Backpack loading position and self-selected foot position as measured by foot tracings.

BACKGROUND: It is known that even under static conditions a backpack wearer will need to make some adjustments to maintain postural stability. There is a paucity of research exploring the impact of altering the position of the feet with imposed loads of variable distance from the posterior midline. OBJECTIVE: Therefore, the aim of this study was to determine if changes in the horizontal position of a fixed load when wearing a backpack affect specific variables derived from foot tracings of males and females standing with their self-selected natural feet position. METHODS: 150 healthy volunteer participants were instructed to adopt a natural stance across four conditions: Backpack with no weight, backpack with a weight (5% of body mass) placed at 0 cm, 20 cm, and 40 cm distance from the posterior body. Foot tracings were made for each condition. Base of Support (BoS), Feet Width (FW), and Feet Opening Angle (FOA) were calculated. RESULTS: The BoS significantly decreased in loaded conditions (0 cm, 20 cm and 40 cm) compared to unloaded. This was supported by FW and FOA significant findings that once the load was imposed the response was to approximate the feet and reduce 'toeout'. CONCLUSION: This reaction of people to reduce their BoS in response to added backpack load appears counter intuitive and raises the question of whether this is maladaptive. Clarification by further investigation will inform backpack wearers to counter this instinctive response to load and increase postural stability.

Do key measurement parameters derived from specific cervical vertebral segments differ between lordotic and non-lordotic cervical spine alignments? A study of asymptomatic young adults.

BACKGROUND: Measurement parameters derived from specific cervical vertebral segments (e.g., C2 slope) can provide clinicians with important information on cervical sagittal balance and guide pre- and post-surgical decision-making processes. It is unclear however, what constitutes typical values for these types of measurements in an asymptomatic population of young adults, whether values change depending upon the classification of the cervical spine's global alignment, and if any non-lordotic cervical subtypes display values that are comparable to those reported for pre-surgery patients. METHODS: Neutral lateral cervical radiographs of 150 asymptomatic participants (18-30 years) were taken. Global cervical alignment was classified as lordotic or one of four non-lordotic subtypes using a multi-method subtyping protocol. Four key measurement parameters - the anterior translation of the head measure (ATHM), C0-C2 angle, C2 slope, and C7 slope - were derived from specific cervical segments. Independent samples t-tests were used to compare lordotic and non-lordotic groups. RESULTS: There was considerable variation in the four key measurement parameters amongst this asymptomatic population of young adults. Thirty-four percent of the sample were classified as lordotic and 66% were classified as non-lordotic. There was a significant difference (p ≤ 0.0125) between lordotic and non-lordotic groups for the C0-C2 angle, C2 slope and C7 slope. There was no difference between groups for the ATHM (p ≥ 0.0125). Within the non-lordotic group, the global-kyphotic (GK) subtype had the largest mean C2 slope, largest mean C0-C2 angle, and smallest mean C7 slope. CONCLUSIONS: Long term prospective investigations are required to determine whether possible biomarkers (alignment parameters/radiological measurements) for spinal degenerative changes can be identified so that early interventions can be put in place to try and reduce the impact of neck pain on society.

An investigation of the reproducibility of a self-selected natural feet position when standing: Implications for the assessment of upright standing posture.

BACKGROUND: Photogrammetry is often used to evaluate standing static postural alignment. Patients are often instructed to self-select a natural feet position but it's unclear whether this position can be consistently replicated across repeated assessments. OBJECTIVE: To determine whether people can replicate a self-selected natural feet position in upright standing across three sessions on different days. DESIGN: Between days test-retest reliability. SETTING: University laboratory. METHODS: Three variables - Base of Support (BoS), Foot Width (FW), Feet Opening Angle (FOA) - were measured from foot tracings of 150 participants (18-30 years) using established procedures. BoS data were assessed for systematic bias (Analysis of Variance), and absolute (Coefficient of Variation - CV%) and relative (Intraclass Correlation Coefficient - ICC) reliability. RESULTS: There was systematic bias in the BoS data across the three testing sessions. The CV% for the BoS data was 15.2%. The ICC (95% CI) for the BoS data was 0.84 (0.79-0.87). There were moderate-large correlations between the BoS and both FOA and FW respectively within each session. CONCLUSION: If clinicians want to allow patients to use their self-selected natural feet position for repeated photogrammetric assessment of their static postural alignment it would be better to standardise the position of the feet, for example, by creating a tracing of a patient's self-selected natural feet position.

