Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Brain Ischemia/chemically induced , Drug Hypersensitivity Syndrome/etiology , Myocardial Ischemia/chemically induced , Sulfasalazine/adverse effects , Adrenal Cortex Hormones/therapeutic use , Aged , Brain Ischemia/diagnostic imaging , Brain Ischemia/drug therapy , Drug Hypersensitivity Syndrome/drug therapy , Female , Humans , Immunoglobulins, Intravenous/therapeutic use , Myocardial Ischemia/diagnostic imaging , Myocardial Ischemia/drug therapy , Spondylarthritis/drug therapy
We report the perioperative management of a patient with pulmonary hypertension under new-generation treatments who underwent laparoscopic surgery. Preoperatively, arterial catheter, central venous line, and transesophageal echocardiography probe were inserted in addition to standard monitoring. Intraoperatively, inhaled nitric oxide was used because of increasing pressure in the right heart chambers related to the Trendelenburg position and the pneumoperitoneum. The operation finally lasted <2 hours without complication. The prognosis of patients with pulmonary hypertension has evolved since the advent of new management strategies. Thorough preoperative assessment and multidisciplinary discussion in a referral center are essential for medical optimization.
Hypertension, Pulmonary/drug therapy , Rectal Prolapse/surgery , Aged , Antihypertensive Agents , Bosentan/therapeutic use , Female , Head-Down Tilt , Humans , Hypertension, Pulmonary/complications , Laparoscopy , Preoperative Care , Tadalafil/therapeutic use , Treatment Outcome
We report a 54-year-old man who presented with abdominal pain and severe hyponatremia a few days after a left lower lobectomy for lung cancer. An abdominal computed tomography scan without contrast showed a bilateral adrenal hemorrhagic infarction, mainly on the right side. Serum sodium level was 113 mmol/L, and cortisol level was 0 microg/L. Anticardiolipin-type antibodies (immunoglobulin G isotype) level was 75 GPL/mL (normal value < 10). With hydrocortisone supplementation and curative doses of low-molecular-weight heparin, the patient recovered progressively and was discharged on postoperative day 17. Final diagnosis was bilateral adrenal gland hemorrhagic necrosis leading to adrenal insufficiency, associated with antiphospholipid syndrome. We discuss the mechanism and the role of the operation in the occurrence of this particularly rare and potentially life-threatening complication. Recommendations to prevent thrombosis in surgical patients who have antiphospholipid antibodies are lacking.
Adrenal Insufficiency/etiology , Antiphospholipid Syndrome/complications , Carcinoma, Squamous Cell/surgery , Lung Neoplasms/surgery , Pneumonectomy , Postoperative Complications , Abdominal Pain/etiology , Adrenal Gland Diseases/etiology , Adrenal Gland Diseases/pathology , Adrenal Glands/blood supply , Carcinoma, Squamous Cell/complications , Humans , Hyponatremia/etiology , Infarction , Lung Neoplasms/complications , Male , Middle Aged
Enzyme-Linked Immunosorbent Assay , Fibrin Fibrinogen Degradation Products/analysis , Inpatients , Medical Futility , Pulmonary Embolism/diagnosis , Venous Thrombosis/diagnosis , Algorithms , Biomarkers/blood , Guideline Adherence , Humans , Practice Guidelines as Topic , Predictive Value of Tests , Pulmonary Embolism/blood , Retrospective Studies , Venous Thrombosis/etiology
Anesthesia, Obstetrical/adverse effects , Anesthesia, Spinal/adverse effects , Anesthetics, Local/adverse effects , Postoperative Complications/etiology , Restless Legs Syndrome/etiology , Adult , Anesthesia, Obstetrical/instrumentation , Anesthesia, Spinal/instrumentation , Anesthetics, Local/administration & dosage , Bupivacaine/administration & dosage , Bupivacaine/adverse effects , Cerebrospinal Fluid , Female , Humans , Male , Mepivacaine/administration & dosage , Mepivacaine/adverse effects , Needles/adverse effects , Postoperative Complications/chemically induced , Postoperative Complications/diagnosis , Pregnancy , Prospective Studies , Punctures/adverse effects , Restless Legs Syndrome/chemically induced , Restless Legs Syndrome/diagnosis