[Les effets de la méditation de pleine conscience sur les symptômes cognitivo- émotionnels dans le trouble cognitif léger et la maladie d'Alzheimer : une revue de littérature narrative].

La maladie d'Alzheimer se manifeste par des troubles de la mémoire et un déclin cognitif plus général, le plus souvent associés à des troubles de l'humeur et du comportement. Les traitements médicamenteux ayant une efficacité assez modeste, il apparaît nécessaire de leur associer une prise en charge non pharmacologique. La méditation de pleine conscience, qui a des effets bénéfiques sur le fonctionnement cognitif et sur l'état émotionnel, semble être une piste intéressante. Cette revue de littérature narrative se propose de recenser les études ayant testé l'efficacité d'une intervention basée sur la pleine conscience auprès de personnes souffrant de la maladie d'Alzheimer ou à risque de développer cette maladie. Il apparaît que ces interventions présentent un intérêt pour réduire les symptômes cognitifs (troubles attentionnels et mnésiques notamment) et émotionnels (affects dépressifs et anxiété en particulier). Cependant, elles nécessitent un certain nombre de modifications pour être adaptées à ce public.

Effects of combined physical and cognitive program performed in socially enriched environment on older people's cognitive abilities and quality of life (StimCoAPS): study protocol for a randomized controlled trial.

The number of older people worldwide is constantly increasing. However, ageing is accompanied by a decline in cognitive ability that can affect quality of life. Cognitive, physical and social activities can all slow this decline but social factors and their contribution to the well-being remain under-researched. The aim of this study is to analyse how the practice environment can foster these social relations and thus enhance well-being and to identify the psychological dimensions that are activated by social relations. This study is a 3-year randomised controlled trial designed to assess the effects on participants' cognitive abilities and quality of life of a combined (ie, physical and cognitive) training programme in different social practice environments. A total of 159 older people (≥65 years old) will be recruited and randomly assigned to one of three practice environments: individual practice at home (n=53), group practice in a gymnasium (n=53) and group practice in an enriched environment (n=53). All participants will complete 12-week combined training sessions and will be assessed four times: before the start, in the middle, at the end and 6 months after the end of the programme. They will undergo cognitive function (episodic memory and executive functions), physical capacity (aerobic fitness, muscle strength and dynamic balance) and psychosocial assessments (indicators of psychological well-being, social support, self-esteem, anxiety, depression and achievement goal strategies), as well as semistructured interviews. Statistical analyses will be conducted to assess the effect of the practice environment on the perceived benefits of this programme in terms of cognitive abilities and quality of life, and to determine the role of psychosocial factors in this relationship. This protocol has been approved by an institutional review board (CERSTAPS: IRB00012476-2022-20-01-146). Trials registration number: NCT05721508.

Positive impact of social relationships fostered by physical and/or cognitive group activity on older people's quality of life: PRISMA systematic review.

Introduction: This review identified and examined the research literature on the effect of participating in physical and/or cognitive activities on older people's quality of life, to establish whether the social relationships fostered by these activities can be a vector of better physical, mental and social quality of life. Method: A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched four databases (MEDLINE, APA PsycArticles/PsycInfo, PubMed, and Web of Science) for articles published between 1975 and 2022 using search terms related to psychosocial, population, and intervention topics. Studies were eligible if they involved older adults, participation in at least one activity (physical or cognitive), and at least one quality of life related outcome measure. Results: We selected 20 articles published between 1990 and 2021, the majority concerning studies conducted in English-speaking countries. Ten studies were interventional (introduction of program of activities), and 10 studies were observational (60% quantitative, 40% qualitative). Overall, results revealed a positive impact of the activities on every aspect of quality of life (i.e., cognitive, physical, social, psychological, and quality of life in general). Conclusion: The present review confirmed the beneficial impact of practicing physical and/or cognitive group activities on older people's quality of life, but the contribution of social factors and social relationships remains underestimated and not well defined in researches.

Posttraumatic Stress Symptoms Increase the Efficiency of Memory Functioning for Trauma-Related Information.