Testing the association between shoulder pain prevalence and occupational, physical activity, and mental health factors in two generations of Australian adults.

BACKGROUND: Shoulder pain is common among the adult population, but it appears to reduce in prevalence around retirement age. Associations between shoulder pain and work-place exposures, physical activity, or mental health status are unclear and may change with age. This study aimed to determine the prevalence of self-reported shoulder pain in Australian adults across two generations and test the association with occupational factors, physical activity, and mental health. METHODS: In this cross-sectional study we used data from a longitudinal Australian pregnancy cohort (the Raine Study). We analysed data from the children (Gen2) at the 22-year follow-up (N = 1128) and parents (Gen1) at the 26-year follow-up (N = 1098). Data were collected on self-reported shoulder pain, occupational factors (employment status and work description), physical activity, and mental health at the respective follow-ups. Prevalence rates were provided as percentages with 95% confidence intervals. Univariate analysis for group comparisons included chi squared for categorical comparisons. The association of predictor variables and shoulder pain was assessed using logistical regression. RESULTS: In Gen1 31.4% of adults aged 40-80 reported the presence of shoulder pain in the last month, with no significant difference between females and males. Gen1 participants younger than 65 reported more shoulder pain (OR[95%CI] = 1.80 [1.04-3.09]). Gen2 females (14.7%) reported shoulder pain in either shoulder more frequently than males (7.7%) and bilateral shoulder pain (8.0%) more frequently than males (1.9%). Gen1 had increased odds of reporting shoulder pain if their work was "physical or heavy manual" compared to "sedentary" (OR [95% CI] = 1.659 [1.185-2.323]) and when categorised with depression (OR [95% CI] = 1.940 [1.386-2.715]) or anxiety (OR [95% CI] = 1.977 [1.368-2.857]). Gen2 participants with depression (OR [95% CI] = 2.356 [1.620-3.427]) or anxiety (OR [95% CI] = 2.003 [1.359-2.952]) reported more shoulder pain. CONCLUSION: Overall, shoulder pain was more prevalent in young females than males and was more prevalent in those under the age of 65. Cross-sectional associations were established between some occupational factors in older adults and depression in all adults, and shoulder pain.

Changing the horizontal position of a fixed backpack load: The effect on postural stability in young adults.

BACKGROUND: Modifying the horizontal position of the load in a backpack will change the size of the external torque it creates on the wearer but the effect on postural stability is unclear. OBJECTIVE: To determine if changing the horizontal position of a fixed backpack load affects postural stability in young adults. METHODS: A backpack was attached to a steel frame with a bar protruding posteriorly. A fixed load (5% body mass) was placed at three distances along the bar - 0 m, 0.20 m, and 0.40 m. Centre of pressure (CoP) derived measurements were recorded from a force platform sampling at 100 Hz. For each condition participants performed three 90s narrow stance trials with their eyes closed whilst standing on a firm surface. A comparison was made across unloaded (no backpack) and loaded conditions. RESULTS: There was an immediate decrease in postural stability when a loaded backpack was worn. Only two of the CoP derived measures (Total Excursion - TEx, and Mean Velocity Total Excursion - MVel TEx) differed between the loaded at 0.20 m and loaded at 0 m conditions. All CoP derived measures differed between the loaded at 0.40 m and loaded at 0 m conditions. Furthermore, three of the CoP derived measures (Anterior/Posterior Root Mean Square - A/P RMSq, TEx, and MVel TEx) differed between the loaded at 0.40 m and loaded at 0.20 m conditions. CONCLUSION: The distribution of a load within a backpack must be carefully considered. The findings for the 0.40 m condition are important for the use and design of large backpacks used by multi-day hikers, travellers, and the military.

The effect of backpack load position on photographic measures of craniovertebral posture in 150 asymptomatic young adults.

