RESUMEN
Alginate nanocomposite films incorporating sepiolite (Sep) modified with myrtle berries extract (MBE) rich in polyphenols were prepared by solution casting method. The effects of different extract concentrations on the film properties were determined by measuring physicochemical, mechanical and antioxidant properties of the films. Fourier transform infrared (FTIR) spectra indicated that strong interactions between the polyphenols present in the MBE and sepiolite were involved in the films. The results suggested that incorporation of Sep-MBE hybrids into the films improved elongation at break, tensile strength, water vapor and UV barrier properties compared to the control film. The antioxidant activity of the films was significantly improved and raised with increasing content of MBE. The release kinetics results of MBE polyphenols from the active films into alcoholic food simulant indicated that the addition of Sep-MBE hybrids to alginate film is able to slow the release of MBE polyphenols. This study revealed the benefits of incorporation of Sep-MBE hybrids into the alginate films and their potential application as active packaging films or coating material.
Asunto(s)
Alginatos/química , Frutas/química , Silicatos de Magnesio/química , Myrtus/química , Nanocompuestos/química , Extractos Vegetales/química , Polifenoles/química , Adsorción , Antioxidantes/farmacología , Rastreo Diferencial de Calorimetría , Módulo de Elasticidad , Humedad , Nanocompuestos/ultraestructura , Fenómenos Ópticos , Permeabilidad , Polifenoles/farmacología , Espectroscopía Infrarroja por Transformada de Fourier , Vapor/análisis , Temperatura , Resistencia a la Tracción , Termogravimetría , Agua/químicaRESUMEN
Chitosan (CS) and purified sodium beidellite (Na-Bd) were used to obtain a nanocomposite able to carry anionic pharmaceutical ingredients. Diclofenac sodium (DS) was chosen as a model drug and was loaded by intercalation solution technique. Solid state characterization of the resultant hybrids was performed, including X-ray diffraction, Fourier transformed infrared spectroscopy, Thermal analysis and high resolution transmission electron microscopy coupled with energy dispersive X-Ray analysis. Drug loading capacity and encapsulation efficiency were quantified by measuring equilibrium concentration by UV-Vis spectroscopy at 276â¯nm. Solid-state characterization of the samples confirmed both chemical and physical interaction of DS with the nanocomposites. High drug loading along with a modified cumulative release of the drug in simulated intestinal fluid was obtained. The developed clay/polymer hybrids can act as potential candidates for the design of modified dosage forms of anionic drugs.
