Influencia del tratamiento de los puntos gatillo miofasciales en pacientes con ictus isquémico agudo: estudio piloto aleatorizado, doble ciego / Influence of the treatment of miofascial trigger points in acute ischaemic stroke patients: Randomized pilot study, double blind

Objetivos Evaluar la influencia del tratamiento de los puntos gatillo miofasciales (PGM) en el balance motor y en la autonomía funcional en pacientes con ictus isquémico agudo. Participantes y métodos Se incluyeron 22 pacientes con ictus isquémico de menos de cinco días de evolución, con paresia braquial y/o crural en un estudio piloto, aleatorizado, a doble ciego, de tratamiento experimental vs. control. Durante la hospitalización, ambos grupos recibieron la fisioterapia. Adicionalmente, al grupo experimental (GE) se le trataron los PGM detectados en hombro y cadera paréticos y al grupo control (GC) se le aplicó un tratamiento sin efectos sobre los PGM. Fueron registrados al alta y a los 90 días postictus el grado fuerza de las extremidades paréticas mediante la National Institute of Health Stroke Scale, y el grado de autonomía funcional mediante la escala de Rankin modificada. Resultados Se detectó una mejoría tanto en la fuerza de las extremidades paréticas (probabilidad al alta de un mejor balance motor del 75,6% en la extremidad superior y del 69% en la extremidad inferior), como en la autonomía funcional (probabilidad de una mejor funcionalidad del 68%) en el GE comparado con el GC. Estos resultados no se mantuvieron a los 90 días de seguimiento. Conclusiones El tratamiento de los PGM como complemento al tratamiento de fisioterapia durante el ingreso hospitalario parece mejorar el balance motor y el grado de autonomía funcional al alta. Son necesarios futuros estudios que permitan confirmar nuestros resultados y evaluar el beneficio de una intervención más allá del ingreso hospitalario (AU)

Objectives To assess the influence of treatment of MTrPs on motor balance and functional autonomy in patients with acute ischaemic stroke. Patients and methods 22 patients with ischaemic stroke of less than 5 days’ evolution, with brachial and / or leg paresis were included in a randomized, double-blind, pilot study of experimental versus control treatment. During hospitalization, both groups received physiotherapy. In addition, the MTrPs detected in the paretic shoulder and hip were treated in the experimental group (EG). In contrast, the control group (CG) were given treatment without effects on the MTrPs. At the time of hospital discharge and 90 days post-stroke, we recorded the degree of strength of the paretic limbs using the National Institute of Health Stroke Scale, and the degree of functional autonomy using the modified Rankin Scale. Results We detected an improvement both in the strength of the paretic limbs (probability at discharge of a better motor balance of 75.6% in the upper limb and 69% in the lower limb) and in functional autonomy (68% probability of better functionality) in the EG compared to the CG. These results were not maintained at 90 days of follow-up. Conclusions Treatment of MTrPs as a complement to physiotherapy treatment during hospital admission seems to improve the degree of strength of paretic limbs and the degree of functional autonomy at hospital discharge. Future studies are necessary to confirm our results and evaluate the benefit of an intervention beyond hospital admission (AU)

Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation.

In this 3-year prospective inpatient study, 220 patients received stem-cell transplantation (SCT) for hematologic cancer at a single institution. The objective of the study is to provide data on patient-rated emotional (depression and anxiety) and physical (overall physical status, energy level, and systemic symptomatology) functioning during hospitalization for SCT and to compare whether these differ between autologous and allogeneic SCT. Patients were assessed at hospital admission (T1), day of SCT (T2), and 7 days (T3) and 14 days (T4) after SCT, yielding a total of 852 evaluations. For the overall sample, anxiety was highest at T1 and decreased afterwards; a marked worsening in physical health status variables corresponded with a sharp increase in depression from T1 to T3, and was followed by an improvement in physical health and a reduction of depression. Compared to allogeneic SCT, a better physical outcome for autologous SCT was demonstrated by the significant group effect for systemic symptomatology and by the significant group x time interaction for overall physical status and energy level; there were no significant differences in depression or anxiety between SCT groups. These findings have implications for treatment decision making, coping with the transplantation process, and improving prevention and treatment strategies.

Social inequalities in perinatal mortality in a Southern European city.