BACKGROUND: Altering the horizontal position of the weight in a backpack will influence the magnitude of the external torque it creates but the effect on posture is unclear. OBJECTIVE: To use photogrammetry to determine if changes in the horizontal position of a fixed backpack weight affect external measures of craniovertebral posture in 150 asymptomatic young adults. METHODS: A backpack was attached to a steel frame with a bar protruding posteriorly. A fixed load (5% body mass) was placed at three distances along the bar -0 m, 0.20 m, and 0.40 m. Sagittal and frontal plane photogrammetry was used to measure the craniovertebral angle (CVA), upper cervical gaze angle (UCGA) and lateral head tilt angle (LHTA). A comparison was made across unloaded (no backpack) and loaded conditions. RESULTS: There was a significant decrease in the CVA between unloaded and loaded conditions. Changes in the UCGA were small and, while significant, may not have practical importance. There were no differences in the LHTA between the conditions. CONCLUSIONS: Changes in the horizontal position of a fixed load affect external measures of craniovertebral posture so consideration needs to be given to not only the weight of a backpack but how the weight is positioned within the backpack.

Internal and external sagittal craniovertebral alignment: A comparison between radiological and photogrammetric approaches in asymptomatic participants.

BACKGROUND: Photogrammetric measures are a commonly applied, highly reliable tool for appraising craniovertebral postures during clinical assessments, rehabilitation, and research interventions. OBJECTIVE: This study aimed to compare and contrast three external measures of postural alignment (EMPA) using photogrammetric and radiological approaches, and to discuss whether the craniovertebral angle (CVA) reflects the shape of the underlying cervical spine. DESIGN: Cross Sectional Correlation Study. METHOD: Young adults attended three assessment sessions (S1, S2 and S3). S1 involved a standardised photogrammetric protocol. S2 involved radiographic image acquisition. S3 followed the same protocol in S1 but excluded the self-balancing procedure. Each session's EMPA were compared through either paired or independent samples t-tests. The different radiographic cervical subtypes and their corresponding CVAs were assessed. RESULTS: There were no significant differences in any EMPA between the two photogrammetric sessions. The CVA was the only EMPA to show a significant difference between photogrammetric (S3) and radiographic approaches. Cervical subtype variability is present throughout the full CVA range. CONCLUSIONS: Despite the statistically significant difference in the CVA between approaches, the mean difference was small and unlikely to be clinically meaningful. Accordingly, the quantification of EMPA can be undertaken with high levels of precision and reliability using standardised photogrammetric procedures. The CVA, however, does not provide an indication of the shape of the underlying cervical spine. The distinct radiological differences in the inter-segmental orientation of each vertebral motion segment in conjunction with the differences in the overall global cervical alignment, both within and between participants, negate this possibility.

The effect of cervical spine subtypes on center of pressure parameters in a large asymptomatic young adult population.

BACKGROUND: Recent research highlighted that non-lordotic subtypes are common within an asymptomatic population of young adults. The potential mechanisms responsible for the decreased postural control witnessed in healthy participants exhibiting non-lordotic cervical alignment are unclear. RESEARCH QUESTION: Therefore, the aim of this study is to compare and contrast asymptomatic radiographically derived sagittal cervical alignment subtypes with Center of Pressure (CoP) parameters. METHODS: In this cross-sectional study strict asymptomatic inclusion criteria were met by 150 of the original 182 volunteers. All radiographs were assessed using a multi-method subtype system with participants classified into lordotic and non-lordotic groups. Participants performed 90s narrow stance trials with their eyes closed whilst standing on both a firm surface (FS) and compliant surface (CS) (3 trials per surface). CoP parameters were recorded from a force platform sampling at 100 Hz. Nonparametric statistical tests were conducted to assess differences between groups for each surface type and to determine differences in CoP parameters between FS and CS types. RESULTS: Significant differences were found between groups on both surfaces for the anterior to posterior range (FS: p = 0.013; CS: p = 0.023), total excursion (FS: p = 0.029; CS: p = 0.005) and mean velocity of total excursion (FS: p = 0.032; CS: p = 0.004). SIGNIFICANCE: Our data suggest that sagittal plane cervical alignment is a measure capable of distinguishing between the postural control of asymptomatic lordotic and non-lordotic young adult participants on both surfaces types. Furthermore, decreased postural control is present in asymptomatic participants across all non-lordotic subtypes and is not isolated exclusively to those with forward head posture. Consequently, future research endeavours should investigate the clinical significance of these non-lordotic findings in relation to both the potential for early cervical osseous degeneration and the transitional stages of non-specific pain sufferers from previously asymptomatic young adults.

