RESUMEN
Meeting of the Advisory Committee on Medical Research, 7. Pan American Health Organization; 24-28 Jun. 1968
Asunto(s)
Investigación , Indígenas Norteamericanos , Enfermedades de la Vejiga Urinaria , América Latina , Región del Caribe , Formulación de PolíticasRESUMEN
A Pilot campaign against onchocerciasis based upon the administration of suramin sodium was conducted in Yepocapa, Chenaltenango, Guatemala. This caused a spectacular reduction in the incidence of persons with demonstrable microfilariae. Suramin administered orally to children was not effective
The suramin used in this trial was considerably more toxic than that used in preliminary studies. It is felt that the brand used in this pilot campaign should only be used on hospitalized patients or those with constant medical supervision. Future medical programs should use only well established brands such as those in constant use in Africa for the treatment of sleeping sickness(AU)
Asunto(s)
Oncocercosis/tratamiento farmacológico , Estudios de Seguimiento , GuatemalaRESUMEN
1. In preparation for a pilot project for the medical treatment of onchocerciasis with suramin (USP III) 1,142 inhabitants from Yepocapa, Chimaltenango, Guatemala, were examined for various manifestations of onchocerciasis
2. Approximately half of all adults examined had demonstrable microfilariae on skin biopsies. The youngest individuals with a positive biopsy was two years old
3. One fourth of the subjects examined had palpable nodules. Fifty-four per cent of the nodules were located on the head. The remaining were fairly evenly distributed between the thorax and pelvic region with but one per cent palpated on the arms or legs
4. The youngest patient on whom a nodule was proved to be onchocercal was a twenty-six month old child. A nodule was palpated on an eighteen month infant, but examination following excision proved it to be a hypertrophied lymph node
5. Twenty-six or 2.2 per cent of the population examined were blind in one of both eyes
6. Ocular symptoms consisting of entopic vision of worms, hazy vision and unpleasant sensations were encountered in approximately one fourth of the subjects interviewed
7. Visula acuity was diminished in a little more than one third and visual fields constricted in one eighth of the individuals tested
8. Examination with a hand slit lamp showed alterations of the conjunctiva and limbus in 15.9 per cent of the patients examined. ...(AU)
Asunto(s)
Oncocercosis/epidemiología , Oncocercosis/prevención & control , Oncocercosis/tratamiento farmacológico , Suramina/terapia , Salud Ocular , Proyectos Piloto , Estados UnidosRESUMEN
1. In preparation for a pilot project for the medical treatment of onchocerciasis with suramin (USP III) 1,142 inhabitants from Yepocapa, Chimaltenango, Guatemala, were examined for various manifestations of onchocerciasis
2. Approximately half of all adults examined had demonstrable microfilariae on skin biopsies. The youngest individuals with a positive biopsy was two years old
3. One fourth of the subjects examined had palpable nodules. Fifty-four per cent of the nodules were located on the head. The remaining were fairly evenly distributed between the thorax and pelvic region with but one per cent palpated on the arms or legs
5. Twenty-six or 2.2 per cent of the population examined were blind in one of both eyes
6. Ocular symptoms consisting of entopic vision of worms, hazy vision and unpleasant sensations were encountered in approximately one fourth of the subjects interviewed
7. Visula acuity was diminished in a little more than one third and visual fields constricted in one eighth of the individuals tested
8. Examination with a hand slit lamp showed alterations of the conjunctiva and limbus in 15.9 per cent of the patients examined. ...(AU)
4. The youngest patient on whom a nodule was proved to be onchocercal was a twenty-six month old child. A nodule was palpated on an eighteen month infant, but examination following excision proved it to be a hypertrophied lymph node
Asunto(s)
Oncocercosis , Suramina , Proyectos Piloto , Estados Unidos , Salud OcularRESUMEN
A Pilot campaign against onchocerciasis based upon the administration of suramin sodium was conducted in Yepocapa, Chenaltenango, Guatemala. This caused a spectacular reduction in the incidence of persons with demonstrable microfilariae. Suramin administered orally to children was not effective
The suramin used in this trial was considerably more toxic than that used in preliminary studies. It is felt that the brand used in this pilot campaign should only be used on hospitalized patients or those with constant medical supervision. Future medical programs should use only well established brands such as those in constant use in Africa for the treatment of sleeping sickness(AU)