The objective of this study was to describe and explain inequalities in perinatal mortality by educational level and occupational social class in Barcelona for the years 1993-1997. This was a case-control study. Cases were singleton perinatal deaths, controls were singleton live births obtained from a 2% random sample of births. The association among educational level, social class, other confounding and explanatory variables and perinatal mortality was studied through crude and adjusted odds ratios (OR) obtained by logistic regression. The study comprised 423 cases and 1032 controls. The model with mother's age and educational level showed that women with primary education had an OR of 1.75 (95% CI: 1.26-2.42), this association disappearing when explanatory variables were included. We also found inequalities by educational level in fetal mortality. These results point out the need to improve the living conditions, behavioural factors and also the management of pregnancy, labour and the health care of the newborn of these mothers with greater risk.

Factors promoting colonization by legionellae in residential water distribution systems: an environmental case-control survey.

As part of a case-control study of community-acquired Legionnaires' disease, several factors related to residential water distribution systems and public drinking water systems were studied in the homes of 124 patients with community-acquired Legionnaire's disease and in the homes of 354 controls. The presence of water reservoirs and hot water tanks was studied in residential systems. Factors such as deficient chlorine levels, pipe repairs and other work, water flow interruptions, the use of alternative water sources, inadequate cleaning operations in public water reservoirs, and the position of the home within the public network (and whether this location constituted an endpoint) were studied in public water supply systems. Levels of legionellae in domestic water samples were also measured. Although the use of water reservoirs and hot water tanks promotes colonization by legionellae in residential systems, none of the variables studied seems to increase the incidence of community-acquired Legionnaires' disease.

Factors associated with severity and hospital admission of motor-vehicle injury cases in a southern European urban area.

OBJECTIVES: To describe the characteristics of motor-vehicle (MV) injury cases admitted to Emergency departments (ED), and to assess factors related to injury severity and hospital admission. SETTING: Subjects were MV injury patients, aged 16 or more, admitted to four EDs in the city of Barcelona (Spain), from July 1995 to June 1996. METHODS: Cross-sectional design. The data analyzed were obtained from the information routinely transmitted from the EDs to the Municipal Institute of Health, based on the processing of ED logs. Severity was assessed with the Abbreviated Injury Scale and the Injury Severity Score. Univariate and bivariate descriptive statistical analyses were performed, as well as multiple logistic regressions. RESULTS: For the 3791 MV-injury cases included in the study period, a larger contribution of cases was noted for males (63.1%), for cases younger than 30 years (55.3%) and for motorcycle or moped occupants (47.1%). After adjusting for age, sex and the presence of multiple injuries, pedestrians, followed by moped and motorcycle occupants were at a higher risk of a more severe injury (OR: 1.77, 1.61 and 1.50 respectively). Correspondingly, these user groups also showed a higher likelihood of a hospital admission (OR: 2.03, 1.92 and 2.00 respectively), when attended to in an ED. Injury cases attended to in the ED during night hours (OR: 2.06) were also at a higher risk of a hospital admission. CONCLUSIONS: In Barcelona, pedestrians and two-wheel MV occupants, besides accounting for two-thirds of MV injury cases, are the user groups with a greater risk of a more severe injury. as well as a higher chance of a hospital admission, independently of demographic and health care factors.

Trends in young adult mortality in three European cities: Barcelona, Bologna and Munich, 1986-1995.

OBJECTIVE: In recent decades, in most European countries young adult mortality has risen, or at best has remained stable. The aim of this study was to describe trends in mortality attributable to the principal causes of death: AIDS, drug overdose, suicide and motor vehicle traffic accidents, among adults aged between 15 and 34 years in three European cities (Barcelona, Bologna and Munich), over the period 1986 to 1995. METHODS: The population studied consisted of all deaths that occurred between 1986 and 1995 among residents of Barcelona, Bologna and Munich aged from 15 to 34 years. Information about deaths was obtained from mortality registers. The study variables were sex, age, the underlying cause of death and year of death. Causes of death studied were: drug overdose, AIDS, suicide and motor vehicle traffic accidents. Age standardised mortality rates (direct adjustment) were obtained in all three cities for the age range 15-34. To investigate trends in mortality over the study period Poisson regression models were fitted, obtaining the average relative risk (RR) associated with a one year increment. RESULTS: Young adult mortality increased among men in Barcelona and Bologna (RR per year: 1.04, 95% confidence intervals (95%CI): 1.03, 1.06 in Barcelona and RR:1.03, 95%CI:1.01, 1.06 in Bologna) and among women in Barcelona (RR:1.02, 95%CI: 1.01, 1.04), with a change in the pattern of the main causes of death attributable to the increase in AIDS and drug overdose mortality. In Munich, the pattern did not change as much, suicides being the main cause of death during the 10 years studied, although they have been decreasing since 1988 (RR:0.92, 95%CI:0.88, 0.96 for men and 0.81, 95%CI: 0.75-0.87 for women). CONCLUSION: The increase in AIDS mortality observed in the three European cities in the mid-80s and mid-90s has yielded substantial changes in the pattern of the main causes of death at young ages in Barcelona and Bologna. Munich presented a more stable pattern, with suicide as the main cause of death.

