[Evaluating adaptogenic properties of Rhodiola rosea extract in human mononuclear cell culture and rat tissues].

The administration of various doses of Rhodiola rosea roots and rhizome spissum with known concentrations of salidroside, n-tyrosol, and rosavine leads to an increase in stress proteins 70 content in human mononuclear cell culture and in tissues of Wistar rats. A one-week peroral administration of Rh. Rosea preparation increases the content of constitutive Hsc70 in liver and the amount of hepatocytes with low succinate dehydrogenase activity. A two-week administration of Rh. Rosea extract leads to an increase in the levels of inducible Hsp70 and constitutive Hsc70 proteins in liver, hippocampus and left heart ventricle. These results are indicative of an increase in nonspecific resistance and the activation of adaptogenic processes.

[HSC70 protein of human blood mononuclears as a sign of adaptation under normobaric hypoxia training].

We investigated two isoforms of heat shock protein 70 kDa: HSP70 and HSC70, in the human blood mononuclears under normobaric hypoxia training. It was shown that hypoxia regimen does not lead to manifestation of stress but exerts activation of the organism. The obtained organism adaptation is achieved with a little cost that is confirmed by absence of HSP70 content increase. HSC70 content in the blood mononuclears was increased in most case up to 1.5-2.0 fold. HSC70 displays itself as a sign of adaptation. We connect the increase of HSC70 with mitochondria biogenesis which is given a leading importance under adaptation of aerobic organism cells to hypoxia.

[Adaptation to hyperthermia and changes in peripheral blood leukocytes in humans]. / Adaptatsiia cheloveka k gipertermii i izmeneniia v leikotsitakh perifericheskoi krovi.

Heating humans up to rectal temperature 39.0-39.5 degrees C induces a heat stress and a physiological adaptation. Blood cells were found to produce nitric oxide under these conditions, neutrophiles playing a major role in the process. In our opinion, the HSC 70 takes part in the process of the long cell adaptation augmenting the cells' functional activity. Hyperthermia leads to a massive temporal HSP 72 expression in the blood mononuclears. This expression seems to be due to alterations in the cellular proteins and to oxidative stress.