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Food Funct ; 14(22): 10014-10030, 2023 Nov 13.
Artículo en Inglés | MEDLINE | ID: mdl-37840453

RESUMEN

This study investigated the potential benefits of black chokeberry polyphenol (BCP) supplementation on lipopolysaccharide (LPS)-stimulated inflammatory response in RAW264.7 cells and obesity-induced colonic inflammation in a high fat diet (HFD)-fed rat model. Our findings demonstrated that BCP treatment effectively reduced the production of nitric oxide (NO) and pro-inflammatory cytokines (TNF-α, IL-1ß, IL-6, and MCP-1) in LPS-induced RAW264.7 cells and concurrently mitigated oxidative stress by modulating the levels of malondialdehyde (MDA), catalase (CAT), and glutathione peroxidase (GSH-Px) in a dose-dependent manner. Furthermore, BCP supplementation significantly ameliorated HFD-induced obesity, improved glucose tolerance, and reduced systemic inflammation in HFD-fed rats. Notably, BCP treatment suppressed the mRNA expression of pro-inflammatory cytokines and alleviated intestinal barrier dysfunction by regulating the mRNA and protein expression of key tight junction proteins (ZO-1, occludin, and claudin-1), thereby inhibiting colonic inflammation caused by the TLR4/NF-κB signaling pathway. Additionally, BCP treatment altered the composition and function of the gut microbiota, leading to an increase in the total content of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, isobutyric acid, and butyric acid. Collectively, our results highlighted the potential of BCP supplementation as a promising prebiotic strategy for treating obesity-induced colonic inflammation.


Asunto(s)
Microbioma Gastrointestinal , Photinia , Ratas , Animales , FN-kappa B/genética , FN-kappa B/metabolismo , Dieta Alta en Grasa/efectos adversos , Photinia/metabolismo , Receptor Toll-Like 4/genética , Lipopolisacáridos/farmacología , Polifenoles/farmacología , Obesidad/metabolismo , Inflamación/metabolismo , Transducción de Señal , Citocinas/metabolismo , ARN Mensajero
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