OBJECTIVE: The present study explored the resources reallocation explanation for memory biases in posttraumatic stress disorder (PTSD), whereby a preferential allocation of cognitive resources to the processing of threatening stimuli could result in both improvements in their memorization and deficits for other types of information. METHOD: To this end, 25 participants presenting significant symptoms of PTSD (i.e., total PCL-5 score ≥33) and 32 participants presenting low levels of symptoms (i.e., total PCL-5 score <20) took part in a Remember/Know recognition procedure associated with a dual-task encoding of positive, neutral, negative, and trauma-related words. In order to manipulate the availability of cognitive resources, the encoding of each word was associated with a simultaneous encoding of series of letters and numbers. RESULTS: Results replicated the increased production of Remember recognitions for trauma-related words in participants with significant PTSD symptoms. However, the dual-task load only impaired remember recognitions for non-trauma-related words. CONCLUSIONS: Contrary to expectations, these findings suggest that the encoding of trauma-related information in PTSD is relatively independent from the availability of cognitive resources. Thus, rather than reflecting an increased allocation of cognitive resources to the processing of threatening information, memory biases in PTSD appeared to be supported by an enhanced efficiency of their processing.

Combining Trauma Script Exposure With rTMS to Reduce Symptoms of Post-Traumatic Stress Disorder: Randomized Controlled Trial.

BACKGROUND: Innovative therapeutic interventions for post-traumatic stress disorder (PTSD) are required. We opted to facilitate fear extinction by combining trauma script exposure with repetitive transcranial magnetic stimulation (rTMS) to reduce symptoms of PTSD. OBJECTIVE: The efficacy and safety of 10 Hz rTMS of the right dorsolateral prefrontal cortex simultaneously with exposure to personal traumatic narrative were studied in patients with PTSD. MATERIALS AND METHODS: This trial was a single-center randomized controlled trial (NCT02584894). Patients were randomly assigned 1:1 to receive eight daily sessions of 110% of motor threshold high frequency (HF) 10 Hz rTMS (110% HF rTMS) or 70% low frequency (LF) 1 Hz rTMS (70% LF rTMS) with trauma script exposure in both groups. Severity of PTSD, depression, and anxiety were assessed before and after study treatment (one month, three months) by an assessor masked to the trial group assignment. The primary outcome was the severity of PTSD assessed by the Clinician Administered PTSD Scale (CAPS). We used mixed linear regression models for statistical comparisons. RESULTS: Thirty-eight patients (65.8% females) were randomly assigned to 110% HF rTMS (n = 18, 31.3 ± 10.0 years, 13 females) or 70% LF rTMS (n = 20, 33.5 ± 11.1 years, 12 females). From baseline to three months, mean CAPS scores decreased by 51% in the 110% HF rTMS group (from 83.7 ± 14.4 to 41.8 ± 31.9) and by 36.9% in the 70% LF rTMS group (from 81.8 ± 15.6 to 51.6 ± 23.7), but with no significant difference in improvement (time by treatment interaction -3.61 [95% confidence interval (CI), -9.70 to 2.47]; p = 0.24; effect size 0.53). One serious adverse event occurred during the study (psychogenic nonepileptic seizure). CONCLUSION: We found no evidence of difference in clinical improvement or remission rates between the 110% HF and 70% LF stimulation. These findings may reflect the importance of exposure procedure and that larger number of participants is needed.

The memory deficit hypothesis of compulsive checking in OCD: what are we really talking about? A narrative review.

We reviewed studies that have specifically explored the memory deficit hypothesis of Obsessive Compulsive Disorder (OCD) checking, highlighting the methodological differences between these studies that may explain inconsistencies regarding memory deficits in OCD checkers. Based on Conway's proposition that one function of episodic memories is to keep an adaptive record of recent goal processing in order to check that actions have actually been accomplished, we suggest that impaired autonoetic consciousness -one of the main features of episodic memory- may be at the heart of the issue of checking compulsion. Autonoetic consciousness, that can be experimentally assessed by the Remember/Know/Guess paradigm,could be impaired in OCD checkers leading them to be unable to mentally relive their actions in order to be assured that they have been accomplished (e.g., having locked the door). We make methodological suggestions to improve the assessment of autonoetic consciousness deficit in OCD checkers and understand its role in the etiology and maintenance of compulsive checking.

Beyond Clinical Outcomes: Posttraumatic Stress Symptoms Favor Attentional and Memory Control Abilities for Trauma-Related Words.

