Compression stress-strain curve of lithium slag recycled fine aggregate concrete.

As one of the key materials used in the civil engineering industry, concrete has a global annual consumption of approximately 10 billion tons. Cement and fine aggregate are the main raw materials of concrete, and their production causes certain harm to the environment. As one of the countries with the largest production of industrial solid waste, China needs to handle solid waste properly. Researchers have proposed to use them as raw materials for concrete. In this paper, the effects of different lithium slag (LS) contents (0%, 10%, 20%, 40%) and different substitution rates of recycled fine aggregates (RFA) (0%, 10%, 20%, 30%) on the axial compressive strength and stress-strain curve of concrete are discussed. The results show that the axial compressive strength, elastic modulus, and peak strain of concrete can increase first and then decrease when LS is added, and the optimal is reached when the LS content is 20%. With the increase of the substitution rate of RFA, the axial compressive strength and elastic modulus of concrete decrease, but the peak strain increases. The appropriate amount of LS can make up for the mechanical defects caused by the addition of RFA to concrete. Based on the test data, the stress-strain curve relationship of lithium slag recycled fine aggregate concrete is proposed, which has a high degree of agreement compared with the test results, which can provide a reference for practical engineering applications. In this study, LS and RFA are innovatively applied to concrete, which provides a new way for the harmless utilization of solid waste and is of great significance for the control of environmental pollution and resource reuse.

Personalized Fair Split Learning for Resource-Constrained Internet of Things.

With the flourishing development of the Internet of Things (IoT), federated learning has garnered significant attention as a distributed learning method aimed at preserving the privacy of participant data. However, certain IoT devices, such as sensors, face challenges in effectively employing conventional federated learning approaches due to limited computational and storage resources, which hinder their ability to train complex local models. Additionally, in IoT environments, devices often face problems of data heterogeneity and uneven benefit distribution between them. To address these challenges, a personalized and fair split learning framework is proposed for resource-constrained clients. This framework first adopts a U-shaped structure, dividing the model to enable resource-constrained clients to offload subsets of the foundational model to a central server while retaining personalized model subsets locally to meet the specific personalized requirements of different clients. Furthermore, to ensure fair benefit distribution, a model-aggregation method with optimized aggregation weights is used. This method reasonably allocates model-aggregation weights based on the contributions of clients, thereby achieving collaborative fairness. Experimental results demonstrate that, in three distinct data heterogeneity scenarios, employing personalized training through this framework exhibits higher accuracy compared to existing baseline methods. Simultaneously, the framework ensures collaborative fairness, fostering a more balanced and sustainable cooperation among IoT devices.

Effect on Microstructure and Mechanical Properties of Microwave-Assisted Sintered H13 Steel Powder with Different Vanadium Contents.

The present work demonstrated the first-ever preparation of block specimens by the microwave sintering of H13 alloy powder. Varying proportions of vanadium powder (1.5%, 2.5%, 3.5%, 4.5%, and 5.5% on a mass basis) were added to H13 mold steel and these mixtures were sintered using microwaves. X-ray fluorescence spectroscopy was employed to determine the compositions of the resulting specimens and vanadium percentages of 1.56%, 2.04%, 3.10%, 4.06%, and 4.20% were determined. These results demonstrate a clear trend, with significantly lower vanadium amounts than expected based on the nominal values at higher vanadium loadings. Different samples were also found to exhibit different degrees of ablation, and this effect was related to the presence of voids in the materials. The surface compositions of these specimens were examined by laser-induced breakdown spectroscopy and were found to be relatively uniform. The microstructures as well as the hardness properties of the materials were assessed. Microwave sintering of 100 g specimens at 1300 °C for 10-min generated samples with hardness values ranging from 205 HV (at the lowest vanadium content) to 175.2 HV (at the highest vanadium content). The wear behavior of samples prepared by microwave sintering H13 die steel with different vanadium contents at room temperature has been studied. The results showed that 1.5% vanadium content is the best mass ratio.

Design and Processing Method for Doppler-Tolerant Stepped-Frequency Waveform Using Staggered PRF.

Stepped-frequency waveform may be used to synthesize a wideband signal with several narrow-band pulses and achieve a high-resolution range profile without increasing the instantaneous bandwidth. Nevertheless, the conventional stepped-frequency waveform is Doppler sensitive, which greatly limits its application to moving targets. For this reason, this paper proposes a waveform design method using a staggered pulse repetition frequency to improve the Doppler tolerance effectively. First, a generalized echo model of the stepped-frequency waveform is constructed in order to analyze the Doppler sensitivity. Then, waveform design is carried out in the stepped-frequency waveform by using a staggered pulse repetition frequency so as to eliminate the high-order phase component that is caused by the target's velocity. Further, the waveform design method is extended to the sparse stepped-frequency waveform, and we also propose corresponding methods for high-resolution range profile synthesis and motion compensation. Finally, experiments with electromagnetic data verify the high Doppler tolerance of the proposed waveform.

