In an attempt to evaluate the latent distal renal tubular acidosis (dRTA7) in patients with primary biliary cirrhosis (PBC), and chronic autoimmune hepatitis (CAH), and differences between them in relation to the sodium urinary excretion ([Na]u), thirty four patients divided in two groups were studied. Group A: 17 patients who fulfilled criteria for PBC diagnosis (clinical and humoral evidence antimitochondrial antibody titles of 1/80 or above by indirect immunofluorescence technique, and liver biopsy). Group B: 17 patients who fulfilled criteria for CAH diagnosis (clinical and humoral evidence, antinuclear and smooth muscle antibody titles of 1/80 or above and liver biopsy). Patients with ascitis and/or edema were excluded from the study. Ability to acidify urine was evaluated by gradient between pC02 in urine and blood (U-BpC02) after alkali infusion. Five patients in Group A (29.4%7) and six in Group B(35.2%) had dRTA, (p = 0.49). When analyzing patients with dRTA in both groups, the mean [Na]u in Group A was 152.2 +/- 33.8, versus 50.8 +/- 8.1 mEq/l, in Group B. (p = 0.00016). We concluded that the prevalence of dRTA was similar in patients with PBC and CAH but the urinary acidifications impairment of the former did not correlate with [Na]u, as it did with the latter.
Acidosis, Renal Tubular/etiology , Autoimmune Diseases/complications , Hepatitis/diagnosis , Liver Cirrhosis, Biliary/complications , Acidosis, Renal Tubular/urine , Adult , Autoimmune Diseases/urine , Chronic Disease , Female , Hepatitis/urine , Humans , Liver Cirrhosis, Biliary/urine , Male , Middle Aged
In an attempt to evaluate the latent distal renal tubular acidosis (dRTA7) in patients with primary biliary cirrhosis (PBC), and chronic autoinmmune hepatitis (CAH), and differences between them in relation to the sodium urinary excretion ([a]u), thirty four patients divided in two groups were studied. Group A: 17 patients who fullfilled criteria for PBC diagnosis (clinical and humoral and liver biopsy). Group B: 17 patients who fullfilled criteria for CAH diagnosis (clinical and humoral evidence, antinuclear and smooth muscle antibody tiles of 1/80 or above and liver biopsy). Patients with ascitis and/or edema were excluded form the study. Ability to acidify urine was evaluated by gradient between pCO2 in urine and blood (U-BpC02) after alkali infusion. Five patients with dRTA in both groups, the mean [Na]u in Group A was 152.2 ñ 33.8, versus 50.8 ñ 8.1 mEq/l, in Group B. (p=0.00016). We concluded that the prevalence of dRTA was similar en patiens with PBC and CAH but the urinary acidifications impairment of the former did not correlate with [Na]u, as it did whit the latter (AU)
Comparative Study , Humans , Male , Female , Adult , Middle Aged , Acidosis, Renal Tubular/urine , Liver Cirrhosis, Biliary/diagnosis , Autoimmune Diseases/diagnosis , Hepatitis/diagnosis , Liver Cirrhosis, Biliary/urine , Autoimmune Diseases/urine , Kidney Tubules, Distal/metabolism , Philippines , Carbon Dioxide/analysis , Sodium/urine , Chronic Disease , Fluorescent Antibody Technique , Hepatitis/urine
In an attempt to evaluate the latent distal renal tubular acidosis (dRTA7) in patients with primary biliary cirrhosis (PBC), and chronic autoimmune hepatitis (CAH), and differences between them in relation to the sodium urinary excretion ([Na]u), thirty four patients divided in two groups were studied. Group A: 17 patients who fulfilled criteria for PBC diagnosis (clinical and humoral evidence antimitochondrial antibody titles of 1/80 or above by indirect immunofluorescence technique, and liver biopsy). Group B: 17 patients who fulfilled criteria for CAH diagnosis (clinical and humoral evidence, antinuclear and smooth muscle antibody titles of 1/80 or above and liver biopsy). Patients with ascitis and/or edema were excluded from the study. Ability to acidify urine was evaluated by gradient between pC02 in urine and blood (U-BpC02) after alkali infusion. Five patients in Group A (29.4
7) and six in Group B(35.2
) had dRTA, (p = 0.49). When analyzing patients with dRTA in both groups, the mean [Na]u in Group A was 152.2 +/- 33.8, versus 50.8 +/- 8.1 mEq/l, in Group B. (p = 0.00016). We concluded that the prevalence of dRTA was similar in patients with PBC and CAH but the urinary acidifications impairment of the former did not correlate with [Na]u, as it did with the latter.
