Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children.

The FTO gene rs9936909 polymorphism is one of the well-documented single nucleotide polymorphisms in the context of increased risk of obesity, including in children. Few studies have tested the association of the FTO gene with cognitive functions. Deficits of "cool" executive functions (EFs) are considered a potential risk factor for excessive weight. The aims of our study were to investigate whether cool EFs are associated with the Body Mass Index, the Fat Mass Index and the risk of excess body mass and overfatness in neurotypically school-aged children, and whether the FTO gene polymorphism is involved in development of this possible association. The sample consisted of 553 children aged 6-12 years old. A body composition analysis, a neuropsychological assessment of EFs, and FTO polymorphism genotyping were performed in the children studied. The study found a significant association of an interference effect in theStroop Color-Word Interference Task and the risk of excessive body fatness, but not excessive body mass. There were no explicit associations between the FTO genotype and EFs deficits. Environmental factors, and particularly low maternal education, appeared to be the strongest contributors to the increased risk of obesity.

Association of adverse childhood experiences (ACEs) with obesity and underweight in children.

PURPOSE: The aim of the study was to test the hypothesis that adverse childhood experiences (ACEs) are related to both obesity and underweight from childhood, and that the association of ACEs with weight abnormalities is modulated by type of ACEs, sex and socioeconomic status (SES) indices. METHODS: The relations between ACEs (0 vs ≥ 1), ACE accumulation and ACE type with weight status and z scores BMI were assessed in 503 children aged 6-12 years from Poznan, Poland. The effects of interaction of ACEs with sex and SES on z scores BMI were included in the analyses. RESULTS: ACEs were significantly related to both obesity and underweight, in unadjusted analysis, and when sex and SES indices, such as size of place of residence, people per room in household, and parental education were controlled. The relation of ACEs with z scores BMI was modulated by ACE type, parental subjective assessment of economic situation of a family and parental education. ACE accumulation was not related to an increase of obesity or underweight rate, or z scores BMI. CONCLUSION: The study implicates the need for both obesity and underweight prevention in individuals with adverse experiences as early as in childhood. LEVEL OF EVIDENCE: III: evidence obtained from well-designed cohort study.

Significance of the Diagnosis of Executive Functions in Patients with Relapsing-Remitting Multiple Sclerosis.

Multiple sclerosis (MS) is a progressive chronic disease of the Central Nervous System (CNS). Cognitive decline occurs rather rarely in relapsing-remitting multiple sclerosis (RRMS) compared to other types. The present study aimed to assess executive functions (EF) in relation to clinical and demographic variables in patients with RRMS. The study involved 22 individuals with RRMS (aged 23 to 49 years) and 22 matching controls. All the individuals with RRMS were in the remission phase. The assessments were carried out using MoCA, BDI-II, Halstead Category Test, Porteus Maze Test, verbal fluency tasks and Stroop Colour-Word Interference Test. The findings show that the two groups differed significantly in all the tests. All patients with RRMS in the remission phase presented at least one cognitive deficit, observed in general cognitive functioning, abstract reasoning or other executive functions, i.e., fluency, interference suppression, planning, or ability to modify activity in response to feedback. The deficits in most cases (except for those measured with the MoCA, Category Tests and phonemic fluency), are not related to intensity of depression and duration of the disease. Findings suggest that the diagnostic process in the case of patients with RRMS may include psychological assessment focusing on potentially existing cognitive, mainly executive, deficits and their severity.

Do Hot Executive Functions Relate to BMI and Body Composition in School Age Children?

Deficits of 'hot' executive functions (EFs) involving emotional and motivational processes are considered as a risk factor for excessive weight, but few studies have tested the relationship between hot EFs and body composition in children. The aim of the study was to assess the association of the ability to delay gratification and affective decision-making with the body mass index (BMI) and body composition in children with typical neurocognitive development. The sample consisted of 553 Polish children aged between 6-12 y. The delay of gratification task (DGT) was applied to assess the ability to delay gratification. The Hungry Donkey test (HDT) was applied to assess affective decision-making. The indicators of decision-making in the HDT were net score and learning rate. The relationships between hot EFs and BMI, fat mass index (FMI), lean body mass index (LBMI) were tested. The association of the z scores of BMI and FMI, overweight/obesity, and the ability to delay gratification was found insignificant after controlling cofounding factors. Most of the results on affective decision-making and z scores for BMI, FMI and LBMI were insignificant as well. The relationship between the ability to delay gratification, affective decision-making, and adiposity is not pronounced in typically developed children.

Pragmatic aspects of verbal communication in elderly people: A study of Polish seniors.

