Ionic Conductive Cellulose Mats by Solution Blow Spinning as Substrate and a Dielectric Interstrate Layer for Flexible Electronics.

Renewable cellulose substrates with submicron- and nanoscale structures have revived interest in paper electronics. However, the processes behind their production are still complex and time- and energy-consuming. Besides, the weak electrolytic properties of cellulose with submicron- and nanoscale structures have hindered its application in transistors and integrated circuits with low-voltage operation. Here, we report a simple, low-cost approach to produce flexible ionic conductive cellulose mats using solution blow spinning, which are used both as dielectric interstrate and substrate in low-voltage devices. The electrochemical properties of the cellulose mats are tuned through infiltration with alkali hydroxides (LiOH, NaOH, or KOH), enabling their application as dielectric and substrate in flexible, low-voltage, oxide-based field-effect transistors and pencil-drawn resistor-loaded inverters. The transistors exhibit good transistor performances under operation voltage below 2.5 V, and their electrical performance is strictly related to the type of alkali ionic specie incorporated. Devices fabricated on K+-infiltrated cellulose mats present the best characteristics, indicating pure capacitive charging of the semiconductor. The pencil-drawn load resistor inverter presents good dynamic performance. These findings may pave the way for a new generation of low-power, wearable electronics, enabling concepts such as the "Internet of Things".

Anaphylaxis to Agaricus bisporus ingestion.

A 33-year-old male with house dust mite allergic rhinitis and asthma reported an episode of facial and lip angioedema, dyspnea, cough and dysphagia at the age of 25, minutes after eating a mushroom ( Agaricus bisporus ) pizza. He denied any drug intake, hymenoptera stings or other possible triggers, and no identifiable cofactors were present. Since then he avoided all types of mushrooms, however an accidental contact occurred with mushroom sauce that resulted in angioedema of the lip within minutes. The allergy workup included measurements of total IgE and specific IgE to mushroom, and skin prick test to aeroallergens sources, possible food allergen sources and mushroom extract, a prick to prick test with raw and cooked A. bisporus , in addition to a SDS-PAGE and immunoblotting assay. The study revealed a specific IgE to mushroom of 0.76kUA/L positive skin prick test to mushroom extract, and prick to prick test positive to white and brown A. bisporus (raw and cooked). The immunoblotting identified two IgE binding proteins with 10kDa and 27kDa. We report a case of A. bisporus anaphylaxis probably due to primary mushroom sensitization. We detected two IgE-reactive proteins with 10kDa and 27kDa as possible culprit allergens.

Anaphylaxis to Agaricus bisporus ingestion / Anafilaxia por ingestão de Agaricus bisporus

ABSTRACT A 33-year-old male with house dust mite allergic rhinitis and asthma reported an episode of facial and lip angioedema, dyspnea, cough and dysphagia at the age of 25, minutes after eating a mushroom ( Agaricus bisporus ) pizza. He denied any drug intake, hymenoptera stings or other possible triggers, and no identifiable cofactors were present. Since then he avoided all types of mushrooms, however an accidental contact occurred with mushroom sauce that resulted in angioedema of the lip within minutes. The allergy workup included measurements of total IgE and specific IgE to mushroom, and skin prick test to aeroallergens sources, possible food allergen sources and mushroom extract, a prick to prick test with raw and cooked A. bisporus , in addition to a SDS-PAGE and immunoblotting assay. The study revealed a specific IgE to mushroom of 0.76kUA/L positive skin prick test to mushroom extract, and prick to prick test positive to white and brown A. bisporus (raw and cooked). The immunoblotting identified two IgE binding proteins with 10kDa and 27kDa. We report a case of A. bisporus anaphylaxis probably due to primary mushroom sensitization. We detected two IgE-reactive proteins with 10kDa and 27kDa as possible culprit allergens.

RESUMO Paciente do sexo masculino, 33 anos, com asma e rinite alérgica desencadeadas por ácaros, relatou episódio de angioedema facial e labial, dispneia, tosse e disfagia aos 25 anos, minutos após a ingestão de uma pizza de cogumelo ( Agaricus bisporus ). O paciente negou consumo de medicamentos, picadas de himenópteros, ou quaisquer outros possíveis desencadeadores ou cofatores que pudessem estar presentes. Desde então, evita todos os tipos de cogumelos, até a ocorrência de um contato acidental com molho de cogumelo, que resultou em angioedema labial minutos após. O estudo imunoalergológico incluiu doseamento de IgE total e específica para cogumelos, testes cutâneos para aeroalérgenos, possíveis alérgenos alimentares e extrato de cogumelos, teste prick to prick com A. bisporus cru e cozido e teste de SDS-PAGE immunoblotting . O estudo revelou IgE específica para cogumelos de 0,76kUA/L, teste cutâneo positivo para extrato de cogumelos e teste prick to prick positivo para A. bisporus branco e castanho (cru e cozido). O immunoblotting identificou duas proteínas de ligação de IgE, de 10kDa e 27kDa. Relatamos, assim, um caso de anafilaxia por ingestão de A. bisporus , provavelmente explicado por sensibilização primária a cogumelos. Detectamos duas proteínas IgE-reativas de 10kDa e 27kDa como os possíveis alérgenos responsáveis.

