A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations.

Here in this study we adopted genome-wide association studies (GWAS) to investigate the genetic components of the personality constructs in the Chinese Personality Assessment Inventory 2 (CPAI-2) in Taiwanese Hakka populations, who are likely the descendants of a recent admixture between a group of Chinese immigrants with high emigration intention and a group of the Taiwanese aboriginal population generally without it. A total of 279 qualified participants were examined and genotyped by an Illumina array with 547,644 SNPs to perform the GWAS. Although our sample size is small and that unavoidably limits our statistical power (Type 2 error but not Type 1 error), we still found three genomic regions showing strong association with Enterprise, Diversity, and Logical vs. Affective Orientation, respectively. Multiple genes around the identified regions were reported to be nervous system related, which suggests that genetic variants underlying the certain personalities should indeed exist in the nearby areas. It is likely that the recent immigration and admixture history of the Taiwanese Hakka people created strong linkage disequilibrium between the emigration intention-related genetic variants and their neighboring genetic markers, so that we could identify them despite with only limited statistical power.

Feasibility of manufacturing ultra-high performance cement-based composites (UHPCCs) with recycled sand: A preliminary study.

Due to the excellent mechanical and durability properties, ultra-high performance cement-based composites (UHPCCs) have attracted a lot of attention during the past decades. It is noted that most existing UHPCCs are manufactured from raw materials with high quality, for instance, well-graded river sands. However, the huge consumption of river sands as construction materials has inevitably resulted in some serious ecological impacts, as reported around the world. In this regard, it shall be much beneficial if some substitutes, such as recycled sands produced through processing of construction and demolition waste (CDW), could be used to replace natural sands to manufacture the qualified UHPCCs. This paper presents such a preliminary study on the feasibility of manufacturing UHPCCs with recycled sands. A total of five UHPCCs are designed and cast with different replacement percentages of recycled sand, i.e., 0%, 30% 50%, 70% and 100% (in mass). The associated packing density of the mixed sands is estimated based on the linear packing model. The fresh and hardened properties of the UHPCCs, including the workability, strength and shrinkage, are experimentally examined. The test results indicate that it is possible to use recycled sand to replace natural river sand in the manufacture of UHPCCs; however, the amount of the recycled sand needs to be limited. In the case when the replacement percentage of the recycled sand is lower than 50% (in mass), the properties of the UHPCCs with the recycled sand are comparable with those containing river sand only.

Galvanic corrosion of duplex corrosion-resistant steel rebars under carbonated concrete conditions.

Galvanic corrosion between two different kinds of steel rebars is usually the case in practical engineering. Open circuit potential (OCP), linear polarization resistance (LPR), Tafel polarization, scanning vibrating electrode technique (SVET), scanning electron microscopy (SEM) and reflection digital holographic microscopy (DHM) were used to study the galvanic corrosion of a novel corrosion-resistant steel bar (CR) and low-carbon steel bar (LC) in simulated concrete pore solutions with different pH values and a chloride ion concentration of 5 mol L-1. The pH of the simulated concrete pore solution had a significant impact on the corrosion behaviour of CR and LC when they were in contact and were attacked by chloride ions. As the pH increased, the potential between CR and LC decreased and the driving force for the galvanic corrosion decreased. When the pH was 9.0, galvanic corrosion occurred on CR and LC at a high rate. CR developed local pitting corrosion, while LC mainly developed uniform corrosion, each with an apparent accumulation of corrosion products on the sample's surfaces. When the pH was 11.3, galvanic corrosion occurred when CR and LC were in contact. CR showed a relatively smooth surface, with only a small amount of pitting corrosion. In contrast, LC developed both pitting corrosion and uniform corrosion, and both apparent pitting corrosion and an accumulation of corrosion products on the sample surface were observed. When the pH was 13.6, there was no galvanic corrosion when CR and LC were in contact; the corrosion of CR and LC was mainly pitting corrosion. Therefore, for regions with chloride ion corrosion and severe carbonization, the galvanic corrosion between CR and LC cannot be ignored.

The Subthalamic Neurons are Activated by Both Orexin-A and Orexin-B.

