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1.
Clin Case Rep ; 11(4): e7115, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37064741

RESUMEN

Considering the rarity and underdiagnoses of this disorder, a pigmented and hyperkeratotic skin lesion located on the trunk, resembling to acanthosis nigricans should always be investigated for terra firma-forme dermatosis (TFFD) and thus alcohol must be applied. TFFD should be known among dermatologists and can be easily diagnosed and treated with isopropyl alcohol.

2.
Clin Case Rep ; 11(4): e7163, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37020670

RESUMEN

Considering the clinical polymorphism of the disease, longstanding skin lesions located on the face, resembling erysipelas in an endemic area should always be investigated for CL and thus, atypical presentations should be kept in mind.

3.
Clin Case Rep ; 10(12): e6702, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36514472

RESUMEN

The anal region is an unusual site of Hailey-Hailey disease. It manifests with lichenoid lesions with crusted erosions around the anus. It should be differentiated from condylomata acuminata, extramammary Paget disease, and bowenoid papulosis.

4.
Clin Case Rep ; 10(9): e6315, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36177083

RESUMEN

Malignant melanoma presenting as an inflammatory skin metastasis has been described but is an exceedingly rare phenomenon. We report a case of inflammatory metastasis of cutaneous melanoma (CM).

5.
Int J Dermatol ; 61(11): 1380-1384, 2022 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-35609142

RESUMEN

BACKGROUND: Erysipeloid cutaneous leishmaniasis (ECL) is known as the chronic form of cutaneous leishmaniasis (CL). However, keeping its clinical presentation in view, there is a need to revisit this form of the disease. AIMS: To describe ECL in view of clinical features and treatment modalities. METHODS: We include a case series seen in Sfax (Southern Tunisia) from January 2017 to January 2021. All patients clinically suggestive and laboratory confirmed with a diagnosis of CL were registered. Patients of all age groups and of either gender having cutaneous lesions resembling erysipela on the face were included in the study. Different demographic features of the patients and clinical aspects were identified. Descriptive statistics were used for analysis. RESULTS: Of 1300 registered patients with CL, 40 (3%) were diagnosed as ECL. Ages ranged from 15 to 65 years, and duration of lesions varied from 15 to 180 days. All patients had lesions over the face. Clinically, a painful infiltrated inflammatory placard of the central facial area with a butterfly shape was observed in 14 cases, as well as zones of the cheekbone (11 cases), cheekbone and nose (5 cases), cheekbone and eyelid (8 cases), and cheekbone with ear (2 cases). Several therapeutic methods were prescribed with a sufficient result with no recurrence. CONCLUSION: ECL is a rare presentation that typically occurs on the face, looking like erysipelas, in patients who are native from an endemic region of CL.


Asunto(s)
Erisipeloide , Leishmaniasis Cutánea , Erisipeloide/diagnóstico , Erisipeloide/patología , Párpados/patología , Humanos , Lactante , Recién Nacido , Leishmaniasis Cutánea/diagnóstico , Leishmaniasis Cutánea/tratamiento farmacológico , Leishmaniasis Cutánea/epidemiología , Nariz/patología , Túnez
9.
Int J Dermatol ; 60(6): 742-748, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33598928

RESUMEN

BACKGROUND: Hydroxychloroquine (HCQ)-induced acute generalized exanthematous pustulosis (AGEP) is poorly described in the literature. The aim of our study was to characterize the clinical, laboratory, allergological, and genetic features of HCQ-induced AGEP. METHODS: We conducted a retrospective study of patients with HCQ-induced AGEP diagnosed between 2011 and 2019. We performed molecular analysis to identify variations in the IL36RN gene. We also reviewed similar cases reported between 1991 and March 2020. RESULTS: Seven female patients were included. The mean age was 47 years old, and the average time from HCQ start to onset of symptoms was 40 days. All patients received topical steroids with a full resolution of the rash within an average of 39 days after HCQ withdrawal. Patch tests were performed for three patients with positive results in one case. Genetic analyses were performed for three patients, and no mutation in the IL36RN gene was identified. CONCLUSION: The latent period and the duration for resolution of HCQ-induced AGEP may be longer than with other drugs due to the metabolic characteristics of HCQ. Mutations in the IL36RN gene were not identified in our patients.