In an attempt to evaluate the latent distal renal tubular acidosis (dRTA7) in patients with primary biliary cirrhosis (PBC), and chronic autoinmmune hepatitis (CAH), and differences between them in relation to the sodium urinary excretion ([a]u), thirty four patients divided in two groups were studied. Group A: 17 patients who fullfilled criteria for PBC diagnosis (clinical and humoral and liver biopsy). Group B: 17 patients who fullfilled criteria for CAH diagnosis (clinical and humoral evidence, antinuclear and smooth muscle antibody tiles of 1/80 or above and liver biopsy). Patients with ascitis and/or edema were excluded form the study. Ability to acidify urine was evaluated by gradient between pCO2 in urine and blood (U-BpC02) after alkali infusion. Five patients with dRTA in both groups, the mean [Na]u in Group A was 152.2 ñ 33.8, versus 50.8 ñ 8.1 mEq/l, in Group B. (p=0.00016). We concluded that the prevalence of dRTA was similar en patiens with PBC and CAH but the urinary acidifications impairment of the former did not correlate with [Na]u, as it did whit the latter
Humans , Male , Female , Adult , Middle Aged , Acidosis, Renal Tubular/urine , Autoimmune Diseases/diagnosis , Liver Cirrhosis, Biliary/diagnosis , Hepatitis/diagnosis , Autoimmune Diseases/urine , Chronic Disease , Liver Cirrhosis, Biliary/urine , Carbon Dioxide/analysis , Fluorescent Antibody Technique , Hepatitis/urine , Philippines , Sodium/urine , Kidney Tubules, Distal/metabolism
Se presentan tres pacientes de sexo femenino que sufrieron el síndrome de shok tóxico (TSS) descrito por S. K. Todd en 1978. Una niña de 8 años con una septicemia estafilocóccica a punto de partida de una osteomielitis esternal, tuvo el cuadro dermatológico escarlatiniforme con descamación y compromiso multiorgánico. Después de treinta días de enfermedad se demuestra una nueva colección purulenta en la articulación coxofemoral y una recaída del brote enantemoexantemático con empeoramiento del cuadro clínico general. La peladura fina en el cuerpo y gruesa en manos y pies se repitió. Este fenómeno de recidiva en el curso de la misma enfermedad no lo hemos encontrado descrito en la literatura. El segundo caso corresponde a una paciente de 25 años que tuvo un TSS a punto de partida de una vaginitis purulenta estafocóccica que comenzó con la menstruación en la cual utilizó tampones. El tercer caso 31 años de edad tuvo igual cuadro a punto de partida de una herida quirúrgica infectada con Sthaphylococcus aureus. Los tres casos cumplieron los criterios mayores (temperatura mayor de 38,9-C, hipotensión arterial, eritrodermia con descamación e hiperemia de mucosas) y compromiso de más de tres sistemas padeciendo una enfermedad grave que comenzó una infección por Sthaphylococcus aureus (AU)
Child , Adult , Humans , Female , Shock, Septic/etiology , Staphylococcal Infections , Dermatitis, Exfoliative/complications
Se presentan tres pacientes de sexo femenino que sufrieron el síndrome de shok tóxico (TSS) descrito por S. K. Todd en 1978. Una niña de 8 años con una septicemia estafilocóccica a punto de partida de una osteomielitis esternal, tuvo el cuadro dermatológico escarlatiniforme con descamación y compromiso multiorgánico. Después de treinta días de enfermedad se demuestra una nueva colección purulenta en la articulación coxofemoral y una recaída del brote enantemoexantemático con empeoramiento del cuadro clínico general. La peladura fina en el cuerpo y gruesa en manos y pies se repitió. Este fenómeno de recidiva en el curso de la misma enfermedad no lo hemos encontrado descrito en la literatura. El segundo caso corresponde a una paciente de 25 años que tuvo un TSS a punto de partida de una vaginitis purulenta estafocóccica que comenzó con la menstruación en la cual utilizó tampones. El tercer caso 31 años de edad tuvo igual cuadro a punto de partida de una herida quirúrgica infectada con Sthaphylococcus aureus. Los tres casos cumplieron los criterios mayores (temperatura mayor de 38,9-C, hipotensión arterial, eritrodermia con descamación e hiperemia de mucosas) y compromiso de más de tres sistemas padeciendo una enfermedad grave que comenzó una infección por Sthaphylococcus aureus
Child , Adult , Humans , Female , Shock, Septic/etiology , Staphylococcal Infections , Dermatitis, Exfoliative/complications