The subthalamic nucleus is an important nucleus in the indirect pathway of the basal ganglia circuit and therefore is involved in motor control under both normal and pathological conditions. Morphological studies reveal that the subthalamic nucleus receives relatively dense orexinergic projections originating from the hypothalamus. Both orexin-1 (OX1) and orexin-2 (OX2) receptors are expressed in the subthalamic nucleus. To explore the functions of orexinergic system in the subthalamic nucleus, extracellular electrophysiological recordings and behavioral tests were performed in the present study. Exogenous application of orexin-A significantly increased the spontaneous firing rate from 5.70 ±â€¯0.66 Hz to 9.87 ±â€¯1.18 Hz in 64.00% subthalamic neurons recorded. OX1 receptors are involved in orexin-A-induced excitation. Application of orexin-B increased the firing rate from 7.47 ±â€¯0.92 Hz to 11.85 ±â€¯1.39 Hz in 80.95% subthalamic neurons recorded, entirely through OX2 receptors. Both OX1 and OX2 receptor antagonists decreased the firing rate in 43.75% and 62.50% subthalamic neurons recorded respectively, suggesting the involvement of endogenous orexinergic system in the control of spontaneous firing activity. Further elevated body swing test revealed that microinjection of orexins and the receptor antagonists into the subthalamic nucleus induced contralateral-biased swing and ipsilateral-biased swing, respectively. Taken together, the present study suggests that orexins play important roles in the subthalamic nucleus which may provide further evidence for the involvement of subthalamic orexinergic tone in Parkinson's disease. SIGNIFICANCE: Previous morphological studies indicate that the subthalamic nucleus receives orexinergic innervation and expresses both OX1 and OX2 receptors. Using in vivo multibarrel electrophysiological recordings, the present study revealed that exogenous application of orexin-A and orexin-B increased the spontaneous firing rate of the subthalamic neurons through OX1 and OX2 receptors. Endogenous orexinergic system was involved in the control of spontaneous firing of the subthalamic neurons. Further behavioral test revealed that intrasubthalamic application of orexins and the receptor antagonists induced biased swing behavior. The present study may provide further evidence for the involvement of subthalamic orexinergic tone in Parkinson's disease.

The Passive Film Growth Mechanism of New Corrosion-Resistant Steel Rebar in Simulated Concrete Pore Solution: Nanometer Structure and Electrochemical Study.

An elaborative study was carried out on the growth mechanism and properties of the passive film for a new kind of alloyed corrosion-resistant steel (CR steel). The passive film naturally formed in simulated concrete pore solutions (pH = 13.3). The corrosion resistance was evaluated by various methods including open circuit potential (OCP), linear polarization resistance (LPR) measurements, and electrochemical impedance spectroscopy (EIS). Meanwhile, the 2205 duplex stainless steel (SS steel) was evaluated for comparison. Moreover, the passive film with CR steel was studied by means of X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), Atomic Force Microscope (AFM), and the Mott­Schottky approach. The results showed that the excellent passivity of CR steel could be detected in a high alkaline environment. The grain boundaries between the fine passive film particles lead to increasing Cr oxide content in the later passivation stage. The filling of cation vacancies in the later passivation stage as well as the orderly crystalized inner layer contributed to the excellent corrosion resistance of CR steel. A passive film growth model for CR steel was proposed.

Pitting Corrosion Behaviour of New Corrosion-Resistant Reinforcement Bars in Chloride-Containing Concrete Pore Solution.

In this study, the pitting behaviour of a new corrosion-resistant alloy steel (CR) is compared to that of low-carbon steel (LC) in a simulated concrete pore solution with a chloride concentration of 5 mol/L. The electrochemical behaviour of the bars was characterised using linear polarisation resistance (LPR) and electrochemical impedance spectroscopy (EIS). The pitting profiles were detected by reflective digital holographic microscopy (DHM), scanning electron microscopy (SEM), and the chemical components produced in the pitting process were analysed by X-ray energy dispersive spectroscopy (EDS). The results show that the CR bars have a higher resistance to pitting corrosion than the LC bars. This is primarily because of the periodic occurrence of metastable pitting during pitting development. Compared to the pitting process in the LC bars, the pitting depth grows slowly in the CR bars, which greatly reduces the risk of pitting. The possible reason for this result is that the capability of the CR bars to heal the passivation film helps to restore the metastable pits to the passivation state.