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1.
J Voice ; 2024 May 20.
Artículo en Inglés | MEDLINE | ID: mdl-38772831

RESUMEN

INTRODUCTION: Previous studies show that performers face higher risk of voice injury and experience greater impairment compared to nonperformers. Understanding the factors influencing support for performers is important for improving outcomes. METHODS: An anonymous online survey was distributed to a target audience of performers with past voice injury, inquiring about their understanding of voice injury "red flags," access to voice care support resources, treatment adherence, and comfort discussing injury with others. Responses were analyzed considering various clinicodemographic factors and aspects related to care and treatment. RESULTS: The survey was completed by 151 performers with self-reported history of voice injury, representing multiple performance genres. Participants commonly sought help from a general otolaryngologist (52; 34.44%), laryngologist (41; 27.15%), or voice teacher (40; 26.49%) and treatments included voice therapy, rest, medication, and surgery, with a majority reporting high treatment adherence (129; 87.16%), a statistically significant factor in resolving symptoms. Those with partial or nonadherence cited financial/insurance barriers, scheduling/availability conflicts, or treatment dissatisfaction. Participants reported high awareness of voice injury "red flags" (mean 86.80; SD 18.87%), and moderate access to voice care tools/resources (mean 74.76; SD 29.1) and a voice team (mean 71.23; SD 36.52), but low support from management/production teams (mean 50.69; SD 37.23). Several expressed a desire for better education about preventive care (mean 70.06; SD 37.78). Comfort levels in discussing voice injuries varied across social contexts, but those working with voice teachers were more comfortable discussing their voice problems with colleagues and peers. CONCLUSION: This study explores performers' perspectives on accessing care for voice injuries and emphasizes the importance of increased preventive education to address the ongoing stigma surrounding voice injuries and to foster a supportive environment for performers seeking help. Additionally, the study highlights the role of voice professionals in both providing and advocating for support systems for performers with voice injury.

2.
JAMA Otolaryngol Head Neck Surg ; 150(6): 457-458, 2024 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-38635259

RESUMEN

This essay reports on fictitious source materials created by AI chatbots, encourages human oversight to identify fabricated information, and suggests a creative use for these tools.


Asunto(s)
Inteligencia Artificial , Alucinaciones , Humanos , Alucinaciones/diagnóstico , Masculino , Femenino
3.
J Voice ; 2024 Jan 12.
Artículo en Inglés | MEDLINE | ID: mdl-38218688

RESUMEN

OBJECTIVES: Social media plays an ever-growing part in modern life and is a frequent source of health information for patients. Singers are particularly likely to receive health information solely from fellow musicians and may experience barriers to seeking vocal healthcare. However, there have been no studies to date evaluating vocal health information on social media. Our study aimed to assess the quality, reliability, and accuracy of vocal health content on TikTok. STUDY DESIGN: Cross-sectional analysis. METHODS: Three searches were carried out on Tiktok, using the terms "vocal health," "vocal injury," and "voice tips." The top 50 videos in each category were cataloged for extraction of data and for analysis on three discrete scales. Two independent reviewers rated each video using the Global Quality Scale (GQS), modified DISCERN scale, and Accuracy in Digital-health Instrument (ANDI). RESULTS: After the removal of duplicates and unavailable content, 146 videos were analyzed. The mean (range) length was 59.8 seconds (5-239), and number of views per video was 886,265 (432-36,700,000). The vast majority of videos (94.5%) were created by non-clinicians; only two videos (1.37%) were posted by otolaryngologists. The mean (SD) GQS score was 2.34 (0.75) out of a maximum of five, the DISCERN score was 0.97 (0.56) out of five, and the ANDI score was 2.85 (0.87) out of four. Video length was positively correlated with GQS and DISCERN scores, but views, likes, and shares were either not associated or negatively associated with GQS, DISCERN, and ANDI. CONCLUSIONS: Most videos were of low quality and reliability and moderate accuracy. Measures of popularity were either uncorrelated or negatively correlated with quality, reliability, and accuracy, suggesting that TikTok users are more likely to engage with lower-quality content online. This implies a potential role for vocal health professionals to fill a crucial gap with reliable information on social media.