Memory alterations and biases are core features of posttraumatic stress symptoms (PTSS). Although a large number of studies have investigated memory biases associated with PTSS, some inconsistencies remain regarding the nature of the mechanisms behind the threat-related biases observed in prior findings. The present study explored the extent to which inhibitory deficits, both for automatic and controlled processes, can account for these biases. Participants (N = 64) took part in a remember/know recognition procedure for positive, neutral, negative, and trauma-related words associated with negative priming and directed forgetting encoding. Half of the participants had high levels of PTSS (i.e., PCL-5 score > 40) and half had low levels (i.e., total PCL-5 score < 20). As both negative priming and directed forgetting effects are posited to depend on inhibitory abilities, we expected these effects to be absent for trauma-related words in participants with more severe PTSS. Replicating classic memory biases, participants with high levels of PTSS produced more "remember" recognition responses for trauma-related words, ηp 2 = .10. However, contrary to our expectations, directed forgetting, ηp 2 = .26; and negative priming effects were observed for trauma-related words but not for words of other valences, ηp 2 = .07 and .06, respectively. Hence, rather than the expected inhibitory deficits, our results suggest that PTSS preserve the ability to inhibit trauma-related information in both attentional and memory processes. As it appears to occur at the expense of other information, this preserved cognitive functioning for trauma-related stimuli is discussed with regard to resource reallocation theories.

Trauma reactivation under propranolol among traumatized Syrian refugee children: preliminary evidence regarding efficacy.

Background: There is a dearth of therapeutic solutions for traumatized young patients. Trauma reactivation conducted under the influence of the reconsolidation blocker propranolol (Reconsolidation Therapy) is a simple, cost-effective treatment option that has some promising initial results in adults suffering from posttraumatic stress disorder (PTSD). Objective: To explore the usefulness of this novel treatment in children. The primary outcome was the reduction of PTSD symptoms at the end of treatment, while secondary outcomes included reduction in anxiety and in depressive symptoms. Method: An open-label clinical trial was conducted in a refugee camp in Syria, investigating the safety and efficacy of this therapeutic strategy in 117 children suffering from enduring PTSD symptoms. Participants received propranolol 90 minutes before briefly recalling (i.e. reactivating) a single personal traumatic memory, for 5 consecutive days. Self-reported anxiety, depressive, and PTSD symptoms were assessed at baseline, as well as 4 and 13 weeks after treatment. Results: A significant, clinically meaningful symptom reduction was observed at all post-treatment measurement times vs. baseline. More specifically, between baseline and the 13-week follow-up we observed a 64% PTSD symptoms reduction (d = 2.71). In a similar vein, we obtained a 39% symptoms reduction for depressive symptoms (d = 1.01). The general anxiety symptoms improved, but eventually returned to prior level, probably because of the deteriorating living conditions in the camp. Conclusions: This therapy appeared as a potentially safe and useful treatment strategy for children suffering from PTSD symptoms, warranting replication studies using stronger study designs. The social acceptability and ease of implementation of the treatment should also be noted.

Introducción: Existe una escasez de soluciones terapéuticas para pacientes jóvenes traumatizados. La reactivación del trauma conducida bajo los efectos del propanolol bloqueador de reconsolidación (Terapia de Reconsolidación) es una opción de tratamiento simple, costo-efectiva, que tiene algunos resultados iniciales prometedores en adultos que sufren del trastorno de estrés postraumático (TEPT).Objetivos: Explorar la utilidad de este novedoso tratamiento en niños. El resultado primario fue la reducción de los síntomas de TEPT al final del tratamiento, mientras que los resultados secundarios incluyeron la reducción de los síntomas ansiosos y depresivos.Métodos: Se condujo un estudio clínico abierto en un campo de refugiados en Siria, investigando la seguridad y eficacia de esta estrategia terapéutica en 117 niños que permanecían con síntomas de TEPT. Los participantes recibieron propranolol 90 minutos antes de recordar brevemente (es decir, reactivación) un único recuerdo personal traumático, por 5 días consecutivos. Se evaluó los síntomas de ansiedad, depresión y TEPT auto-reportados, tanto al inicio, como a las 4 y 13 semanas después del tratamiento.Resultados: Se observó una reducción sintomática significativa, clínicamente importante en todas las mediciones post tratamiento versus el nivel basal. Más específicamente, observamos un 64% de reducción de síntomas de TEPT entre el nivel basal y el seguimiento en la semana 13 (d = 2.71). De forma similar, obtuvimos un 39% de reducción de los síntomas depresivos (d =1.01). Los síntomas generales de ansiedad mejoraron, pero retornaron a sus niveles previos al final, probablemtente por las condiciones de vida deteriorantes en el campo de refugiados.Conclusiones: Esta terapia pareciera ser una estrategia de tratamiento potencialmente segura y útil en niños que sufren síntomas de TEPT, justificando estudios de replicación que usen diseños más estrictos. Se debería hacer notar también la aceptabilidad social y la fácil implementación del tratamiento.

