RESUMEN
Nostalgia is a social, self-relevant, and bittersweet (although mostly positive) emotion that arises when reflecting on fond past memories and serves key psychological functions. The majority of evidence concerning the prevalence, triggers, and functions of nostalgia has been amassed in samples from a handful of largely Western cultures. If nostalgia is a fundamental psychological resource, it should perform similar functions across cultures, although its operational dynamics may be shaped by culture. This study (N = 2,606) examined dispositional nostalgia, self-reported triggers of nostalgia, and functions of experimentally induced nostalgia in young adults across 28 countries and a special administrative region of China (i.e., Hong Kong). Results indicated that nostalgia is frequently experienced across cultures, albeit better valued in more-developed countries (i.e., higher national wealth and life-expectancy). Nostalgia is triggered by psychological threats (especially in warmer countries), sensory stimuli (especially in more-developed countries), and social gatherings (especially in less-developed countries). The positive or negative affect prompted by experimentally induced nostalgia varied by country, but was mild overall. More importantly, recalling a nostalgic (vs. ordinary) memory increased social connectedness, self-continuity, and meaning in life across cultures. In less-developed countries, recalling an ordinary memory also conferred some of these functions, reducing the effect size of nostalgia. Finally, recalling a nostalgic (vs. ordinary) memory augmented state satisfaction with life in countries with lower quality of living (i.e., lower life-expectancy and life-satisfaction). Overall, findings confirm the relevance of nostalgia across a wide range of cultures and indicate cultural nuances in its functioning. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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Emociones , Recuerdo Mental , Adulto Joven , Humanos , Prevalencia , ChinaRESUMEN
OBJECTIVE: Immunization is a primary method for addressing COVID-19. Uptake in high-risk groups has been strong, however, vaccination hesitancy is more prominent among younger adults. This research sought to identify the factors influencing vaccine uptake in 18-55-year-olds. METHOD: Study 1, a qualitative survey (n = 80), identified beliefs about COVID vaccines and immunization programs. Study 2 (n = 473) tested whether the factors identified in study 1 predicted intention for self-vaccination and parental intention to vaccinate children. Data on vaccination behavior was obtained in Study 3 (n = 309). RESULTS: Analysis showed individuals recognized the benefits of vaccination as a path to "return to normality" and "protect others" but concerns, such as side-effects to fertility, were apparent and for some, the personal value in vaccination was questioned. Data were interpreted as largely reflective of Health Belief Model constructs. Study 2 supported this interpretation. Specifically, Benefits of, and Barriers to, vaccination predicted intention to vaccinate oneself and their children, across Black, Asian, other minority groups (BAME) and White communities. Additionally, for BAME communities, cues to action positively predicted intention. For vaccine behavior, benefits of, and Barriers to, vaccination remained relevant in predicting vaccination behaviors, along with susceptivity and severity of COVID (no differences between ethnic communities were found). Willingness to vaccinate children decreases as the age of the child is reduced. CONCLUSIONS: Addressing vaccine hesitancy is crucial to managing COVID-19. Findings indicate emphasizing specific benefits, such as protecting others, while addressing barriers, including side-effect misinformation, is key to driving vaccine uptake. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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Vacunas contra la COVID-19 , COVID-19 , Niño , Adulto , Humanos , Vacilación a la Vacunación , COVID-19/prevención & control , Vacunación , Reino UnidoRESUMEN
Anticipated nostalgia is the foreseeing of looking back on life events and expecting to feel nostalgic about it in the future. I review recent findings on the content, affective profile, and psychological benefits of anticipated nostalgia. I also review neurological and cognitive evidence that may explain the mechanism underlying anticipated nostalgia. Finally, I discuss anticipated nostalgia in an applied setting, consumer behavior.
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Emociones , Humanos , PredicciónRESUMEN
We sought to clarify the psychological profile of experimentally induced nostalgia, compared to two other modes of thinking about one's past-reflection and brooding-also experimentally induced. We tested both British and Chinese participants. Our main hypothesis was that nostalgia's profile is more positive in terms of six psychological benefits and seven autobiographical memory functions. The results were consistent with the hypothesis. In regard to psychological benefits, nostalgia (vs. reflection and brooding) increased positive affect, self-esteem, self-continuity, social connectedness, and meaning in life. Furthermore, nostalgia increased optimism relative to brooding (but not reflection). In regard to autobiographical memory functions, nostalgia (vs. reflection and brooding) led to higher boredom reduction, conversation, intimacy maintenance, and death preparation, as well as lower bitterness revival. Nostalgia also elevated teach/inform relative to brooding (but not reflection). The findings were similar for British and Chinese participants.