[Hyperviscosity syndrome and mental disorders]. / Síndrome de hiperviscosidad y alteraciones mentales.

The hyperviscosity syndrome has been described clinically as the triad of bleeding, visual signs and neurological manifestations associated with elevated serum viscosity. Several reports have recognised an association between hyperviscosity and altered mental status. Since to our knowledge only a case of hyperviscosity-induced delirium has been described (1), we raise the possibility of this diagnosis in the most of this reported cases, based on the nature of the symptoms, sudden onset and fluctuating course, and its resolution with plasmapheresis. In this paper we review the literature about hyperviscosity syndrome and altered mental status. In conclusion, serum hyperviscosity should be added to the large list of causes altered mental status, especially of delirium. Since plasmapheresis can reverse clinical symptoms, it early recognition and the measurement of serum viscosity is essential in patients suffering from diseases that may lead to this syndrome, and who develop psychiatric symptoms.

Síndrome de hiperviscosidad y alteraciones mentales / Hyperviscosity syndrome and altered mental status

El síndrome de hiperviscosidad ha sido descrito por la tríada de alteraciones oftalmológicas, neurológicas y diátesis hemorrágica, asociado al incremento patológico de la viscosidad sanguínea. Es un hecho reconocido en la literatura la asociación entre hiperviscosidad y alteración del estado mental. Hasta nuestro conocimiento sólo se ha descrito un caso definido como delirium inducido por hiperviscosidad (1). No obstante, es posible que presentasen un síndrome de delirium gran parte de los casos descritos que cursaban con alteraciones del estado mental de inicio agudo, curso fluctuante, y que remitieron tras la plasmaféresis. En este artículo se realiza una revisión de los casos descritos de hiperviscosidad que presentaron síntomas neurológicos y psiquiátricos, y se concluye que la hiperviscosidad plasmática debe añadirse a la lista de causas de alteraciones mentales y principalmente de delirium. Su reconocimiento es crítico, ya que el tratamiento con plasmaféresis revierte los síntomas. Por ello, la determinación de la viscosidad plasmática es esencial en pacientes en que aparecen síntomas psiquiátricos y padecen enfermedades que pueden cursar con hiperviscosidad (AU)

[An evaluation of the impact of primary care reform on health]. / Evaluación del impacto de la reforma de la atención primaria sobre la salud.

OBJECTIVE: Evaluation of the impact of the reform of primary health care services on the population health. DESIGN: Comparative analysis of mortality rates for the 1984-96 period in three zones of homogeneous socioeconomic level, assessing the effect of the differential development of the reform of public primary health care services. SETTING: The study is restricted to the 23 health areas with lower socioeconomic status in the city of Barcelona (443092 inhabitants). MEASUREMENTS AND MAIN RESULTS: The study areas are categorized in three groups, according to the sequence of the reform: reformed between 1984 and 1989, RAP1 zone, reformed between 1990 and 1991, RAP2 zone, and those still served by the old scheme in 1992, NORAP zone. General mortality rates are analyzed, and also mortality rates by those avoidable conditions. Significant differences among the three zones are initially visible. The mortality decline is 13.6% in the RAP1 zone and 10.3% in the NORAP zone, so that the decline in the RAP1 zone is 32% greater than in the NORAP zone. At the end of the study, mortality due to stroke and hypertension is lower in the RAP zones than in the NORAP zone. Perinatal mortality shows a clear decline in the three zones. No relevant changes are seen for tuberculosis or cervical cancer. Lung cancer mortality increases except in RAP1 zone where it declines, to the point that the excess mortality from that cause estimated by comparison with the NORAP zone in the initial phase of the study vanishes. Death rates from cirrhosis and motor vehicle accident decline in all zones. CONCLUSIONS: There is a clear association between the process of reform of primary care and the decrease in general mortality in these zones of low socioeconomic level. These results suggest that the reform of primary health care services in Spain may have a significant impact in the mortality of the population of lower socioeconomic level. The study highlight the cost in health and human lives of maintaining obsolete and overburdened services for some segments of the population, and justify the need and urgency of completing the process of reform initiated in 1984 and still unfinished in 1999.

