Validación de un instrumento sobre conocimiento táctico-ofensivo para jugadores con discapacidad intelectual / Validation of an Instrument on Tactical-Offensive Knowledge for Players with Intellectual Disability

El objetivo de este trabajo se centra en construir y validar una herramienta que permita, de forma fiable, evaluar el conocimiento de base de jugadores con discapacidad intelectual leve en aspectos de táctica ofensiva en FS, permitiendo usarlo como evaluación inicial complementaria que guíe el proceso de entrenamiento. El tamaño muestral fue de 68 jugadores (Medad=27; SDedad=9.06 y Mexperiencia=11.78; SDexperiencia=1,29). Los resultados muestran valores adecuados de consistencia interna y de fiabilidad (α=0.64, ω=0.74, ICC=0.64 y test-retest). De manera complementaria, se realizó un análisis cualitativo, mediante una entrevista colectiva a un grupo de expertos, sobre la utilidad del instrumento en esta población de deportistas. Los resultados permiten establecer una sólida base para el empleo de este instrumento en futuros estudios

The objective of this work is to build and validate a tool that allows, reliably, evaluate the base knowledge of players with mild intellectual impairment in aspects of offensive tactical in FS, so that it can be used as an additional initial evaluation to guide the training process of coaches. The sample size is constituted by 68 subjects (Mage=27; SDage=9.06 y Mexperience=11.78; SDexperience=1,29). The results show satisfactory internal consistency and reliability values (α=0.64, ω=0.74, ICC=0.64 and test-retest). In a complementary manner, a qualitative analysis was carried out, through a collective interview with a group of experts, about the utility of the instrument in this population of athletes. The results allow to establish a solid base for the use of this instrument in future studies

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.

AIM: The long pentraxin PTX3 plays a non-redundant role during acute myocardial infarction, atherosclerosis and in the orchestration of tissue repair and remodeling during vascular injury, clotting and fibrin deposition. The aim of this work is to investigate the molecular mechanisms underlying the protective role of PTX3 during arterial thrombosis. METHODS AND RESULTS: PTX3 KO mice transplanted with bone marrow from WT or PTX3 KO mice presented a significant reduction in carotid artery blood flow following FeCl3 induced arterial thrombosis (-80.36±11.5% and -95.53±4.46%), while in WT mice transplanted with bone marrow from either WT or PTX3 KO mice, the reduction was less dramatic (-45.55±1.37% and -53.39±9.8%), thus pointing to a protective effect independent of a hematopoietic cell's derived PTX3. By using P-selectin/PTX3 double KO mice, we further excluded a role for P-selectin, a target of PTX3 released by neutrophils, in vascular protection played by PTX3. In agreement with a minor role for hematopoietic cell-derived PTX3, platelet activation (assessed by flow cytometric expression of markers of platelet activation) was similar in PTX3 KO and WT mice as were haemostatic properties. Histological analysis indicated that PTX3 localizes within the thrombus and the vessel wall, and specific experiments with the N-terminal and the C-terminal PTX3 domain showed the ability of PTX3 to selectively dampen either fibrinogen or collagen induced platelet adhesion and aggregation. CONCLUSION: PTX3 interacts with fibrinogen and collagen and, by dampening their pro-thrombotic effects, plays a protective role during arterial thrombosis.