RESUMEN
Circumscribed palmar hypokeratosis (CPH) is a localized disorder of epidermal keratinization that is presented as a well-delimited, depressed, erythematous plaque on the palms or on the soles. It is histopathologically characterized by an abrupt thinning of the corneal epidermal layer. CPH is considered a benign condition, but a few cases with dysplastic changes/carcinoma in situ in the hypokeratotic epidermis have been described. We report hereby a case of invasive squamous cell carcinoma developed within a plaque of CPH. The pathogenesis of the malignant changes in this disorder remains to be clarified. Clinicians should be aware of the potential for developing malignancy in CPH and carry out a closer follow-up of this disorder.
Asunto(s)
Dermatitis Alérgica por Contacto/etiología , Dermatitis Profesional/etiología , Harina/efectos adversos , Industria de Alimentos , Dermatosis de la Mano/inducido químicamente , Proteínas de Plantas/efectos adversos , Asma Ocupacional/etiología , Harina/análisis , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Irritante/diagnóstico , Dermatitis Profesional/diagnóstico , Vidrio/análisis , Microscopía de Polarización , Fibras Minerales/análisis , Manejo de Especímenes/métodos , Cinta Quirúrgica , Humanos , Queratinocitos/ultraestructura , Laceraciones/complicaciones , Fibras Minerales/toxicidadRESUMEN
No disponible
Asunto(s)
Humanos , Femenino , Embarazo , Adulto , Exantema/etiología , Artralgia/etiología , Virus Chikungunya/aislamiento & purificación , Fiebre Chikungunya/microbiología , Complicaciones Infecciosas del EmbarazoRESUMEN
We report the case of a 56 year-old male with an atypical leiomyoma in the context of a cutaneous leiomyomatosis and a family history of uterine leiomyomatosis. The genetic study revealed a mutation in the gene for the enzyme fumarate hydratase, but he has not had any renal malignancy so far. Atypical leiomyoma is a rare tumor that usually presents as a single lesion and is exceptional in patients with cutaneous leiomyomatosis. The relation between fumarate hydratase enzyme mutations with multiple leiomyomas, uterine leiomyomatosis and an increased risk of developing kidney cancer is widely known. However, the role of these mutations in the development of atypical leiomyomas is still impossible to clarify given the few cases reported in the literature.
Asunto(s)
Fumarato Hidratasa/genética , Leiomiomatosis/genética , Mutación , Neoplasias Cutáneas/genética , Humanos , Leiomioma/enzimología , Leiomioma/genética , Leiomioma/patología , Leiomiomatosis/enzimología , Leiomiomatosis/patología , Masculino , Persona de Mediana Edad , Neoplasias Cutáneas/enzimología , Neoplasias Cutáneas/patologíaRESUMEN
Se presenta un varón de 56 años con un leiomioma atípico en el contexto de una leiomiomatosis cutánea, con antecedentes familiares de miomatosis uterina y con estudio genético que revela una mutación en el gen de la enzima fumarato hidratasa, sin que hasta el momento presente ningún tipo de neoplasia maligna renal. El leiomioma atípico es un tumor poco frecuente, que usualmente ocurre de forma aislada, siendo excepcional la presentación en pacientes con leiomiomatosis cutánea. Es ampliamente conocida la relación de la mutación de la enzima fumarato hidratasa con leiomiomas mútiples, miomas uterinos y el mayor riesgo de desarrollar cáncer renal; sin embargo, el papel de esta mutación en el desarrollo de leiomiomas atípicos es por hoy imposible de esclarecer debido a los escasos casos recogidos en la literatura.
We report the case of a 56 year-old male with an atypical leiomyoma in the context of a cutaneous leiomyomatosis and a family history of uterine leiomyomatosis. The genetic study revealed a mutation in the gene for the enzyme fumarate hydratase, but he has not had any renal malignancy so far. Atypical leiomyoma is a rare tumor that usually presents as a single lesion and is exceptional in patients with cutaneous leiomyomatosis. The relation between fumarate hydratase enzyme mutations with multiple leiomyomas, uterine leiomyomatosis and an increased risk of developing kidney cancer is widely known. However, the role of these mutations in the development of atypical leiomyomas is still impossible to clarify given the few cases reported in the literature.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Neoplasias Cutáneas/genética , Leiomiomatosis/genética , Fumarato Hidratasa/genética , Mutación , Neoplasias Cutáneas/enzimología , Neoplasias Cutáneas/patología , Leiomiomatosis/enzimología , Leiomiomatosis/patología , Leiomioma/enzimología , Leiomioma/genética , Leiomioma/patologíaRESUMEN
The presence of a subcutaneous foreign body may not be easily suspected after the initial history and exploration of the patient. The authors report a 54-year-old male who came to the Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain with a firm plaque, fixed to deep structures, which showed several draining orifices over the costal grid. After several tests, the authors performed an ultrasonography that revealed the presence of a fistula from a foreign body secondary to a previously untreated costal fracture that occurred several years before. The authors believe ultrasonography is a readily available and useful tool that may help dermatologists in daily clinical practice, with the advantage of being a noninvasive test.