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Memoria Episódica , Tedio , Emociones , Humanos , Optimismo , AutoimagenRESUMEN
Empirical research on the social psychological antecedents of collective action has been conducted almost exclusively in democratic societies, where activism is relatively safe. The present research examines the psychological predictors of collective action intentions in contexts where resistance is met with significant repression by the authorities. Combining recent advancements in the collective action literature, our model examines the unique predictive roles of emotion (anger and fear), political identity consolidation and participative efficacies, politicized identification, and moral obligation, over and above past participation. It further investigates how these variables are shaped by perceptions of risks attributable to repression. Four survey studies test this model among protesters in Russia (N = 305), Ukraine (N = 136), Hong Kong (N = 115), and Turkey (N = 296). Meta-analytic integration of the findings highlights that, unlike in most current accounts of collective action, protesters in these contexts are not primarily driven by political efficacy. Rather, their involvement is contingent upon beliefs in the ability of protest to build a movement (identity consolidation and participative efficacies) and motivated by outrage at state repression, identification with the social movement, and a sense of moral obligation to act on their behalf. Results also confirm that risks attributable to state repression spur rather than quell resistance by increasing outrage, politicized identification, identity consolidation and participative efficacies, and moral obligation. The implications of these findings for models of collective action and our understanding of the motives underlying engagement in repressive contexts are discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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Conducta Cooperativa , Justicia Social/psicología , Femenino , Hong Kong , Humanos , Masculino , Modelos Psicológicos , Obligaciones Morales , Política , Federación de Rusia , Identificación Social , Encuestas y Cuestionarios , Turquía , Ucrania , Adulto JovenRESUMEN
OBJECTIVE: Nostalgia is a sentimental longing for one's past. We examined the hypotheses (rooted in attachment theory and research) that nostalgia prone individuals, by virtue of their greater attachment security, are more empathic and enact more prosocial behavior. METHOD: In five studies, testing 1,923 participants (Nrange = 132-823, 52.42% women, Agerange = 8-90 years), we measured nostalgia proneness and affective empathy. Additionally, we measured cognitive empathy in Study 3, attachment security in Studies 4-5, and prosocial behavior in Study 5. RESULTS: Nostalgia proneness was positively related to affective empathy among younger and older adults (Studies 1, 3-5) and among children (Study 2). This association was stronger for affective empathy than cognitive empathy (Study 3). Also, attachment security mediated the relation between nostalgia proneness and affective empathy (Studies 4-5). Finally, nostalgia prone individuals were more likely to engage in prosocial behavior, and this relation was serially mediated by attachment security and affective empathy (Study 5). CONCLUSION: The findings establish the empathic and prosocial character of nostalgia prone individuals, and clarify their personality profile.
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Afecto/fisiología , Altruismo , Empatía/fisiología , Apego a Objetos , Personalidad/fisiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
Anticipated nostalgia is a new construct that has received limited empirical attention. It concerns the anticipation of having nostalgic feelings for one's present and future experiences. In three studies, we assessed its prevalence, content, emotional profile, and implications for self-regulation and psychological functioning. Study 1 revealed that anticipated nostalgia most typically concerns interpersonal relationships, and also concerns goals, plans, current life, and culture. Further, it is affectively laden with happiness, sadness, bittersweetness, and sociality. Studies 2 and 3 assessed the implications of anticipated nostalgia for self-regulation and psychological functioning. In both studies, positive evaluation of a personal experience was linked to stronger anticipated nostalgia, and anticipated nostalgia was linked to savouring of the experience. In Study 3, anticipated nostalgia measured prior to an important life transition predicted nostalgia a few months after the transition, and post-transition nostalgia predicted heightened self-esteem, social connectedness, and meaning in life.
