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The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.

Keck, Jonathon; Chambers, James P; Kancharla, Aravind; Bashir, Dona Haj; Henley, Laura; Schenkel, Katherine; Castillo, Kevin; Neal Guentzel, M; Gupta, Rishein; Arulanandam, Bernard P.

Microbes Infect ; 22(8): 360-365, 2020 09.

Article En | MEDLINE | ID: mdl-32084556

Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-Î³ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.

Chlamydia Infections/microbiology , Chlamydia muridarum/physiology , Lung/immunology , MicroRNAs/immunology , Animals , Bacterial Load , Chlamydia Infections/genetics , Chlamydia Infections/immunology , Disease Models, Animal , Disease Progression , Gene Expression Regulation/immunology , Interferon-gamma/metabolism , Lung/microbiology , Mice , MicroRNAs/genetics