Asunto(s)
Pustulosis Exantematosa Generalizada Aguda , Exantema , Pustulosis Exantematosa Generalizada Aguda/genética , Exantema/inducido químicamente , Femenino , Humanos , Hidroxicloroquina/efectos adversos , Interleucinas , Persona de Mediana Edad , Pruebas del Parche , Estudios Retrospectivos
12.
14.
Dermatol Online J ; 24(5)2018 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-30142739

RESUMEN

Diffuse dermal angiomatosis (DDA) is a type of reactive skin angioproliferation. Clinically, this rare disorder presents as red-violet purpuric papules and/or plaques (some with a greater tendency towards necrosis and ulceration), which can be localized in any body area, but is most often seen in the upper and lower extremities. Localization in the breast commonly presents with severe intractable breast pain and characteristic reticular violaceous erythematous plaques with central ulcerations. Histological examination is fundamental for the diagnosis and is characterized by varied patterns of lobular or diffuse hyperplasia of endothelial cells at the extravascular level. The condition is associated with various underlying conditions, many of which result in local tissue ischemia. In this report, we present a patient with DDA with an underlying mass lesion of the breast, which proved to be an adjacent fat necrosis. Various treatments have proven beneficial, including revascularization, oral corticosteroids, smoking cessation, and isotretinoin. In this case, our patient benefited from secondary excision of the affected area.


Asunto(s)
Angiomatosis/patología , Mama/patología , Dermis/irrigación sanguínea , Necrosis Grasa/patología , Enfermedades Cutáneas Vasculares/patología , Anciano , Mama/irrigación sanguínea , Dermis/patología , Femenino , Humanos , Necrosis
15.
Pediatr Dermatol ; 35(6): e412-e413, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30152554

RESUMEN

Pathological conditions of the hymen are rare in everyday medical practice. Hymenal polyps are polypoid formations originating from the hymenal rim and are benign and disappear spontaneously within a few weeks of onset. We report two cases of hymenal polyps in two infants.


Asunto(s)
Himen/patología , Pólipos/diagnóstico , Enfermedades Vaginales/diagnóstico , Preescolar , Femenino , Humanos , Lactante
16.
Int J Dermatol ; 55(9): 1033-9, 2016 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26967709

RESUMEN

BACKGROUND: Sweet's syndrome (SS) is a neutrophilic dermatosis characterized by the abrupt onset of cutaneous, systemic and histopathological alterations in response to different stimuli. OBJECTIVES: The aim of this study was to assess the epidemioclinical, histological, and therapeutic features and outcomes of SS. METHODS: A retrospective study of all patients diagnosed with SS over a 20-year period (1993-2012) was conducted. Data were analyzed using a level of significance of 5%. RESULTS: Ninety patients (mean age: 46.5 years) fulfilled the inclusion criteria. The ratio of women to men was 5. Significant associations emerged between dermohypodermic nodes and location on the lower limbs (P = 0.042), and vesiculobullous lesions and location on the legs (P = 0.030), dorsum of the hand (P = 0.015), and forearms (P = 0.003), and paraneoplastic forms (P = 0.012). The upper extremities were involved in the majority of patients (83.3%). Correlations were found between edema of the superficial dermis and vesiculobullous lesions and between leukocytoclastic vasculitis and atypical targetoid lesions. Sweet's syndrome was associated with cytomegalovirus infection (n = 1), inflammatory bowel disease (n = 4), neoplasm (n = 6), and pregnancy (n = 3). First-line treatment consisted of colchicine. CONCLUSIONS: To the best of the present authors' knowledge, this is the largest series of SS to be reported. Clinical presentations are similar to those described in the literature. Colchicine was efficient and facilitates the reduced use of corticosteroids. The association between SS and neoplasms should be considered in the context of vesiculobullous lesions.


