RESUMEN
RATIONALE: Previous studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas rats tested outside the home prefer cocaine to heroin. Here, we investigated whether drug history would influence subsequent drug preference in distinct settings. Based on a theoretical model of drug-setting interaction, we predicted that regardless of drug history rats would prefer heroin at home and cocaine outside the home. METHODS: Rats with double-lumen catheters were first trained to self-administer either heroin (25 µg/kg) or cocaine (400 µg/kg) for 12 consecutive sessions. Twenty-six rats were housed in the self-administration chambers (thus, they were tested at home), whereas 30 rats lived in distinct home cages and were transferred to self-administration chambers only for the self-administration session (thus, they were tested outside the home). The rats were then allowed to choose repeatedly between heroin and cocaine within the same session for seven sessions. RESULTS: Regardless of the training drug, the rats tested outside the home preferred cocaine to heroin, whereas the rats tested at home preferred heroin to cocaine. There was no correlation between drug preference and drug intake during the training phase. CONCLUSION: Drug preferences were powerfully influenced by the setting but, quite surprisingly, not by drug history. This suggests that, under certain conditions, associative learning processes and drug-induced neuroplastic adaptations play a minor role in shaping individual preferences for one drug or the other.
Asunto(s)
Conducta de Elección/efectos de los fármacos , Conducta de Elección/fisiología , Cocaína/administración & dosificación , Ambiente , Heroína/administración & dosificación , Analgésicos Opioides/administración & dosificación , Animales , Condicionamiento Clásico/efectos de los fármacos , Condicionamiento Clásico/fisiología , Inhibidores de Captación de Dopamina/administración & dosificación , Masculino , Ratas , Ratas Sprague-Dawley , AutoadministraciónRESUMEN
BACKGROUND: We have recently observed an unforeseen dissociation in the effect of environmental context on heroin versus cocaine self-administration in rats. Rats housed in the self-administration chambers (Residents) took more heroin than rats that were transferred to the self-administration chambers only for the test sessions (Nonresidents). The contrary was found for cocaine. The twofold aim of the present study was to investigate: 1) drug choice as a function of ambience in rats given access to both cocaine and heroin, and 2) ambience of choice for cocaine- versus heroin-taking in human addicts. METHODS: Resident and Nonresident rats with double-lumen intrajugular catheters were trained to self-administer cocaine (400 microg/kg/infusion) and heroin (25 microg/kg/infusion) on alternate days and then given the opportunity to choose between the two drugs during seven daily sessions. In the human study, we asked heroin and cocaine abusers where they preferred to take these drugs. RESULTS: Approximately 46.7% of Resident rats exhibited a preference for heroin over cocaine; 33.3% preferred cocaine, and 20% expressed no preference. In contrast, only 8.3% of Nonresident rats preferred heroin, whereas 66.7% preferred cocaine, and 25% expressed no preference. In the human study, 73% of co-abusers reported that they used heroin exclusively or mostly at home (22% used it outside the home), whereas only 25% reported using cocaine at home (67% took it outside their homes). CONCLUSIONS: Environmental context plays an important role in drug choice in both humans and rats self-administering heroin and cocaine.
Asunto(s)
Conducta de Elección/efectos de los fármacos , Cocaína/administración & dosificación , Condicionamiento Operante/efectos de los fármacos , Ambiente , Heroína/administración & dosificación , Trastornos Relacionados con Sustancias/psicología , Adulto , Animales , Cocaína/farmacología , Extinción Psicológica/efectos de los fármacos , Femenino , Heroína/farmacología , Humanos , Inyecciones Intravenosas , Masculino , Ratas , Ratas Sprague-Dawley , AutoadministraciónRESUMEN
RATIONALE: We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin. MATERIALS AND METHODS: We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 microg/kg) and cocaine (400 microg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of "self-administration doses" of heroin (25.0 microg/kg) and cocaine (400 microg/kg). RESULTS: We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression. CONCLUSIONS: Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat.