The efficacy of sagittal cervical spine subtyping: Investigating radiological classification methods within 150 asymptomatic participants.

AIMS: The aim of this study is to (1) compare and contrast cervical subtype classification methods within an asymptomatic population, and (2) identify inter-methodological consistencies and describe examples of inconsistencies that have the potential to affect subtype classification and clinical decision-making. METHODS: A total of 150 asymptomatic 18-30-year-old participants met the strict inclusion criteria. An erect neutral lateral radiograph was obtained using standard procedures. The Centroid, modified Takeshima/Herbst methods and the relative rotation angles in cases of nonagreement were used to determine subtype classifications. Cohen's kappa coefficient (κ) was used to assess the level of agreement between the two methods. RESULTS: Nonlordotic classifications represented 66% of the cohort. Subtype classification identified the cohort as, lordosis (51), straight (37), global kyphosis (30), sigmoidal (13), and reverse sigmoidal (RS) (19). Cohen's kappa coefficient indicated that there was only a moderate level of agreement between methods (κ = 0.531). Methodological agreement tended to be higher within the lordotic and global kyphotic subtypes whereas, straight, sigmoidal, and RS subtypes demonstrated less agreement. CONCLUSION: This is the first study of its type to compare and contrast cervical classification methods. Subtypes displaying predominantly extended or flexed segments demonstrated higher levels of agreement. Our findings highlight the need for establishing a standardized multi-method approach to classify sagittal cervical subtypes.

Combined administration of subthreshold doses of the nitric oxide inhibitor, nitro-L-arginine, and muscarinic receptor antagonist, scopolamine, impairs complex maze learning in rats.

Traditionally, research into the neurobiological mechanisms of age-related memory impairments has focused on single neurotransmitter systems. As normal and abnormal age-related declines in memory function probably involve alterations in more than one system, a more effective approach for elucidating underlying neurobiological changes and resulting impairments may be to evaluate the roles of multiple systems simultaneously. This study evaluated the interaction of the cholinergic and nitric oxide systems in rats on acquisition in the 14-unit T-maze. This task requires learning a series of turns to avoid foot shock, and most likely reflects procedural learning. Administration of scopolamine (0.1 mg/kg) or N-nitro-L-arginine methyl ester (30 mg/kg) alone did not impair acquisition, whereas administration of the same doses in combination increased both the latency to complete the maze and number of errors committed. These data suggest that manipulation of learning and memory processes with multiple compounds potentially offers a clinically relevant paradigm for investigating cognitive function in normal and abnormal aging.

Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester.

In a previous study, our laboratory reported that sildenafil citrate, a cyclic nucleotide phosphodiesterase type 5 inhibitor, reversed a learning impairment in rats induced by systemic inhibition of nitric oxide synthase (60 mg/kg, i.p., Nomega-nitro-L-arginine methyl ester; L-NAME). To limit the peripheral effects of L-NAME and further localize the site of action of sildenafil, L-NAME (48 microg, i.c.v.) was infused bilaterally into the lateral cerebral ventricles 30 min prior to maze training. Saline or sildenafil citrate (1.5 or 3.0 mg/kg, i.p.) was administered systemically 15 min before training. Drug injections occurred 24 h after pretraining rats to avoid foot shock on a one-way active avoidance straight runway. Following drug treatment, the rats received 15 training trials on a 14-unit T-maze task that requires learning a complex sequence of turns to avoid mild foot shock. This complex maze paradigm is sensitive to aging and blockade of cholinergic, N-methyl-D-aspartate and nitric oxide signaling systems. Behavioral measures of performance included deviations from the correct pathway (errors), runtime from start to goal (latency), shock frequency and shock duration. Statistical analysis revealed that central infusion of L-NAME impaired maze performance and that sildenafil (3.0 mg/kg) significantly attenuated the impairment. These results suggest that sildenafil citrate may serve as a cognitive enhancer by modulating central nitric oxide/cGMP signal transduction following N-methyl-D-aspartate receptor activation. This pathway has been implicated in age-related cognitive decline and may be a useful target for pharmacological intervention of neurodegenerative disease.