RESUMEN
The aim of the study was to investigate changes in the oral cavity and the gastroesophageal zone of the patients receiving rabeprazol, a proton pump inhibitor (PPI). The subjects were 88 patients with gastroesophageal reflux disease (GERD), who had changes in the oral cavity typical of this disease. The patients were divided into four groups. Group I included patients with non-erosive reflux disease; the other three groups were formed according to the degree of the severity of reflux esophagitis in accordance with Los Angeles classification of GERD: A, B, and C. The patients were administered rabeprazol as a PPI. The study found that oral cavity changes are associated with the degree of the gastroesophageal reflux. The study demonstrated high efficacy of rabeprazol in GERD patients with oral cavity changes.
Asunto(s)
Reflujo Gastroesofágico/complicaciones , Estomatitis/etiología , 2-Piridinilmetilsulfinilbencimidazoles , Bencimidazoles/uso terapéutico , Inhibidores Enzimáticos/uso terapéutico , Esófago/metabolismo , Femenino , Estudios de Seguimiento , Reflujo Gastroesofágico/tratamiento farmacológico , Reflujo Gastroesofágico/metabolismo , Humanos , Concentración de Iones de Hidrógeno , Masculino , Boca/efectos de los fármacos , Boca/metabolismo , Boca/patología , Omeprazol/análogos & derivados , Omeprazol/uso terapéutico , ATPasas de Translocación de Protón/antagonistas & inhibidores , Rabeprazol , Saliva/metabolismo , Índice de Severidad de la Enfermedad , Estomatitis/patología , Estomatitis/prevención & control , Resultado del TratamientoRESUMEN
Gastroesophageal reflux disease (GERD) is a wide spread disease characterized by distinct clinical polymorphism manifesting with various symptoms and/or inflammatory changes of a distal portion of the esophagus. Current first-line therapy in GERD consists in administration of proton pump inhibitors (PPI) which promote faster relief of the symptoms and healing of erosive-ulcerous lesions of esophageal mucosa in GERD patients. Clinical efficacy of standard and novel PPI is compared. Wide use of PPI and their long-term courses require further study of PPI side effects which now lack attention from the clinical researchers.
Asunto(s)
Reflujo Gastroesofágico/tratamiento farmacológico , Omeprazol/análogos & derivados , Inhibidores de la Bomba de Protones , 2-Piridinilmetilsulfinilbencimidazoles , Bencimidazoles/uso terapéutico , Inhibidores Enzimáticos/uso terapéutico , Humanos , Lansoprazol , Omeprazol/uso terapéutico , Pantoprazol , Rabeprazol , Sulfóxidos/uso terapéutico , Resultado del TratamientoAsunto(s)
Infecciones Oportunistas Relacionadas con el SIDA , Antivirales/uso terapéutico , Esofagitis , Herpes Simple , Herpesvirus Humano 1/efectos de los fármacos , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Infecciones Oportunistas Relacionadas con el SIDA/virología , Antivirales/efectos adversos , Esofagitis/tratamiento farmacológico , Esofagitis/virología , Herpes Simple/tratamiento farmacológico , Herpes Simple/virología , Herpesvirus Humano 1/aislamiento & purificación , HumanosRESUMEN
AIM: To investigate the prevalence of gastroesophageal reflux disease (GERD) among patients with bronchial asthma (BA) and to determine the effects of omeprazole therapy on the outcome of asthma in patients with GERD. MATERIAL AND METHODS: 117 BA patients were examined. Those who had a concomitant GERD were divided into two groups to receive outpatiently omeprazole 40 mg/day or placebo for 8 weeks. Spirometry was performed before and after the treatment. Clinical indices were calculated by daily summarizing of pulmonary (CIEI I) and gastric (CIEI II) symptoms improvement. RESULTS: The trial showed a significant correlation between CIEI I and CIEI II (r = 0.574, p < 0.001) during 8-week omeprazole therapy. The analysis of PEV and FEV1 dynamics showed a significant improvement (p < 0.05) of bronchial conduction in BA patients receiving omeprazole vs placebo. CONCLUSION: A significant correlation exists between the severity of gastroesophageal refluxes and bronchoobstructive syndrome in BA and GERD patients. Omeprazole treatment of such patients relieves BA and GERD symptoms.