Casos de síndrome com polissomia do cromossomo X / Cases of chromosome X polysomy syndrome

Os autores relatam dois casos da síndrome 49,XXXXY e um caso da Síndrome de Klinefelter associada à trissomia do cromossomo 22, atendidos inicialmente no ambulatório de Genética Clínica do Centro de Reabilitação Infantil (Natal, RN) e encaminhados ao Laboratório de Genética Humana, no mesmo centro, para diagnóstico laboratorial. A síndrome XXXXY é uma rara desordem caracterizada por anomalias múltiplas incluindo deficiência mental, hipogonadismo, pronação limitada do cotovelo e outras; esses pacientes são freqüentemente rotulados como tendo uma variação da síndrome de Klinefelter. Neste trabalho são mostradas as diferenças entre o fenótipo e a gravidade das síndromes XXXXY e de Klinefelter, observadando-se maior gravidade na síndrome XXXXY. O reconhecimento precoce do padrão de malformações da síndrome XXXXY e de Klinefelter possibilita as devidas terapias medicamentosas e de reabilitação social, psicológica e fonaudiológica desses pacientes. (AU)

The authors report two cases of the 49 XXXXY syndrome and a case of the Klinefelter syndrome associated with the trissomy of chromosome 22, attended initially in the ambulatory of Clinical Genetics of Centro de Reabilitação Infantil (Natal, RN) and directed to the Laboratory of Human Genetic, in the same center, for laboratorial diagnosis. The XXXXY syndrome is a rare disorder characterized by multiple anomalies including mental retardation, hipogonadism, limited pronation of the elbow and others; these patients are frequently labeled as having a variation of the Klinefelter syndrome. In this work the differences of phenotypes and severity in XXXXY and Klinefelter syndromes are discussed, observing the greater severity in XXXXY syndrome. Early recognition of the standard of malformations of XXXXY syndrome and Klinefelter make possible medical, social, psychological and phonoaudiological therapies of these patients. (AU)

Casos de síndrome com polissomia do cromossomo X / Cases of chromosome X polysomy syndrome

Os autores relatam dois casos da síndrome 49,XXXXY e um caso da Síndrome de Klinefelter associada à trissomia do cromossomo 22, atendidos inicialmente no ambulatório de Genética Clínica do Centro de Reabilitação Infantil (Natal, RN) e encaminhados ao Laboratório de Genética Humana, no mesmo centro, para diagnóstico laboratorial. A síndrome XXXXY é uma rara desordem caracterizada por anomalias múltiplas incluindo deficiência mental, hipogonadismo, pronação limitada do cotovelo e outras; esses pacientes são freqüentemente rotulados como tendo uma variação da síndrome de Klinefelter. Neste trabalho são mostradas as diferenças entre o fenótipo e a gravidade das síndromes XXXXY e de Klinefelter, observadando-se maior gravidade na síndrome XXXXY. O reconhecimento precoce do padrão de malformações da síndrome XXXXY e de Klinefelter possibilita as devidas terapias medicamentosas e de reabilitação social, psicológica e fonaudiológica desses pacientes.

The authors report two cases of the 49 XXXXY syndrome and a case of the Klinefelter syndrome associated with the trissomy of chromosome 22, attended initially in the ambulatory of Clinical Genetics of Centro de Reabilitação Infantil (Natal, RN) and directed to the Laboratory of Human Genetic, in the same center, for laboratorial diagnosis. The XXXXY syndrome is a rare disorder characterized by multiple anomalies including mental retardation, hipogonadism, limited pronation of the elbow and others; these patients are frequently labeled as having a variation of the Klinefelter syndrome. In this work the differences of phenotypes and severity in XXXXY and Klinefelter syndromes are discussed, observing the greater severity in XXXXY syndrome. Early recognition of the standard of malformations of XXXXY syndrome and Klinefelter make possible medical, social, psychological and phonoaudiological therapies of these patients.