The optimization of nuclear medicine procedures for the diagnosis and management of thyroid disorders in developing countries.

Thyroid disease is common in developing countries and its management is based on the measurement of thyroid function and the investigation of thyroid masses. This report discusses techniques and outlines a strategy for the measurement of thyroid function using radioimmunoassays of thyroid-related hormones in the blood. It makes proposals for the evaluation of thyroid morphology using echography, pertechnetate imaging and fine needle biopsy. Note is taken of the difficulties facing laboratories in developing countries and the International Atomic Energy Agency is concerned with the practical assessment of these recommendations and of any alternative proposals in this field.

Radioassay services in developing countries. Findings and recommendations of an International Atomic Energy Agency advisory group.

The findings and recommendations of an advisory group convened by the IAEA to give guidance relating to the development of IAEA projects involving radioassay are presented. The current status of radioassay services in different countries is reviewed; guiding principles relating to the organization of such services are affirmed, with particular reference to services in developing countries; the needs of services at various levels as regards accommodation, staff, equipment, supporting services and running costs, including minimum initial needs, are specified; operational problems are identified and indications given how they may be solved; facilities for training in radioassay are reviewed; finally, reference is made to IAEA activities in the field in question.

Total body water, total exchangeable sodium and related variables in the Ghanaian.

1. Standard radioisotope dilution techniques employing [3H]water and [22Na]sodium chloride have been used to determine the total body water and total exchangeable sodium of 20 male and 10 female normal Ghanaians (Africans) aged 19--25 years. 2. Lean body mass and total body fat are calculated as a percentage of body weight; the total exchangeable sodium values have been expressed in relation to lean body mass. 3. Comparison of the data for Ghanaian subjects with published figures for Caucasian subjects of similar age shows that the Ghanaian men have much less total body fat and the women a little less total body fat than their Caucasian counterparts. 4. Total exchangeable sodium expressed in terms of lean body mass shows close agreement in both men and women.