Physical and psychosocial functioning of 117 survivors of bone marrow transplantation.

All surviving patients receiving a BMT at our center since 1976 were surveyed. Among 163 eligible patients, 145 were contacted and 117 (81%) responded. Their median follow-up was 55 months (range 6-154). The research instruments consisted of a demographic questionnaire, a current medical status form, a quality of life questionnaire (Nottingham Health Profile), and a screening instrument for psychiatric morbidity (the 28-item version of the General Health Questionnaire). Current functioning varied considerably across patients. They reported a high use of medical services (37%) and varied ongoing medical problems within the last 6 months. Most of them (93%) received Karnofsky ratings of 80 or above. Eight percent had current chronic GVHD. Comparing our patients' quality of life with a British reference population, most important differences were found for physical mobility, work, and sex life. Psychiatric morbidity in BMT survivors was higher than in a Spanish general population. Multivariate analyses revealed that a higher systemic symptomatology score, a lower educational level, an older age at BMT, a shorter time post-BMT, a female gender, and impotence were significant predictors of an impaired overall quality of life. Similarly, a higher systemic symptomatology score, a shorter time post-BMT, a higher number of major infections, and a lower educational level were predictive factors of a higher psychosocial distress. No differences in quality of life or psychosocial status between allogeneic and autologous transplants were found. Quality of life and psychosocial distress improved with the passage of time, specially within the first 3 years.

[Delirium in an elderly population admitted at a general hospital]. / Delirium en población anciana ingresada en un hospital general.

BACKGROUND: Delirium is an organic mental disorder frequently seen in elderly patients admitted to hospital for medical or surgical diseases. The prevalence, triggering factors, the relationship with prior existence of dementia and the evolution of delirium were studied. METHODS: One hundred eight elderly patients admitted to the Internal Medicine, General Surgery and Traumatology Departments of the Hospital Clínic i Provincial in Barcelona, Spain were randomly selected with clinical evaluation being performed following the DSM-III-R diagnostic criteria. Likewise a structured clinical interview (CAMDEX) was carried out, and the establishment of delirium, the possible causes and its evolution were evaluated. RESULTS: Eighteen of the elderly patients studied presented delirium at some time during hospital stay. Of these patients 15 had previously been clinically diagnosed with dementia. These patients did not require longer hospital stay than those not presenting dementia. The most frequent etiology was surgery and fever due to an infectious process. In addition to etiologic treatment, 12 of the patients also received symptomatic treatment with a neuroleptic drug (haloperidol). CONCLUSIONS: Most of the elderly who have presented delirium admitted in a general hospital had been diagnosed with dementia during hospital stay thus indicating the high comorbidity of the two entities. In many cases it is important to carry out symptomatic in addition to etiologic treatment to achieve rapid reversibility of the disorder.

Rapidly cycling bipolar II disorder following liver transplantation.

During the last decade the psychiatric aspects of liver transplantation have been widely described. Although affective complications are some of the most prevalent, a complete and persistent bipolar II syndrome following transplantation has never been reported before. In this paper we describe a patient who developed a rapidly cycling bipolar II disorder after liver transplantation. He presented a major depressive episode within the first 48 hours following transplantation, and subsequently started cycling from depression to hypomania with only brief periods of euthymia. One year after transplantation, only lithium carbonate has proved to be useful to ameliorate his persistent disorder. There was no premorbid or family history of affective illness. Although the course of the disorder seemed to be independent from any pharmacologic or psychosocial factor, it is suggested that transplantation, corticosteroids, and cyclosporine may have played some role in the pathogenesis of the syndrome.