Microstructures and Properties of Cu-rGO Composites Prepared by Microwave Sintering.

This study investigated the effects of microwave sintering on the microstructures and properties of copper-rGO composites. Graphene oxide was coated onto copper particles by wet ball milling, and copper-rGO composites were formed upon microwave sintering in an argon atmosphere. Scanning electron microscopy was then used to observe the mixing in the ball-milled composite powder, and the morphology of the bulk composite after microwave sintering. Raman spectra revealed how graphene oxide changed with ball milling and with microwave sintering. The microhardness, electrical conductivity, and thermal conductivity of the composite were also measured. The results showed that graphene oxide and copper particles were well combined and uniformly distributed after wet ball milling. The overall microhardness of microwave-sintered samples was 81.1 HV, which was 14.2% greater than that of pure copper (71 HV). After microwave sintering, the microhardness of the samples in areas showing copper oxide precipitates with eutectic structures was 89.5 HV, whereas the microhardness of the precipitate-free areas was 70.6 HV. The electrical conductivity of the samples was 87.10 IACS%, and their thermal conductivity was 391.62 W·m-1·K-1.

Antiviral Therapy for Chronic HBV Infection With Persistently Normal Alanine Aminotransferase: Controversy and Consensus.

ALT is one of the most sensitive biochemical indexes to reflect liver injury. It is generally believed that hepatitis B virus (HBV) infected patients with normal ALT levels are in either immune tolerance or low replication stage of the natural history of hepatitis B, and there is no or only mild inflammation in liver tissue, so antiviral therapy is not recommended. However, chronic HBV-infected patients with normal ALT levels are not always in a stable state. A considerable number of patients will develop active hepatitis or occult progress to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Therefore, whether antiviral therapy should be recommended for chronic HBV infection with normal ALT level has been a hot topic in clinical practice. In this paper, the definition of immune tolerance, the relationship between ALT and liver inflammation, and the benefits of antiviral therapy were reviewed, and we hope it will be helpful for clinicians to have a deeper understanding of whether antiviral therapy should be considered for chronic HBV infection with normal ALT.

Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway.

To evaluate the role of ghrelin in cardiac fibrosis after myocardial infarction (MI) and to investigate the underlying mechanisms of ghrelin-regulated Nrf2/NADPH/ROS pathway-mediated cardioprotection, the profile of Nrf2, fibrosis markers, and oxidative stress markers were characterized in a rat model of MI and Angiotensin II (Ang II)-stimulated cardiac fibroblasts (CFs). The effects of ghrelin on cardiac function, fibrosis and oxidative stress were investigated after MI in vivo. The role of ghrelin in CF migration and proliferation was evaluated in Ang II-stimulated CFs in vitro. Inhibition of ghrelin receptors using the antagonist, d-Lys3-GHRP-6, in addition to ghrelin was employed in MI and CFs to investigate the direct effect of ghrelin on cardiac fibrosis. Loss function of Nrf2 in CFs was performed to investigate the effect of ghrelin-regulated Nrf2 on oxidative stress and cardiac fibrosis. Ghrelin improved the post-MI cardiac function and reduced cardiac fibrosis. This phenotype is associated with the upregulation of Nrf2 and downregulation of fibrotic proteins, NADPH oxidase and ROS production. In line with in vivo findings, ghrelin attenuated Ang II-stimulated CF migration, proliferation, and oxidative stress in vitro. Inhibition of the ghrelin receptor or knockdown of Nrf2 abolished the beneficial effects of ghrelin on MI or Ang II-stimulated cardiac fibroblasts. In conclusion, ghrelin ameliorates post-MI and Ang II-induced cardiac fibrosis by activating Nrf2, which in turn inhibits the NADPH/ROS pathway.

Numerical investigation of dynamic responses and mooring forces of submerged floating tunnel driven by surface waves.