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Anticipación Psicológica , Emociones , Predicción , Recuerdo Mental , Autocontrol , Adolescente , Adulto , Afecto , Anciano , Femenino , Humanos , Relaciones Interpersonales , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
Osteoarthritis (OA) is characterized by cartilage degradation and chronic joint inflammation. Mesenchymal stem cells (MSCs) have shown promising results in OA, but their mechanism of action is not fully understood. We hypothesize that MSCs polarize macrophages, which are strongly associated with joint inflammation to more homeostatic sub-types. We tracked ferumoxytol (Feraheme™, iron oxide nanoparticle)-labeled murine MSCs (Fe-MSCs) in murine OA joints, and quantified changes to joint inflammation and fibrosis. 10-week-old C57BL/6 male mice (n = 5/group) were induced to undergo osteoarthritis by destabilization of medical meniscus (DMM) or sham surgery. 3 weeks post-surgery, mice were injected intra-articularly with either fluorescent dye-(DiR) labeled or DiR-Fe-MSC or saline to yield 4 groups (n = 5 per group for each timepoint [1, 2 and 4weeks]). 4 weeks after injection, mice were imaged by MRI, and scored for i) OARSI (Osteoarthritis Research Society International) to determine cartilage damage; ii) immunohistochemical changes in iNOS, CD206, F4/80 and Prussian Blue/Sca-1 to detect pro-inflammatory, homeostatic and total macrophages and ferumoxytol -labeled MSCs respectively, and iii) Masson's Trichrome to detect changes in fibrosis. Ferumoxytol-labeled MSCs persisted at greater levels in DMM vs. SHAM-knee joints. We observed no difference in OARSI scores between MSC and vehicle groups. Sca-1 and Prussian Blue co-staining confirmed the ferumoxytol label resides in MSCs, although some ferumoxytol label was detected in proximity to MSCs in macrophages, likely due to phagocytosis of apoptotic MSCs, increasing functionality of these macrophages through MSC efferocytosis. MRI hypertintensity scores related to fluid edema decreased in MSC-treated vs. control animals. For the first time, we show that MSC-treated mice had increased ratios of %CD206+: %F4/80+ (homeostatic macrophages) (p<0.05), and decreased ratios of %iNOS+: %F4/80+ macrophages (p<0.01), supporting our hypothesis that MSCs may modulate synovial inflammation.
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Células Madre Mesenquimatosas/fisiología , Nanopartículas del Metal/uso terapéutico , Osteoartritis/terapia , Animales , Antiinflamatorios/farmacología , Cartílago Articular , Modelos Animales de Enfermedad , Compuestos Férricos , Humanos , Inflamación/tratamiento farmacológico , Inyecciones Intraarticulares , Hierro/metabolismo , Hierro/uso terapéutico , Articulación de la Rodilla , Masculino , Trasplante de Células Madre Mesenquimatosas/métodos , Ratones , Ratones Endogámicos C57BL , NanopartículasRESUMEN
How are nostalgic memories created? We considered savouring as one process involved in the genesis of nostalgia. Whereas nostalgia refers to an emotional reflection upon past experiences, savouring is a process in which individuals deeply attend to and consciously capture a present experience for subsequent reflection. Thus, having savoured an experience may increase the likelihood that it will later be reflected upon nostalgically. Additionally, to examine how cognitive and emotional processes are linked across time, we tested whether nostalgia for a previously savoured experience predicts optimism for the future. Retrospective reports of having savoured a positive event were associated with greater nostalgia for the event (Study 1). Retrospective reports of savouring a time period (college) were associated with greater nostalgia for that time period when participants were in a setting (alumni reunion event) that prompted thoughts of the time period (Study 2). Savouring an experience predicted nostalgia for the experience 4-9 months later (Study 3). Additionally, nostalgia was associated with greater optimism (Studies 2-3). Thus, savouring provides a foundation for nostalgic memories and an ensuing optimism.
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Memoria Episódica , Optimismo , Adolescente , Adulto , Estado de Conciencia , Emociones , Femenino , Predicción , Humanos , Masculino , Recuerdo Mental , Persona de Mediana Edad , Estudios Retrospectivos , Adulto JovenRESUMEN
We compared and contrasted nostalgia with rumination and counterfactual thinking in terms of their autobiographical memory functions. Specifically, we assessed individual differences in nostalgia, rumination, and counterfactual thinking, which we then linked to self-reported functions or uses of autobiographical memory (Self-Regard, Boredom Reduction, Death Preparation, Intimacy Maintenance, Conversation, Teach/Inform, and Bitterness Revival). We tested which memory functions are shared and which are uniquely linked to nostalgia. The commonality among nostalgia, rumination, and counterfactual thinking resides in their shared positive associations with all memory functions: individuals who evinced a stronger propensity towards past-oriented thought (as manifested in nostalgia, rumination, and counterfactual thinking) reported greater overall recruitment of memories in the service of present functioning. The uniqueness of nostalgia resides in its comparatively strong positive associations with Intimacy Maintenance, Teach/Inform, and Self-Regard and weak association with Bitterness Revival. In all, nostalgia possesses a more positive functional signature than do rumination and counterfactual thinking.