BACKGROUND: Behavioural and neuropsychological studies on elderly populations concentrate on many aspects of cognitive functioning, but significantly less research concerns communication processes, including aspects of verbal communication skills, pragmatic issues that are important for performing social tasks at every age. AIMS: To characterize the variability in changes that occur with age in the domain of pragmatic aspects of verbal communication skills in a group of individuals aged > 65 years and to define their determinants. METHODS & PROCEDURES: A group of 109 normally ageing individuals (aged 64.9-90 years) participated in the study (62 women and 47 men). Participants were divided into two age groups: < 70 and > 71 years old. The verbal communication skills were examined using the Polish version of the Right Hemisphere Language Battery (RHLB-PL), and cognitive skills using the Mini Mental State Examination (MMSE). OUTCOMES & RESULTS: Comparison between the subgroups showed that there was a significant decline in the older group in all the subtests except for the Discourse Analysis. Age did not differentiate discursive abilities in seniors. These data apparently confirm the hypothesis that discursive competences are stable throughout one's lifespan. In order to compare younger and older seniors in terms of the 11 aspects of pragmatic communication, two performance profiles were prepared for the groups and subjected to comparative analyses. The shape of the two profiles of all communication competences was similar. The biggest differences were identified between the groups in the Comments, Humour and Metaphor comprehension and explanation subtests. Analysis of the determinants of changes in pragmatic aspects of verbal communication skills in elderly individuals revealed that the important factors include age, overall level of cognitive function, higher education and female sex. CONCLUSION & IMPLICATIONS: The relationship between age and pragmatic aspects of verbal communication skills is complex. The results indicate that treating seniors as a homogenous group in terms of pragmatic aspects of verbal communication functioning is incorrect. Age differentially affects the various aspects of communication functions. The level of cognitive functioning mediates the relationship between age and pragmatic aspects of verbal communication skills. What this paper adds What is already known on the subject? Behavioural and neuropsychological studies on elderly populations concentrate on many aspects of mnestic functions, executive functions, cognitive flexibility, fluency, cognitive control, working memory, semantic processing, arithmetic competences and perception speed. Significantly less research concerns communication processes, including verbal communication. Older and younger people have usually been compared in particular areas of communication: discourse, understanding of metaphors or prosody. At present there is a paucity of research regarding changes in communication functions at different stages of ageing and profiles of various aspects of verbal communication in old age. What this paper adds to existing knowledge The study indicates that normally ageing individuals are a non-homogeneous group in terms of pragmatic aspects of verbal communication. Various communication functions change at different rate at various stages of ageing. The study clarified the determinants of changes in pragmatic aspects of verbal communication skills in elderly individuals. These aspects are cognitive abilities, age, a high education level and sex. What are the potential or actual clinical implications of this work? The research shows that diagnosis of communication competencies in elderly individuals is necessary. Furthermore, the kind of abilities is very important for social relationships and quality of life. It is essential to inform a senior's family about communication changes that occur in normal ageing. Understanding potential verbal communication difficulties in seniors and their determinants are fundamental issues.

[Selected aspects of social cognition in patient with total agenesis of the corpus callosum (ACC) and Arnold-Chiari desease--case study]. / Wybrane aspekty poznania spolecznego u pacjenta z pelna agenezja ciala modzelowatego (ACC) i zespolem Arnolda-Chiari--studium przypadku.

AIM: The goal of the research was a characteristic of emotional-social competencies and communicative abilities in a 16-years old patient with ACC and Arnold-Chiari disease and higher than average intelligence. METHOD: RHLB-PL was applied. RESULTS: Total score in RHLB-PL suggested language and communication impairment. The greatest problems were observed in the field of behavioral self-control and discourse abilities. The patient had difficulties in the topic of the discourse maintaining, resisting from production of unconnected topics and comments, interject inappropriate remarks. Problems in humor comprehension and the dissociation between relative high level of written metaphors analysis abilities and low level of Picture Metaphors perception and explanation were observed. Linguistic Prosody was average. CONCLUSION: Patient M.J. with agenesis of corpus callosum presented high number of deficits typical in right hemisphere damage patients. It is possible to explain that fact in the context of interhemispheric transfer disorders, specially when complex material was processed.

[Visual-spatial functions and organisation of grapho-motor actions in ADHD children]. / Funkcje wzrokowo-przestrzenne i organizacja czynnosci ci grafomotorycznych u dzieci z ADHD.

AIM: The aim of the study was to test whether children with a diagnosis of ADHD at the age of 7-16 years have deficits in visual-spatial, visual memory, planning, and organisation of the visual-motor functions. METHODS: The study included 186 unrelated patients aged 7-16 years diagnosed with ADHD. The control group consisted of 156 healthy individuals aged 7-16 years. The methods applied were the Rey-Osterrieth Complex Figure Test (ROCF) and Matching (MFFT). RESULTS: The number of errors in the MFFT was significantly different between healthy combined subtype. There were no differences between inattentive and healthy children. In the Rey-Osterieth Complex Figure test, statistically significant differences were found between the control group and a group of combined ADHD in the number of points obtained when drawing back and reproduction from memory. In the latter index were also differences between ADHD inattentive children and the combined subtype. Children with ADHD obtained statistically significant different results than healthy children in the drawing category (which were treated as an indicator of the executive functions of planning) but only in reproduction from memory. Quality of the copy does not differentiate the groups. CONCLUSIONS: ROCF and MFFT are useful measures of visual-spatial function and visual memory of children with ADHD. They have less relevance in the assessment of executive functions. Visual-spatial disorders were found only in children with ADHD combined subtype.

Rapid automatized naming, phonology and dyslexia in Polish children.

BACKGROUND: Many studies have showed that children with reading difficulties have deficits in both rapid automatized naming (RAN) and phonological skills (PS). The double-deficit hypothesis suggests that phonological and naming-speed deficits are two separable causes of reading problems. The main goal of our study was to investigate naming speed in Polish fourth grade children with dyslexia. MATERIAL/METHODS: 33 dyslexic children (10 girls and 23 boys) and 30 good readers participated in the study. They were given the Wechsler Intelligence Test for Children (WISC-R) and a battery of diagnostic tests for dyslexia for fourth-grade children, consisting of tests for single word reading, nonsense word reading, reading with word canceling, text comprehension, spelling on dictation, rapid automatic naming, phoneme elision, and phonological skills, as well as the Zetotest (a phonological memory test). RESULTS: The dyslexic children performed significantly more slowly than controls on the RAN tests, which suggests a generalized deficit in the speed of access to the mental lexicon. Significant correlations were found only between the RAN test and the text comprehension text. Among all the phonological measures applied in the study, slight but significant correlations were found only between phonological memory and speed naming. Dyslexic children with low speed naming abilities and high speed naming abilities showed no differences in phonological functions. CONCLUSIONS: Our results confirm the double-deficit hypothesis of dyslexia.