Based on Navier-Stokes equations, a numerical model for studying the dynamic responses and mooring forces of the moored Submerged Floating Tunnel (SFT) driven by surface waves is presented in this paper. The mechanics models of the vertically and inclinedly moored floating body under wave forces are built, and the overset meshing method is employed to dynamically configure the computational meshes. Two laboratory experiments are used for validating the numerical model in terms of motion responses and mooring forces of the SFT, indicating the proposed model is capable of accurately simulating the instantaneous position of the body under the wave action. This hydrodynamic model is then utilized to simulate the wave-structure interaction of the prototype SFT designed for Qiongzhou Strait located between Mainland China and Hainan Island. The effects of the fundamental structure parameter, or the inclined mooring angle (IMA), on the dynamic responses of SFT are analyzed. The numerical experiments not only shed light on the mooring forces, as well as pitch, sway and heave responses of the SFT with various values of IMA, but also provide guidance for the choice of IMA in engineering design. The range of IMA is separated into five zones, and Zone 2 is regarded as the best choice for the design of IMA for both motion displacements and mooring forces are relatively small in this zone. Zone 3 is considered to be the worst choice as not only are motion responses of SFT severe in this zone, but also the mooring chains are at the risk of going slack under severe wave conditions.

Efficacy and safety of sofosbuvir-based pangenotypic direct-acting antiviral agents for chronic hepatitis C patients without genotype determination: Real-world experience of a retrospective study.

Several new, pangenotypic direct-acting antiviral agents (DAAs) have been approved, may reduce the need for genotyping to guide therapy decisions for patients with chronic hepatitis C (CHC).This study aimed to investigate the efficacy and safety of Sofosbuvir (SOF)-based pangenotypic DAAs therapy for CHC patients without genotype (GT determination in the real-world practice.This retrospective cohort study included treatment-naïve CHC patients without GT determination, who received SOF-based DAAs therapy, including 400 mg SOF plus 60 mg daclatasvir (DCV) daily or 400 mg SOF plus 100 mg velpatasvir (VEL) daily for 12 or 24 weeks. Clinical and laboratory data, including sustained virologic response (SVR), were obtained at baseline, end of treatment (EOT), 12 weeks after EOT, and 48 weeks after EOT.A total of 95 CHC patients, including 30 (31.58%) had liver cirrhosis were enrolled. SVR rates after 12 weeks of treatment (SVR12) was 96.84% (92/95), including 96.20% (76/79) of patients receiving SOF plus DCV and 100% (16/16) of patients receiving SOF plus VEL. For 92 patients achieving an SVR12, no virological relapse was observed at 48 weeks after EOT. Furthermore, serum evaluation of liver fibrosis aspartate aminotransferase-to-platelet ratio index and Fibrosis-4 score were decreased significantly at EOT and 12 weeks after EOT, compared to pre-treatment values (both P < .05). Treatment was well-tolerated by our patients.SOF-based pangenotypic DAAs including SOF plus DCV and SOF plus VEL, were effective and safe for CHC patients without GT determination in this study. This may provide a potential simple strategy for CHC treatment without GT determination.

Low-Bandgap Porphyrins for Highly Efficient Organic Solar Cells: Materials, Morphology, and Applications.

With developments in materials, thin-film processing, fine-tuning of morphology, and optimization of device fabrication, the performance of organic solar cells (OSCs) has improved markedly in recent years. Designing low-bandgap materials has been a focus in order to maximize solar energy conversion. However, there are only a few successful low-bandgap donor materials developed with near-infrared (NIR) absorption that are well matched to the existing efficient acceptors. Porphyrin has shown great potential as a useful building block for constructing low-bandgap donor materials due to its large conjugated plane and strong absorption. Porphyrin-based donor materials have been shown to contribute to many record-high device efficiencies in small molecule, tandem, ternary, flexible, and OSC/perovskite hybrid solar cells. Specifically, non-fullerene small-molecule solar cells have recently shown a high power conversion efficiency of 12% using low-bandgap porphyrin. All these have validated the great potential of porphyrin derivatives as effective donor materials and made DPPEZnP-TRs a family of best low-bandgap donor materials in the OSC field so far. Here, recent progress in the rational design, morphology, dynamics, and multi-functional applications starting from 2015 will be highlighted to deepen understanding of the structure-property relationship. Finally, some future directions of porphyrin-based OSCs are presented.

Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil.