4.
Eur Arch Otorhinolaryngol ; 281(4): 2055-2062, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37695363

RESUMEN

PURPOSE: To develop and validate a deep learning model for distinguishing healthy vocal folds (HVF) and vocal fold polyps (VFP) on laryngoscopy videos, while demonstrating the ability of a previously developed informative frame classifier in facilitating deep learning development. METHODS: Following retrospective extraction of image frames from 52 HVF and 77 unilateral VFP videos, two researchers manually labeled each frame as informative or uninformative. A previously developed informative frame classifier was used to extract informative frames from the same video set. Both sets of videos were independently divided into training (60%), validation (20%), and test (20%) by patient. Machine-labeled frames were independently verified by two researchers to assess the precision of the informative frame classifier. Two models, pre-trained on ResNet18, were trained to classify frames as containing HVF or VFP. The accuracy of the polyp classifier trained on machine-labeled frames was compared to that of the classifier trained on human-labeled frames. The performance was measured by accuracy and area under the receiver operating characteristic curve (AUROC). RESULTS: When evaluated on a hold-out test set, the polyp classifier trained on machine-labeled frames achieved an accuracy of 85% and AUROC of 0.84, whereas the classifier trained on human-labeled frames achieved an accuracy of 69% and AUROC of 0.66. CONCLUSION: An accurate deep learning classifier for vocal fold polyp identification was developed and validated with the assistance of a peer-reviewed informative frame classifier for dataset assembly. The classifier trained on machine-labeled frames demonstrates improved performance compared to the classifier trained on human-labeled frames.


Asunto(s)
Aprendizaje Profundo , Pólipos , Humanos , Laringoscopía/métodos , Pliegues Vocales/diagnóstico por imagen , Redes Neurales de la Computación , Estudios Retrospectivos , Aprendizaje Automático , Pólipos/diagnóstico por imagen
5.
Otolaryngol Head Neck Surg ; 170(3): 788-794, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-37890071

RESUMEN

OBJECTIVE: To assess the nature and impact surgical ergonomic challenges experienced by female otolaryngologists. STUDY DESIGN: National survey study. SETTING: Female otolaryngology residents, fellows and attendings recruited via social media posting and email distribution. METHODS: We distributed a survey study to female otolaryngologists throughout the United States. The height and glove size of participants reporting difficulties with equipment and instruments were compared to those not reporting difficulties. RESULTS: Ninety-six female otolaryngologists participated in our study, comprised of 43% residents, 10% fellows, and 47% attendings. Ninety percent of participants reported difficulties using equipment and 77% of participants reported difficulty with instruments, the most common being nasal endoscopic instruments (28%). The vast majority of participants reported pain during and (or) after the operation (92%). Head and neck (53%) and rhinology (44%) were identified as particularly challenging specialities, but only 25% of participants reported that ergonomics affected their career plans. Participants felt that adjustable equipment (60%), a variety of sizes of instruments (43%), and more discussion around ergonomics (47%) would help. Respondents reported adjusting the operating room to accommodate their size took extra time (44%) and was a mental burden (39%). Participants reporting difficulties with operating room equipment were significantly shorter than those without difficulties (64 inches vs 67 inches, P = .037), and those reporting difficulties with instruments had a smaller median glove size (6 vs 6.5, P = .018). CONCLUSION: Surgical ergonomics represent a challenge for female otolaryngologists, particularly those with smaller hands and shorter height. Partnering with industry, we must address the needs of an increasingly diverse workforce to ensure that all surgeons can operate effectively and comfortably.


Asunto(s)
Otolaringología , Humanos , Femenino , Estados Unidos , Otorrinolaringólogos , Ergonomía , Endoscopía , Encuestas y Cuestionarios
6.
J Voice ; 2023 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-37648624