Ageing stereotypes and prodromal Alzheimer's disease (AGING): study protocol for an ongoing randomised clinical study.

INTRODUCTION: The number of older people diagnosed with amnestic mild cognitive impairment (aMCI), the prodromal state of Alzheimer's disease (AD), is increasing worldwide. However, some patients with aMCI never convert to the AD type of dementia, with some remaining stable and others reverting to normal. This overdiagnosis bias has been largely overlooked and gone unexplained. There is ample evidence in the laboratory that negative ageing stereotypes (eg, the culturally shared belief that ageing inescapably causes severe cognitive decline) contribute to the deteriorating cognitive performances of healthy older adults, leading them to perform below their true abilities. The study described here is intended to test for the first time whether such stereotypes also impair patients' cognitive performances during neuropsychological examinations in memory clinics, resulting in overdiagnosis of aMCI. METHODS AND ANALYSIS: The ongoing study is a 4-year randomised clinical trial comparing patients' physiological stress and cognitive performances during neuropsychological testing in memory clinics. A total of 260 patients attending their first cognitive evaluation will be randomised to either a standard condition of test administration, assumed here to implicitly activate negative ageing stereotypes or a reduced-threat instruction condition designed to alleviate the anxiety arising from these stereotypes. Both groups will be tested with the same test battery and stress biomarkers. For 30 patients diagnosed with aMCI in each group (n=60), biomarkers of neurodegeneration and amyloidopathy will be used to distinguish between aMCI with normal versus abnormal AD biomarkers. A 9-month follow-up will be performed on all patients to identify those whose cognitive performances remain stable, deteriorate or improve. ETHICS AND DISSEMINATION: This protocol has been approved by the French National Agency for Medicines and Health Products Safety and the Sud-Est I French Ethics Committee (2017-A00946-47). Results will be published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03138018.

Inhibitory control of threat remembering in PTSD.

Intrusive traumatic recollections suggest an inability in Posttraumatic Stress Disorder (PTSD) to control and notably to inhibit memories for trauma-related information. Supported by inhibitory deficits found on experimental settings in PTSD, memory functioning and memory biases in the disorder were usually explained through inhibitory and control deficits in the processing of trauma-related information. The present study aimed to directly assess this hypothesis by investigating memory control abilities for emotional information in PTSD. For this purpose, 34 patients diagnosed with PTSD were compared to 37 non-PTSD controls on an item-cued directed forgetting paradigm for emotional words combined with a Remember/Know recognition procedure. Results revealed enhanced amounts of Remember recognitions for trauma-related words in PTSD. Moreover, we replicated findings of memory control impairments in the disorder. However, such impairments only occurred for non-trauma-related words. Accordingly, it appeared that PTSD patients presented preserved memory control abilities for trauma-related words, at the expenses of other emotional valences. Surprisingly, PTSD patients presented a preserved ability to control and notably to inhibit their memory functioning for trauma-related material. In addition to potential theoretical and clinical relevance, these results are discussed in the light of resource reallocation hypotheses and vigilant-avoidant theories of information processing in PTSD.

Effortful memory processes under stereotype threat and self-concept in aging.

The present study aimed at exploring the effect of stereotype threat on the controlled part of memory in older adults using a deep level of processing, namely, self-reference encoding. To meet this objective, 25 younger adults and 25 older adults performed a Remember/Know recognition task following self-reference versus other-reference encoding of adjective traits, under stereotype threat or not. The results indicated that under stereotype threat, older adults' production of Remember responses was specifically impaired following self-reference encoding. Moreover, whereas executive functioning and group identification did not moderate stereotype threat effect, measure of self-worth did. These findings suggest that stereotype threat in older adults may be a self-concept threat and that moderators of stereotype threat found in other groups (i.e., group identification and executive functioning) may not be generalised to this group. Rather, as stereotype threat in aging may represent a threat to the self, self-worth might have a central role, whereby individuals with high self-worth remain self-confident even under stereotype threat and are thus able to down-regulate their negative affects to face such a threat.