A novel bacterial strain designated as Rhodococcus pyridinivorans XB, capable of utilizing various endocrine disruptor phthalates or phthalic acid (PA) as sole source of carbon and energy, was isolated from activated sludge. Under the optimal culture conditions (pH 7.08, 30.4 °C, inoculum size (OD600 nm) of 0.6) obtained by response surface methodology, di-(2-ethylhexyl) phthalate (DEHP, 200 mg/L) could be degraded by strain XB with a removal rate of 98% within 48 h. Under the observation of an atomic force microscope, it was confirmed that DEHP did not inhibit the growth of strain XB which might produce some extracellular polymeric substances as a response to DEHP stress, resulting in rapid degradation of DEHP. At initial concentrations of 50-800 mg/L DEHP, its degradation curves were well fitted with the first-order kinetic model, and the half-life of DEHP degradation varied from 5.44 to 23.5 h. The degradation intermediates of DEHP were identified by both GC-MS and high performance liquid chromatography-time of flight-mass spectrometry (HPLC-TOF-MS). Significant up-regulation was observed for the relative expression levels of genes (i.e., phthalate hydrolase, PA 3,4-dioxygenase, protocatechuate 3,4-α and 3,4-ß dioxygenase) involved in DEHP degradation determined by real-time quantitative PCR (RT-qPCR). A DEHP biodegradation pathway by strain XB was proposed based on the identified intermediates and the degrading genes. Bioaugmentation of DEHP-contaminated soils with strain XB could efficiently promote DEHP removal, offering great potential in bioremediation of DEHP-contaminated environment.

Dimeric Porphyrin Small Molecules for Efficient Organic Solar Cells with High Photoelectron Response in the Near-Infrared Region.

Small molecules (SMs) with elongated backbones are promising for achieving a higher photovoltaic performance. Herein, a dimeric porphyrin small molecule, ZnP2-DPP, consisting of two porphyrin units linked with an ethynylene as the core and two diketopyrrolopyrrole (DPP) units as the arms is designed and synthesized as an electron donor for solution-processed bulk-heterojunction (BHJ) organic solar cells (OSCs). A significantly enhanced power conversion efficiency of 8.45% with an impressive short-circuit current density (Jsc) up to 19.65 mA cm-2 is achieved for the BHJ OSCs based on ZnP2-DPP under AM 1.5G irradiation (100 mW cm-2) compared to that for the OSCs based on the dimeric porphyrin linked with bis-ethynylenes reported previously. Furthermore, the devices show broad photoelectron responses up to 1000 nm with high near-infrared external quantum efficiency up to 66% at 780 nm. This is the first study reporting SM OSCs displaying such a large Jsc of about 20 mA cm-2 simultaneously with a considerably high and deep photoelectron response of up to 1000 nm.

Ternary Solar Cells Based on Two Small Molecule Donors with Same Conjugated Backbone: The Role of Good Miscibility and Hole Relay Process.

Ternary organic solar cells (OSCs) are very attractive for further enhancing the power conversion efficiencies (PCEs) of binary ones but still with a single active layer. However, improving the PCEs is still challenging because a ternary cell with one more component is more complicated on phase separation behavior. If the two donors or two acceptors have similar chemical structures, good miscibility can be expected to reduce the try-and-error work. Herein, we report ternary devices based on two small molecule donors with the same backbone but different substituents. Whereas both binary devices show PCEs about 9%, the PCE of the ternary cells is enhanced to 10.17% with improved fill factor and short-circuit current values and external quantum efficiencies almost in the whole absorption wavelength region from 440 to 850 nm. The same backbone enables the donors miscible at molecular level, and the donor with a higher HOMO level plays hole relay process to facilitate the charge transportation in the ternary devices. Since side-chain engineering has been well performed to tune the active materials' energy levels in OSCs, our results suggest that their ternary systems are promising for further improving the binary cells' performance although their absorptions are not complementary.

Conjugated D-A porphyrin dimers for solution-processed bulk-heterojunction organic solar cells.

Three conjugated D-A porphyrin dimers (DPP-ZnP-E)2, (DPP-ZnP-E)2-2T and (DPP-ZnP-E)2-Ph linked with diethynylene, diethynylene-dithiophene and diethynylene-phenylene have been developed for bulk heterojunction solar cells with high power conversion efficiencies of 4.50%, 5.50% and 6.42%, respectively, when blended with PC61BM as the electron acceptor material.

Hydrodynamic analysis of human swimming based on VOF method.

A 3-D numerical model, based on the Navier-Strokes equations and the RNG k-ε turbulence closure, for studying hydrodynamic drag on a swimmer with wave-making resistance taken into account is established. The volume of fluid method is employed to capture the undulation of the free surface. The simulation strategy is evaluated by comparison of the computed results with experimental data. The computed results are in good agreement with data from mannequin towing experiments. The effects of the swimmer's head position and gliding depth on the drag force at different velocities are then investigated. It is found that keeping the head aligned with the body is the optimal posture in streamlined gliding. Also wave-making resistance is significant within 0.3 m depth from the free surface.