RESUMEN

INTRODUCTION: Past studies show that performers are more susceptible to voice injury, have higher incidence of injury, and experience greater vocal impairment than non-performers. Despite literature demonstrating otherwise, there remains fear and stigma that voice injury is a career-ending circumstance. Much of this is due to a lack of information about post-treatment vocal function. METHODS: An anonymous online survey was distributed via email, flyer, and social media to a target audience of performers with a history of voice injury. It inquired about occupation, vocal symptoms, professionals consulted, and treatment adherence. Outcome measures included ability to perform, resolution of symptoms, and attitudes about their voices after voice injury. Findings were analyzed descriptively with statistical analysis to determine factors that may be related to favorable outcomes. RESULTS: The survey was completed by 151 performers representing a range of genres, including musical theatre, classical, and popular genres. The most reported vocal symptoms were decreased range, singing voice quality changes, increased singing effort, and vocal fatigue. Most initially sought care from an otolaryngologist, laryngologist, or voice teacher. Diagnoses and recommendations varied, but those who adhered to treatment were more likely to report resolution of voice symptoms (P = 0.025). Those with symptoms for 2-4 weeks reported greater vocal confidence than those with a longer symptom duration (P = 0.0251). Performers working with a voice teacher were more likely to find treatment helpful (P = 0.0174). Those with neurogenic voice conditions reported less vocal reliability than participants with other pathologies (P = 0.0155). CONCLUSION: The majority of participants continued to perform, reported resolved or improved voice symptoms after treatment, and reported positive attitudes about their voices, regardless of their injury or current presence or absence of pathology on exam. Findings of this study highlight a need for continued outreach to voice teachers, education programs, and production teams about vocal function after voice injury.

7.
Laryngoscope ; 133(11): 3034-3041, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37096670

RESUMEN

OBJECTIVE: To explore the surgical ergonomic challenges experienced by women in otolaryngology, identify specific equipment that is ergonomically challenging, and assess the impact of suboptimal ergonomics on female otolaryngologists. METHODS: We performed a qualitative study using an interpretive framework rooted in grounded theory. We performed semi-structured qualitative interviews of 14 female otolaryngologists from nine institutions at various stages in training and across subspecialties. Interviews were independently analyzed by thematic content analysis by two researchers and inter-rater reliability was assessed via Cohen's kappa. Differing opinions were reconciled via discussion. RESULTS: Participants noted difficulties with equipment including microscopes, chairs, step stools, and tables as well as difficulty using larger surgical instruments, preference for smaller instruments, frustration with lack of smaller instruments, and a desire for a larger spectrum of instrument sizes. Participants reported neck, hand, and back pain associated with operating. Participants suggested modifications to the operative environment, including a wider variety of instrument sizes, adjustable instruments, and more focus and attention on ergonomic issues and the range of surgeon physiques. Participants felt that optimizing their operating room set-up was an additional burden on them, and that lack of inclusive instrumentation affected their sense of belonging. Participants emphasized positive stories of mentorship and empowerment from peers and superiors of all genders. CONCLUSION: Female otolaryngologists face unique ergonomic challenges. As the otolaryngology workforce becomes increasingly diverse, it is important to address the needs of a diverse set of physiques to avoid inadvertently disadvantaging certain individuals. LEVEL OF EVIDENCE: N/A Laryngoscope, 133:3034-3041, 2023.


Asunto(s)
Enfermedades Musculoesqueléticas , Enfermedades Profesionales , Otolaringología , Humanos , Masculino , Femenino , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Enfermedades Profesionales/etiología , Enfermedades Profesionales/prevención & control , Ergonomía
8.
J Voice ; 2022 Nov 04.
Artículo en Inglés | MEDLINE | ID: mdl-36344348

RESUMEN

OBJECTIVES: The objective of this study was to examine the types of accounts that create posts related to laryngology on Instagram, using hashtags derived from common diagnoses and procedures within the field, in order to assess the source and ownership of laryngology social media discussions. METHODS: Fellowship-trained laryngologists were surveyed to determine the most common diagnoses treated and procedures performed in laryngology. These terms were then queried as hashtags on Instagram. The top 15 posts found per hashtag were classified by the category of individual who shared the content. The categories included laryngologists/otolaryngologists, speech-language pathologists (SLP), vocalists, other physicians, and "other individuals." RESULTS: After surveying 20 fellowship-trained laryngologists, 25 different hashtags related to common diagnoses and procedures in laryngology were created and queried for the top 15 posts on Instagram. 260 posts on Instagram were identified, out of which 30.8% were posted by laryngologists/otolaryngologists, 19.2% by SLPs, 3.1% by vocalists, 6.1% by other physicians, and 40.8% by "other individuals." CONCLUSIONS: A significant portion of top resulted posts on Instagram sharing laryngology-related content is not posted by laryngologists. This raises an issue of the reliability of health information available on social media to patients regarding laryngological conditions.

