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Front Immunol ; 12: 753558, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34630432

RESUMEN

To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient's transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host's ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.


Asunto(s)
Basiliximab/uso terapéutico , COVID-19/inmunología , Glomerulonefritis por IGA/terapia , Rechazo de Injerto/inmunología , Inmunosupresores/uso terapéutico , Trasplante de Riñón , SARS-CoV-2/fisiología , Adulto , Humanos , Tolerancia Inmunológica , Inmunidad , Masculino , Periodo Perioperatorio , Transcriptoma
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