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Emociones/fisiología , Memoria Episódica , Rumiación Cognitiva/fisiología , Pensamiento , Adulto , Femenino , Humanos , Masculino , Recuerdo Mental/fisiologíaRESUMEN
Three studies tested whether individualism-collectivism moderates the extent to which values are endorsed as ideal self-guides and ought self-guides, and the consequences for regulatory focus and emotion. Across Studies 1 and 2, individualists endorsed values that are relatively central to the self as stronger ideals than oughts, whereas collectivists endorsed them as ideals and oughts to a similar degree. Study 2 found that individualists justified central values using reasons that were more promotion focused than prevention focused, whereas collectivists used similar amount of prevention-focused and promotion-focused reasons. In Study 3, individualists felt more dejected after violating a central (vs. peripheral) value and more agitated after violating a peripheral (vs. central) value. Collectivists felt a similar amount of dejection regardless of values centrality and more agitation after violating central (vs. peripheral) values. Overall, culture has important implications for how we regulate values that are central or peripheral to our self-concept.
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Comparación Transcultural , Emociones , Autoimagen , Valores Sociales , Adolescente , Adulto , Anciano , Características Culturales , Femenino , Humanos , India , Masculino , Persona de Mediana Edad , Reino Unido , Estados Unidos , Adulto JovenRESUMEN
Bone is often subject to harsh temperatures during orthopaedic procedures resulting in thermally induced bone damage, which may affect the healing response. Postsurgical healing of bone is essential to the success of surgery, therefore, an understanding of the thermally induced responses of bone cells to clinically relevant temperatures in vivo is required. Osteocytes have been shown to be integrally involved in the bone remodelling cascade, via apoptosis, in micro-damage systems. However, it is unknown whether this relationship is similar following thermal damage. Sprague-Dawley rat tibia were exposed to clinically relevant temperatures (47°C or 60°C) to investigate the role of osteocytes in modulating remodelling related factors. Immunohistochemistry was used to quantify osteocyte thermal damage (activated caspase-3). Thermally induced pro-osteoclastogenic genes (Rankl, Opg and M-csf), in addition to genes known to mediate osteoblast and osteoclast differentiation via prostaglandin production (Cox2), vascularization (Vegf) and inflammatory (Il1a) responses, were investigated using gene expression analysis. The results demonstrate that heat-treatment induced significant bone tissue and cellular damage. Pro-osteoclastogenic genes were upregulated depending on the amount of temperature elevation compared with the control. Taken together, the results of this study demonstrate the in vivo effect of thermally induced osteocyte damage on the gene expression profile.