9.
J Voice ; 2022 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-35850888

RESUMEN

BACKGROUND: In the past decade, there has been a rise in social media applications and usage among individuals in the otolaryngology- head and neck surgery (OHNS) community. Hashtags (#), used to identify posts relating to similar topics, are utilized to search medical information, build a network, find providers, and discuss research. Previous OHNS literature in this arena includes a standard ontology, or list of hashtags, developed for the otology subspecialty. To date, the ontology of laryngology hashtags has not been created. The objective of this study is to propose a standardized ontology to use when discussing topics in laryngology on social media to maximize reach and effect. METHODS: Using a combination of previously published techniques, along with laryngology specific adjustments, the authors developed a list of suggested hashtags. An initial list was systematically culled from laryngology Instagram accounts including academic programs, laryngology influencers (fellowship-trained laryngologists with publicly available professional accounts with greater than 500 followers), and professional societies/conferences. The list was abbreviated using current rate of use, specificity, and expert opinion. These were then categorized to include general terms, diseases and diagnoses, and treatment strategies RESULTS: Across all culled Instagram posts, there were 240 unique laryngology hashtags used and 1152 total hashtags were applied. The authors derived unique terms to be included in the ontology for laryngology by expert opinion of fellowship-trained laryngologists. CONCLUSION: Laryngology is in the early stages of utilization of social media. Developing a specific ontology of hashtags to be used will optimize the reach and connections of term specific searches.

11.
Med Clin North Am ; 105(5): 917-938, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34391543

RESUMEN

Hoarseness is a common problem, typically of transient nature. When hoarseness does not resolve, or when it is associated with concerning symptoms, it is important to consider a wide differential and refer to an otolaryngologist. This article discusses the physiology of the voice and possible causes of dysphonia, and explores when it warrants further work-up by ENT. A discussion of diagnostic techniques and the myriad of tools to treat hoarseness follows. Additionally, the role of reflux in dysphonia is examined with a critical eye to aid in accurate assessment of the patient's complaint.


Asunto(s)
Ronquera/patología , Diagnóstico Diferencial , Disfonía/diagnóstico , Disfonía/patología , Ronquera/diagnóstico , Ronquera/etiología , Ronquera/terapia , Humanos , Laringoscopía , Atención Primaria de Salud
12.
Otolaryngol Head Neck Surg ; 165(6): 876-880, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-33528307

RESUMEN

OBJECTIVE: To determine if time to tracheostomy decannulation differs among children by socioeconomic status. STUDY DESIGN: Case series with chart review. SETTING: Tertiary pediatric medical center. METHODS: Patients (≤21 years old) who underwent tracheostomy from January 1, 2011, to December 31, 2016. Patients were divided into 2 groups based on their socioeconomic status (SES), low SES and high SES. Principal components analysis was used to create an index for SES using census data obtained by the US Census Bureau's American Community Survey 5 year data profile from 2013 to 2017. Statistical analysis was performed using a χ2 for categorical variables and Wilcoxon rank-sum test for continuous variables. A general linear model was constructed to control for clinical factors to understand the independent effect of SES on time to decannulation. RESULTS: In total, 215 patients were included; of these patients, 111 patients (52%) were included in the high-SES group and 104 patients (48%) were included in the low-SES group. There was a significant difference in the time to decannulation for children based on SES status, with those children in the low-SES group taking on average 10 months longer to decannulate (38.7 vs 28.0 months, P = .0007). Median follow-up was 44.1 months (interquartile range, 29.6-61.3 months). CONCLUSION: Health care disparities appear to exist among children undergoing decannulation of their tracheostomy tube. Patients with lower SES had a significantly longer time to decannulation than those with higher SES.