Asunto(s)
Trastornos Relacionados con Cocaína/psicología , Cocaína/farmacología , Genes fos/efectos de los fármacos , Dependencia de Heroína/psicología , Heroína/farmacología , Narcóticos/farmacología , ARN Mensajero/biosíntesis , Animales , Condicionamiento Operante/efectos de los fármacos , Expresión Génica/efectos de los fármacos , Hibridación in Situ , Masculino , ARN Mensajero/genética , Ratas , Ratas Sprague-Dawley , Esquema de Refuerzo , Autoadministración , Abuso de Sustancias por Vía Intravenosa/psicologíaRESUMEN
RATIONALE: The circumstances of drug taking are thought to play a role in drug abuse but the evidence of it is anecdotal. Previous studies have shown that the intravenous self-administration of cocaine is facilitated in rats non-residing in the test chambers relative to rats that live in the test chambers at all times. We investigated here whether environmental context could exert its modulatory influence on heroin and amphetamine self-administration as well. MATERIALS AND METHODS: Independent groups of rats were given the possibility to self-administer different doses of heroin or amphetamine (12.5, 25.0, or 50.0 microg/kg). Some animals were housed in the self-administration chambers (resident groups) whereas other rats were transported to the self-administration chambers only for the test sessions (non-resident groups). RESULTS: Amphetamine-reinforcing effects were more pronounced in non-resident rats than in resident rats, as previously reported for cocaine. Quite unexpectedly, the opposite was found for heroin. Because of this surprising dissociation, some of the rats trained to self-administer amphetamine were later given the opportunity to self-administer heroin. Also in this case, resident rats took more heroin than non-resident rats. CONCLUSIONS: These findings suggest an unforeseen dissociation between opioid and psychostimulant reward and demonstrate that even in the laboratory rat some contexts are associated with the propensity to self-administer more opioid than psychostimulant drugs and vice versa, thus indicating that drug taking is influenced not only by economical or cultural factors but also can be modulated at a much more basic level by the setting in which drugs are experienced.
Asunto(s)
Trastornos Relacionados con Anfetaminas/psicología , Ambiente , Dependencia de Heroína/psicología , Anfetamina/farmacología , Animales , Estimulantes del Sistema Nervioso Central/farmacología , Condicionamiento Operante/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Interacciones Farmacológicas , Heroína/farmacología , Masculino , Narcóticos/farmacología , Ratas , Ratas Sprague-Dawley , Esquema de Refuerzo , AutoadministraciónRESUMEN
The aim of this review is to provide an overview of the main types of animal models used to investigate the modulatory role of environment on drug addiction. The environment can alter the responsiveness to addictive drugs in at least three major ways. First, adverse life experiences can make an individual more vulnerable to develop drug addiction or to relapse into drug seeking. Second, neutral environmental cues can acquire, through Pavlovian conditioning, the ability to trigger drug seeking even after long periods of abstinence. Third, the environment immediately surrounding drug taking can alter the behavioral, subjective, and rewarding effects of a given drug, thus influencing the propensity to use the same drug again. We have focused in particular on the results obtained using an animal model we have developed to study the latter type of drug-environment interaction.
Asunto(s)
Ambiente , Trastornos Relacionados con Sustancias/psicología , Animales , Condicionamiento Psicológico , Privación de Alimentos/fisiología , Genes fos , Humanos , Modelos Psicológicos , ARN Mensajero/biosíntesis , ARN Mensajero/genética , Medio Social , Estrés Psicológico/psicología , Trastornos Relacionados con Sustancias/fisiopatologíaRESUMEN
RATIONALE: Previous studies have shown that environmental context can powerfully modulate the induction of psychomotor sensitization to cocaine in the rat. Rats that receive repeated administrations of cocaine in association with environmental novelty exhibit greater psychomotor sensitization than animals that receive the same treatments in their home cages. OBJECTIVES: The goal of the present study was to investigate whether environmental context can exert its modulatory influence also on cocaine self-administration. MATERIALS AND METHODS: Independent groups of rats with intravenous catheters were given the possibility to self-administer different doses of cocaine (0.0, 0.2, 0.4, and 0.8 mg/kg per infusion) under two environmental conditions. Some animals were housed in the self-administration cages (home groups), whereas other rats were transported to the self-administration cages only for the test sessions (novelty groups). RESULTS: Environmental "novelty" facilitated the acquisition of cocaine self-administration at the doses of 0.2 and 0.4 mg/kg per infusion. When rats were given access to a higher dose of cocaine (0.8 mg/kg per infusion), there were no significant group differences in drug taking. Environmental context had no effect on the self-administration of the vehicle. Thus, it appears that environmental "novelty" produced a shift to the left in the dose-effect curve for cocaine self-administration. Furthermore, "novelty" enhanced the motivation of the rats to work for cocaine, as indicated by the results of a progressive ratio procedure. CONCLUSIONS: The present findings demonstrate for the first time that the environment surrounding drug taking can alter both the intake of and motivation for cocaine.