Prospective and retrospective episodic metamemory in posttraumatic stress disorder.

OBJECTIVES: Posttraumatic stress disorder (PTSD) has been consistently associated with episodic memory deficits. To some extent, these deficits could be related to an impairment of metamemory in individuals with PTSD. This research consequently aims at investigating prospective (feeling-of-knowing, FOK) and retrospective (confidence) metamemory judgments for episodic information in PTSD. METHOD: Twenty participants with PTSD and without depression were compared to 30 healthy comparison participants on metamemory judgments during an episodic memory task. The concordance between metamemory judgments and recognition performance was then assessed by gamma correlations. RESULTS: The results confirmed that PTSD is associated with episodic memory impairment. Regarding metamemory, gamma correlations indicated that participants with PTSD failed to accurately predict their future memory performance as compared to the comparison group (mean FOK gamma correlations: .23 vs. .42, respectively). Furthermore, participants with PTSD made less accurate confidence judgments than comparison participants (mean confidence gamma correlations: .62 vs. .74, respectively). CONCLUSION: Our results demonstrate an alteration of both prospective and retrospective metamemory processes in PTSD, which could be of particular relevance to future therapeutic interventions focusing on metacognitive strategies.

Some further clarifications on age-related differences in Stroop interference.

Both the locus and processes underlying the age-related differences in Stroop interference are usually inferred from changes in magnitudes of standard (i.e., overall) Stroop interference. Therefore, this study addressed these still-open issues directly. To this end, a sample of younger (18-26 years old) and healthy older (72-97 years old) was administered the semantic Stroop paradigm (that assesses the relative contribution of semantic compared to response conflict both of which contribute to overall Stroop interference) combined with a single-letter coloring and cuing (SLCC) procedure. Independently of an increased attentional focus on the relevant color dimension of Stroop words induced by SLCC (as compared to all letters colored and cued, ALCC), greater magnitudes of standard Stroop interference were observed in older (as compared to younger) adults. These differences were due to greater magnitudes of response conflict whereas magnitudes of semantic conflict remained significant and unchanged by healthy aging and SLCC. Thus, this direct evidence places the locus of age-related differences in Stroop interference at the level of response conflict (as opposed to semantic and/or both conflicts). In terms of processes underlying these differences, the reported evidence shows that both age-groups are equally (in)efficient in (a) focusing on the relevant color dimension and (b) suppressing the meaning of the irrelevant word-dimension of Stroop words. Healthy older adults are simply less efficient in suppressing the (pre-)response activity primed by the fully processed meaning of the irrelevant word-dimension. Standard interpretations of age-related differences in Stroop interference and a more general issue of how attentional selectivity actually operates in the Stroop task are therefore reconsidered in this paper.

Remembering - but not knowing - disturbs the relational bindings newly established in short-term/working memory: an age-group comparison.

The aim of this study was to highlight that episodic memory and working memory compete for the same resource, which would be diminished in aging. Using the remember/know paradigm, we compared the interference related to the retrieval of words on the parallel processing of preestablished relational bindings (Shifting condition) or newly established relational bindings (Updating condition). Within each age-group, participants had comparable performances in remembering across recognition conditions. However, the results showed that only updating activity was impaired after a remember response was given in the younger group. This specific interaction between updating and remembering - but not knowing - tends to indicate that both working memory and episodic memory rely on the ability to establish contextualized representations. In the older group, the performance in updating activity was impaired regardless of the kind of the competing retrieval. Limitations in terms of interference hypothesis and limited resource hypothesis are discussed.

Cognitive stimulation in healthy older adults: a cognitive stimulation program using leisure activities compared to a conventional cognitive stimulation program.

The aim of this study was to compare two methods of cognitive stimulation for the cognitive functions. The first method used an usual approach, the second used leisure activities in order to assess their benefits on cognitive functions (speed of processing; working memory capacity and executive functions) and psychoaffective measures (memory span and self esteem). 67 participants over 60 years old took part in the experiment. They were divided into three groups: 1 group followed a program of conventional cognitive stimulation, 1 group a program of cognitive stimulation using leisure activities and 1 control group. The different measures have been evaluated before and after the training program. Results show that the cognitive stimulation program using leisure activities is as effective on memory span, updating and memory self-perception as the program using conventional cognitive stimulation, and more effective on self-esteem than the conventional program. There is no difference between the two stimulated groups and the control group on speed of processing. Neither of the two cognitive stimulation programs provides a benefit over shifting and inhibition. These results indicate that it seems to be possible to enhance working memory and to observe far transfer benefits over self-perception (self-esteem and memory self-perception) when using leisure activities as a tool for cognitive stimulation.