Asunto(s)
Remoción de Dispositivos , Disparidades en Atención de Salud , Clase Social , Traqueostomía , Preescolar , Femenino , Humanos , Lactante , Modelos Lineales , Masculino , Análisis de Componente Principal , Estadísticas no Paramétricas , Tiempo de Tratamiento
13.
Pediatr Emerg Care ; 37(12): e1718-e1720, 2021 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-30907848

RESUMEN

ABSTRACT: Pilomatrixomas, also known as epithelioma calcificans, are benign tumors of hair follicle matrix cells that are often mistaken for other lesions, especially cutaneous abscesses. We report an illustrative case in which a teenage girl developed a red, swollen earlobe that required multiple care visits and interventions until definitive diagnosis and treatment were provided. Although the lesion was initially treated as an abscess, it continued to progress in size and discomfort. The correct diagnosis was established after imaging and complete excision with pathologic examination. Ultimately, our patient was subjected to avoidable procedures that carried the risk of potentially negative cosmetic sequelae before the proper intervention. Although abscesses are common, it is important for clinicians to avoid incision and drainage of lesions, unless the diagnosis is certain.


Asunto(s)
Absceso , Enfermedades de la Piel , Absceso/diagnóstico , Absceso/cirugía , Adolescente , Drenaje , Femenino , Humanos
14.
Ann Otol Rhinol Laryngol ; 129(10): 1003-1010, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32468891

RESUMEN

OBJECTIVE(S): To describe a single institution's experience with the use of steroid-eluting stents after endoscopic transnasal repair of choanal atresia. METHODS: A case series with review of children who underwent choanal atresia repair at a tertiary children's hospital from June 2017 to January 2018 was performed. Those who had a mometasone drug-eluting stent (Propel® Mini, Intersect ENT Inc., Palo Alto, CA) placed after primary or secondary choanal atresia repair at our institution were included. The primary outcome measure was need for revision surgery due to stenosis. Postoperative regimens, duration of stenting, and need for return to the operating room (OR) were also assessed. RESULTS: Five patients with a median age of 22 months at the time of repair met inclusion criteria. Two (40%) had bilateral atresia and 3 (60%) had confirmed CHARGE syndrome. A total of 6 mometasone drug-eluting stents were used in the 5 cases. Three patients were reassessed at least once in the OR; however, the majority (57.1%) of postoperative evaluations were able to be performed in the office or bedside setting. The first and last evaluations occurred a mean of 14 and 124 days after surgery, respectively. There were no instances of restenosis, repeat surgical interventions, or stent-related complications noted. CONCLUSION: Placement of a mometasone drug-eluting stent is a promising method to improve postoperative results and management of choanal atresia repair by limiting the need for repeat anesthetics and OR procedures, as well as the complications of traditional stents.


Asunto(s)
Antiinflamatorios/administración & dosificación , Atresia de las Coanas/cirugía , Furoato de Mometasona/administración & dosificación , Reoperación/estadística & datos numéricos , Síndrome CHARGE , Niño , Preescolar , Constricción Patológica , Stents Liberadores de Fármacos , Endoscopía , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Procedimientos Quirúrgicos Otorrinolaringológicos , Complicaciones Posoperatorias/epidemiología , Procedimientos de Cirugía Plástica
15.
Otolaryngol Head Neck Surg ; 162(3): 362-366, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31959060

RESUMEN

OBJECTIVE: To determine the optimal timing of the first posttracheostomy microlaryngoscopy and bronchoscopy (MLB). STUDY DESIGN: Case series with chart review. SETTING: Tertiary pediatric medical center. SUBJECTS AND METHODS: Patients (<21 years of age) who underwent tracheostomy placement from January 1, 2011, to December 31, 2016. Patients were divided into early and late posttracheostomy surveillance groups (<6 weeks vs 6 to 14 weeks, respectively) based on the timing of their first posttracheostomy MLB. The primary outcome was to ascertain the clinical yield of the initial posttracheostomy MLB by documenting whether a medical or surgical treatment decision was made based on MLB findings. RESULTS: In total, 202 patients were included; of these patients, 162 met criteria for placement in the early group and 40 met criteria for the late group. There was no significant difference between the early and late groups regarding whether a medical or surgical decision was made at the time of the first MLB (21.5% vs 19%, respectively; P = .49). Multiple logistic regression identified that the presence of tracheostomy-related symptoms prior to MLB (odds ratio, 6.75; 95% confidence interval, 2.78-16.39) was the sole predictor of a medical or surgical decision being made at the first posttracheostomy MLB. CONCLUSION: The presence of tracheostomy-related symptoms was predictive of a medical or surgical decision being made using information obtained at the time of the first posttracheostomy MLB. We thus recommend that surveillance endoscopy be initiated when tracheotomized children start to develop tracheostomy-related symptoms.