Asunto(s)
Neoplasias/complicaciones , Complicaciones del Embarazo/patología , Síndrome de Sweet/complicaciones , Síndrome de Sweet/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Vesícula/etiología , Niño , Preescolar , Colchicina/uso terapéutico , Infecciones por Citomegalovirus/complicaciones , Femenino , Supresores de la Gota/uso terapéutico , Dermatosis de la Mano/etiología , Humanos , Enfermedades Inflamatorias del Intestino/complicaciones , Extremidad Inferior , Masculino , Persona de Mediana Edad , Embarazo , Complicaciones del Embarazo/tratamiento farmacológico , Estudios Retrospectivos , Síndrome de Sweet/tratamiento farmacológico , Centros de Atención Terciaria , Extremidad Superior , Adulto Joven
17.
Int J Dermatol ; 54(12): 1370-5, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26016611

RESUMEN

BACKGROUND: Aplasia cutis congenita (ACC) is a rare malformation characterized by absent or scarred areas of skin at birth. Although most commonly found on the scalp, ACC can also involve other locations. Its etiology and pathogenesis remain unclear. OBJECTIVE: To describe the epidemiologic, clinical, therapeutic, and evolutionary aspects of ACC through a hospital series. METHODS: We conducted a retrospective study from 1995 to 2012 and reported all cases of ACC. RESULTS: We enrolled 22 cases (14 girls and eight boys) of ACC during 18 years. The mean age at diagnosis was 5.7 years. Sixteen ACC involved the scalp, five the trunk, and one the left buttock. ACC was oval-shaped in 20 cases, triangular in one case, and linear in one case. The mean size was 4 cm. ACC was associated with bone defects in two cases, various malformations in eight (37.1%), and with syndromic malformation in three (Adams-Olivier syndrome: two cases; Goltz syndrome: one case). Conservative treatment consisting of wound dressing with vaseline was indicated in six cases. Bone reconstruction was performed in two cases. Regular follow-up and no treatment was recommended in 14 cases. CONCLUSION: Our study emphasizes the frequent association of ACC with malformations (37.1%) and bone defects (9%).


Asunto(s)
Huesos/anomalías , Displasia Ectodérmica/complicaciones , Displasia Ectodérmica/patología , Adolescente , Adulto , Huesos/cirugía , Nalgas , Niño , Preescolar , Displasia Ectodérmica/terapia , Femenino , Hipoplasia Dérmica Focal/complicaciones , Humanos , Lactante , Recién Nacido , Deformidades Congénitas de las Extremidades/complicaciones , Masculino , Estudios Retrospectivos , Dermatosis del Cuero Cabelludo/complicaciones , Dermatosis del Cuero Cabelludo/congénito , Dermatosis del Cuero Cabelludo/patología , Dermatosis del Cuero Cabelludo/terapia , Torso , Adulto Joven
19.
Tunis Med ; 91(8-9): 514-20, 2013.
Artículo en Francés | MEDLINE | ID: mdl-24227509

RESUMEN

BACKGROUND: Few prospective studies are available on the incidence and analysis of the characteristics of adverse cutaneous drug reactions. AIM: To describe the adverse cutaneous reactions, their epidemiologic characteristics as well as the different causative drugs through a prospective hospital study. METHODS: A 12-month prospective study was managed in our department of dermatology of the teaching hospital Hedi Chaker of Sfax. Requested information included patient characteristics (associated disorders), drug intake (list and chronology of the drug intake during the 3 weeks preceding the adverse reaction) and characteristics of the skin reaction (type, course). The diagnosis was based on a beam of clinical and anamnestic arguments. The drug imputability was evaluated according to the Begaud's French method. RESULTS: One hundred eighteen cases were collected. A prevalence of 1.08/100 among patients consulting in dermatology department was estimated. The macular and papular exanthema represented the most frequent clinical aspects (42 cases) followed by acute urticaria (23 cases), photosensitivity (19 cases) and fixed drug eruption (15 cases). Principal imputable drugs were antibiotics, mainly penicillins followed by analgesics and non-steroidal anti-inflammatory. CONCLUSION: Although it was monocentric, this study revealed a high frequency of drug-induced dermatitis with different clinical presentation. The high incidence of drug-induced dermatitis induced by antibiotics, analgesics and anti-inflammatory is due to their widespread use, often in self-medication.


Asunto(s)
Analgésicos/efectos adversos , Antibacterianos/efectos adversos , Antiinflamatorios/efectos adversos , Dermatitis/epidemiología , Dermatitis/etiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Estudios de Cohortes , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Adulto Joven
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