâneas é maior na ponte nasal e nas áreas paranasais. Esta metodologia pode aumentar a aplicabilidade na investigação biomecânica das interfaces de ventilação não invasiva, fornecendo informações necessárias para a escolha de uma IO que minimize o risco de lesão ...

Facial pressure zones of an oronasal interface for noninvasive ventilation: a computer model analysis.

OBJECTIVE: To study the effects of an oronasal interface (OI) for noninvasive ventilation, using a three-dimensional (3D) computational model with the ability to simulate and evaluate the main pressure zones (PZs) of the OI on the human face. METHODS: We used a 3D digital model of the human face, based on a pre-established geometric model. The model simulated soft tissues, skull, and nasal cartilage. The geometric model was obtained by 3D laser scanning and post-processed for use in the model created, with the objective of separating the cushion from the frame. A computer simulation was performed to determine the pressure required in order to create the facial PZs. We obtained descriptive graphical images of the PZs and their intensity. RESULTS: For the graphical analyses of each face-OI model pair and their respective evaluations, we ran 21 simulations. The computer model identified several high-impact PZs in the nasal bridge and paranasal regions. The variation in soft tissue depth had a direct impact on the amount of pressure applied (438-724 cmH2O). CONCLUSIONS: The computer simulation results indicate that, in patients submitted to noninvasive ventilation with an OI, the probability of skin lesion is higher in the nasal bridge and paranasal regions. This methodology could increase the applicability of biomechanical research on noninvasive ventilation interfaces, providing the information needed in order to choose the interface that best minimizes the risk of skin lesion.

OBJETIVO: Estudar os efeitos de uma interface oronasal (IO) durante a ventilação não invasiva usando um modelo computacional tridimensional (3D) com a capacidade de simular e avaliar os principais pontos de pressão (PP) na face humana. MÉTODOS: Foi utilizado um modelo digital 3D da face humana, baseado em um geométrico pré-estabelecido. O modelo simulava tecidos moles, crânio e cartilagem nasal. O modelo geométrico foi obtido por varredura a laser 3D e pós-processado para uso no modelo criado. Uma simulação computacional foi realizada para determinar a pressão necessária para criar os PP faciais com o objetivo de separar a almofada da parte rígida da IO. Imagens gráficas descritivas dos PP e de sua intensidade foram obtidas. RESULTADOS: Para as análises gráficas de cada par de modelos face-IO e suas respectivas avaliações, foram realizadas 21 simulações. O modelo computacional identificou vários PP com alto impacto sobre a ponte nasal e área paranasal. A variação da profundidade nos tecidos moles teve um impacto direto na quantidade da pressão aplicada (438-724 cmH2O). CONCLUSÕES: Os resultados da simulação computacional indicam que, em pacientes submetidos à ventilação não invasiva com uma IO, a probabilidade de ocorrência de lesões cutâneas é maior na ponte nasal e nas áreas paranasais. Esta metodologia pode aumentar a aplicabilidade na investigação biomecânica das interfaces de ventilação não invasiva, fornecendo informações necessárias para a escolha de uma IO que minimize o risco de lesão na pele.