Asunto(s)
Broncoscopía , Laringoscopía , Vigilancia de la Población , Cuidados Posoperatorios , Traqueostomía , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Factores de Tiempo
16.
Ann Otol Rhinol Laryngol ; 129(3): 301-305, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31640397

RESUMEN

OBJECTIVES: To understand that yolk sac tumors (YSTs) of the head and neck (H&N) are exceedingly rare and typically carry a poor prognosis. To acknowledge the possibility of increased incidence in patients with Aicardi Syndrome and the ramifications this has on early diagnosis and treatment in this population. METHODS: To date, four germ cells tumors of the H&N have been reported in patients with Aicardi Syndrome. This report presents the second known case of a H&N YST in a patient with Aicardi syndrome. In both cases, the patient was initially misdiagnosed given unconvincing radiologic evidence. However, tissue diagnosis and elevated alpha-fetoprotein (AFP) levels were suggestive of a YST. RESULTS: In contrast to the poor prognosis previously described, both patients with Aicardi syndrome had an excellent chemotherapeutic response exhibited by normalization of AFP levels and imaging. CONCLUSIONS: Rare germ cell tumors of the H&N, such as YSTs, have now been documented in several patients with Aicardi syndrome, indicating a possible association given the rarity of these tumors in the population. YSTs should be considered in the differential diagnosis of H&N masses in these patients, with emphasis on early tissue diagnosis and treatment.


Asunto(s)
Síndrome de Aicardi/complicaciones , Tumor del Seno Endodérmico/diagnóstico por imagen , Neoplasias de Cabeza y Cuello/diagnóstico por imagen , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Tumor del Seno Endodérmico/tratamiento farmacológico , Femenino , Neoplasias de Cabeza y Cuello/tratamiento farmacológico , Humanos , Lactante , Imagen por Resonancia Magnética , Tomografía Computarizada por Rayos X , alfa-Fetoproteínas/análisis
17.
Int J Pediatr Otorhinolaryngol ; 120: 64-67, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-30771555

RESUMEN

Despite various studies that have demonstrated risk of cochlear implant magnet displacement following MRI, minimal literature is available on radiologic recognition of magnet displacement. Current literature emphasizes the status and placement of the electrode component of the implant. This case report examines the consequences of a delay in radiologic diagnosis of a displaced magnet including hospital admission, unnecessary radiation, and prolonged patient discomfort. Additionally, it provides a framework for successful radiologic recognition of a displaced magnet, detailing specific imaging modalities and magnet characteristics that should be evaluated to expedite and facilitate radiologic recognition of displacement.


Asunto(s)
Implantes Cocleares/efectos adversos , Imanes/efectos adversos , Falla de Prótesis/efectos adversos , Hueso Temporal/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Niño , Implantación Coclear/efectos adversos , Implantación Coclear/instrumentación , Femenino , Hospitalización , Humanos
18.
Otolaryngol Head Neck Surg ; 160(3): 512-518, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-30322353

RESUMEN

OBJECTIVES: (1) To determine the short-term effectiveness of oral steroids in women with benign vocal fold lesions and (2) to determine the effectiveness of adjuvant oral steroids in women undergoing voice therapy for benign vocal fold lesions. STUDY DESIGN: Randomized, double-blind, placebo-controlled clinical trial. SETTING: Tertiary voice care center. SUBJECTS AND METHODS: Thirty-six patients undergoing voice therapy for the treatment of phonotraumatic vocal fold lesions randomly received either a 4-day course of oral steroids or a placebo prior to initiating voice therapy. Voice Handicap Index-10 (VHI-10) scores, video and audioperceptual analyses, acoustic and aerodynamic analyses at baseline, and patient perception of improvement after a short course of steroids or a placebo and at the conclusion of voice therapy were collected. RESULTS: Thirty patients completed the study, of whom 27 (only female) were analyzed. The primary outcome measure, VHI-10, did not improve after the 4-day course of steroids or placebo. Secondary measures similarly showed no improvement with steroids relative to placebo. Voice therapy demonstrated a positive effect on both VHI-10 and patient-perceived improvement of voice in all subjects. CONCLUSION: A short course of oral steroids did not benefit women with phonotraumatic vocal fold lesions. In addition, steroids had little beneficial effect when used adjunctively with voice therapy in this patient cohort.