The effect of ageing on recollection: the role of the binding updating process.

The aim of this study was to highlight the underlying process responsible for the age-related deficit in recollection. Through two experiments using the Remember-Know-Guess procedure (Gardiner, J. M., & Richardson-Klavehn, A. [2000]. Remembering and knowing. In The Oxford handbook of memory (pp. 229-244). New York, NY: Oxford University Press) in recognition, we manipulated the opportunity to update bindings between target items and their encoding context, in young and older adults. In the first experiment we impaired the binding updating process during the encoding of items, while in the second we supported this process. The results indicated that the "Remember" responses in the younger group were specifically reduced by the impairment of the binding updating process (Exp. 1), suggesting that this ability is useful for them to encode a specific episode. Conversely, only the "Remember" responses in the older group were improved in accuracy by supporting the binding updating process (Exp. 2), suggesting that their weakness in this ability is the source of their failure to improve the accuracy of their memories. The overall results support the hypothesis that the age-related decline in episodic memory is partly due to a greater vulnerability to interference on bindings, impairing the ability to update content-context bindings as and when events occur.

The positivity bias in aging: Motivation or degradation?

The question of an emotional memory enhancement in aging, and of a positivity bias in particular, has been the subject of numerous empirical studies in the last decade. However, the roots of such positive preference are not yet well established. Partisans of a motivation-based perspective contend with those arguing that positivity is related to a cognitive or neural degradation. The aim of this study was to introduce some elements concerning positivity effect in aging. We compared immediate (i.e., immediate recall) versus delayed (i.e., delayed recall and recognition) emotional memory performance in 38 young adults, 39 old adults, 37 very old adults, and 41 Alzheimer's disease patients. Moreover, we manipulated the encoding instruction: Either participants received no particular processing instruction, or they had to process the material in a semantic way. The results indicated that the positivity bias is most likely to occur in individuals whose cognitive functions are preserved, after long retention delay, and in experimental conditions that do not constrain encoding. We concluded by highlighting that although these findings seem to be better in line with the motivation, rather than the degradation, perspective, they do not fully support either theory. (PsycINFO Database Record

Aging Stereotypes Must be Taken Into Account for the Diagnosis of Prodromal and Early Alzheimer Disease.

Because of a dramatic increase of older people worldwide, screening for prodromal state of Alzheimer disease (AD) is a major societal challenge. Many individuals diagnosed with prodromal AD, do not convert to AD, some remaining stable and others reversing back to normal. We argue that an important source of this overdiagnosis comes from negative aging stereotypes (eg, the culturally shared beliefs that aging inescapably causes severe cognitive decline and diseases). Many laboratory studies show that such stereotypes impair memory performance in healthy older adults, producing inflated age differences. Research is needed to examine how aging stereotypes implicitly permeate neuropsychological testing and contribute to false positives.

The emotional memory effect in Alzheimer's disease: emotional words enhance recollective experience similarly in patients and control participants.

The purpose of the present study was to investigate emotional memory enhancement (EME) in Alzheimer's disease (AD). In particular, we were interested in exploring which memory process (i.e., recollection or familiarity) could be improved by emotional information in the course of the disease. Eighteen AD patients were compared with 15 normal controls on the Remember/Know/Guess paradigm following encoding of emotional and neutral words. AD patients' recollective experience was improved for emotional compared to neutral words to the same extent as that of normal controls, whereas emotion had no effect on participants' memory performance involving familiarity processes. Our results showed that AD patients' memory can be enhanced qualitatively but not quantitatively by an emotional material. Furthermore, we found that AD patients were as able as normal controls to benefit from the emotional content of information to improve the recollection of details.

Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease.

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials [Self-Reference Effect (SRE) and Self-Reference Recollection Effect (SRRE)]. The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer's disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for self-relevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in a Magnetic Resonance Imaging (MRI) scanner. Brain activation as measured by functional MRI (fMRI) was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs recollective experience). The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of self-related information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgements. However, the variable and limited memory advantage for self-related information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgements, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC.