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Neurosci Res
; 134: 56-60, 2018 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29246683
RESUMEN
The dentate gyrus (DG) has distinct roles along its dorso-ventral axis. In the mouse, we recently demonstrated that dorsal DG (dDG) stimulation enhances exploratory behavior (Kheirbek et al., 2013). Dopamine (DA) release in the Nucleus Accumbens (NAcc), which belongs to the reward system, could be a key target of dDG mediating this motivation-related behavior. Here, an optogenetic stimulation of either ventral (vDG) or dDG granule cells was coupled with NAcc DA release monitoring using in vivo microdialysis. Only dDG stimulation enhanced NAcc DA release, indicating differential interconnections between dDG and vDG to the reward system.
Asunto(s)
Giro Dentado/citología , Dopamina/metabolismo , Vías Nerviosas/fisiología , Núcleo Accumbens/metabolismo , Optogenética , Transmisión Sináptica/fisiología , Análisis de Varianza , Animales , Channelrhodopsins/genética , Channelrhodopsins/metabolismo , Estimulación Eléctrica , Ratones , Ratones Transgénicos , Microdiálisis , Núcleo Accumbens/citología , Proopiomelanocortina/genética , Proopiomelanocortina/metabolismo , Transmisión Sináptica/genética , Factores de Tiempo
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