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Regulación de la Expresión Génica , Calor , Osteocitos/metabolismo , Tibia/metabolismo , Animales , Remodelación Ósea , Caspasa 3/biosíntesis , Ciclooxigenasa 2/biosíntesis , Interleucina-1alfa/biosíntesis , Factor Estimulante de Colonias de Macrófagos/biosíntesis , Osteocitos/patología , Osteoprotegerina/biosíntesis , Ligando RANK/biosíntesis , Ratas , Ratas Sprague-Dawley , Tibia/patología , Factor A de Crecimiento Endotelial Vascular/biosíntesisRESUMEN
Nostalgia, a sentimental longing for one's past, is an emotion that arises from self-relevant and social memories. Nostalgia functions, in part, to foster self-continuity, that is, a sense of connection between one's past and one's present. This article examined, in 6 experiments, how nostalgia fosters self-continuity and the implications of that process for well-being. Nostalgia fosters self-continuity by augmenting social connectedness, that is, a sense of belongingness and acceptance (Experiments 1-4). Nostalgia-induced self-continuity, in turn, confers eudaimonic well-being, operationalized as subjective vitality (i.e., a feeling of aliveness and energy; Experiments 5-6). The findings clarify and expand the benefits of nostalgia for both the self-system and psychological adjustment. (PsycINFO Database Record
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Emociones/fisiología , Conducta Social , Femenino , HumanosRESUMEN
Osteocyte apoptosis is required to induce intracortical bone remodeling after microdamage in animal models, but how apoptotic osteocytes signal neighboring "bystander" cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release adenosine diphosphate (ATP) as a "find-me" signal for phagocytic cells. To address whether apoptotic osteocytes use this signaling mechanism, we adapted the rat ulnar fatigue-loading model to reproducibly introduce microdamage into mouse cortical bone and measured subsequent changes in osteocyte apoptosis, receptor activator of NF-κB ligand (RANKL) expression and osteoclastic bone resorption in wild-type (WT; C57Bl/6) mice and in mice genetically deficient in Panx1 (Panx1KO). Mouse ulnar loading produced linear microcracks comparable in number and location to the rat model. WT mice showed increased osteocyte apoptosis and RANKL expression at microdamage sites at 3 days after loading and increased intracortical remodeling and endocortical tunneling at day 14. With fatigue, Panx1KO mice exhibited levels of microdamage and osteocyte apoptosis identical to WT mice. However, they did not upregulate RANKL in bystander osteocytes or initiate resorption. Panx1 interacts with P2X7 R in ATP release; thus, we examined P2X7 R-deficient mice and WT mice treated with P2X7 R antagonist Brilliant Blue G (BBG) to test the possible role of ATP as a find-me signal. P2X7 RKO mice failed to upregulate RANKL in osteocytes or induce resorption despite normally elevated osteocyte apoptosis after fatigue loading. Similarly, treatment of fatigued C57Bl/6 mice with BBG mimicked behavior of both Panx1KO and P2X7 RKO mice; BBG had no effect on osteocyte apoptosis in fatigued bone but completely prevented increases in bystander osteocyte RANKL expression and attenuated activation of resorption by more than 50%. These results indicate that activation of Panx1 and P2X7 R are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.
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Apoptosis , Efecto Espectador , Conexinas/metabolismo , Proteínas del Tejido Nervioso/metabolismo , Osteocitos/metabolismo , Ligando RANK/metabolismo , Receptores Purinérgicos P2X7/metabolismo , Animales , Conexinas/genética , Ratones , Ratones Noqueados , Proteínas del Tejido Nervioso/genética , Osteocitos/patología , Ligando RANK/genética , Ratas , Receptores Purinérgicos P2X7/genéticaRESUMEN
Six studies examined the nostalgia-inspiration link and its motivational implications. In Study 1, nostalgia proneness was positively associated with inspiration frequency and intensity. In Studies 2 and 3, the recollection of nostalgic (vs. ordinary) experiences increased both general inspiration and specific inspiration to engage in exploratory activities. In Study 4, serial mediational analyses supported a model in which nostalgia increases social connectedness, which subsequently fosters self-esteem, which then boosts inspiration. In Study 5, a rigorous evaluation of this serial mediational model (with a novel nostalgia induction controlling for positive affect) reinforced the idea that nostalgia-elicited social connectedness increases self-esteem, which then heightens inspiration. Study 6 extended the serial mediational model by demonstrating that nostalgia-evoked inspiration predicts goal pursuit (intentions to pursue an important goal). Nostalgia spawns inspiration via social connectedness and attendant self-esteem. In turn, nostalgia-evoked inspiration bolsters motivation.
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Emociones , Motivación , Autoimagen , Adolescente , Adulto , Anciano , Femenino , Objetivos , Humanos , Masculino , Recuerdo Mental , Persona de Mediana Edad , Percepción Social , Adulto JovenRESUMEN
We examined predictors of collective action among bystander group members in solidarity with a disadvantaged group by extending the dual pathway model of collective action, which proposes one efficacy-based and one emotion-based path to collective action (Van Zomeren, Spears, Fischer, & Leach, 2004). Based on two proposed functions of social identity performance (Klein, Spears, & Reicher, 2007), we distinguished between the efficacy of collective action at consolidating the identity of a protest movement and its efficacy at achieving social change (political efficacy). We expected identity consolidation efficacy to positively predict collective action tendencies directly and indirectly via political efficacy. We also expected collective action tendencies to be positively predicted by moral outrage and by sympathy in response to disadvantaged outgroup's suffering. These hypotheses were supported in two surveys examining intentions to protest for Palestine in Britain (Study 1), and intentions to attend the June 4th vigil in Hong Kong to commemorate the Tiananmen massacre among a sample of Hong Kong citizens (Study 2). The contributions of these findings to research on the dual pathway model of collective action and the different functions of collective action are discussed.