Concentrations of and health risks posed by polychlorinated dibenzo-p-dioxins and dibenzofurans around industrial sites in Hebei Province, China.

Sintering and steel production as the main emission sources of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) may affect environment and human health. The concentrations, profiles, and distributions of PCDD/Fs in soil samples from around four typical sintering and steel production plants in Hebei Province, China, were determined. Forty-six soil samples were collected at distances from 500 to 9000 m from industrial plant chimneys. The concentrations of total 17 2,3,7,8-substituted PCDD/F congeners in the soil samples from sites A, B, C, and D were in the range 11-130, 13-284, 2.6-378, and 21-231 pg/g, respectively, and the internationally accepted toxic equivalent (I-TEQ) concentrations were 0.37-13.2, 0.31-12.1, 0.13-13.7, and 1.60-22.7 pg I-TEQ/g, respectively. Soil ingestion was estimated the major exposure pathway to PCDD/Fs. At current PCDD/F concentrations, the local population will be exposed to low amounts of PCDD/Fs in soil from around the industrial sites, and this exposure will pose potential health risks for the local population living at distances of less than 1000 m from nearest stack but will have no high health risks for people living further away. These results will be helpful when planning measures to control PCDD/F sources. The data will also benefit local environmental monitoring studies and be useful when assessing the risks posed by PCDD/Fs around the industrial sites to the environment and humans.

Influence of long-range atmospheric transportation (LRAT) on mono-to octa-chlorinated PCDD/Fs levels and distributions in soil around Qinghai Lake, China.

Long-range atmospheric transportation (LRAT) of persistent organic pollutants followed by their deposition in cold, arid regions is of wide concern. This problem occurs at Qinghai Lake in the northeastern Tibetan Plateau, a sparsely populated area with extreme weather conditions and little current or historical anthropogenic pollution. The concentrations and distribution patterns of the mono-to octa-chlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) congeners in surface soil samples collected from around Qinghai Lake were quantified. Concentration differences between low-(mono-to tri-) chlorinated PCDD/Fs and high-(tetra-to octa-) chlorinated PCDD/Fs were measured. High PCDD/F levels were detected, with total concentrations of 15,108 ± 6323 pg/g for the 27 PCDD/F congeners and 15,104 ± 6324 pg/g for the low-chlorinated PCDD/Fs. The concentrations of 17 2,3,7,8-substituted PCDD/Fs were only 3.1 ± 4.4 pg/g and the corresponding international toxicity equivalency (I-TEQ) was 0.11 ± 0.22 pg I-TEQ/g. Given their higher vapor pressures and lower boiling points, low-chlorinated PCDD/Fs, were predominantly gaseous, whereas high-chlorinated PCDD/Fs were predominantly solid, indicating that there is a higher potential for long-range transport of low-chlorinated PCDD/Fs. Overall, because of their high LRAT potential, low-chlorinated PCDD/Fs may pose a greater risk to local ecosystems in cold, remote areas than high-chlorinated PCDD/Fs.

Removal of polychlorinated naphthalenes by desulfurization and emissions of polychlorinated naphthalenes from sintering plant.

The sintering flue gas samples were collected at the inlets and outlets of the desulfurization systems to evaluate the influence of the systems on PCNs emission concentrations, profiles, and emission factors. The PCNs concentrations at the inlets and outlets were 27888-153672 pg m(-3) and 11988-42245 pg m(-3),respectively. Desulfurization systems showed excellent removal for PCNs, and the removal efficiencies of PCNs increase with increasing chlorination level. Lower chlorinated homologs are more sensitive to the desulfurization process than higher ones. High levels of PCNs were also detected in the gypsum (11600-29720 pg g(-1)) and fly ash samples (4946-64172 pg g(-1)). The annual total emissions of PCNs released to flue gas and gypsum from the sintering plants were about 394 kg, 48.5% of which was in gypsum. The surface area of the fly ash samples increased significantly from the first to the fourth stage of the series-connected electrostatic precipitator, accompanying obvious rising of concentration of PCNs in the fly ash samples.

miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7.

MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level, and play pivotal roles in cancer development and progression. miR-100 has been reported to be significantly downregulated in a variety of cancers, including esophageal cancer. However, the role of miR-100 in human esophageal cancer has not been fully elucidated. We demonstrated that overexpression of miR-100 in esophageal cancer cells markedly inhibited cell proliferation, migration and invasion as well as tumor growth. We subsequently showed that CXCR7 is a direct target gene of miR-100. Our results indicated that miR-100 plays a tumor-suppressor role in esophageal cancer and suggest its potential application for esophageal cancer treatment.