Enriching the FIDEO ontology with food-drug interactions from online knowledge sources.

The increasing number of articles on adverse interactions that may occur when specific foods are consumed with certain drugs makes it difficult to keep up with the latest findings. Conflicting information is available in the scientific literature and specialized knowledge bases because interactions are described in an unstructured or semi-structured format. The FIDEO ontology aims to integrate and represent information about food-drug interactions in a structured way. This article reports on the new version of this ontology in which more than 1700 interactions are integrated from two online resources: DrugBank and Hedrine. These food-drug interactions have been represented in FIDEO in the form of precompiled concepts, each of which specifies both the food and the drug involved. Additionally, competency questions that can be answered are reviewed, and avenues for further enrichment are discussed.

Broad Trends in Public Health and Epidemiology Informatics.

OBJECTIVES: The objective of this study is to highlight innovative research and contemporary trends in the area of Public Health and Epidemiology Informatics (PHEI). METHODS: Following a similar approach to last year's edition, a meticulous search was conducted on PubMed (with keywords including topics related to Public Health, Epidemiological Surveillance and Medical Informatics), examining a total of 2,022 scientific publications on Public Health and Epidemiology Informatics (PHEI). The resulting references were thoroughly examined by the three section editors. Subsequently, 10 papers were chosen as potential candidates for the best paper award. These selected papers were then subjected to peer-review by six external reviewers, in addition to the section editors and two chief editors of the IMIA yearbook of medical informatics. Each paper underwent a total of five reviews. RESULTS: Out of the 539 references retrieved from PubMed, only two were deemed worthy of the best paper award, although four papers had the potential to qualify in total. The first best paper by pertains to a study about the need for a new annotation framework due to inadequacies in existing methods and resources. The second paper elucidates the use of Weibo data to monitor the health of Chinese urbanites. The correlation between air pollution and health sensing was measured via generalized additive models. CONCLUSIONS: One of the primary findings of this edition is the dearth of studies identified for the PHEI section, which represents a significant decline compared to the previous edition. This is particularly surprising given that the post-COVID period should have led to an increased use of information and communication technology for public health issues.

Novelty in Public Health and Epidemiology Informatics.

OBJECTIVES: To highlight novelty studies and current trends in Public Health and Epidemiology Informatics (PHEI). METHODS: Similar to last year's edition, a PubMed search of 2021 scientific publications on PHEI has been conducted. The resulting references were reviewed by the two section editors. Then, 11 candidate best papers were selected from the initial 782 references. These papers were then peer-reviewed by selected external reviewers. They included at least two senior researchers, to allow the Editorial Committee of the 2022 IMIA Yearbook edition to make an informed decision for selecting the best papers of the PHEI section. RESULTS: Among the 782 references retrieved from PubMed, two were selected as the best papers. The first best paper reports a study which performed a comprehensive comparison of traditional statistical approaches (e.g., Cox Proportional Hazards models) vs. machine learning techniques in a large, real-world dataset for predicting breast cancer survival, with a focus on explainability. The second paper describes the engineering of deep learning models to establish associations between ocular features and major hepatobiliary diseases and to advance automated screening and identification of hepatobiliary diseases from ocular images. CONCLUSION: Overall, from this year edition, we observed that the number of studies related to PHEI has decreased. The findings of the two studies selected as best papers on the topic suggest that a significant effort is still being made by the community to compare traditional learning methods with deep learning methods. Using multimodality datasets (images, texts) could improve approaches for tackling public health issues.

Public Health and Epidemiology Informatics: Recent Research Trends.

OBJECTIVES: To introduce and analyse current trends in Public Health and Epidemiology Informatics. METHODS: PubMed search of 2020 literature on public health and epidemiology informatics was conducted and all retrieved references were reviewed by the two section editors. Then, 15 candidate best papers were selected among the 920 references. These papers were then peer-reviewed by the two section editors, two chief editors, and external reviewers, including at least two senior faculty, to allow the Editorial Committee of the 2021 International Medical Informatics Association (IMIA) Yearbook to make an informed decision regarding the selection of the best papers. RESULTS: Among the 920 references retrieved from PubMed, four were suggested as best papers and the first three were finally selected. The fourth paper was excluded because of reproducibility issues. The first best paper is a very public health focused paper with health informatics and biostatistics methods applied to stratify patients within a cohort in order to identify those at risk of suicide; the second paper describes the use of a randomized design to test the likely impact of fear-based messages, with and without empowering self-management elements, on patient consultations or antibiotic requests for influenza-like illnesses. The third selected paper evaluates the perception among communities of routine use of Whole Genome Sequencing and Big Data technologies to capture more detailed and specific personal information. CONCLUSIONS: The findings from the three studies suggest that using Public Health and Epidemiology Informatics methods could leverage, when combined with Deep Learning, early interventions and appropriate treatments to mitigate suicide risk. Further, they also demonstrate that well informing and empowering patients could help them to be involved more in their care process.

Visualizing Food-Drug Interactions in the Thériaque Database.

This paper presents a prototype for the visualization of food-drug interactions implemented in the MIAM project, whose objective is to develop methods for the extraction and representation of these interactions and to make them available in the Thériaque database. The prototype provides users with a graphical visualization showing the hierarchies of drugs and foods in front of each other and the links between them representing the existing interactions as well as additional details about them, including the number of articles reporting the interaction. The prototype is interactive in the following ways: hierarchies can be easily folded and unfolded, a filter can be applied to view only certain types of interactions, and details about a given interaction are displayed when the mouse is moved over the corresponding link. Future work includes proposing a version more suitable for non-health professional users and the representation of the food hierarchy based on a reference classification.

Enabling West African Herbal-Based Traditional Medicine Digitizing: The WATRIMed Knowledge Graph.

The purpose of this study is to describe the design and development of the first release of the West African Herbal based Traditional Medicine Knowledge Graph (WATRIMed). It is a resource containing Traditional Medicine (TM) related entities and linked with publicly available knowledge bases in order to facilitate bringing West African TM into the digital world. The core model comprises currently 556 concepts including 143 identified West African medicinal plants and 108 recipes used by tradi-practitioners to treat 110 diseases and symptoms which are commonly encountered in this part of the world.

Design Considerations for a Knowledge Graph: The WATRIMed Use Case.

The World Health Organization estimates that as much as 80% of the population uses Traditional Medicine (TM) in some form, and in particular, herbal-based Traditional Medicine (HTM). However, TM is mostly orally transmitted and suffers from lack of standardizations and lack of computable TM data. Shareable standards could enable computational support of TM data management. In this paper, we outline the design and development of the West African Herbal Traditional Medicine (WATRIMed) Knowledge Graph (KG), which is an effort for bringing West Africa TM to the digital world and help establishing bridges with conventional medicine. WATRIMed entities have been enriched with knowledge from external publicly available knowledge bases and further mapped with the BioTopLite Upper Level Ontology. As of result, the model of the publicly available KG currently comprises 472 Concepts and 75 Properties (57 object properties and 18 data properties). It describes formally 115 medicinal plants, 179 chemical compounds and 67 recipes.