[Postoperative psychiatric complications following liver transplantation]. / Complicaciones psiquiátricas del postoperatorio del trasplante hepático.

BACKGROUND: The aim of the study was to describe the psychiatric complications of the postoperative period of liver transplantation. METHODS: Sixty-three adult liver transplant recipients were seen weekly before surgery and during the postoperative period until discharge. They were assessed through Goldberg's Clinical Interview Schedule (CIS) and diagnosed according to DSM-III-R criteria. RESULTS: Psychiatric morbidity was 29%. Organic mental disorders were the most prevalent, especially delirium (13%), followed by adjustment disorders (8%), major depression (5%) and organic anxiety disorders (3%). One of the depressed patients showed subsequently a rapidly cycling bipolar course. Most patients had a good outcome of their psychiatric disorder at discharge. In contrast, patients with delirium presented a higher mortality rate. CONCLUSIONS: The prevalence of short-term psychiatric complications in patients undergoing liver transplantation is close to 30%. Delirium, which is significantly related to mortality, is the most frequent of them, followed by adjustment disorders and affective disorders, which, in contrast, seem to have a good prognosis.

Suicide attempts of high medical seriousness in schizophrenic patients.

A retrospective study was conducted that included all patients who in the previous 6 years had required admission to our hospital for medical reasons following attempted suicide (N = 253). Those diagnosed as schizophrenic (n = 43) in accordance with DSM-III-R criteria were compared with the other nonschizophrenic suicide attempters. Schizophrenic patients were significantly different in that they were younger and generally unmarried, usually used violent methods, made more attempts while in a psychiatric center, and presented a lower incidence of concurrent organic illness than the nonschizophrenics; almost all of them were chronic. A large majority (80%) showed delusional and hallucinatory symptoms at the time of the attempt. In contrast, depressive symptoms were noted in an appreciably lower percentage of subjects than that in other studies of suicidal behavior in schizophrenics.

[Suicide attempts in patients with organic disease]. / Intentos de suicidio en pacientes con enfermedad orgánica.

BACKGROUND: The aim of the present was to study the relation between organic disease and suicidal behavior. METHODS: The characteristics of 257 patients hospitalized for medical or surgical causes following attempted suicide were studied between June 1984 and June 1990 with 45 cases previously having had physical disease being compared with 212 that had not. RESULTS: Ninety-seven percent of the attempted suicides with organic disease fulfilled the DSM-III-R criteria for some psychiatric diagnosis with affective disorders predominating (64%). Suicides with organic illness tended to be older (p less than 0.0001), present a larger number of widowed patients (p less than 0.0001), have affective disorders (p less than 0.0001), non violent modes of suicidal behavior (p less than 0.008), and have a preference for non psychotropic drugs and barbiturates (p less than 0.007). CONCLUSIONS: Patients with organic disease who make serious attempts to commit suicide are characterized by high psychiatric morbidity (97%) with a predominance in the diagnosis of severe depression.

Serious suicide attempts in affective patients.

A retrospective study was carried out including all patients who in the previous 6 years had required admission to our hospital for medical or surgical reasons following attempted suicide (n = 257). Those diagnosed as having affective disorder (n = 96), according to DSM-IIIR criteria, were compared with the other non-affective suicide attempters (n = 161). Affective patients were significantly different in that they were older, more often women, married or widowed, usually used non-violent methods, made more serious attempts and presented a higher incidence of concomitant physical illness. Affective patients with a history of previous attempts were more likely to be recurrent unipolar depressives or first episode unipolars with a concurrent diagnosis of personality disorder. Most of the depressed patients made the attempt within the first 12 months of the episode. Patients who attempted suicide in the first 12 months of the depression were more likely to use non-violent methods and to receive a diagnosis of bipolar or unipolar recurrent disorder.

Serious suicide attempts in the elderly.

A retrospective study was carried out including all those patients who, over the last 6 years (n = 257), required admission to our hospital for medical or surgical reasons following attempted suicide. The authors examined a series of clinical and demographic variables. Thirty-eight patients over 65 years of age were compared with 120 patients aged between 30 and 64 years and 99 aged under 30 years. When compared with the other two groups, a significantly higher proportion of elderly patients were widowed and showed affective disorders and concurrent physical illness.