Asunto(s)
Asma/complicaciones , Reflujo Gastroesofágico/tratamiento farmacológico , Omeprazol/uso terapéutico , Adulto , Reflujo Gastroesofágico/complicaciones , Humanos , Persona de Mediana Edad , Placebos , Resultado del TratamientoRESUMEN
Adaptive reactions were studied in 80 patients with acute pneumonia. In the hospital 94.1% patients showed reactions of stress and incomplete reactions of training and activation. With improvement of the clinical condition the number of stress reactions reduces, while the number of physiological reactions of training and activation increased. The stress reaction is an unfavourable factor as to transition of acute pneumonia into chronic unspecific pulmonary diseases. These studies may be of value for evaluation of the prognosis and care of acute pneumonia.
Asunto(s)
Adaptación Fisiológica , Neumonía/fisiopatología , Enfermedad Aguda , Humanos , Recuento de Leucocitos , Modalidades de Fisioterapia/métodos , Neumonía/sangre , Neumonía/rehabilitación , Pronóstico , Estrés Fisiológico/sangre , Estrés Fisiológico/fisiopatología , Estrés Fisiológico/rehabilitaciónRESUMEN
The paper presents clinical and instrumental evidence on 47 patients with hepatic cirrhosis. The revealed ventilatory disorders and worse bronchial permeability closely correlated with the degree of pulmonary hypertension which in its turn depended on portal hypertension degree. Pulmonary hypertension decreased with a decline in the activity of the pathological process in the liver due to treatment. External respiration insufficiency observed in hepatic cirrhosis contributes to the onset of arterial hypoxemia and hypoxic impairment of the liver activating in it a pathological process. It is recommended that such patients should receive a combined treatment incorporating oxygen therapy, calcium antagonists, antioxidants.
Asunto(s)
Hipertensión Pulmonar/diagnóstico por imagen , Cirrosis Hepática/fisiopatología , Circulación Pulmonar/fisiología , Respiración/fisiología , Insuficiencia Respiratoria/diagnóstico por imagen , Función Ventricular Derecha/fisiología , Adulto , Anciano , Ecocardiografía Doppler , Humanos , Hipertensión Pulmonar/etiología , Cirrosis Hepática/complicaciones , Cirrosis Hepática/diagnóstico por imagen , Persona de Mediana Edad , Insuficiencia Respiratoria/etiologíaAsunto(s)
Enfisema Pulmonar/diagnóstico , Humanos , Pulmón/diagnóstico por imagen , Pulmón/fisiopatología , Pleura/diagnóstico por imagen , Neumotórax/etiología , Enfisema Pulmonar/complicaciones , Enfisema Pulmonar/etiología , Enfisema Pulmonar/fisiopatología , Enfisema Pulmonar/terapia , Radiografía , Cintigrafía , Pruebas de Función RespiratoriaAsunto(s)
Enfermedades Pulmonares Obstructivas/complicaciones , Insuficiencia Respiratoria/etiología , Corteza Suprarrenal/fisiopatología , Pruebas de Función de la Corteza Suprarrenal , Corticoesteroides/uso terapéutico , Adulto , Femenino , Humanos , Enfermedades Pulmonares Obstructivas/fisiopatología , Masculino , Persona de Mediana Edad , Circulación Pulmonar , Enfermedad Cardiopulmonar/tratamiento farmacológico , Enfermedad Cardiopulmonar/etiologíaRESUMEN
The method of perfusion scanning of the lungs with albumin microaggregate 131I was used for studying the state of pulmonary blood flow in patients with acute pneumonia (AP). The outcome of the disease was chronic non-specific lung disease (CNLD). The results of study demonstrated the improvement of microcirculation by the time of discharge from a hospital, but in 54.2 per cent of the patients blood flow was reduced. It was proved that reduced blood flow, by the time of discharge, together with impaired external respiration function, X-ray changes and biochemical blood shifts are the unfavourable factors with respect to prognosis which contribute to the transition of AP into CNLD. Combined therapy of AP should include measures directed to the improvement of pulmonary microcirculation.