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Conducta Cooperativa , Procesos de Grupo , Modelos Psicológicos , Adulto , Disentimientos y Disputas , Femenino , Hong Kong , Humanos , Masculino , Persona de Mediana Edad , Principios Morales , Política , Cambio Social , Encuestas y Cuestionarios , Reino Unido , Adulto JovenRESUMEN
In light of its role in maintaining psychological equanimity, we proposed that nostalgia--a self-relevant, social, and predominantly positive emotion--regulates avoidance and approach motivation. We advanced a model in which (a) avoidance motivation triggers nostalgia and (b) nostalgia, in turn, increases approach motivation. As a result, nostalgia counteracts the negative impact of avoidance motivation on approach motivation. Five methodologically diverse studies supported this regulatory model. Study 1 used a cross-sectional design and showed that avoidance motivation was positively associated with nostalgia. Nostalgia, in turn, was positively associated with approach motivation. In Study 2, an experimental induction of avoidance motivation increased nostalgia. Nostalgia then predicted increased approach motivation. Studies 3-5 tested the causal effect of nostalgia on approach motivation and behavior. These studies demonstrated that experimental nostalgia inductions strengthened approach motivation (Study 3) and approach behavior as manifested in reduced seating distance (Study 4) and increased helping (Study 5). The findings shed light on nostalgia's role in regulating the human motivation system.
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Afecto/fisiología , Reacción de Prevención/fisiología , Emociones/fisiología , Modelos Psicológicos , Motivación , Adolescente , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Países Bajos , Vigilancia de la Población , Análisis de Regresión , Controles Informales de la Sociedad , Adulto JovenRESUMEN
The multifaceted-self effect is the ascription of more traits to self than others. Consensus is that this effect occurs for positive, but not negative, traits. We propose that the effect also occurs for negative traits when they can be endorsed with low intensity ("I am a little bit lazy"), thereby circumventing self-protection concerns. In Experiment 1, the multifaceted-self effect occurred for positive, but not negative, traits on a high-intensity trait-endorsement measure. However, it occurred irrespective of trait valence on a low-intensity trait-endorsement measure. In Experiment 2, the multifaceted-self effect occurred for positive, but not negative, traits on a strong trait-endorsement measure. However, it occurred irrespective of trait valence on a diminuted trait-endorsement measure--a finding conceptually replicated in Experiment 3. In Experiment 4, participants spontaneously adopted diminutive terms ("a little bit") when describing their negative traits. Individuals reconcile negative self-knowledge with self-protection concerns by expressing it in muted terms.
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Autoimagen , Adolescente , Adulto , Afecto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Personalidad , Adulto JovenRESUMEN
Osteocytes comprise the overwhelming majority of cells in bone and are its only true "permanent" resident cell population. In recent years, conceptual and technological advances on many fronts have helped to clarify the role osteocytes play in skeletal metabolism and the mechanisms they use to perform them. The osteocyte is now recognized as a major orchestrator of skeletal activity, capable of sensing and integrating mechanical and chemical signals from their environment to regulate both bone formation and resorption. Recent studies have established that the mechanisms osteocytes use to sense stimuli and regulate effector cells (e.g., osteoblasts and osteoclasts) are directly coupled to the environment they inhabit-entombed within the mineralized matrix of bone and connected to each other in multicellular networks. Communication within these networks is both direct (via cell-cell contacts at gap junctions) and indirect (via paracrine signaling by secreted signals). Moreover, the movement of paracrine signals is dependent on the movement of both solutes and fluid through the space immediately surrounding the osteocytes (i.e., the lacunar-canalicular system). Finally, recent studies have also shown that the regulatory capabilities of osteocytes extend beyond bone to include a role in the endocrine control of systemic phosphate metabolism. This review will discuss how a highly productive combination of experimental and theoretical approaches has managed to unearth these unique features of osteocytes and bring to light novel insights into the regulatory mechanisms operating in bone.