Asunto(s)
Glucocorticoides/administración & dosificación , Enfermedades de la Laringe/tratamiento farmacológico , Prednisona/administración & dosificación , Pliegues Vocales/lesiones , Administración Oral , Adulto , Método Doble Ciego , Esquema de Medicación , Femenino , Humanos , Enfermedades de la Laringe/etiología , Enfermedades de la Laringe/rehabilitación , Resultado del Tratamiento , Entrenamiento de la Voz , Adulto Joven
19.
Int J Pediatr Otorhinolaryngol ; 116: 34-37, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30554704

RESUMEN

Acquired laryngomalacia in the pediatric population is rare, especially from a neurogenic cause. This case report describes a pediatric patient who developed laryngomalacia following a neurologic insult. A proposed physiologic pathway is reviewed. A thorough literature review was performed to identify cases of acquired laryngomalacia ascribed to a neurologic cause and are compared to this case.


Asunto(s)
Laringomalacia/etiología , Laringoplastia/métodos , Enfermedad de Moyamoya/complicaciones , Arterias Carótidas/patología , Arterias Carótidas/cirugía , Niño , Femenino , Humanos , Lactante , Recién Nacido , Laringomalacia/cirugía , Laringoscopía/métodos , Laringe/patología , Laringe/cirugía , Enfermedad de Moyamoya/cirugía , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares/métodos
20.
Laryngoscope ; 126(4): 928-35, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26371887

RESUMEN

OBJECTIVES/HYPOTHESIS: To optimize decellularization of porcine vocal folds (VF) and quantify human bone marrow-derived mesenchymal stem cell (BM-MSC) interactions with this matrix to provide a foundation for regenerative approaches to VF repair. STUDY DESIGN AND METHODS: Vocal folds were dissected from porcine larynges and three decellularization protocols were compared, each consisting of washes and mechanical agitations with different combinations of reagents. DNA content was analyzed via Quant-iT Picogreen assay and hematoxylin and eosin staining. Bone marrow-derived MSCs were then seeded onto the decellularized VF matrices. Morphology, metabolic activity, DNA content, and gene expression were assessed using LIVE/DEAD Cell Viability, alamarBlue Cell Viability Assay, Quant-iT Picogreen assay, and quantitative polymerase chain reaction, respectively. RESULTS: The most successful decellularization protocol removed 95% DNA content within 1 day, compared to several days required for previously described protocols. Histology confirmed the retention of extracellular matrix (ECM) and its components, including glycosaminoglycans, collagen, and fibrin, while void of nuclear/cellular content. Decellularized scaffolds were then seeded with BM-MSCs. Similar DNA quantities were observed after 24 hours of seeding within the VF-ECM scaffold when compared to cells on tissue culture plastic (TCP). LIVE/DEAD staining of the seeded VF-ECM confirmed excellent cell viability, and the metabolic activity of BM-MSCs increased significantly on VF-ECM compared to TCP. Endoglin gene expression decreased, suggestive of differentiation. CONCLUSION: Porcine VFs can be efficiently decellularized within 5 hours using a combination of sodium deoxycholate and peracetic acid. Decellularized VF-ECM supported attachment and growth of human BM-MSCs, with evidence of differentiation. LEVEL OF EVIDENCE: N/A.


Asunto(s)
Matriz Extracelular/fisiología , Células Madre Mesenquimatosas/citología , Ingeniería de Tejidos/métodos , Pliegues Vocales/citología , Animales , Células Cultivadas , ADN/análisis , Ácido Desoxicólico , Expresión Génica , Ácido Peracético , Porcinos , Andamios del Tejido
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